SUMF2 (sulfatase modifying factor 2)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25870
• Gene name: Sulfatase modifying factor 2
• Gene symbol: SUMF2
• Synonyms (NCBI Gene): pFGE
• Chromosome: 7
• Chromosome location: 7p11.2
• Summary: The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this rec

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1584599101	A>-	Pathogenic	Intron variant, splice acceptor variant

miRNA Show/Hide all (418)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019274	hsa-miR-148b-3p	Microarray	17612493
MIRT021342	hsa-miR-9-5p	Microarray	17612493
MIRT453091	hsa-miR-302f	PAR-CLIP	20371350
MIRT550164	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT453083	hsa-miR-635	PAR-CLIP	20371350
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT453072	hsa-miR-8085	PAR-CLIP	20371350
MIRT453073	hsa-miR-296-5p	PAR-CLIP	20371350
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT453071	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT453070	hsa-miR-1273e	PAR-CLIP	20371350
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	20371350
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	20371350
MIRT453091	hsa-miR-302f	PAR-CLIP	21572407
MIRT550164	hsa-miR-3922-5p	PAR-CLIP	21572407
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT453083	hsa-miR-635	PAR-CLIP	21572407
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	21572407
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT453078	hsa-miR-7854-3p	PAR-CLIP	21572407
MIRT453077	hsa-miR-6134	PAR-CLIP	21572407
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT453072	hsa-miR-8085	PAR-CLIP	21572407
MIRT453073	hsa-miR-296-5p	PAR-CLIP	21572407
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	21572407
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	21572407
MIRT453071	hsa-miR-561-5p	PAR-CLIP	21572407
MIRT453070	hsa-miR-1273e	PAR-CLIP	21572407
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	21572407
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	21572407
MIRT453077	hsa-miR-6134	PAR-CLIP	23446348
MIRT515024	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515023	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT515022	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT515021	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT515019	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT515020	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT515018	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	23446348
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT515015	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT515014	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT515013	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT515012	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT515011	hsa-miR-3689c	PAR-CLIP	23446348
