Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	30815
Gene name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Gene symbol	ST6GALNAC6
Synonyms (NCBI Gene)	SIAT7-FSIAT7FST6GALNACVI
Chromosome	9
Chromosome location	9q34.11
Summary	ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]

149 Show/Hide all (149)

miRTarBase ID	miRNA	Experiments
MIRT1393782	hsa-miR-1207-3p	CLIP-seq
MIRT1393783	hsa-miR-1252	CLIP-seq
MIRT1393784	hsa-miR-3064-5p	CLIP-seq
MIRT1393785	hsa-miR-3184	CLIP-seq
MIRT1393786	hsa-miR-3192	CLIP-seq
MIRT1393787	hsa-miR-329	CLIP-seq
MIRT1393788	hsa-miR-338-3p	CLIP-seq
MIRT1393789	hsa-miR-361-3p	CLIP-seq
MIRT1393790	hsa-miR-362-3p	CLIP-seq
MIRT1393791	hsa-miR-3652	CLIP-seq
MIRT1393792	hsa-miR-423-5p	CLIP-seq
MIRT1393793	hsa-miR-4286	CLIP-seq
MIRT1393794	hsa-miR-4430	CLIP-seq
MIRT1393795	hsa-miR-4489	CLIP-seq
MIRT1393796	hsa-miR-4505	CLIP-seq
MIRT1393797	hsa-miR-4530	CLIP-seq
MIRT1393798	hsa-miR-4722-5p	CLIP-seq
MIRT1393799	hsa-miR-4768-3p	CLIP-seq
MIRT1393800	hsa-miR-508-5p	CLIP-seq
MIRT1393801	hsa-miR-509-3p	CLIP-seq
MIRT1393802	hsa-miR-647	CLIP-seq
MIRT1393803	hsa-miR-759	CLIP-seq
MIRT1393804	hsa-miR-766	CLIP-seq
MIRT1393805	hsa-miR-885-3p	CLIP-seq
MIRT2118219	hsa-miR-1915	CLIP-seq
MIRT1393786	hsa-miR-3192	CLIP-seq
MIRT2118220	hsa-miR-4726-3p	CLIP-seq
MIRT2340203	hsa-miR-106a	CLIP-seq
MIRT2340204	hsa-miR-106b	CLIP-seq
MIRT2340205	hsa-miR-125a-3p	CLIP-seq
MIRT2340206	hsa-miR-1281	CLIP-seq
MIRT2340207	hsa-miR-142-5p	CLIP-seq
MIRT2340208	hsa-miR-17	CLIP-seq
MIRT2340209	hsa-miR-199a-5p	CLIP-seq
MIRT2340210	hsa-miR-199b-5p	CLIP-seq
MIRT2340211	hsa-miR-19a	CLIP-seq
MIRT2340212	hsa-miR-19b	CLIP-seq
MIRT2340213	hsa-miR-20a	CLIP-seq
MIRT2340214	hsa-miR-20b	CLIP-seq
MIRT2340215	hsa-miR-22	CLIP-seq
MIRT2340216	hsa-miR-3176	CLIP-seq
MIRT1393788	hsa-miR-338-3p	CLIP-seq
MIRT2340217	hsa-miR-3609	CLIP-seq
MIRT2340218	hsa-miR-3614-3p	CLIP-seq
MIRT1393791	hsa-miR-3652	CLIP-seq
MIRT2340219	hsa-miR-3920	CLIP-seq
MIRT2340220	hsa-miR-3922-3p	CLIP-seq
MIRT2340221	hsa-miR-4297	CLIP-seq
MIRT2340222	hsa-miR-4302	CLIP-seq
MIRT2340223	hsa-miR-4323	CLIP-seq
MIRT1393794	hsa-miR-4430	CLIP-seq
MIRT2340224	hsa-miR-4484	CLIP-seq
MIRT1393797	hsa-miR-4530	CLIP-seq
MIRT2340225	hsa-miR-4688	CLIP-seq
MIRT2340226	hsa-miR-4691-5p	CLIP-seq
MIRT2340227	hsa-miR-4709-5p	CLIP-seq
MIRT2118220	hsa-miR-4726-3p	CLIP-seq
MIRT2340228	hsa-miR-4757-5p	CLIP-seq
MIRT2340229	hsa-miR-4796-3p	CLIP-seq
MIRT2340230	hsa-miR-4797-5p	CLIP-seq
MIRT2340231	hsa-miR-486-3p	CLIP-seq
MIRT1393800	hsa-miR-508-5p	CLIP-seq
MIRT1393801	hsa-miR-509-3p	CLIP-seq
MIRT2340232	hsa-miR-515-3p	CLIP-seq
MIRT2340233	hsa-miR-519d	CLIP-seq
MIRT2340234	hsa-miR-519e	CLIP-seq
MIRT2340235	hsa-miR-524-3p	CLIP-seq
MIRT2340236	hsa-miR-525-3p	CLIP-seq
MIRT2340237	hsa-miR-548ah	CLIP-seq
MIRT2340238	hsa-miR-550a	CLIP-seq
