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Gene Gene information from NCBI Gene database.
Entrez ID 339745
Gene name Speckle type BTB/POZ protein like
Gene symbol SPOPL
Synonyms (NCBI Gene)
BTBD33
Chromosome 2
Chromosome location 2q22.1
miRNA miRNA information provided by mirtarbase database.
601 Show/Hide all (601)
miRTarBase ID miRNA Experiments Reference
MIRT020138 hsa-miR-130b-3p Sequencing 20371350
MIRT027973 hsa-miR-93-5p Sequencing 20371350
MIRT043207 hsa-miR-324-5p CLASH 23622248
MIRT715424 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT203478 hsa-miR-138-2-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22632832, 25416956, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0016567 Process Protein ubiquitination IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6IQ16
Protein name Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2)
Protein function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 190 → 297 BTB/POZ domain Domain
PF00917 MATH 48 → 163 MATH domain Domain
Sequence
MSREPTPPLPGDMSTGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSG
PSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQ
RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSV
VQDSVNISGHTNTNTLK
VPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNR
VEINDLDPEVFKEMMRFIYTGRAPNLDKMADNLLAAADKYALERLKVMCEEALCSNL
SVE
NVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETSGWKSMI
QSHPHLVAEAFRALASAQCPQFGIPRKRLKQS
Sequence length 392
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Hedgehog signaling pathway Hedgehog 'on' state