MIRT515010	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT515008	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT515009	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT515007	hsa-miR-3122	PAR-CLIP	23446348
MIRT515006	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT515005	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT515004	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT453091	hsa-miR-302f	PAR-CLIP	23592263
MIRT453089	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT453088	hsa-miR-3929	PAR-CLIP	23592263
MIRT453087	hsa-miR-4419b	PAR-CLIP	23592263
MIRT453086	hsa-miR-4478	PAR-CLIP	23592263
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT453084	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT453083	hsa-miR-635	PAR-CLIP	23592263
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453080	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT453079	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT453078	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT453077	hsa-miR-6134	PAR-CLIP	23592263
MIRT453076	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT453072	hsa-miR-8085	PAR-CLIP	23592263
MIRT453073	hsa-miR-296-5p	PAR-CLIP	23592263
MIRT453071	hsa-miR-561-5p	PAR-CLIP	23592263
MIRT453070	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	23592263
MIRT453064	hsa-miR-665	PAR-CLIP	23592263
MIRT439510	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439510	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT453091	hsa-miR-302f	PAR-CLIP	20371350
MIRT550164	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT453083	hsa-miR-635	PAR-CLIP	20371350
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	20371350
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	20371350
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT453072	hsa-miR-8085	PAR-CLIP	20371350
MIRT453073	hsa-miR-296-5p	PAR-CLIP	20371350
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	20371350
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	20371350
MIRT453071	hsa-miR-561-5p	PAR-CLIP	20371350
MIRT453070	hsa-miR-1273e	PAR-CLIP	20371350
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	20371350
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	20371350
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	20371350
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	20371350
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	20371350
MIRT453091	hsa-miR-302f	PAR-CLIP	21572407
MIRT550164	hsa-miR-3922-5p	PAR-CLIP	21572407
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT453083	hsa-miR-635	PAR-CLIP	21572407
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	21572407
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT453078	hsa-miR-7854-3p	PAR-CLIP	21572407
MIRT453077	hsa-miR-6134	PAR-CLIP	21572407
