Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	22938
Gene name	SNW domain containing 1
Gene symbol	SNW1
Synonyms (NCBI Gene)	Bx42FUN20NCOA-62PRPF45Prp45SKIIPSKIPSKIP1
Chromosome	14
Chromosome location	14q24.3
Summary	This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, ret

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051793	hsa-let-7c-5p	CLASH	23622248
MIRT641538	hsa-miR-4318	HITS-CLIP	23824327
MIRT641537	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT641536	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT641535	hsa-miR-1208	HITS-CLIP	23824327
MIRT641534	hsa-miR-5193	HITS-CLIP	23824327
MIRT641533	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641532	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT641531	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT641530	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT641529	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT641535	hsa-miR-1208	HITS-CLIP	28735896
MIRT641532	hsa-miR-1304-3p	HITS-CLIP	28735896
MIRT641537	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT641538	hsa-miR-4318	HITS-CLIP	28735896
MIRT641531	hsa-miR-4691-5p	HITS-CLIP	28735896
MIRT641534	hsa-miR-5193	HITS-CLIP	28735896
MIRT641533	hsa-miR-660-3p	HITS-CLIP	28735896
MIRT641529	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT641536	hsa-miR-6760-3p	HITS-CLIP	28735896
MIRT641530	hsa-miR-6792-3p	HITS-CLIP	28735896
MIRT641538	hsa-miR-4318	HITS-CLIP	23824327
MIRT641537	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT641536	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT641535	hsa-miR-1208	HITS-CLIP	23824327
MIRT641534	hsa-miR-5193	HITS-CLIP	23824327
MIRT641533	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT641532	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT641531	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT641530	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT641529	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT1376648	hsa-miR-1301	CLIP-seq
MIRT1376649	hsa-miR-2116	CLIP-seq
MIRT1376650	hsa-miR-3145-5p	CLIP-seq
MIRT1376651	hsa-miR-451b	CLIP-seq
MIRT1376652	hsa-miR-4660	CLIP-seq
MIRT1376653	hsa-miR-4677-5p	CLIP-seq
MIRT1376654	hsa-miR-494	CLIP-seq
MIRT1376655	hsa-miR-5047	CLIP-seq
MIRT1376656	hsa-miR-767-5p	CLIP-seq
MIRT2112066	hsa-miR-1273g	CLIP-seq
MIRT2335277	hsa-miR-1207-5p	CLIP-seq
MIRT2335278	hsa-miR-1271	CLIP-seq
MIRT2112066	hsa-miR-1273g	CLIP-seq
MIRT2335279	hsa-miR-1286	CLIP-seq
MIRT1376648	hsa-miR-1301	CLIP-seq
MIRT2335280	hsa-miR-145	CLIP-seq
MIRT2335281	hsa-miR-182	CLIP-seq
MIRT1376649	hsa-miR-2116	CLIP-seq
MIRT2335282	hsa-miR-3941	CLIP-seq
MIRT2335283	hsa-miR-4282	CLIP-seq
MIRT2335284	hsa-miR-4436a	CLIP-seq
MIRT2335285	hsa-miR-4501	CLIP-seq
MIRT2335286	hsa-miR-466	CLIP-seq
MIRT1376652	hsa-miR-4660	CLIP-seq
MIRT2335287	hsa-miR-4672	CLIP-seq
MIRT1376653	hsa-miR-4677-5p	CLIP-seq
MIRT2335288	hsa-miR-4712-5p	CLIP-seq
MIRT2335289	hsa-miR-4731-3p	CLIP-seq
MIRT2335290	hsa-miR-4736	CLIP-seq
MIRT2335291	hsa-miR-4763-3p	CLIP-seq
MIRT2335292	hsa-miR-4801	CLIP-seq
MIRT1376655	hsa-miR-5047	CLIP-seq
MIRT2335293	hsa-miR-600	CLIP-seq
MIRT2335294	hsa-miR-770-5p	CLIP-seq
MIRT2335295	hsa-miR-96	CLIP-seq
MIRT2629260	hsa-miR-103a	CLIP-seq
MIRT2629261	hsa-miR-107	CLIP-seq
MIRT2335277	hsa-miR-1207-5p	CLIP-seq
MIRT2629262	hsa-miR-1270	CLIP-seq
MIRT2335278	hsa-miR-1271	CLIP-seq
MIRT2112066	hsa-miR-1273g	CLIP-seq
MIRT2335279	hsa-miR-1286	CLIP-seq
MIRT2629263	hsa-miR-1298	CLIP-seq
MIRT2335280	hsa-miR-145	CLIP-seq
MIRT2335281	hsa-miR-182	CLIP-seq
MIRT2629264	hsa-miR-185	CLIP-seq
MIRT2629265	hsa-miR-1912	CLIP-seq
