Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4809
Gene name	Small nuclear ribonucleoprotein 13
Gene symbol	SNU13
Synonyms (NCBI Gene)	15.5KFA-1FA1NHP2L1NHPXOTK27SNRNP15-5SPAG12SSFA1
Chromosome	22
Chromosome location	22q13.2
Summary	Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5` stem-loop o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT722942	hsa-miR-6507-3p	HITS-CLIP	19536157
MIRT722941	hsa-miR-5588-3p	HITS-CLIP	19536157
MIRT722940	hsa-miR-1226-3p	HITS-CLIP	19536157
MIRT722939	hsa-miR-4733-3p	HITS-CLIP	19536157
MIRT722938	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT472195	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT472194	hsa-miR-4476	PAR-CLIP	23592263
MIRT472193	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT472192	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT472191	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT472190	hsa-miR-3179	PAR-CLIP	23592263
MIRT472189	hsa-miR-4419a	PAR-CLIP	23592263
MIRT472188	hsa-miR-4510	PAR-CLIP	23592263
MIRT472186	hsa-miR-6127	PAR-CLIP	23592263
MIRT472187	hsa-miR-6129	PAR-CLIP	23592263
MIRT472185	hsa-miR-6130	PAR-CLIP	23592263
MIRT472184	hsa-miR-6133	PAR-CLIP	23592263
MIRT472183	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT472182	hsa-miR-3202	PAR-CLIP	23592263
MIRT472181	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT472180	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT472179	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT472178	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT472177	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT472176	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT472175	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT472174	hsa-miR-4525	PAR-CLIP	23592263
MIRT472172	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT472173	hsa-miR-6124	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28781166
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	30975767
GO:0000492	Process	Box C/D snoRNP assembly	IEA
GO:0001651	Component	Dense fibrillar component	IDA	10593953
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	10593953, 17412961, 17636026, 22190034, 30021884, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	28781166
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	30975767
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	30975767
GO:0005690	Component	U4atac snRNP	IDA	21784869
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	10593953
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0007338	Process	Single fertilization	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0030515	Function	SnoRNA binding	IDA	17636026
GO:0030621	Function	U4 snRNA binding	IDA	11081632, 16857676
GO:0030622	Function	U4atac snRNA binding	IDA	16857676, 21784869
GO:0031428	Component	Box C/D methylation guide snoRNP complex	IBA
GO:0031428	Component	Box C/D methylation guide snoRNP complex	IDA	11081632, 39570315
GO:0031428	Component	Box C/D methylation guide snoRNP complex	IEA
GO:0031428	Component	Box C/D methylation guide snoRNP complex	NAS	17636026
GO:0032040	Component	Small-subunit processome	IBA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032991	Component	Protein-containing complex	IDA	17636026
GO:0034511	Function	U3 snoRNA binding	IDA	11081632
GO:0034512	Function	Box C/D sno(s)RNA binding	IDA	11081632
GO:0034512	Function	Box C/D sno(s)RNA binding	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IBA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	26912367
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767
GO:0051117	Function	ATPase binding	IPI	17636026
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166
GO:0071011	Component	Precatalytic spliceosome	IBA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
601304	7819	ENSG00000100138

P55769

Protein name

NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]

Protein function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associat

PDB

1E7K , 2JNB , 2OZB , 3JCR , 3SIU , 3SIV , 5O9Z , 6AH0 , 6AHD , 6QW6 , 6QX9 , 7MQ8 , 7MQ9 , 7MQA , 8H6E , 8H6J , 8H6K , 8H6L , 8Q7N , 8QO9 , 8QOZ , 8QPA , 8QPB , 8QPE , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A , 8R0B , 8RM5 , 8Y6O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01248	Ribosomal_L7Ae	20 → 114	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADA
EPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQ
QSIERLLV

Sequence length

128

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome biogenesis in eukaryotes	Major pathway of rRNA processing in the nucleolus and cytosol
Spliceosome	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway

SNU13 (small nuclear ribonucleoprotein 13)

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