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT453072	hsa-miR-8085	PAR-CLIP	21572407
MIRT453073	hsa-miR-296-5p	PAR-CLIP	21572407
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	21572407
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	21572407
MIRT453071	hsa-miR-561-5p	PAR-CLIP	21572407
MIRT453070	hsa-miR-1273e	PAR-CLIP	21572407
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	21572407
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	21572407
MIRT453077	hsa-miR-6134	PAR-CLIP	23446348
MIRT515024	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515023	hsa-miR-7106-5p	PAR-CLIP	23446348
MIRT515022	hsa-miR-149-3p	PAR-CLIP	23446348
MIRT515021	hsa-miR-4728-5p	PAR-CLIP	23446348
MIRT515019	hsa-miR-6785-5p	PAR-CLIP	23446348
MIRT515020	hsa-miR-6883-5p	PAR-CLIP	23446348
MIRT515018	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT515017	hsa-miR-1233-5p	PAR-CLIP	23446348
MIRT515016	hsa-miR-6778-5p	PAR-CLIP	23446348
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT515015	hsa-miR-1273h-5p	PAR-CLIP	23446348
MIRT515014	hsa-miR-30b-3p	PAR-CLIP	23446348
MIRT515013	hsa-miR-3689a-3p	PAR-CLIP	23446348
MIRT515012	hsa-miR-3689b-3p	PAR-CLIP	23446348
MIRT515011	hsa-miR-3689c	PAR-CLIP	23446348
MIRT515010	hsa-miR-6779-5p	PAR-CLIP	23446348
MIRT515008	hsa-miR-6780a-5p	PAR-CLIP	23446348
MIRT515009	hsa-miR-450a-1-3p	PAR-CLIP	23446348
MIRT515007	hsa-miR-3122	PAR-CLIP	23446348
MIRT515006	hsa-miR-3913-5p	PAR-CLIP	23446348
MIRT515005	hsa-miR-887-5p	PAR-CLIP	23446348
MIRT515004	hsa-miR-6513-5p	PAR-CLIP	23446348
MIRT453091	hsa-miR-302f	PAR-CLIP	23592263
MIRT453089	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT453088	hsa-miR-3929	PAR-CLIP	23592263
MIRT453087	hsa-miR-4419b	PAR-CLIP	23592263
MIRT453086	hsa-miR-4478	PAR-CLIP	23592263
MIRT453085	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT453084	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT453083	hsa-miR-635	PAR-CLIP	23592263
MIRT453082	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT453081	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT453080	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT453079	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT453078	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT453077	hsa-miR-6134	PAR-CLIP	23592263
MIRT453076	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT453075	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT453074	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT453072	hsa-miR-8085	PAR-CLIP	23592263
MIRT453073	hsa-miR-296-5p	PAR-CLIP	23592263
MIRT453071	hsa-miR-561-5p	PAR-CLIP	23592263
MIRT453070	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453069	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT453068	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT453067	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT453066	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT453065	hsa-miR-6773-5p	PAR-CLIP	23592263
