TEAD3 (TEA domain transcription factor 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7005
• Gene name: TEA domain transcription factor 3
• Gene symbol: TEAD3
• Synonyms (NCBI Gene): DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5
• Chromosome: 6
• Chromosome location: 6p21.31
• Summary: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorioni

miRNA Show/Hide all (298)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029870	hsa-miR-26b-5p	Microarray	19088304
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT627430	hsa-miR-4487	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT627430	hsa-miR-4487	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT614728	hsa-miR-708-5p	HITS-CLIP	23824327
MIRT614727	hsa-miR-28-5p	HITS-CLIP	23824327
MIRT614726	hsa-miR-3139	HITS-CLIP	23824327
MIRT614725	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT614724	hsa-miR-6165	HITS-CLIP	23824327
MIRT614723	hsa-miR-4468	HITS-CLIP	23824327
MIRT614722	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT614721	hsa-miR-4775	HITS-CLIP	23824327
MIRT614720	hsa-miR-8055	HITS-CLIP	23824327
MIRT614719	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT1417530	hsa-miR-101	CLIP-seq
MIRT1417531	hsa-miR-1207-5p	CLIP-seq
MIRT1417532	hsa-miR-122	CLIP-seq
MIRT1417533	hsa-miR-1224-5p	CLIP-seq
MIRT1417534	hsa-miR-1236	CLIP-seq
MIRT1417535	hsa-miR-1285	CLIP-seq
MIRT1417536	hsa-miR-1304	CLIP-seq
MIRT1417537	hsa-miR-150	CLIP-seq
MIRT1417538	hsa-miR-188-3p	CLIP-seq
MIRT1417539	hsa-miR-2278	CLIP-seq
MIRT1417540	hsa-miR-2861	CLIP-seq
MIRT1417541	hsa-miR-296-5p	CLIP-seq
MIRT1417542	hsa-miR-3064-5p	CLIP-seq
MIRT1417543	hsa-miR-3179	CLIP-seq
MIRT1417544	hsa-miR-3183	CLIP-seq
MIRT1417545	hsa-miR-3187-5p	CLIP-seq
MIRT1417546	hsa-miR-3202	CLIP-seq
MIRT1417547	hsa-miR-3616-3p	CLIP-seq
MIRT1417548	hsa-miR-3652	CLIP-seq
MIRT1417549	hsa-miR-4265	CLIP-seq
MIRT1417550	hsa-miR-4270	CLIP-seq
MIRT1417551	hsa-miR-4279	CLIP-seq
MIRT1417552	hsa-miR-4296	CLIP-seq
MIRT1417553	hsa-miR-4322	CLIP-seq
MIRT1417554	hsa-miR-4417	CLIP-seq
MIRT1417555	hsa-miR-4430	CLIP-seq
MIRT1417556	hsa-miR-4441	CLIP-seq
MIRT1417557	hsa-miR-4476	CLIP-seq
MIRT1417558	hsa-miR-4505	CLIP-seq
MIRT1417559	hsa-miR-4688	CLIP-seq
MIRT1417560	hsa-miR-4713-5p	CLIP-seq
MIRT1417561	hsa-miR-4721	CLIP-seq
MIRT1417562	hsa-miR-4723-3p	CLIP-seq
MIRT1417563	hsa-miR-4736	CLIP-seq
