STARD9 (StAR related lipid transfer domain containing 9)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57519
• Gene name: StAR related lipid transfer domain containing 9
• Gene symbol: STARD9
• Synonyms (NCBI Gene): KIF16A
• Chromosome: 15
• Chromosome location: 15q15.2

miRNA Show/Hide all (54)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1395598	hsa-let-7a	CLIP-seq
MIRT1395599	hsa-let-7b	CLIP-seq
MIRT1395600	hsa-let-7c	CLIP-seq
MIRT1395601	hsa-let-7d	CLIP-seq
MIRT1395602	hsa-let-7e	CLIP-seq
MIRT1395603	hsa-let-7f	CLIP-seq
MIRT1395604	hsa-let-7g	CLIP-seq
MIRT1395605	hsa-let-7i	CLIP-seq
MIRT1395606	hsa-miR-1301	CLIP-seq
MIRT1395607	hsa-miR-2113	CLIP-seq
MIRT1395608	hsa-miR-2861	CLIP-seq
MIRT1395609	hsa-miR-3125	CLIP-seq
MIRT1395610	hsa-miR-3146	CLIP-seq
MIRT1395611	hsa-miR-3916	CLIP-seq
MIRT1395612	hsa-miR-3927	CLIP-seq
MIRT1395613	hsa-miR-3944-5p	CLIP-seq
MIRT1395614	hsa-miR-4458	CLIP-seq
MIRT1395615	hsa-miR-4468	CLIP-seq
MIRT1395616	hsa-miR-4500	CLIP-seq
MIRT1395617	hsa-miR-4660	CLIP-seq
MIRT1395618	hsa-miR-4773	CLIP-seq
MIRT1395619	hsa-miR-4797-5p	CLIP-seq
MIRT1395620	hsa-miR-5047	CLIP-seq
MIRT1395621	hsa-miR-526b	CLIP-seq
MIRT1395622	hsa-miR-661	CLIP-seq
MIRT1395623	hsa-miR-877	CLIP-seq
MIRT1395624	hsa-miR-98	CLIP-seq
MIRT2118666	hsa-miR-1202	CLIP-seq
MIRT2118667	hsa-miR-22	CLIP-seq
MIRT2118668	hsa-miR-28-5p	CLIP-seq
MIRT2118669	hsa-miR-3139	CLIP-seq
MIRT2118670	hsa-miR-3194-5p	CLIP-seq
MIRT2118671	hsa-miR-3972	CLIP-seq
MIRT2118672	hsa-miR-548a-5p	CLIP-seq
MIRT2118673	hsa-miR-548ab	CLIP-seq
MIRT2118674	hsa-miR-548ak	CLIP-seq
MIRT2118675	hsa-miR-548b-5p	CLIP-seq
MIRT2118676	hsa-miR-548c-5p	CLIP-seq
MIRT2118677	hsa-miR-548d-5p	CLIP-seq
MIRT2118678	hsa-miR-548h	CLIP-seq
MIRT2118679	hsa-miR-548i	CLIP-seq
MIRT2118680	hsa-miR-548j	CLIP-seq
MIRT2118681	hsa-miR-548q	CLIP-seq
MIRT2118682	hsa-miR-548w	CLIP-seq
MIRT2118683	hsa-miR-548y	CLIP-seq
MIRT2118684	hsa-miR-558	CLIP-seq
MIRT2118685	hsa-miR-559	CLIP-seq
MIRT2118686	hsa-miR-708	CLIP-seq
MIRT2340915	hsa-miR-1206	CLIP-seq
MIRT2340916	hsa-miR-3064-3p	CLIP-seq
MIRT2340917	hsa-miR-3157-5p	CLIP-seq
MIRT2340918	hsa-miR-4691-3p	CLIP-seq
MIRT2340919	hsa-miR-4727-5p	CLIP-seq
MIRT2340920	hsa-miR-4769-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IDA	22153075
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	22153075
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22153075
GO:0005737	Component	Cytoplasm	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	22153075
GO:0005814	Component	Centriole	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IDA	22153075
GO:0008017	Function	Microtubule binding	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0051225	Process	Spindle assembly	IBA
GO:0051225	Process	Spindle assembly	IMP	22153075

Other IDs

• MIM: 614642
• HGNC: 19162
• e!Ensembl: ENSG00000159433

Protein

• UniProt ID: Q9P2P6
• Protein name: StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9)
• Protein function: Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	9 → 384	Kinesin motor domain	Domain
  PF00498	FHA	503 → 569	FHA domain	Family
  PF01852	START	4512 → 4696	START domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the central nervous system, muscle cells (heart and skeletal muscle), pancreas, prostate and lung. {ECO:0000269|PubMed:16964419}.
• Sequence:

  MANVQVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFGFD
  YCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPASV
  GLTPRICEGLFVREKDCASLPSSCRIKVSFLEIYNERVRDLLKQSGQKKSYTLRVREHPE
  MGPYVQGLSQHVVTNYKQVIQLLEEGIANRITAATHVHEASSRSHAIFTIHYTQAILENN
  LPSEMASKINLVDLAGSERADPSYCKDRIAEGANINKSLVTLGIVISTLAQNSQVFSSCQ
  SLNSSVSNGGDSGILSSPSGTSSGGAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVAT
  VSPAHTSYSETMSTLRYASSAKNIINKPRVNEDANLKLIRELREEIERLKALLLSFELRN
  FSSLSDENLKELVLQNELKIDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPH
  LMALEDDVLSTGVVLYHLKEGTTKIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLR
  PARGARCTVNGREVTASCRLTQGAVITLGKAQKFRFNHPAEAAVLRQRRQVGEAAAGRGS
  LEWLDLDGDLAASRLGLSPLLWKERRALEEQCDEDHQTPRDGETSHRAQIQQQQSYVEDL
  RHQILAEEIRAAKELEFDQAWISQQIKENQQCLLREETWLASLQQQQQEDQVAEKELEAS
  VALDAWLQTDPEIQPSPFVQSQKRVVHLQLLRRHTLRAAERNVRRKKVSFQLERIIKKQR
  LLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDATVPRPPCRSKLTSCSSLSPQRLCSKH
  MPQLHSIFLSWDPSTTLPPRPDPTHQTSEKTSSEEHLPQAASYPARTGCLRKNGLHSSGH
  GQPCTARAALARKGASAPDACLTMSPNSVGIQEMEMGVKQPHQMVSQGLASLRKSANKLK
  PRHEPKIFTSTTQTRGAKGLADPSHTQAGWRKEGNLGTHKAAKGASCNSLYPHGPRQTAG
  HGKAVKTFWTEYKPPSPSRASKRHQRVLATRVRNITKKSSHLPLGSPLKRQQNTRDPDTM
  VPLTDFSPVMDHSREKDNDLSDTDSNYSLDSLSCVYAKALIEPLKPEERKWDFPEPENSE
  SDDSQLSEDSLAEKRYQSPKNRLGGNRPTNNRGQPRTRTRASVRGFTAASDSDLLAQTHR
  SFSLDSLIDAEEELGEDQQEEPFPGSADEIPTETFWHLEDSSLPVMDQEAICRLGPINYR
  TAARLDAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAESQVEPSYSEQADS
  LQGMQLSRESPLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQEFHSCKGERPGYWPNT
  EELKPSDAETVLPYSSKLHQGSTELLCSARDEHTASAADTSRLSLWGIQRLIQPGADGTF
  QGRCIPDMTQQGSSEASHNSSVSNVLAASATTLTHVGSTHERDWSALQQKYLLELSCPVL
  EAIGAPKPAYPYLEEDSGSLAQASSKGGDTLLPVGPRVSSNLNLNNFPVHLSRIRRLRAE
  KEQDSLNAKLEGVSDFFSTSEKEASYDETYSADLESLSASRSTNAQVFATENAIPDSMTE
  ACEVKQNNLEECLQSCRKPGLMTSSDEDFFQKNACHSNVTTATKADHWSQGWAPLRKNSA
  VQPGQLSPDSHYPLEEEKTDCQESSKEAVRRHINVSFALPSGPELYLHSAPWNPLSSSLQ
  PPLLETFYVTKSRDALTETALEIPACREVRVPSPPPREAWGFGHNHQALQGAYLKNNLPV
  LLQNQNSKIASSQQVTAEIPVDLNTREVIRESGKCPGNITEESHDSVYSSVTQNRHFLPS
  TSTKVCEFENQVVILNKKHSFPALEGGEVTAQSCCGASSDSTESGKSLLFRESEAREEEE
  LDQNTVLRQTINVSLEKDMPGESAVSLKSRSVDRRVSSPVMVAQGGGPTPKWEGKNETGL
  LEKGLRPKDSSEEFKLPGTKPAYERFQLVACPQERNPSECKSQEMLNPNREPSGKKQNKR
  VNNTDEMARLIRSVMQLENGILEIESKQNKQVHASHTPGTDKELVFQDQKEQEKTDHAFR
  PDSSGNPLPSKDQPSSPRQTDDTVFRDSEAGAMEVNSIGNHPQVQKITPNPFRSREGVRE
  SEPVREHTHPAGSDRPARDICDSLGKHTTCREFTNTSLHPQRMKALARALPLQPRLERSS
  KNNGQFVKASASLKGQPWGLGSLEELETVKGFQESQVAEHVSSSNQEEPKAQGKVEEMPM
  QRGGSLQEENKVTQKFPSLSQLCRDTFFRQETVSPLLSRTEFCTAPLHQDLSNTLPLNSP
