Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9755
Gene name	TBK1 binding protein 1
Gene symbol	TBKBP1
Synonyms (NCBI Gene)	ProSAPiP2SINTBAD
Chromosome	17
Chromosome location	17q21.32
Summary	TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

160 Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017616	hsa-miR-335-5p	Microarray	18185580
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414252	hsa-miR-1224-3p	CLIP-seq
MIRT1414253	hsa-miR-1275	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414255	hsa-miR-2467-3p	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414259	hsa-miR-3144-5p	CLIP-seq
MIRT1414260	hsa-miR-3174	CLIP-seq
MIRT1414261	hsa-miR-3191	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT1414263	hsa-miR-3609	CLIP-seq
MIRT1414264	hsa-miR-3659	CLIP-seq
MIRT1414265	hsa-miR-3689a-3p	CLIP-seq
MIRT1414266	hsa-miR-3689c	CLIP-seq
MIRT1414267	hsa-miR-3714	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414271	hsa-miR-3973	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT1414273	hsa-miR-4292	CLIP-seq
MIRT1414274	hsa-miR-4419a	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414277	hsa-miR-4510	CLIP-seq
MIRT1414278	hsa-miR-4640-3p	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414280	hsa-miR-4652-5p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414282	hsa-miR-4658	CLIP-seq
MIRT1414283	hsa-miR-4665-5p	CLIP-seq
MIRT1414284	hsa-miR-4667-5p	CLIP-seq
MIRT1414285	hsa-miR-4690-3p	CLIP-seq
MIRT1414286	hsa-miR-4700-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414288	hsa-miR-4728-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414290	hsa-miR-520g	CLIP-seq
MIRT1414291	hsa-miR-520h	CLIP-seq
MIRT1414292	hsa-miR-548ah	CLIP-seq
MIRT1414293	hsa-miR-548an	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT1414295	hsa-miR-661	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1554480	hsa-miR-148a	CLIP-seq
MIRT1554481	hsa-miR-148b	CLIP-seq
MIRT1554482	hsa-miR-152	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1554483	hsa-miR-3616-3p	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1554484	hsa-miR-4459	CLIP-seq
MIRT1554485	hsa-miR-4688	CLIP-seq
MIRT1554486	hsa-miR-4733-3p	CLIP-seq
MIRT1554487	hsa-miR-4755-3p	CLIP-seq
MIRT1554488	hsa-miR-4761-3p	CLIP-seq
MIRT1554489	hsa-miR-4779	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1554490	hsa-miR-665	CLIP-seq
MIRT2124278	hsa-miR-1286	CLIP-seq
MIRT2124279	hsa-miR-1289	CLIP-seq
MIRT2124280	hsa-miR-1825	CLIP-seq
MIRT2124281	hsa-miR-199a-5p	CLIP-seq
MIRT2124282	hsa-miR-199b-5p	CLIP-seq
MIRT2124283	hsa-miR-28-5p	CLIP-seq
MIRT2124284	hsa-miR-296-3p	CLIP-seq
MIRT2124285	hsa-miR-3139	CLIP-seq
MIRT2124286	hsa-miR-3154	CLIP-seq
MIRT2124287	hsa-miR-3185	CLIP-seq
MIRT2124288	hsa-miR-3190	CLIP-seq
MIRT2124289	hsa-miR-3198	CLIP-seq
MIRT2124290	hsa-miR-3690	CLIP-seq
MIRT2124291	hsa-miR-3909	CLIP-seq
MIRT2124292	hsa-miR-3925-3p	CLIP-seq
MIRT2124293	hsa-miR-3929	CLIP-seq
MIRT2124294	hsa-miR-4254	CLIP-seq
MIRT2124295	hsa-miR-4283	CLIP-seq
MIRT2124296	hsa-miR-4294	CLIP-seq
MIRT2124297	hsa-miR-4309	CLIP-seq
MIRT2124298	hsa-miR-4419b	CLIP-seq
MIRT2124299	hsa-miR-4478	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT2124300	hsa-miR-4722-5p	CLIP-seq
MIRT2124301	hsa-miR-7	CLIP-seq
MIRT2124302	hsa-miR-708	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT2346567	hsa-miR-122	CLIP-seq
MIRT2346568	hsa-miR-1912	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414256	hsa-miR-27a	CLIP-seq
MIRT1414257	hsa-miR-27b	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT2346569	hsa-miR-3127-3p	CLIP-seq
MIRT2346570	hsa-miR-3160-3p	CLIP-seq
MIRT2346571	hsa-miR-3179	CLIP-seq
MIRT1414262	hsa-miR-3192	CLIP-seq
MIRT2346572	hsa-miR-3202	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT2346573	hsa-miR-3919	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT2346574	hsa-miR-3936	CLIP-seq
MIRT1414272	hsa-miR-4260	CLIP-seq
MIRT2346575	hsa-miR-4329	CLIP-seq
MIRT2346576	hsa-miR-4426	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT2346577	hsa-miR-4647	CLIP-seq
MIRT2346578	hsa-miR-4648	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT2346579	hsa-miR-4654	CLIP-seq
MIRT2346580	hsa-miR-4662b	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT2346581	hsa-miR-4747-5p	CLIP-seq
MIRT2346582	hsa-miR-4756-3p	CLIP-seq
MIRT2346583	hsa-miR-4769-5p	CLIP-seq
MIRT2346584	hsa-miR-4786-5p	CLIP-seq
MIRT1414289	hsa-miR-513a-5p	CLIP-seq
MIRT1414294	hsa-miR-574-5p	CLIP-seq
MIRT2346585	hsa-miR-769-5p	CLIP-seq
MIRT2346586	hsa-miR-939	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq
MIRT1414244	hsa-let-7a	CLIP-seq
MIRT1414245	hsa-let-7b	CLIP-seq
MIRT1414246	hsa-let-7c	CLIP-seq
MIRT1414247	hsa-let-7d	CLIP-seq
MIRT1414248	hsa-let-7e	CLIP-seq
MIRT1414249	hsa-let-7f	CLIP-seq
MIRT1414250	hsa-let-7g	CLIP-seq
MIRT1414251	hsa-let-7i	CLIP-seq
MIRT1414254	hsa-miR-202	CLIP-seq
MIRT1414258	hsa-miR-3125	CLIP-seq
MIRT1414268	hsa-miR-3916	CLIP-seq
MIRT1414269	hsa-miR-3921	CLIP-seq
MIRT1414270	hsa-miR-3927	CLIP-seq
MIRT1414275	hsa-miR-4458	CLIP-seq
MIRT1414276	hsa-miR-4500	CLIP-seq
MIRT1414279	hsa-miR-4649-3p	CLIP-seq
MIRT1414281	hsa-miR-4653-5p	CLIP-seq
MIRT1414287	hsa-miR-4714-5p	CLIP-seq
MIRT1414296	hsa-miR-98	CLIP-seq