MIRT2629266	hsa-miR-296-3p	CLIP-seq
MIRT2629267	hsa-miR-297	CLIP-seq
MIRT2629268	hsa-miR-299-3p	CLIP-seq
MIRT2629269	hsa-miR-3115	CLIP-seq
MIRT1376650	hsa-miR-3145-5p	CLIP-seq
MIRT2629270	hsa-miR-3149	CLIP-seq
MIRT2629271	hsa-miR-3151	CLIP-seq
MIRT2629272	hsa-miR-3545-5p	CLIP-seq
MIRT2629273	hsa-miR-361-3p	CLIP-seq
MIRT2629274	hsa-miR-3679-3p	CLIP-seq
MIRT2629275	hsa-miR-3923	CLIP-seq
MIRT2335282	hsa-miR-3941	CLIP-seq
MIRT2629276	hsa-miR-4255	CLIP-seq
MIRT2335283	hsa-miR-4282	CLIP-seq
MIRT2629277	hsa-miR-4306	CLIP-seq
MIRT2335284	hsa-miR-4436a	CLIP-seq
MIRT2629278	hsa-miR-4447	CLIP-seq
MIRT2629279	hsa-miR-4472	CLIP-seq
MIRT2629280	hsa-miR-4491	CLIP-seq
MIRT2335285	hsa-miR-4501	CLIP-seq
MIRT1376651	hsa-miR-451b	CLIP-seq
MIRT2629281	hsa-miR-4531	CLIP-seq
MIRT2629282	hsa-miR-4644	CLIP-seq
MIRT2629283	hsa-miR-4657	CLIP-seq
MIRT2335286	hsa-miR-466	CLIP-seq
MIRT2335287	hsa-miR-4672	CLIP-seq
MIRT2629284	hsa-miR-4688	CLIP-seq
MIRT2629285	hsa-miR-4711-5p	CLIP-seq
MIRT2335288	hsa-miR-4712-5p	CLIP-seq
MIRT2335289	hsa-miR-4731-3p	CLIP-seq
MIRT2335290	hsa-miR-4736	CLIP-seq
MIRT2335291	hsa-miR-4763-3p	CLIP-seq
MIRT2335292	hsa-miR-4801	CLIP-seq
MIRT2629286	hsa-miR-486-3p	CLIP-seq
MIRT2629287	hsa-miR-491-5p	CLIP-seq
MIRT1376654	hsa-miR-494	CLIP-seq
MIRT2629288	hsa-miR-520d-5p	CLIP-seq
MIRT2629289	hsa-miR-520g	CLIP-seq
MIRT2629290	hsa-miR-520h	CLIP-seq
MIRT2629291	hsa-miR-524-5p	CLIP-seq
MIRT2629292	hsa-miR-548a-5p	CLIP-seq
MIRT2629293	hsa-miR-548ab	CLIP-seq
MIRT2629294	hsa-miR-548ak	CLIP-seq
MIRT2629295	hsa-miR-548b-5p	CLIP-seq
MIRT2629296	hsa-miR-548c-5p	CLIP-seq
MIRT2629297	hsa-miR-548d-5p	CLIP-seq
MIRT2629298	hsa-miR-548h	CLIP-seq
MIRT2629299	hsa-miR-548i	CLIP-seq
MIRT2629300	hsa-miR-548j	CLIP-seq
MIRT2629301	hsa-miR-548n	CLIP-seq
MIRT2629302	hsa-miR-548t	CLIP-seq
MIRT2629303	hsa-miR-548w	CLIP-seq
MIRT2629304	hsa-miR-548y	CLIP-seq
MIRT2629305	hsa-miR-555	CLIP-seq
MIRT2629306	hsa-miR-559	CLIP-seq
MIRT2629307	hsa-miR-567	CLIP-seq
MIRT2629308	hsa-miR-591	CLIP-seq
MIRT2629309	hsa-miR-597	CLIP-seq
MIRT2629310	hsa-miR-606	CLIP-seq
MIRT2629311	hsa-miR-620	CLIP-seq
MIRT2629312	hsa-miR-659	CLIP-seq
MIRT1376656	hsa-miR-767-5p	CLIP-seq
MIRT2335294	hsa-miR-770-5p	CLIP-seq
MIRT2335295	hsa-miR-96	CLIP-seq
MIRT2335277	hsa-miR-1207-5p	CLIP-seq
MIRT2335278	hsa-miR-1271	CLIP-seq
MIRT2335279	hsa-miR-1286	CLIP-seq
MIRT2335280	hsa-miR-145	CLIP-seq
MIRT2335281	hsa-miR-182	CLIP-seq
MIRT2629265	hsa-miR-1912	CLIP-seq
MIRT2629266	hsa-miR-296-3p	CLIP-seq
MIRT2629269	hsa-miR-3115	CLIP-seq
MIRT1376650	hsa-miR-3145-5p	CLIP-seq
MIRT2629273	hsa-miR-361-3p	CLIP-seq
MIRT2629274	hsa-miR-3679-3p	CLIP-seq
MIRT2629275	hsa-miR-3923	CLIP-seq
MIRT2335282	hsa-miR-3941	CLIP-seq
MIRT2629276	hsa-miR-4255	CLIP-seq
MIRT2335283	hsa-miR-4282	CLIP-seq
MIRT2335284	hsa-miR-4436a	CLIP-seq
MIRT2335285	hsa-miR-4501	CLIP-seq
MIRT1376651	hsa-miR-451b	CLIP-seq
MIRT2335286	hsa-miR-466	CLIP-seq
MIRT2335287	hsa-miR-4672	CLIP-seq
MIRT2629284	hsa-miR-4688	CLIP-seq
MIRT2629285	hsa-miR-4711-5p	CLIP-seq
MIRT2335288	hsa-miR-4712-5p	CLIP-seq
MIRT2335289	hsa-miR-4731-3p	CLIP-seq
MIRT2335290	hsa-miR-4736	CLIP-seq
MIRT2335291	hsa-miR-4763-3p	CLIP-seq
MIRT2335292	hsa-miR-4801	CLIP-seq
MIRT1376654	hsa-miR-494	CLIP-seq
MIRT2629288	hsa-miR-520d-5p	CLIP-seq
MIRT2629289	hsa-miR-520g	CLIP-seq
MIRT2629290	hsa-miR-520h	CLIP-seq
MIRT2629291	hsa-miR-524-5p	CLIP-seq
MIRT2629305	hsa-miR-555	CLIP-seq
MIRT2629308	hsa-miR-591	CLIP-seq
MIRT2629309	hsa-miR-597	CLIP-seq
MIRT2629310	hsa-miR-606	CLIP-seq
MIRT2629312	hsa-miR-659	CLIP-seq
MIRT1376656	hsa-miR-767-5p	CLIP-seq
MIRT2335294	hsa-miR-770-5p	CLIP-seq
MIRT2335295	hsa-miR-96	CLIP-seq