  RWPRRCLHVPVALGISSLDCVLDLTMLKIHNSPLVTGVEHQDQSTETRSHSPEGNVRGRS
  SEAHTAWCGSVRSMAMGSHSQSGVPESIPLGTEDRISASTSPQDHGKDLRITLLGFSTSE
  DFASEAEVAVQKEIRVSSLNKVSSQPEKRVSFSLEEDSDQASKPRQKAEKETEDVGLTSG
  VSLAPVSLPRVPSPEPRLLEPSDHASMCLAILEEIRQAKAQRKQLHDFVARGTVLSYCET
  LLEPECSSRVAGRPQCKQIDQSSSDQTRNEGEAPGFHVASLSAEAGQIDLLPDERKVQAT
  SLSADSFESLPNTETDREPWDPVQAFSHAAPAQDRKRRTGELRQFAGASEPFICHSSSSE
  IIEKKKDATRTPSSADPLAPDSPRSSAPVEEVRRVVSKKVVAALPSQAPYDDPRVTLHEL
  SQSVPQETAEGIPPGSQDSSPEHQEPRTLDTTYGEVSDNLLVTAQGEKTAHFESQSVTCD
  VQNSTSASGPKQDHVQCPEASTGFEEGRASPKQDTILPGALTRVALEAPTQQCVQCKESV
  GSGLTEVCRAGSKHSRPIPLPDQRPSANPGGIGEEAPCRHPREALDGPVFSRNPEGSRTL
  SPSRGKESRTLPCRQPCSSQPVATHAYSSHSSTLLCFRDGDLGKEPFKAAPHTIHPPCVV
  PSRAYEMDETGEISRGPDVHLTHGLEPKDVNREFRLTESSTCEPSTVAAVLSRAQGCRSP
  SAPDVRTGSFSHSATDGSVGLIGVPEKKVAEKQASTELEAASFPAGMYSEPLRQFRDSSV
  GDQNAQVCQTNPEPPATTQGPHTLDLSEGSAESKLVVEPQHECLENTTRCFLEKPQFSTE
  LRDHNRLDSQAKFVARLKHTCSPQEDSPWQEEEQHRDQASGGGEGFAQGVNPLPDEDGLD
  GCQILDAGREEVAVAKPPVSKILSQGFKDPATVSLRQNETPQPAAQRSGHLYTGREQPAP
  NHRGSLPVTTIFSGPKHSRSSPTPQFSVVGSSRSLQELNLSVEPPSPTDEDTQGPNRLWN
  PHLRGYSSGKSVARTSLQAEDSNQKASSRLDDGTTDHRHLKPATPPYPMPSTLSHMPTPD
  FTTSWMSGTLEQAQQGKREKLGVQVRPENWCSQMDKGMLHFGSSDISPYALPWRPEEPAR
  ISWKQYMSGSAVDVSCSQKPQGLTLSNVARCSSMDNGLEDQNSPFHSHLSTYANICDLST
  THSSTENAQGSNEAWEVFRGSSSIALGDPHIPTSPEGVAPTSGHDRRPQFRGPSGEADCL
  RSKPPLAKGSAAGPVDEIMLLYPSEAGCPVGQTRTNTFEQGTQTLGSRRHWSSTDISFAQ
  PEASAVSAFDLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTKRDIPDKAPQ
  ALMMDGSTQTTVDEGSQTDLTLPTLCLQTSEAEPQGANVILEGLGSDTSTVSQEEGDVPG
  VPQKREAEETAQKMAQLLYLQEESTPYKPQSPSIPSSHLRFQKAPVGQHLPSVSPSVSDA
  FLPPSSQPEESYCLVVSSPSPSSPHSPGLFPSTSEYPGDSRVQKKLGPTSALFVDRASSP
  ILTLSASTQEPGLSPGSLTLSAPSTHPVEGHQKLDSSPDPVDAPRTPMDNYSQTTDELGG
  SQRGRSSLQRSNGRSFLELHSPHSPQQSPKLQFSFLGQHPQQLQPRTTIGVQSRLLPPPL
  RHRSQRLGNSFVPEKVASPEHCPLSGREPSQWQSRTENGGESSASPGEPQRTLDRPSSWG
  GLQHLSPCPVSELTDTAGLRGSALGLPQACQPEELLCFSCQMCMAPEHQHHSLRDLPVHN
  KFSNWCGVQKGSPGGLDMTEEELGASGDLSSEKQEQSPPQPPNDHSQDSEWSKREQIPLQ
  VGAQNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVTSTWKELYARQKKAI
  ETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRREYLQQLRKDVVETT
  RSPESVSRSAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERTEQEKLRIHQKIISQL
  LKEEDKLHTLANSSSLCTSSNGSLSSGMTSGYNSSPALSGQLQFPENMGHTNLPDSRDVW
  IGDERGGHSAVRKNSAYSHRASLGSCCCSPSSLSSLGTCFSSSYQDLAKHVVDTSMADVM
  AACSDNLHNLFSCQATAGWNYQGEEQAVQLYYKVFSPTRHGFLGAGVVSQPLSRVWAAVS
  DPTVWPLYYKPIQTARLHQRVTNSISLVYLVCNTTLCALKQPRDFCCVCVEAKEGHLSVM
  AAQSVYDTSMPRPSRKMVRGEILPSAWILQPITVEGKEVTRVIYLAQVELGAPGFPPQLL
  SSFIKRQPLVIARLASFLGR