MIRT1417564	hsa-miR-4738-3p	CLIP-seq
MIRT1417565	hsa-miR-4747-5p	CLIP-seq
MIRT1417566	hsa-miR-4751	CLIP-seq
MIRT1417567	hsa-miR-4763-3p	CLIP-seq
MIRT1417568	hsa-miR-4773	CLIP-seq
MIRT1417569	hsa-miR-518a-3p	CLIP-seq
MIRT1417570	hsa-miR-518b	CLIP-seq
MIRT1417571	hsa-miR-518c	CLIP-seq
MIRT1417572	hsa-miR-518d-3p	CLIP-seq
MIRT1417573	hsa-miR-518f	CLIP-seq
MIRT1417574	hsa-miR-532-3p	CLIP-seq
MIRT1417575	hsa-miR-541	CLIP-seq
MIRT1417576	hsa-miR-574-5p	CLIP-seq
MIRT1417577	hsa-miR-612	CLIP-seq
MIRT1417578	hsa-miR-654-5p	CLIP-seq
MIRT1417579	hsa-miR-873	CLIP-seq
MIRT1417580	hsa-miR-942	CLIP-seq
MIRT2125372	hsa-miR-1178	CLIP-seq
MIRT1417531	hsa-miR-1207-5p	CLIP-seq
MIRT2125373	hsa-miR-1915	CLIP-seq
MIRT2125374	hsa-miR-193a-5p	CLIP-seq
MIRT2125375	hsa-miR-2682	CLIP-seq
MIRT1417542	hsa-miR-3064-5p	CLIP-seq
MIRT1417544	hsa-miR-3183	CLIP-seq
MIRT2125376	hsa-miR-3192	CLIP-seq
MIRT1417548	hsa-miR-3652	CLIP-seq
MIRT2125377	hsa-miR-3927	CLIP-seq
MIRT1417549	hsa-miR-4265	CLIP-seq
MIRT1417550	hsa-miR-4270	CLIP-seq
MIRT2125378	hsa-miR-4290	CLIP-seq
MIRT1417552	hsa-miR-4296	CLIP-seq
MIRT2125379	hsa-miR-4300	CLIP-seq
MIRT2125380	hsa-miR-4314	CLIP-seq
MIRT1417553	hsa-miR-4322	CLIP-seq
MIRT1417554	hsa-miR-4417	CLIP-seq
MIRT1417555	hsa-miR-4430	CLIP-seq
MIRT1417556	hsa-miR-4441	CLIP-seq
MIRT2125381	hsa-miR-449c	CLIP-seq
MIRT1417558	hsa-miR-4505	CLIP-seq
MIRT2125382	hsa-miR-4514	CLIP-seq
MIRT2125383	hsa-miR-4646-5p	CLIP-seq
MIRT2125384	hsa-miR-4692	CLIP-seq
MIRT1417562	hsa-miR-4723-3p	CLIP-seq
MIRT1417563	hsa-miR-4736	CLIP-seq
MIRT1417566	hsa-miR-4751	CLIP-seq
MIRT2125385	hsa-miR-4757-5p	CLIP-seq
MIRT1417567	hsa-miR-4763-3p	CLIP-seq
MIRT2125386	hsa-miR-558	CLIP-seq
MIRT2125387	hsa-miR-645	CLIP-seq
MIRT2125388	hsa-miR-920	CLIP-seq
MIRT2125389	hsa-miR-940	CLIP-seq
MIRT1417531	hsa-miR-1207-5p	CLIP-seq
MIRT1417535	hsa-miR-1285	CLIP-seq
MIRT2347577	hsa-miR-1343	CLIP-seq
MIRT1417537	hsa-miR-150	CLIP-seq
MIRT1417538	hsa-miR-188-3p	CLIP-seq
MIRT1417539	hsa-miR-2278	CLIP-seq
MIRT2347578	hsa-miR-3150a-3p	CLIP-seq
MIRT2347579	hsa-miR-3175	CLIP-seq
MIRT1417544	hsa-miR-3183	CLIP-seq
MIRT1417545	hsa-miR-3187-5p	CLIP-seq
MIRT2347580	hsa-miR-3687	CLIP-seq
MIRT2347581	hsa-miR-4438	CLIP-seq
MIRT2347582	hsa-miR-4442	CLIP-seq
MIRT1417558	hsa-miR-4505	CLIP-seq
MIRT1417560	hsa-miR-4713-5p	CLIP-seq
MIRT1417562	hsa-miR-4723-3p	CLIP-seq
MIRT2347583	hsa-miR-4731-5p	CLIP-seq
