SPCS2 (signal peptidase complex subunit 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9789
• Gene name: Signal peptidase complex subunit 2
• Gene symbol: SPCS2
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q13.4

miRNA Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051434	hsa-let-7e-5p	CLASH	23622248
MIRT712192	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT712191	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT712190	hsa-miR-8485	HITS-CLIP	19536157
MIRT712189	hsa-miR-603	HITS-CLIP	19536157
MIRT712188	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT712187	hsa-miR-3941	HITS-CLIP	19536157
MIRT712186	hsa-miR-4789-5p	HITS-CLIP	19536157
MIRT712192	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT712191	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT712190	hsa-miR-8485	HITS-CLIP	19536157
MIRT712189	hsa-miR-603	HITS-CLIP	19536157
MIRT712188	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT712187	hsa-miR-3941	HITS-CLIP	19536157
MIRT712186	hsa-miR-4789-5p	HITS-CLIP	19536157
MIRT1383181	hsa-miR-1184	CLIP-seq
MIRT1383182	hsa-miR-1205	CLIP-seq
MIRT1383183	hsa-miR-1246	CLIP-seq
MIRT1383184	hsa-miR-1286	CLIP-seq
MIRT1383185	hsa-miR-1290	CLIP-seq
MIRT1383186	hsa-miR-1323	CLIP-seq
MIRT1383187	hsa-miR-136	CLIP-seq
MIRT1383188	hsa-miR-142-5p	CLIP-seq
MIRT1383189	hsa-miR-194	CLIP-seq
MIRT1383190	hsa-miR-2052	CLIP-seq
MIRT1383191	hsa-miR-221	CLIP-seq
MIRT1383192	hsa-miR-222	CLIP-seq
MIRT1383193	hsa-miR-23a	CLIP-seq
MIRT1383194	hsa-miR-23b	CLIP-seq
MIRT1383195	hsa-miR-23c	CLIP-seq
MIRT1383196	hsa-miR-3136-3p	CLIP-seq
MIRT1383197	hsa-miR-3143	CLIP-seq
MIRT1383198	hsa-miR-3158-5p	CLIP-seq
MIRT1383199	hsa-miR-3160-5p	CLIP-seq
MIRT1383200	hsa-miR-3167	CLIP-seq
MIRT1383201	hsa-miR-3189-3p	CLIP-seq
MIRT1383202	hsa-miR-329	CLIP-seq
MIRT1383203	hsa-miR-340	CLIP-seq
MIRT1383204	hsa-miR-361-3p	CLIP-seq
MIRT1383205	hsa-miR-362-5p	CLIP-seq
MIRT1383206	hsa-miR-3662	CLIP-seq
MIRT1383207	hsa-miR-3667-3p	CLIP-seq
MIRT1383208	hsa-miR-3913-3p	CLIP-seq
MIRT1383209	hsa-miR-410	CLIP-seq
MIRT1383210	hsa-miR-4291	CLIP-seq
MIRT1383211	hsa-miR-4305	CLIP-seq
MIRT1383212	hsa-miR-4428	CLIP-seq
MIRT1383213	hsa-miR-4436a	CLIP-seq
MIRT1383214	hsa-miR-4475	CLIP-seq
MIRT1383215	hsa-miR-4495	CLIP-seq
MIRT1383216	hsa-miR-4514	CLIP-seq
MIRT1383217	hsa-miR-451b	CLIP-seq
MIRT1383218	hsa-miR-4643	CLIP-seq
MIRT1383219	hsa-miR-4687-3p	CLIP-seq
MIRT1383220	hsa-miR-4692	CLIP-seq
MIRT1383221	hsa-miR-4721	CLIP-seq
MIRT1383222	hsa-miR-4722-5p	CLIP-seq
MIRT1383223	hsa-miR-4760-3p	CLIP-seq