MIRT2340239	hsa-miR-566	CLIP-seq
MIRT2340240	hsa-miR-648	CLIP-seq
MIRT1393803	hsa-miR-759	CLIP-seq
MIRT1393804	hsa-miR-766	CLIP-seq
MIRT2340241	hsa-miR-93	CLIP-seq
MIRT2118219	hsa-miR-1915	CLIP-seq
MIRT2340215	hsa-miR-22	CLIP-seq
MIRT2340216	hsa-miR-3176	CLIP-seq
MIRT2340220	hsa-miR-3922-3p	CLIP-seq
MIRT2340226	hsa-miR-4691-5p	CLIP-seq
MIRT2118220	hsa-miR-4726-3p	CLIP-seq
MIRT2340228	hsa-miR-4757-5p	CLIP-seq
MIRT2634103	hsa-miR-10a	CLIP-seq
MIRT2634104	hsa-miR-10b	CLIP-seq
MIRT1393782	hsa-miR-1207-3p	CLIP-seq
MIRT2340205	hsa-miR-125a-3p	CLIP-seq
MIRT2340206	hsa-miR-1281	CLIP-seq
MIRT2634105	hsa-miR-1291	CLIP-seq
MIRT2118219	hsa-miR-1915	CLIP-seq
MIRT1393784	hsa-miR-3064-5p	CLIP-seq
MIRT2634106	hsa-miR-3136-5p	CLIP-seq
MIRT2634107	hsa-miR-3148	CLIP-seq
MIRT2634108	hsa-miR-3173-3p	CLIP-seq
MIRT1393785	hsa-miR-3184	CLIP-seq
MIRT2634109	hsa-miR-328	CLIP-seq
MIRT2634110	hsa-miR-3616-3p	CLIP-seq
MIRT2634111	hsa-miR-3658	CLIP-seq
MIRT2634112	hsa-miR-3943	CLIP-seq
MIRT2634113	hsa-miR-3978	CLIP-seq
MIRT1393792	hsa-miR-423-5p	CLIP-seq
MIRT2340223	hsa-miR-4323	CLIP-seq
MIRT2634114	hsa-miR-4419a	CLIP-seq
MIRT2634115	hsa-miR-4436b-3p	CLIP-seq
MIRT2634116	hsa-miR-4439	CLIP-seq
MIRT2340224	hsa-miR-4484	CLIP-seq
MIRT1393795	hsa-miR-4489	CLIP-seq
MIRT2634117	hsa-miR-4510	CLIP-seq
MIRT2634118	hsa-miR-4640-3p	CLIP-seq
MIRT2340225	hsa-miR-4688	CLIP-seq
MIRT2634119	hsa-miR-4695-5p	CLIP-seq
MIRT2340227	hsa-miR-4709-5p	CLIP-seq
MIRT2118220	hsa-miR-4726-3p	CLIP-seq
MIRT2340230	hsa-miR-4797-5p	CLIP-seq
MIRT2340231	hsa-miR-486-3p	CLIP-seq
MIRT1393800	hsa-miR-508-5p	CLIP-seq
MIRT2340235	hsa-miR-524-3p	CLIP-seq
MIRT2340236	hsa-miR-525-3p	CLIP-seq
MIRT2340239	hsa-miR-566	CLIP-seq
MIRT2634120	hsa-miR-671-5p	CLIP-seq
MIRT1393805	hsa-miR-885-3p	CLIP-seq
MIRT2634121	hsa-miR-943	CLIP-seq
MIRT2340205	hsa-miR-125a-3p	CLIP-seq
MIRT2340206	hsa-miR-1281	CLIP-seq
MIRT2634105	hsa-miR-1291	CLIP-seq
MIRT2118219	hsa-miR-1915	CLIP-seq
MIRT2634107	hsa-miR-3148	CLIP-seq
MIRT2634108	hsa-miR-3173-3p	CLIP-seq
MIRT2634109	hsa-miR-328	CLIP-seq
MIRT1393789	hsa-miR-361-3p	CLIP-seq
MIRT2634110	hsa-miR-3616-3p	CLIP-seq
MIRT2634111	hsa-miR-3658	CLIP-seq
MIRT2634112	hsa-miR-3943	CLIP-seq
MIRT2634113	hsa-miR-3978	CLIP-seq
MIRT2340223	hsa-miR-4323	CLIP-seq
MIRT2634114	hsa-miR-4419a	CLIP-seq
MIRT2634115	hsa-miR-4436b-3p	CLIP-seq
MIRT2340224	hsa-miR-4484	CLIP-seq
MIRT2634117	hsa-miR-4510	CLIP-seq
MIRT2340225	hsa-miR-4688	CLIP-seq
MIRT2634119	hsa-miR-4695-5p	CLIP-seq
MIRT2340227	hsa-miR-4709-5p	CLIP-seq
MIRT2118220	hsa-miR-4726-3p	CLIP-seq
MIRT2340230	hsa-miR-4797-5p	CLIP-seq
MIRT2340231	hsa-miR-486-3p	CLIP-seq
MIRT1393800	hsa-miR-508-5p	CLIP-seq
MIRT2340235	hsa-miR-524-3p	CLIP-seq
MIRT2340236	hsa-miR-525-3p	CLIP-seq
MIRT2340239	hsa-miR-566	CLIP-seq
MIRT2634120	hsa-miR-671-5p	CLIP-seq