9 Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	14743216, 17568778, 21903422, 21931555, 27980081, 32707033
GO:0005737	Component	Cytoplasm	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	NAS	21931631
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	21931631
GO:1902554	Component	Serine/threonine protein kinase complex	NAS	21931631

MIM	HGNC	e!Ensembl
608476	30140	ENSG00000198933

A7MCY6

Protein name

TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)

Protein function

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12845	TBD	288 → 342	TBD domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus. {ECO:0000269|PubMed:17568778}.

Sequence

MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLER
ENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKN
KEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAF
SNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEA
RGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTE
LTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPC
PPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPS
CPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQ
AEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTI
RCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDD
ALIKHIDSHLENSKI

Sequence length

615

Interactions

View interactions

KEGG Pathway
RIG-I-like receptor signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	21743469	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	30177863	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	30595370, 36093044, 39067062, 39789286, 41238958	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	22190364	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (6)
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	21743469, 23637848, 25494292, 31523044		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ankylosing spondylitis	Ankylosing Spondylitis	CTD_human_DG	21743469		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma of lung	Lung carcinoma	BEFREE	31792381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Low Tension Glaucoma	Low Tension Glaucoma	BEFREE	23286385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31792381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylitis Ankylosing	Ankylosing spondylitis	Pubtator	23637848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TBKBP1 (TBK1 binding protein 1)

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