MIRT1383224	hsa-miR-4766-3p	CLIP-seq
MIRT1383225	hsa-miR-4768-3p	CLIP-seq
MIRT1383226	hsa-miR-4802-3p	CLIP-seq
MIRT1383227	hsa-miR-490-5p	CLIP-seq
MIRT1383228	hsa-miR-500b	CLIP-seq
MIRT1383229	hsa-miR-5096	CLIP-seq
MIRT1383230	hsa-miR-513a-3p	CLIP-seq
MIRT1383231	hsa-miR-543	CLIP-seq
MIRT1383232	hsa-miR-545	CLIP-seq
MIRT1383233	hsa-miR-548a-3p	CLIP-seq
MIRT1383234	hsa-miR-548c-3p	CLIP-seq
MIRT1383235	hsa-miR-548e	CLIP-seq
MIRT1383236	hsa-miR-548f	CLIP-seq
MIRT1383237	hsa-miR-548o	CLIP-seq
MIRT1383238	hsa-miR-548p	CLIP-seq
MIRT1383239	hsa-miR-548v	CLIP-seq
MIRT1383240	hsa-miR-550b	CLIP-seq
MIRT1383241	hsa-miR-583	CLIP-seq
MIRT1383242	hsa-miR-593	CLIP-seq
MIRT1383243	hsa-miR-607	CLIP-seq
MIRT1383244	hsa-miR-627	CLIP-seq
MIRT1383245	hsa-miR-642b	CLIP-seq
MIRT1383246	hsa-miR-660	CLIP-seq
MIRT1383247	hsa-miR-665	CLIP-seq
MIRT1383248	hsa-miR-876-5p	CLIP-seq
MIRT1383249	hsa-miR-924	CLIP-seq
MIRT2114577	hsa-miR-124	CLIP-seq
MIRT2114578	hsa-miR-203	CLIP-seq
MIRT2114579	hsa-miR-3065-3p	CLIP-seq
MIRT1383206	hsa-miR-3662	CLIP-seq
MIRT1383207	hsa-miR-3667-3p	CLIP-seq
MIRT2114580	hsa-miR-421	CLIP-seq
MIRT2114581	hsa-miR-4264	CLIP-seq
MIRT2114582	hsa-miR-4282	CLIP-seq
MIRT1383210	hsa-miR-4291	CLIP-seq
MIRT1383213	hsa-miR-4436a	CLIP-seq
MIRT2114583	hsa-miR-4450	CLIP-seq
MIRT2114584	hsa-miR-4709-5p	CLIP-seq
MIRT2114585	hsa-miR-4775	CLIP-seq
MIRT2114586	hsa-miR-4797-3p	CLIP-seq
MIRT2114587	hsa-miR-506	CLIP-seq
MIRT1383232	hsa-miR-545	CLIP-seq
MIRT2114588	hsa-miR-548an	CLIP-seq
MIRT2114589	hsa-miR-590-3p	CLIP-seq
MIRT1383244	hsa-miR-627	CLIP-seq
MIRT1383249	hsa-miR-924	CLIP-seq
MIRT2114590	hsa-miR-944	CLIP-seq
MIRT2337460	hsa-miR-1279	CLIP-seq
MIRT1383186	hsa-miR-1323	CLIP-seq
MIRT2114578	hsa-miR-203	CLIP-seq
MIRT2337461	hsa-miR-214	CLIP-seq
MIRT1383197	hsa-miR-3143	CLIP-seq
MIRT2337462	hsa-miR-3148	CLIP-seq
MIRT1383202	hsa-miR-329	CLIP-seq
MIRT2337463	hsa-miR-338-5p	CLIP-seq
MIRT1383204	hsa-miR-361-3p	CLIP-seq
MIRT2337464	hsa-miR-3619-5p	CLIP-seq
MIRT2337465	hsa-miR-3681	CLIP-seq
MIRT1383208	hsa-miR-3913-3p	CLIP-seq
MIRT2337466	hsa-miR-3923	CLIP-seq
MIRT2114580	hsa-miR-421	CLIP-seq
MIRT2337467	hsa-miR-4261	CLIP-seq
MIRT2114582	hsa-miR-4282	CLIP-seq
MIRT1383210	hsa-miR-4291	CLIP-seq
MIRT1383211	hsa-miR-4305	CLIP-seq
MIRT1383212	hsa-miR-4428	CLIP-seq
MIRT1383213	hsa-miR-4436a	CLIP-seq
MIRT2337468	hsa-miR-4452	CLIP-seq
MIRT1383214	hsa-miR-4475	CLIP-seq
MIRT1383215	hsa-miR-4495	CLIP-seq
MIRT2337469	hsa-miR-4496	CLIP-seq
MIRT1383217	hsa-miR-451b	CLIP-seq
MIRT1383218	hsa-miR-4643	CLIP-seq
