Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	11325
Gene name	DEAD-box helicase 42
Gene symbol	DDX42
Synonyms (NCBI Gene)	DDX42PRHELPRNAHPSF3B8SF3b125
Chromosome	17
Chromosome location	17q23.3
Summary	This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translatio

141 Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023974	hsa-miR-1-3p	Proteomics	18668040
MIRT048682	hsa-miR-99a-5p	CLASH	23622248
MIRT047595	hsa-miR-10a-5p	CLASH	23622248
MIRT045158	hsa-miR-186-5p	CLASH	23622248
MIRT042731	hsa-miR-345-5p	CLASH	23622248
MIRT040200	hsa-miR-615-3p	CLASH	23622248
MIRT040200	hsa-miR-615-3p	CLASH	23622248
MIRT715780	hsa-miR-1324	HITS-CLIP	19536157
MIRT715779	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT715778	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT715777	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT715776	hsa-miR-4469	HITS-CLIP	19536157
MIRT715775	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT715774	hsa-miR-4287	HITS-CLIP	19536157
MIRT715773	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT715772	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT715771	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT715780	hsa-miR-1324	HITS-CLIP	19536157
MIRT715779	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT715778	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT715777	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT715776	hsa-miR-4469	HITS-CLIP	19536157
MIRT715775	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT715774	hsa-miR-4287	HITS-CLIP	19536157
MIRT715773	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT715772	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT715771	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT930724	hsa-miR-1246	CLIP-seq
MIRT930725	hsa-miR-125a-5p	CLIP-seq
MIRT930726	hsa-miR-125b	CLIP-seq
MIRT930727	hsa-miR-1266	CLIP-seq
MIRT930728	hsa-miR-1283	CLIP-seq
MIRT930729	hsa-miR-1287	CLIP-seq
MIRT930730	hsa-miR-1288	CLIP-seq
MIRT930731	hsa-miR-224	CLIP-seq
MIRT930732	hsa-miR-298	CLIP-seq
MIRT930733	hsa-miR-302f	CLIP-seq
MIRT930734	hsa-miR-3064-5p	CLIP-seq
MIRT930735	hsa-miR-3127-5p	CLIP-seq
MIRT930736	hsa-miR-3144-5p	CLIP-seq
MIRT930737	hsa-miR-3149	CLIP-seq
MIRT930738	hsa-miR-3191	CLIP-seq
MIRT930739	hsa-miR-3199	CLIP-seq
MIRT930740	hsa-miR-3618	CLIP-seq
MIRT930741	hsa-miR-3652	CLIP-seq
MIRT930742	hsa-miR-3662	CLIP-seq
MIRT930743	hsa-miR-3678-3p	CLIP-seq
MIRT930744	hsa-miR-3918	CLIP-seq
MIRT930745	hsa-miR-3973	CLIP-seq
MIRT930746	hsa-miR-4319	CLIP-seq
MIRT930747	hsa-miR-4324	CLIP-seq
MIRT930748	hsa-miR-4329	CLIP-seq
MIRT930749	hsa-miR-4430	CLIP-seq
MIRT930750	hsa-miR-4446-3p	CLIP-seq
MIRT930751	hsa-miR-4452	CLIP-seq
MIRT930752	hsa-miR-4492	CLIP-seq
MIRT930753	hsa-miR-4498	CLIP-seq
MIRT930754	hsa-miR-4505	CLIP-seq
MIRT930755	hsa-miR-4518	CLIP-seq
MIRT930756	hsa-miR-4520b-3p	CLIP-seq
MIRT930757	hsa-miR-4529-3p	CLIP-seq
MIRT930758	hsa-miR-4535	CLIP-seq
MIRT930759	hsa-miR-4652-5p	CLIP-seq
MIRT930760	hsa-miR-4709-5p	CLIP-seq
MIRT930761	hsa-miR-4719	CLIP-seq
MIRT930762	hsa-miR-4776-5p	CLIP-seq
MIRT930763	hsa-miR-4786-3p	CLIP-seq
MIRT930764	hsa-miR-490-3p	CLIP-seq
MIRT930765	hsa-miR-513b	CLIP-seq
MIRT930766	hsa-miR-520g	CLIP-seq
MIRT930767	hsa-miR-520h	CLIP-seq
MIRT930768	hsa-miR-561	CLIP-seq
MIRT930769	hsa-miR-568	CLIP-seq
MIRT930770	hsa-miR-670	CLIP-seq
MIRT930771	hsa-miR-711	CLIP-seq
MIRT930772	hsa-miR-762	CLIP-seq
MIRT930773	hsa-miR-934	CLIP-seq
MIRT930728	hsa-miR-1283	CLIP-seq
MIRT930774	hsa-miR-204	CLIP-seq
MIRT930775	hsa-miR-211	CLIP-seq
MIRT930736	hsa-miR-3144-5p	CLIP-seq
MIRT930740	hsa-miR-3618	CLIP-seq
MIRT930776	hsa-miR-362-5p	CLIP-seq
MIRT930777	hsa-miR-3649	CLIP-seq
MIRT930778	hsa-miR-3690	CLIP-seq
MIRT930779	hsa-miR-4254	CLIP-seq
MIRT930780	hsa-miR-4446-5p	CLIP-seq
MIRT930781	hsa-miR-4474-3p	CLIP-seq
MIRT930782	hsa-miR-4755-5p	CLIP-seq
MIRT930783	hsa-miR-492	CLIP-seq
MIRT930784	hsa-miR-500a	CLIP-seq
MIRT930785	hsa-miR-500b	CLIP-seq