MIRT1417567	hsa-miR-4763-3p	CLIP-seq
MIRT2347584	hsa-miR-485-5p	CLIP-seq
MIRT2347585	hsa-miR-490-3p	CLIP-seq
MIRT2347586	hsa-miR-491-5p	CLIP-seq
MIRT1417574	hsa-miR-532-3p	CLIP-seq
MIRT1417575	hsa-miR-541	CLIP-seq
MIRT1417577	hsa-miR-612	CLIP-seq
MIRT1417578	hsa-miR-654-5p	CLIP-seq
MIRT2347587	hsa-miR-661	CLIP-seq
MIRT2347588	hsa-miR-939	CLIP-seq
MIRT1417580	hsa-miR-942	CLIP-seq
MIRT1417531	hsa-miR-1207-5p	CLIP-seq
MIRT1417532	hsa-miR-122	CLIP-seq
MIRT1417537	hsa-miR-150	CLIP-seq
MIRT1417538	hsa-miR-188-3p	CLIP-seq
MIRT1417550	hsa-miR-4270	CLIP-seq
MIRT1417556	hsa-miR-4441	CLIP-seq
MIRT1417560	hsa-miR-4713-5p	CLIP-seq
MIRT1417563	hsa-miR-4736	CLIP-seq
MIRT1417567	hsa-miR-4763-3p	CLIP-seq
MIRT1417568	hsa-miR-4773	CLIP-seq
MIRT1417569	hsa-miR-518a-3p	CLIP-seq
MIRT1417570	hsa-miR-518b	CLIP-seq
MIRT1417571	hsa-miR-518c	CLIP-seq
MIRT1417572	hsa-miR-518d-3p	CLIP-seq
MIRT1417573	hsa-miR-518f	CLIP-seq
MIRT1417574	hsa-miR-532-3p	CLIP-seq
MIRT1417576	hsa-miR-574-5p	CLIP-seq
MIRT2433799	hsa-miR-410	CLIP-seq
MIRT2640511	hsa-miR-1207-3p	CLIP-seq
MIRT2640512	hsa-miR-125a-3p	CLIP-seq
MIRT2640513	hsa-miR-1287	CLIP-seq
MIRT2640514	hsa-miR-1293	CLIP-seq
MIRT2640515	hsa-miR-136	CLIP-seq
MIRT2640516	hsa-miR-149	CLIP-seq
MIRT2640517	hsa-miR-214	CLIP-seq
MIRT1417540	hsa-miR-2861	CLIP-seq
MIRT2640518	hsa-miR-3135b	CLIP-seq
MIRT2640519	hsa-miR-3154	CLIP-seq
MIRT1417543	hsa-miR-3179	CLIP-seq
MIRT2640520	hsa-miR-326	CLIP-seq
MIRT2640521	hsa-miR-330-5p	CLIP-seq
MIRT2640522	hsa-miR-361-3p	CLIP-seq
MIRT2640523	hsa-miR-3619-5p	CLIP-seq
MIRT2640524	hsa-miR-3622a-3p	CLIP-seq
MIRT2640525	hsa-miR-3622b-3p	CLIP-seq
MIRT2640526	hsa-miR-3653	CLIP-seq
MIRT2640527	hsa-miR-3658	CLIP-seq
MIRT2640528	hsa-miR-3665	CLIP-seq
MIRT2640529	hsa-miR-3677-5p	CLIP-seq
MIRT2640530	hsa-miR-4287	CLIP-seq
MIRT2125378	hsa-miR-4290	CLIP-seq
MIRT2640531	hsa-miR-4447	CLIP-seq
MIRT2640532	hsa-miR-4455	CLIP-seq
MIRT2640533	hsa-miR-4472	CLIP-seq
MIRT2640534	hsa-miR-4475	CLIP-seq
MIRT2640535	hsa-miR-4483	CLIP-seq
MIRT2640536	hsa-miR-4488	CLIP-seq
MIRT2640537	hsa-miR-4520a-3p	CLIP-seq
MIRT2640538	hsa-miR-4638-3p	CLIP-seq
MIRT2640539	hsa-miR-4641	CLIP-seq
MIRT2640540	hsa-miR-4667-5p	CLIP-seq
MIRT2640541	hsa-miR-4685-3p	CLIP-seq
MIRT2640542	hsa-miR-4694-5p	CLIP-seq
MIRT2640543	hsa-miR-4697-5p	CLIP-seq
MIRT2640544	hsa-miR-4700-5p	CLIP-seq
MIRT2640545	hsa-miR-4701-5p	CLIP-seq