MIRT2337470	hsa-miR-4680-3p	CLIP-seq
MIRT2114584	hsa-miR-4709-5p	CLIP-seq
MIRT1383221	hsa-miR-4721	CLIP-seq
MIRT1383223	hsa-miR-4760-3p	CLIP-seq
MIRT1383224	hsa-miR-4766-3p	CLIP-seq
MIRT1383225	hsa-miR-4768-3p	CLIP-seq
MIRT2337471	hsa-miR-4789-3p	CLIP-seq
MIRT1383230	hsa-miR-513a-3p	CLIP-seq
MIRT1383231	hsa-miR-543	CLIP-seq
MIRT1383232	hsa-miR-545	CLIP-seq
MIRT1383233	hsa-miR-548a-3p	CLIP-seq
MIRT2337472	hsa-miR-548a-5p	CLIP-seq
MIRT2337473	hsa-miR-548ab	CLIP-seq
MIRT2337474	hsa-miR-548ak	CLIP-seq
MIRT2337475	hsa-miR-548b-5p	CLIP-seq
MIRT2337476	hsa-miR-548c-5p	CLIP-seq
MIRT2337477	hsa-miR-548d-5p	CLIP-seq
MIRT1383235	hsa-miR-548e	CLIP-seq
MIRT1383236	hsa-miR-548f	CLIP-seq
MIRT2337478	hsa-miR-548h	CLIP-seq
MIRT2337479	hsa-miR-548i	CLIP-seq
MIRT2337480	hsa-miR-548j	CLIP-seq
MIRT1383237	hsa-miR-548o	CLIP-seq
MIRT1383238	hsa-miR-548p	CLIP-seq
MIRT2337481	hsa-miR-548w	CLIP-seq
MIRT2337482	hsa-miR-548y	CLIP-seq
MIRT2337483	hsa-miR-559	CLIP-seq
MIRT2337484	hsa-miR-570	CLIP-seq
MIRT1383241	hsa-miR-583	CLIP-seq
MIRT1383245	hsa-miR-642b	CLIP-seq
MIRT1383247	hsa-miR-665	CLIP-seq
MIRT2337485	hsa-miR-761	CLIP-seq
MIRT2337486	hsa-miR-922	CLIP-seq
MIRT1383208	hsa-miR-3913-3p	CLIP-seq
MIRT1383211	hsa-miR-4305	CLIP-seq
MIRT2337460	hsa-miR-1279	CLIP-seq
MIRT1383191	hsa-miR-221	CLIP-seq
MIRT1383192	hsa-miR-222	CLIP-seq
MIRT1383196	hsa-miR-3136-3p	CLIP-seq
MIRT2631032	hsa-miR-3140-5p	CLIP-seq
MIRT1383206	hsa-miR-3662	CLIP-seq
MIRT2337467	hsa-miR-4261	CLIP-seq
MIRT2114582	hsa-miR-4282	CLIP-seq
MIRT2337468	hsa-miR-4452	CLIP-seq
MIRT2337469	hsa-miR-4496	CLIP-seq
MIRT2337470	hsa-miR-4680-3p	CLIP-seq
MIRT2631033	hsa-miR-4709-3p	CLIP-seq
MIRT2114585	hsa-miR-4775	CLIP-seq
MIRT2337471	hsa-miR-4789-3p	CLIP-seq
MIRT1383226	hsa-miR-4802-3p	CLIP-seq
MIRT1383232	hsa-miR-545	CLIP-seq
MIRT1383239	hsa-miR-548v	CLIP-seq
MIRT2114589	hsa-miR-590-3p	CLIP-seq
MIRT1383244	hsa-miR-627	CLIP-seq
MIRT1383249	hsa-miR-924	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	34232536, 34388369
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005787	Component	Signal peptidase complex	IBA
GO:0005787	Component	Signal peptidase complex	IEA
GO:0005787	Component	Signal peptidase complex	IPI	34388369
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	34388369
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006465	Process	Signal peptide processing	IBA
GO:0006465	Process	Signal peptide processing	IDA	34388369
GO:0006465	Process	Signal peptide processing	IEA
GO:0016020	Component	Membrane	IEA
GO:0045047	Process	Protein targeting to ER	IBA