MIRT453064	hsa-miR-665	PAR-CLIP	23592263
MIRT1403008	hsa-miR-1200	CLIP-seq
MIRT1403009	hsa-miR-1245b-3p	CLIP-seq
MIRT1403010	hsa-miR-1260	CLIP-seq
MIRT1403011	hsa-miR-1260b	CLIP-seq
MIRT1403012	hsa-miR-128	CLIP-seq
MIRT1403013	hsa-miR-1299	CLIP-seq
MIRT1403014	hsa-miR-1304	CLIP-seq
MIRT1403015	hsa-miR-140-3p	CLIP-seq
MIRT1403016	hsa-miR-185	CLIP-seq
MIRT1403017	hsa-miR-188-3p	CLIP-seq
MIRT1403018	hsa-miR-205	CLIP-seq
MIRT1403019	hsa-miR-2114	CLIP-seq
MIRT1403020	hsa-miR-218	CLIP-seq
MIRT1403021	hsa-miR-3121-3p	CLIP-seq
MIRT1403022	hsa-miR-3123	CLIP-seq
MIRT1403023	hsa-miR-3126-5p	CLIP-seq
MIRT1403024	hsa-miR-3140-5p	CLIP-seq
MIRT1403025	hsa-miR-3145-3p	CLIP-seq
MIRT1403026	hsa-miR-3154	CLIP-seq
MIRT1403027	hsa-miR-3156-3p	CLIP-seq
MIRT1403028	hsa-miR-3175	CLIP-seq
MIRT1403029	hsa-miR-3179	CLIP-seq
MIRT1403030	hsa-miR-323-5p	CLIP-seq
MIRT1403031	hsa-miR-346	CLIP-seq
MIRT1403032	hsa-miR-3545-3p	CLIP-seq
MIRT1403033	hsa-miR-3612	CLIP-seq
MIRT1403034	hsa-miR-3620	CLIP-seq
MIRT1403035	hsa-miR-3622b-5p	CLIP-seq
MIRT1403036	hsa-miR-3662	CLIP-seq
MIRT1403037	hsa-miR-3664-3p	CLIP-seq
MIRT1403038	hsa-miR-3925-3p	CLIP-seq
MIRT1403039	hsa-miR-3941	CLIP-seq
MIRT1403040	hsa-miR-3942-3p	CLIP-seq
MIRT1403041	hsa-miR-3977	CLIP-seq
MIRT1403042	hsa-miR-412	CLIP-seq
MIRT1403043	hsa-miR-4257	CLIP-seq
MIRT1403044	hsa-miR-4261	CLIP-seq
MIRT1403045	hsa-miR-4270	CLIP-seq
MIRT1403046	hsa-miR-4288	CLIP-seq
MIRT1403047	hsa-miR-4292	CLIP-seq
MIRT1403048	hsa-miR-4306	CLIP-seq
MIRT1403049	hsa-miR-4307	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT1403051	hsa-miR-4434	CLIP-seq
MIRT1403052	hsa-miR-4441	CLIP-seq
MIRT1403053	hsa-miR-4443	CLIP-seq
MIRT1403054	hsa-miR-4459	CLIP-seq
MIRT1403055	hsa-miR-4516	CLIP-seq
MIRT1403056	hsa-miR-4531	CLIP-seq
MIRT1403057	hsa-miR-4644	CLIP-seq
MIRT1403058	hsa-miR-4645-5p	CLIP-seq
MIRT1403059	hsa-miR-466	CLIP-seq
MIRT1403060	hsa-miR-4662a-5p	CLIP-seq
MIRT1403061	hsa-miR-4666-5p	CLIP-seq
MIRT1403062	hsa-miR-4672	CLIP-seq
MIRT1403063	hsa-miR-4673	CLIP-seq
MIRT1403064	hsa-miR-4676-5p	CLIP-seq
MIRT1403065	hsa-miR-4685-5p	CLIP-seq
MIRT1403066	hsa-miR-4690-5p	CLIP-seq
MIRT1403067	hsa-miR-4716-3p	CLIP-seq
MIRT1403068	hsa-miR-4717-5p	CLIP-seq
MIRT1403069	hsa-miR-4720-3p	CLIP-seq
MIRT1403070	hsa-miR-4723-5p	CLIP-seq
MIRT1403071	hsa-miR-4755-3p	CLIP-seq
MIRT1403072	hsa-miR-4762-3p	CLIP-seq
MIRT1403073	hsa-miR-4768-3p	CLIP-seq
MIRT1403074	hsa-miR-4782-5p	CLIP-seq
MIRT1403075	hsa-miR-4786-5p	CLIP-seq
MIRT1403076	hsa-miR-4802-5p	CLIP-seq
MIRT1403077	hsa-miR-4804-3p	CLIP-seq
MIRT1403078	hsa-miR-499-3p	CLIP-seq
MIRT1403079	hsa-miR-499a-3p	CLIP-seq
MIRT1403080	hsa-miR-510	CLIP-seq
MIRT1403081	hsa-miR-511	CLIP-seq
MIRT1403082	hsa-miR-512-5p	CLIP-seq
MIRT1403083	hsa-miR-516a-3p	CLIP-seq
MIRT1403084	hsa-miR-516b	CLIP-seq