MIRT2640546	hsa-miR-4722-3p	CLIP-seq
MIRT1417564	hsa-miR-4738-3p	CLIP-seq
MIRT2640547	hsa-miR-4780	CLIP-seq
MIRT2640548	hsa-miR-4793-5p	CLIP-seq
MIRT2640549	hsa-miR-552	CLIP-seq
MIRT2640550	hsa-miR-588	CLIP-seq
MIRT2640551	hsa-miR-604	CLIP-seq
MIRT2640552	hsa-miR-609	CLIP-seq
MIRT2640553	hsa-miR-623	CLIP-seq
MIRT2640554	hsa-miR-637	CLIP-seq
MIRT2640555	hsa-miR-647	CLIP-seq
MIRT2347587	hsa-miR-661	CLIP-seq
MIRT2640556	hsa-miR-760	CLIP-seq
MIRT2640557	hsa-miR-761	CLIP-seq
MIRT2640511	hsa-miR-1207-3p	CLIP-seq
MIRT2640513	hsa-miR-1287	CLIP-seq
MIRT2640516	hsa-miR-149	CLIP-seq
MIRT2640517	hsa-miR-214	CLIP-seq
MIRT2692870	hsa-miR-2467-3p	CLIP-seq
MIRT1417540	hsa-miR-2861	CLIP-seq
MIRT2640518	hsa-miR-3135b	CLIP-seq
MIRT2640519	hsa-miR-3154	CLIP-seq
MIRT2692871	hsa-miR-3158-5p	CLIP-seq
MIRT2640520	hsa-miR-326	CLIP-seq
MIRT2640521	hsa-miR-330-5p	CLIP-seq
MIRT2640523	hsa-miR-3619-5p	CLIP-seq
MIRT2640526	hsa-miR-3653	CLIP-seq
MIRT2640527	hsa-miR-3658	CLIP-seq
MIRT2692872	hsa-miR-3678-3p	CLIP-seq
MIRT2692873	hsa-miR-4418	CLIP-seq
MIRT2640532	hsa-miR-4455	CLIP-seq
MIRT2640534	hsa-miR-4475	CLIP-seq
MIRT2640536	hsa-miR-4488	CLIP-seq
MIRT2640537	hsa-miR-4520a-3p	CLIP-seq
MIRT2640538	hsa-miR-4638-3p	CLIP-seq
MIRT2640540	hsa-miR-4667-5p	CLIP-seq
MIRT2640542	hsa-miR-4694-5p	CLIP-seq
MIRT2640543	hsa-miR-4697-5p	CLIP-seq
MIRT2640544	hsa-miR-4700-5p	CLIP-seq
MIRT1417564	hsa-miR-4738-3p	CLIP-seq
MIRT2692874	hsa-miR-509-3-5p	CLIP-seq
MIRT2692875	hsa-miR-509-5p	CLIP-seq
MIRT2640549	hsa-miR-552	CLIP-seq
MIRT2640551	hsa-miR-604	CLIP-seq
MIRT2640552	hsa-miR-609	CLIP-seq
MIRT2640554	hsa-miR-637	CLIP-seq
MIRT2640555	hsa-miR-647	CLIP-seq
MIRT2347587	hsa-miR-661	CLIP-seq
MIRT2640556	hsa-miR-760	CLIP-seq
MIRT2640557	hsa-miR-761	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	18579750, 19324877
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18579750, 19324877, 20211142, 25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9148898
GO:0007565	Process	Female pregnancy	TAS	9148898
GO:0035329	Process	Hippo signaling	IBA
GO:0035329	Process	Hippo signaling	IDA	18579750, 19324877
GO:0035329	Process	Hippo signaling	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048568	Process	Embryonic organ development	IBA
GO:0055059	Process	Asymmetric neuroblast division	IGI	23946438
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	23946438