44 Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	14985122
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	15194481, 28076346
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	11514567, 14985122, 23566155
GO:0003714	Function	Transcription corepressor activity	IDA	14985122
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005112	Function	Notch binding	IPI	10713164
GO:0005515	Function	Protein binding	IPI	9569025, 9632709, 10713164, 11278756, 11371506, 12529369, 12840015, 14985122, 15316101, 16102918, 16595688, 18729074, 18794151, 19934264, 20211142, 20368803, 20467437, 21460037, 22365833, 25277244, 25416956, 25500191, 28325809, 28514442, 30021884, 31515488, 32296183, 32814053, 33220
GO:0005634	Component	Nucleus	IDA	9569025, 15878163, 28076346
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	15194481
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9632709
GO:0006397	Process	MRNA processing	IEA
GO:0008024	Component	Cyclin/CDK positive transcription elongation factor complex	IDA	15905409
GO:0008380	Process	RNA splicing	IEA
GO:0016363	Component	Nuclear matrix	IDA	12840015
GO:0016604	Component	Nuclear body	IDA
GO:0016607	Component	Nuclear speck	IDA	23566155
GO:0016922	Function	Nuclear receptor binding	IDA	19934264
GO:0019899	Function	Enzyme binding	IPI	20007319
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IDA	11278756
GO:0042771	Process	Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	21460037
GO:0042809	Function	Nuclear vitamin D receptor binding	IDA	12529369
GO:0042974	Function	Nuclear retinoic acid receptor binding	IDA	11514567
GO:0043923	Process	Host-mediated activation of viral transcription	IDA	15905409
GO:0043923	Process	Host-mediated activation of viral transcription	IMP	19818711
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	15878163
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	10713164
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	14985122, 19934264
GO:0046332	Function	SMAD binding	IDA	11278756
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IMP	12840015
GO:0048384	Process	Retinoic acid receptor signaling pathway	IDA	19934264
GO:0048385	Process	Regulation of retinoic acid receptor signaling pathway	IDA	14985122
GO:0050681	Function	Nuclear androgen receptor binding	IPI	23566155
GO:0050769	Process	Positive regulation of neurogenesis	ISS
GO:0070562	Process	Regulation of vitamin D receptor signaling pathway	IDA	14985122
GO:0070564	Process	Positive regulation of vitamin D receptor signaling pathway	IDA	9632709, 11514567
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071300	Process	Cellular response to retinoic acid	IDA	19934264