Other IDs

• MIM: 619411
• HGNC: 28962
• e!Ensembl: ENSG00000118363

Protein

• UniProt ID: Q15005
• Protein name: Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)
• Protein function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic acti
• PDB: 7P2P , 7P2Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06703	SPC25	55 → 217	Microsomal signal peptidase 25 kDa subunit (SPC25)	Family

• Sequence:

  MAAAAVQGGRSGGSGGCSGAGGASNCGTGSGRSGLLDKWKIDDKPVKIDKWDGSAVKNSL
  DDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVIS
  YFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGR
  TKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK

• Sequence length: 226

Pathways

KEGG Pathway:

Protein export

Reactome Pathway:

Synthesis, secretion, and deacylation of Ghrelin

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SEC11A 2 shared pathwaysProtein export, Synthesis, secretion, and deacylation of Ghrelin Related via 2 shared pathways including Protein export, Synthesis, secretion, and deacylation of Ghrelin. SPCS1 2 shared pathwaysProtein export, Synthesis, secretion, and deacylation of Ghrelin Related via 2 shared pathways including Protein export, Synthesis, secretion, and deacylation of Ghrelin. SPCS3 2 shared pathwaysProtein export, Synthesis, secretion, and deacylation of Ghrelin Related via 2 shared pathways including Protein export, Synthesis, secretion, and deacylation of Ghrelin. SEC11C 2 shared pathwaysProtein export, Synthesis, secretion, and deacylation of Ghrelin Related via 2 shared pathways including Protein export, Synthesis, secretion, and deacylation of Ghrelin.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SEC11A	0	[]	2	["Protein export","Synthesis, secretion, and deacylation of Ghrelin"]	0	[]
SPCS1	0	[]	2	["Protein export","Synthesis, secretion, and deacylation of Ghrelin"]	0	[]
SPCS3	0	[]	2	["Protein export","Synthesis, secretion, and deacylation of Ghrelin"]	0	[]
SEC11C	0	[]	2	["Protein export","Synthesis, secretion, and deacylation of Ghrelin"]	0	[]

Diseases Linked via Similar Genes

Bipolar disorder Linked via 2 of 4 related genesSEC11A, SPCS3 Hypertrophic cardiomyopathy Linked via 1 of 4 related genesSEC11A Meningioma Linked via 1 of 4 related genesSEC11A Schizophrenia Linked via 1 of 4 related genesSEC11A Attention deficit hyperactivity disorder Linked via 1 of 4 related genesSPCS1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Bipolar disorder	2	["SEC11A","SPCS3"]
Hypertrophic cardiomyopathy	1	["SEC11A"]
Meningioma	1	["SEC11A"]
Schizophrenia	1	["SEC11A"]
Attention deficit hyperactivity disorder	1	["SPCS1"]