MIRT930786	hsa-miR-619	CLIP-seq
MIRT930787	hsa-miR-623	CLIP-seq
MIRT930770	hsa-miR-670	CLIP-seq
MIRT930773	hsa-miR-934	CLIP-seq
MIRT930788	hsa-miR-935	CLIP-seq
MIRT1975466	hsa-miR-549	CLIP-seq
MIRT2210929	hsa-miR-4477b	CLIP-seq
MIRT2210930	hsa-miR-548c-3p	CLIP-seq
MIRT1975466	hsa-miR-549	CLIP-seq
MIRT2448119	hsa-miR-4666-3p	CLIP-seq
MIRT2514817	hsa-miR-1237	CLIP-seq
MIRT2514818	hsa-miR-1248	CLIP-seq
MIRT2514819	hsa-miR-2113	CLIP-seq
MIRT2514820	hsa-miR-2115	CLIP-seq
MIRT2514821	hsa-miR-221	CLIP-seq
MIRT2514822	hsa-miR-222	CLIP-seq
MIRT2514823	hsa-miR-3157-3p	CLIP-seq
MIRT2514824	hsa-miR-3174	CLIP-seq
MIRT2514825	hsa-miR-3179	CLIP-seq
MIRT2514826	hsa-miR-338-5p	CLIP-seq
MIRT2514827	hsa-miR-3647-3p	CLIP-seq
MIRT2514828	hsa-miR-3667-5p	CLIP-seq
MIRT2514829	hsa-miR-3936	CLIP-seq
MIRT2514830	hsa-miR-4267	CLIP-seq
MIRT2514831	hsa-miR-4502	CLIP-seq
MIRT2448119	hsa-miR-4666-3p	CLIP-seq
MIRT2514832	hsa-miR-4733-5p	CLIP-seq
MIRT2514833	hsa-miR-4762-3p	CLIP-seq
MIRT2514834	hsa-miR-515-5p	CLIP-seq
MIRT2514835	hsa-miR-516a-3p	CLIP-seq
MIRT1975466	hsa-miR-549	CLIP-seq
MIRT2514836	hsa-miR-570	CLIP-seq
MIRT2514837	hsa-miR-766	CLIP-seq
MIRT2514817	hsa-miR-1237	CLIP-seq
MIRT2514818	hsa-miR-1248	CLIP-seq
MIRT2514820	hsa-miR-2115	CLIP-seq
MIRT2514821	hsa-miR-221	CLIP-seq
MIRT2514822	hsa-miR-222	CLIP-seq
MIRT2514825	hsa-miR-3179	CLIP-seq
MIRT2514826	hsa-miR-338-5p	CLIP-seq
MIRT2514827	hsa-miR-3647-3p	CLIP-seq
MIRT2514829	hsa-miR-3936	CLIP-seq
MIRT2514830	hsa-miR-4267	CLIP-seq
MIRT2514831	hsa-miR-4502	CLIP-seq
MIRT2448119	hsa-miR-4666-3p	CLIP-seq
MIRT2514833	hsa-miR-4762-3p	CLIP-seq
MIRT2514835	hsa-miR-516a-3p	CLIP-seq
MIRT1975466	hsa-miR-549	CLIP-seq
MIRT2514836	hsa-miR-570	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	16397294
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IDA	16397294
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 19377511, 22365833, 35271311, 39251607
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19377511
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	19377511
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008104	Process	Intracellular protein localization	IDA	19377511
GO:0015030	Component	Cajal body	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042981	Process	Regulation of apoptotic process	IMP	19377511
GO:0071004	Component	U2-type prespliceosome	IDA	36797247
GO:1903241	Process	U2-type prespliceosome assembly	IDA	36797247

MIM	HGNC	e!Ensembl
613369	18676	ENSG00000198231

Q86XP3

Protein name

ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)

Protein function

ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also media

PDB

7EVN , 8DPE , 8HK1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	277 → 448	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	483 → 593	Helicase conserved C-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. {ECO:0000269|PubMed:10727850, ECO:0000269|PubMed:16397294}.

Sequence

MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFY
KIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFM
AEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLN
LRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTG
SGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAV
YGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQ
VRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHS
GPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKV
ISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYT
LLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGY
RERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQK
AGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYP
SAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRH
GDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKM
EPKVDSSKMDKVDSKTDKTADGFAVPEPPKRKKSRWDS

Sequence length

938

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway

DDX42 (DEAD-box helicase 42)

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