MIRT1403085	hsa-miR-575	CLIP-seq
MIRT1403086	hsa-miR-632	CLIP-seq
MIRT1403087	hsa-miR-636	CLIP-seq
MIRT1403088	hsa-miR-650	CLIP-seq
MIRT1403089	hsa-miR-654-3p	CLIP-seq
MIRT1403090	hsa-miR-758	CLIP-seq
MIRT1403091	hsa-miR-759	CLIP-seq
MIRT1403092	hsa-miR-766	CLIP-seq
MIRT1403093	hsa-miR-876-3p	CLIP-seq
MIRT2120809	hsa-miR-1179	CLIP-seq
MIRT2120810	hsa-miR-1228	CLIP-seq
MIRT1403009	hsa-miR-1245b-3p	CLIP-seq
MIRT2120811	hsa-miR-1285	CLIP-seq
MIRT1403013	hsa-miR-1299	CLIP-seq
MIRT1403014	hsa-miR-1304	CLIP-seq
MIRT1403015	hsa-miR-140-3p	CLIP-seq
MIRT2120812	hsa-miR-150	CLIP-seq
MIRT1403019	hsa-miR-2114	CLIP-seq
MIRT2120813	hsa-miR-2964a-3p	CLIP-seq
MIRT2120814	hsa-miR-3120-3p	CLIP-seq
MIRT1403025	hsa-miR-3145-3p	CLIP-seq
MIRT2120815	hsa-miR-3187-5p	CLIP-seq
MIRT1403037	hsa-miR-3664-3p	CLIP-seq
MIRT2120816	hsa-miR-3667-3p	CLIP-seq
MIRT2120817	hsa-miR-3692	CLIP-seq
MIRT1403041	hsa-miR-3977	CLIP-seq
MIRT1403042	hsa-miR-412	CLIP-seq
MIRT2120818	hsa-miR-4279	CLIP-seq
MIRT2120819	hsa-miR-4422	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT1403054	hsa-miR-4459	CLIP-seq
MIRT2120820	hsa-miR-4713-5p	CLIP-seq
MIRT1403068	hsa-miR-4717-5p	CLIP-seq
MIRT1403072	hsa-miR-4762-3p	CLIP-seq
MIRT1403073	hsa-miR-4768-3p	CLIP-seq
MIRT1403074	hsa-miR-4782-5p	CLIP-seq
MIRT1403075	hsa-miR-4786-5p	CLIP-seq
MIRT1403078	hsa-miR-499-3p	CLIP-seq
MIRT1403079	hsa-miR-499a-3p	CLIP-seq
MIRT1403080	hsa-miR-510	CLIP-seq
MIRT1403081	hsa-miR-511	CLIP-seq
MIRT1403082	hsa-miR-512-5p	CLIP-seq
MIRT1403084	hsa-miR-516b	CLIP-seq
MIRT2120821	hsa-miR-532-3p	CLIP-seq
MIRT2120822	hsa-miR-612	CLIP-seq
MIRT1403015	hsa-miR-140-3p	CLIP-seq
MIRT2342855	hsa-miR-1226	CLIP-seq
MIRT2342856	hsa-miR-1251	CLIP-seq
MIRT2120811	hsa-miR-1285	CLIP-seq
MIRT1403014	hsa-miR-1304	CLIP-seq
MIRT2342857	hsa-miR-148a	CLIP-seq
MIRT2342858	hsa-miR-148b	CLIP-seq
MIRT2342859	hsa-miR-152	CLIP-seq
MIRT2342860	hsa-miR-1825	CLIP-seq
MIRT2120813	hsa-miR-2964a-3p	CLIP-seq
MIRT2120815	hsa-miR-3187-5p	CLIP-seq
MIRT1403037	hsa-miR-3664-3p	CLIP-seq
MIRT2342861	hsa-miR-4293	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT1403054	hsa-miR-4459	CLIP-seq
MIRT2342862	hsa-miR-4537	CLIP-seq
MIRT2342863	hsa-miR-4733-3p	CLIP-seq
MIRT1403073	hsa-miR-4768-3p	CLIP-seq
MIRT1403080	hsa-miR-510	CLIP-seq
MIRT1403082	hsa-miR-512-5p	CLIP-seq
MIRT2342864	hsa-miR-596	CLIP-seq
MIRT2120822	hsa-miR-612	CLIP-seq
MIRT2342865	hsa-miR-661	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT2342855	hsa-miR-1226	CLIP-seq
MIRT2120810	hsa-miR-1228	CLIP-seq
MIRT2342856	hsa-miR-1251	CLIP-seq
MIRT2636675	hsa-miR-1283	CLIP-seq
MIRT2120811	hsa-miR-1285	CLIP-seq
MIRT2342857	hsa-miR-148a	CLIP-seq
MIRT2342858	hsa-miR-148b	CLIP-seq
MIRT2342859	hsa-miR-152	CLIP-seq
MIRT2342860	hsa-miR-1825	CLIP-seq
MIRT2636676	hsa-miR-186	CLIP-seq
MIRT1403019	hsa-miR-2114	CLIP-seq
MIRT2636677	hsa-miR-24	CLIP-seq
MIRT2120813	hsa-miR-2964a-3p	CLIP-seq