32 Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IBA
GO:0001574	Process	Ganglioside biosynthetic process	ISS
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	ISS
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	16713569, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	NAS	10702226
GO:0006486	Process	Protein glycosylation	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006672	Process	Ceramide metabolic process	IEA
GO:0006677	Process	Glycosylceramide metabolic process	IDA	17123352
GO:0006687	Process	Glycosphingolipid metabolic process	IDA	17123352
GO:0006688	Process	Glycosphingolipid biosynthetic process	IEA
GO:0006688	Process	Glycosphingolipid biosynthetic process	TAS
GO:0008373	Function	Sialyltransferase activity	IDA	17123352
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	ISS	12668675
GO:0009100	Process	Glycoprotein metabolic process	IDA	17123352
GO:0009311	Process	Oligosaccharide metabolic process	IBA
GO:0009312	Process	Oligosaccharide biosynthetic process	ISS	12668675
GO:0009312	Process	Oligosaccharide biosynthetic process	TAS
GO:0009988	Process	Cell-cell recognition	IC	12668675
GO:0009988	Process	Cell-cell recognition	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10702226
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
610135	23364	ENSG00000160408

Q969X2

Protein name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F)

Protein function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc r

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	60 → 327	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}.

Sequence

MACSRPPSQCEPTSLPPGPPAGRRHLPLSRRRREMSSNKEQRSAVFVILFALITILILYS
SNSANEVFHYGSLRGRSRRPVNLKKWSITDGYVPILGNKTLPSRCHQCVIVSSSSHLLGT
KLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVF
IFWGPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS
WLSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEH
SRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT

Sequence length

333

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glycosphingolipid biosynthesis - ganglio series	Sialic acid metabolism
Metabolic pathways	Lewis blood group biosynthesis

ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6)

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