MIM	HGNC	e!Ensembl
603055	16696	ENSG00000100603

Q13573

Protein name

SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)

Protein function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the sp

PDB

5MQF , 5XJC , 5YZG , 5Z58 , 6FF4 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6ZYM , 7A5P , 7AAV , 7ABF , 7ABG , 7ABI , 7DVQ , 7QTT , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8RO2 , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02731	SKIP_SNW	175 → 335	SKIP/SNW domain	Family

Sequence

MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE

Sequence length

536

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	Pre-NOTCH Transcription and Translation
Notch signaling pathway	NOTCH1 Intracellular Domain Regulates Transcription
Epstein-Barr virus infection	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Viral carcinogenesis	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	Notch-HLH transcription pathway
	mRNA Splicing - Major Pathway
	RUNX3 regulates NOTCH signaling
	NOTCH3 Intracellular Domain Regulates Transcription
	NOTCH4 Intracellular Domain Regulates Transcription

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RBPJ	[]	11	["Notch signaling pathway","Epstein-Barr virus infection","Viral carcinogenesis","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Notch-HLH transcription pathway","Pre-NOTCH Transcription and Translation","NOTCH1 Intracellular Domain Regulates Transcription","RUNX3 regulates NOTCH signaling","NOTCH3 Intracellular Domain Regulates Transcription","NOTCH4 Intracellular Domain Regulates Transcription"]	[]
MAML3	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Notch-HLH transcription pathway","Pre-NOTCH Transcription and Translation","NOTCH1 Intracellular Domain Regulates Transcription","RUNX3 regulates NOTCH signaling","NOTCH3 Intracellular Domain Regulates Transcription","NOTCH4 Intracellular Domain Regulates Transcription"]	[]
MAML2	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Notch-HLH transcription pathway","Pre-NOTCH Transcription and Translation","NOTCH1 Intracellular Domain Regulates Transcription","RUNX3 regulates NOTCH signaling","NOTCH3 Intracellular Domain Regulates Transcription","NOTCH4 Intracellular Domain Regulates Transcription"]	[]
MAML1	[]	9	["Notch signaling pathway","Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Notch-HLH transcription pathway","Pre-NOTCH Transcription and Translation","NOTCH1 Intracellular Domain Regulates Transcription","RUNX3 regulates NOTCH signaling","NOTCH3 Intracellular Domain Regulates Transcription","NOTCH4 Intracellular Domain Regulates Transcription"]	[]
MAMLD1	[]	8	["Constitutive Signaling by NOTCH1 PEST Domain Mutants","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants","Notch-HLH transcription pathway","Pre-NOTCH Transcription and Translation","NOTCH1 Intracellular Domain Regulates Transcription","RUNX3 regulates NOTCH signaling","NOTCH3 Intracellular Domain Regulates Transcription","NOTCH4 Intracellular Domain Regulates Transcription"]	[]

SNW1 (SNW domain containing 1)

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