Other IDs

• MIM: 603170
• HGNC: 11716
• e!Ensembl: ENSG00000007866

Protein

• UniProt ID: Q99594
• Protein name: Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3)
• Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas
• PDB: 5EMW , 7CNL , 7ZJQ , 8P0M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01285	TEA	31 → 100	TEA/ATTS domain	Domain
  PF17725	YBD	223 → 432	YAP binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Preferentially expressed in the placenta.
• Sequence:

  MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL
  SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKD
  KALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKP
  FAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDP
  DTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFW
  ADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVY
  RIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVST
  SEHGAQHHVYKLVKD

• Sequence length: 435

Pathways

KEGG Pathway	Reactome Pathway
Hippo signaling pathway	YAP1- and WWTR1 (TAZ)-stimulated gene expression
Hippo signaling pathway - multiple species	RUNX3 regulates YAP1-mediated transcription

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
INSOMNIA	—	GWAS catalog	30804565, 35835914	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEBER CONGENITAL AMAUROSIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 14	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TEAD4 4 shared pathwaysHippo signaling pathway, Hippo signaling pathway - multiple species, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX3 regulates YAP1-mediated transcription Related via 4 shared pathways including Hippo signaling pathway, Hippo signaling pathway - multiple species. TEAD2 4 shared pathwaysHippo signaling pathway, Hippo signaling pathway - multiple species, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX3 regulates YAP1-mediated transcription Related via 4 shared pathways including Hippo signaling pathway, Hippo signaling pathway - multiple species. TEAD1 4 shared pathwaysHippo signaling pathway, Hippo signaling pathway - multiple species, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX3 regulates YAP1-mediated transcription Related via 4 shared pathways including Hippo signaling pathway, Hippo signaling pathway - multiple species. CCN2 3 shared pathwaysHippo signaling pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX3 regulates YAP1-mediated transcription Related via 3 shared pathways including Hippo signaling pathway, YAP1- and WWTR1 (TAZ)-stimulated gene expression. YAP1 4 shared pathwaysHippo signaling pathway, Hippo signaling pathway - multiple species, YAP1- and WWTR1 (TAZ)-stimulated gene expression, RUNX3 regulates YAP1-mediated transcription Related via 4 shared pathways including Hippo signaling pathway, Hippo signaling pathway - multiple species.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TEAD4	0	[]	4	["Hippo signaling pathway","Hippo signaling pathway - multiple species","YAP1- and WWTR1 (TAZ)-stimulated gene expression","RUNX3 regulates YAP1-mediated transcription"]	0	[]
TEAD2	0	[]	4	["Hippo signaling pathway","Hippo signaling pathway - multiple species","YAP1- and WWTR1 (TAZ)-stimulated gene expression","RUNX3 regulates YAP1-mediated transcription"]	0	[]
TEAD1	0	[]	4	["Hippo signaling pathway","Hippo signaling pathway - multiple species","YAP1- and WWTR1 (TAZ)-stimulated gene expression","RUNX3 regulates YAP1-mediated transcription"]	0	[]
CCN2	0	[]	3	["Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression","RUNX3 regulates YAP1-mediated transcription"]	0	[]
YAP1	0	[]	4	["Hippo signaling pathway","Hippo signaling pathway - multiple species","YAP1- and WWTR1 (TAZ)-stimulated gene expression","RUNX3 regulates YAP1-mediated transcription"]	0	[]

Diseases Linked via Similar Genes

Heart failure Linked via 2 of 5 related genesTEAD4, CCN2 Polycystic ovary syndrome Linked via 2 of 5 related genesTEAD2, YAP1 Alzheimer disease Linked via 2 of 5 related genesTEAD1, YAP1 Atrial fibrillation Linked via 1 of 5 related genesTEAD4 Cancer Linked via 1 of 5 related genesTEAD4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Heart failure	2	["TEAD4","CCN2"]
Polycystic ovary syndrome	2	["TEAD2","YAP1"]
Alzheimer disease	2	["TEAD1","YAP1"]
Atrial fibrillation	1	["TEAD4"]
Cancer	1	["TEAD4"]