MIRT1403025	hsa-miR-3145-3p	CLIP-seq
MIRT2120815	hsa-miR-3187-5p	CLIP-seq
MIRT1403030	hsa-miR-323-5p	CLIP-seq
MIRT2636678	hsa-miR-342-3p	CLIP-seq
MIRT2636679	hsa-miR-34c-3p	CLIP-seq
MIRT2636680	hsa-miR-3613-3p	CLIP-seq
MIRT1403034	hsa-miR-3620	CLIP-seq
MIRT1403035	hsa-miR-3622b-5p	CLIP-seq
MIRT1403037	hsa-miR-3664-3p	CLIP-seq
MIRT2636681	hsa-miR-3919	CLIP-seq
MIRT2636682	hsa-miR-4284	CLIP-seq
MIRT1403047	hsa-miR-4292	CLIP-seq
MIRT2342861	hsa-miR-4293	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT1403054	hsa-miR-4459	CLIP-seq
MIRT2636683	hsa-miR-4476	CLIP-seq
MIRT2342862	hsa-miR-4537	CLIP-seq
MIRT1403058	hsa-miR-4645-5p	CLIP-seq
MIRT1403060	hsa-miR-4662a-5p	CLIP-seq
MIRT1403063	hsa-miR-4673	CLIP-seq
MIRT1403064	hsa-miR-4676-5p	CLIP-seq
MIRT2342863	hsa-miR-4733-3p	CLIP-seq
MIRT1403071	hsa-miR-4755-3p	CLIP-seq
MIRT1403072	hsa-miR-4762-3p	CLIP-seq
MIRT1403073	hsa-miR-4768-3p	CLIP-seq
MIRT1403075	hsa-miR-4786-5p	CLIP-seq
MIRT1403080	hsa-miR-510	CLIP-seq
MIRT1403081	hsa-miR-511	CLIP-seq
MIRT1403082	hsa-miR-512-5p	CLIP-seq
MIRT1403085	hsa-miR-575	CLIP-seq
MIRT2342864	hsa-miR-596	CLIP-seq
MIRT2120822	hsa-miR-612	CLIP-seq
MIRT2342865	hsa-miR-661	CLIP-seq
MIRT1403093	hsa-miR-876-3p	CLIP-seq
MIRT2120810	hsa-miR-1228	CLIP-seq
MIRT2636675	hsa-miR-1283	CLIP-seq
MIRT2120811	hsa-miR-1285	CLIP-seq
MIRT1403014	hsa-miR-1304	CLIP-seq
MIRT2636676	hsa-miR-186	CLIP-seq
MIRT1403019	hsa-miR-2114	CLIP-seq
MIRT2636677	hsa-miR-24	CLIP-seq
MIRT2120813	hsa-miR-2964a-3p	CLIP-seq
MIRT1403025	hsa-miR-3145-3p	CLIP-seq
MIRT2120815	hsa-miR-3187-5p	CLIP-seq
MIRT1403030	hsa-miR-323-5p	CLIP-seq
MIRT2636678	hsa-miR-342-3p	CLIP-seq
MIRT2636679	hsa-miR-34c-3p	CLIP-seq
MIRT2636680	hsa-miR-3613-3p	CLIP-seq
MIRT1403034	hsa-miR-3620	CLIP-seq
MIRT1403035	hsa-miR-3622b-5p	CLIP-seq
MIRT1403037	hsa-miR-3664-3p	CLIP-seq
MIRT2636682	hsa-miR-4284	CLIP-seq
MIRT1403047	hsa-miR-4292	CLIP-seq
MIRT1403050	hsa-miR-4433	CLIP-seq
MIRT1403054	hsa-miR-4459	CLIP-seq
MIRT2636683	hsa-miR-4476	CLIP-seq
MIRT2342862	hsa-miR-4537	CLIP-seq
MIRT1403058	hsa-miR-4645-5p	CLIP-seq
MIRT1403060	hsa-miR-4662a-5p	CLIP-seq
MIRT1403063	hsa-miR-4673	CLIP-seq
MIRT1403064	hsa-miR-4676-5p	CLIP-seq
MIRT1403071	hsa-miR-4755-3p	CLIP-seq
MIRT1403072	hsa-miR-4762-3p	CLIP-seq
MIRT1403073	hsa-miR-4768-3p	CLIP-seq
MIRT1403075	hsa-miR-4786-5p	CLIP-seq
MIRT1403080	hsa-miR-510	CLIP-seq
MIRT1403081	hsa-miR-511	CLIP-seq
MIRT1403082	hsa-miR-512-5p	CLIP-seq
MIRT1403085	hsa-miR-575	CLIP-seq
MIRT2120822	hsa-miR-612	CLIP-seq
MIRT1403093	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15962010, 32814053, 32838362, 33845483, 36217030
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	18266766
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	15962010
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 607940
• HGNC: 20415
• e!Ensembl: ENSG00000129103