• Sequence length: 4700

Pathways

KEGG Pathway:

Motor proteins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (15)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
AORTIC STENOSIS	—	GWAS catalog	38494474	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AORTIC VALVE CALCIFICATION	—	GWAS catalog	38494474	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	association	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	31043756, 33686288, 34002096	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER	—	GWAS catalog	34002096	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR I DISORDER, MOST RECENT EPISODE MANIC	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSION, BIPOLAR	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Global developmental delay	Uncertain significance	ClinVar Disgenet	—	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	33686288	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIXED BIPOLAR I DISORDER	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Seizure	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STARD9-related disorder	Benign; Uncertain significance; Conflicting classifications of pathogenicity; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STARD9-related Intellectual Disability	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	31043756		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	CTD_human_DG	31043756		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depression, Bipolar	Bipolar Disorder	CTD_human_DG	31043756		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	29221444		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	28777490		★☆☆☆☆ Found in Text Mining only
Manic	Manic Disorder	CTD_human_DG	31043756		★☆☆☆☆ Found in Text Mining only
Manic Disorder	Manic Disorder	CTD_human_DG	31043756		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	37373553	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SSC4D 2 shared diseasesAortic stenosis, Aortic valve disease 2 shared evidence sourcesGWAS catalog (Aortic stenosis), GWAS catalog (Aortic valve disease) Related via 2 shared diseases including Aortic stenosis, Aortic valve disease — evidence mostly GWAS catalog. ACTR2 2 shared diseasesAortic stenosis, Aortic valve disease 2 shared evidence sourcesGWAS catalog (Aortic stenosis), GWAS catalog (Aortic valve disease) Related via 2 shared diseases including Aortic stenosis, Aortic valve disease — evidence mostly GWAS catalog. DENND4C 2 shared diseasesAortic stenosis, Aortic valve disease 2 shared evidence sourcesGWAS catalog (Aortic stenosis), GWAS catalog (Aortic valve disease) Related via 2 shared diseases including Aortic stenosis, Aortic valve disease — evidence mostly GWAS catalog. FAM210A 2 shared diseasesAortic stenosis, Aortic valve disease 2 shared evidence sourcesGWAS catalog (Aortic stenosis), GWAS catalog (Aortic valve disease) Related via 2 shared diseases including Aortic stenosis, Aortic valve disease — evidence mostly GWAS catalog. KRR1 2 shared diseasesAortic stenosis, Aortic valve disease 2 shared evidence sourcesGWAS catalog (Aortic stenosis), GWAS catalog (Aortic valve disease) Related via 2 shared diseases including Aortic stenosis, Aortic valve disease — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SSC4D	2	["Aortic stenosis","Aortic valve disease"]	0	[]	2	["GWAS catalog (Aortic stenosis)","GWAS catalog (Aortic valve disease)"]
ACTR2	2	["Aortic stenosis","Aortic valve disease"]	0	[]	2	["GWAS catalog (Aortic stenosis)","GWAS catalog (Aortic valve disease)"]
DENND4C	2	["Aortic stenosis","Aortic valve disease"]	0	[]	2	["GWAS catalog (Aortic stenosis)","GWAS catalog (Aortic valve disease)"]
FAM210A	2	["Aortic stenosis","Aortic valve disease"]	0	[]	2	["GWAS catalog (Aortic stenosis)","GWAS catalog (Aortic valve disease)"]
KRR1	2	["Aortic stenosis","Aortic valve disease"]	0	[]	2	["GWAS catalog (Aortic stenosis)","GWAS catalog (Aortic valve disease)"]

Diseases Linked via Similar Genes

Ankylosing spondylitis Linked via 1 of 5 related genesACTR2 Coronary artery disease Linked via 1 of 5 related genesACTR2 Intellectual developmental disorder Linked via 1 of 5 related genesACTR2 Lung cancer Linked via 1 of 5 related genesACTR2 Schizophrenia Linked via 1 of 5 related genesACTR2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Ankylosing spondylitis	1	["ACTR2"]
Coronary artery disease	1	["ACTR2"]
Intellectual developmental disorder	1	["ACTR2"]
Lung cancer	1	["ACTR2"]
Schizophrenia	1	["ACTR2"]