Protein

• UniProt ID: Q8NBJ7
• Protein name: Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)
• Protein function: Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|P
• PDB: 1Y4J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03781	FGE-sulfatase	26 → 292	Sulfatase-modifying factor enzyme 1	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta. {ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}.
• Sequence:

  MARHGLPLLPLLSLLVGAWLKLGNGQATSMVQLQGGRFLMGTNSPDSRDGDGPVREATVK
  PFAIDIFPVTNKDFRDFVREKKYRTEAEMFGWSFVFEDFVSDELRNKATQPMKSVLWWLP
  VEKAFWRQPAGPGSGIRERLEHPVLHVSWNDARAYCAWRGKRLPTEEEWEFAARGGLKGQ
  VYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTAS
  PYQAAEQDMRVLRGASWIDTADGSANHRARVTTRMGNTPDSASDNLGFRCAADAGRPPGE
  L

• Sequence length: 301

Pathways

Reactome Pathway

Glycosphingolipid metabolism

The activation of arylsulfatases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Multiple sulfatase deficiency	Pathogenic	rs1584599101	RCV000002797	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUMF2-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (23)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aortic Dissection	Aortic dissection	Pubtator	39738466	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	17510276		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	1975092		★☆☆☆☆ Found in Text Mining only
Central Diabetes Insipidus	Diabetes Insipidus	BEFREE	19755166		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31445671		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35317099	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	21257989	Associate	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	19024606, 19449044, 21921114, 23105019, 2565081		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	30598261	Associate	★☆☆☆☆ Found in Text Mining only
Cystitis	Cystitis	BEFREE	27130992		★☆☆☆☆ Found in Text Mining only
Guillain-Barre Syndrome	Guillain-Barre Syndrome	BEFREE	16213180		★☆☆☆☆ Found in Text Mining only
Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome	BEFREE	9508303		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	32898862	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	21626145		★☆☆☆☆ Found in Text Mining only
IRAK4 Deficiency	IRAK4 Deficiency	BEFREE	17510276		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	22580916		★☆☆☆☆ Found in Text Mining only
Keratitis	Keratitis	BEFREE	23105019		★☆☆☆☆ Found in Text Mining only
Marfan Syndrome	Marfan Syndrome	BEFREE	16213180		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Facioscapulohumeral	Facioscapulohumeral Muscular Dystrophy	BEFREE	10544225		★☆☆☆☆ Found in Text Mining only
Osteomyelitis	Osteomyelitis	BEFREE	30351268		★☆☆☆☆ Found in Text Mining only
Pharyngitis	Pharyngitis	BEFREE	19279051		★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	10948811		★☆☆☆☆ Found in Text Mining only
Toxic Shock Syndrome	Toxic Shock Syndrome	BEFREE	27902380		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ARSK 2 shared pathwaysGlycosphingolipid metabolism, The activation of arylsulfatases Related via 2 shared pathways including Glycosphingolipid metabolism, The activation of arylsulfatases. ARSI 2 shared pathwaysGlycosphingolipid metabolism, The activation of arylsulfatases Related via 2 shared pathways including Glycosphingolipid metabolism, The activation of arylsulfatases. ARSH 2 shared pathwaysGlycosphingolipid metabolism, The activation of arylsulfatases Related via 2 shared pathways including Glycosphingolipid metabolism, The activation of arylsulfatases. ARSD 2 shared pathwaysGlycosphingolipid metabolism, The activation of arylsulfatases Related via 2 shared pathways including Glycosphingolipid metabolism, The activation of arylsulfatases. ARSL 2 shared pathwaysGlycosphingolipid metabolism, The activation of arylsulfatases Related via 2 shared pathways including Glycosphingolipid metabolism, The activation of arylsulfatases.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ARSK	0	[]	2	["Glycosphingolipid metabolism","The activation of arylsulfatases"]	0	[]
ARSI	0	[]	2	["Glycosphingolipid metabolism","The activation of arylsulfatases"]	0	[]
ARSH	0	[]	2	["Glycosphingolipid metabolism","The activation of arylsulfatases"]	0	[]
ARSD	0	[]	2	["Glycosphingolipid metabolism","The activation of arylsulfatases"]	0	[]
ARSL	0	[]	2	["Glycosphingolipid metabolism","The activation of arylsulfatases"]	0	[]

Diseases Linked via Similar Genes

Autism Linked via 4 of 5 related genesARSK, ARSI, ARSH, ARSL Mucopolysaccharidosis Linked via 1 of 5 related genesARSK Alzheimer disease Linked via 1 of 5 related genesARSI Spastic paraplegia Linked via 1 of 5 related genesARSI Dementia Linked via 1 of 5 related genesARSI

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Autism	4	["ARSK","ARSI","ARSH","ARSL"]
Mucopolysaccharidosis	1	["ARSK"]
Alzheimer disease	1	["ARSI"]
Spastic paraplegia	1	["ARSI"]
Dementia	1	["ARSI"]