SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6634
• Gene name: Small nuclear ribonucleoprotein D3 polypeptide
• Gene symbol: SNRPD3
• Synonyms (NCBI Gene): SMD3, Sm-D3
• Chromosome: 22
• Chromosome location: 22q11.23
• Summary: This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

miRNA Show/Hide all (245)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023211	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024990	hsa-miR-183-5p	Sequencing	20371350
MIRT030561	hsa-miR-24-3p	Microarray	19748357
MIRT044049	hsa-miR-363-3p	CLASH	23622248
MIRT043833	hsa-miR-330-3p	CLASH	23622248
MIRT041313	hsa-miR-193b-3p	CLASH	23622248
MIRT037997	hsa-miR-500a-5p	CLASH	23622248
MIRT720007	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT720006	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720005	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT720004	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720003	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT720002	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT720001	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT720000	hsa-miR-612	HITS-CLIP	19536157
MIRT719999	hsa-miR-6860	HITS-CLIP	19536157
MIRT719998	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT719997	hsa-miR-661	HITS-CLIP	19536157
MIRT719996	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT719995	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719994	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT699100	hsa-miR-3714	HITS-CLIP	23313552
MIRT699099	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699098	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699097	hsa-miR-940	HITS-CLIP	23313552
MIRT699096	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT699095	hsa-miR-3665	HITS-CLIP	23313552
MIRT699094	hsa-miR-4736	HITS-CLIP	23313552
MIRT699093	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT699092	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT699091	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT699090	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT699089	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT699088	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT699087	hsa-miR-3165	HITS-CLIP	23313552
MIRT628981	hsa-miR-7977	HITS-CLIP	23313552
MIRT699086	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT699085	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT699084	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT699083	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT699082	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT699081	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT699080	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT699079	hsa-miR-3689c	HITS-CLIP	23313552
MIRT699078	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT699077	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT699076	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT699075	hsa-miR-3122	HITS-CLIP	23313552
MIRT699074	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT699073	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT699072	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT628985	hsa-miR-6749-5p	HITS-CLIP	23824327
MIRT628984	hsa-miR-4456	HITS-CLIP	23824327
MIRT628983	hsa-miR-4284	HITS-CLIP	23824327
MIRT030561	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628982	hsa-miR-2861	HITS-CLIP	23824327
MIRT628981	hsa-miR-7977	HITS-CLIP	23824327
MIRT564534	hsa-miR-501-3p	PAR-CLIP	20371350
MIRT564533	hsa-miR-502-3p	PAR-CLIP	20371350
MIRT564532	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT564531	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT564530	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT564529	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT564528	hsa-miR-4470	PAR-CLIP	20371350
MIRT545739	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT545736	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT545737	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT545734	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545735	hsa-miR-454-5p	PAR-CLIP	21572407
MIRT545733	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT545732	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT545731	hsa-miR-6883-3p	PAR-CLIP	21572407
MIRT532721	hsa-miR-4418	PAR-CLIP	22012620
MIRT532720	hsa-miR-509-3-5p	PAR-CLIP	22012620
MIRT532719	hsa-miR-509-5p	PAR-CLIP	22012620
MIRT532718	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532717	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT532716	hsa-miR-3155a	PAR-CLIP	22012620
MIRT532715	hsa-miR-3155b	PAR-CLIP	22012620
MIRT532714	hsa-miR-484	PAR-CLIP	22012620
MIRT532713	hsa-miR-1247-3p	PAR-CLIP	22012620
MIRT532712	hsa-miR-4532	PAR-CLIP	22012620
MIRT532711	hsa-miR-1205	PAR-CLIP	22012620
MIRT532710	hsa-miR-1206	PAR-CLIP	22012620
MIRT532709	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT532708	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT462700	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT462699	hsa-miR-649	PAR-CLIP	23592263
MIRT462698	hsa-miR-8080	PAR-CLIP	23592263
MIRT462697	hsa-miR-4330	PAR-CLIP	23592263
MIRT462696	hsa-miR-4766-5p	PAR-CLIP	23592263
MIRT462695	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT462694	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462693	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462692	hsa-miR-4459	PAR-CLIP	23592263
MIRT462691	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462690	hsa-miR-6077	PAR-CLIP	23592263
MIRT462689	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT462688	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT462687	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT462686	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462685	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462684	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT442672	hsa-miR-6858-3p	PAR-CLIP	22100165
MIRT442671	hsa-miR-4676-5p	PAR-CLIP	22100165
MIRT442670	hsa-miR-575	PAR-CLIP	22100165
MIRT442669	hsa-miR-6830-5p	PAR-CLIP	22100165
MIRT442668	hsa-let-7d-3p	PAR-CLIP	22100165
MIRT439575	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439575	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT720007	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT720006	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720005	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT720004	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT720003	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT720002	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT720001	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT720000	hsa-miR-612	HITS-CLIP	19536157
MIRT719999	hsa-miR-6860	HITS-CLIP	19536157
MIRT719998	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT719997	hsa-miR-661	HITS-CLIP	19536157
MIRT719996	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT719995	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719994	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT699100	hsa-miR-3714	HITS-CLIP	23313552
MIRT699099	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699098	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699097	hsa-miR-940	HITS-CLIP	23313552
MIRT699096	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT699095	hsa-miR-3665	HITS-CLIP	23313552
MIRT699094	hsa-miR-4736	HITS-CLIP	23313552
MIRT699093	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT699092	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT699091	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT699090	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT699089	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT699088	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT699087	hsa-miR-3165	HITS-CLIP	23313552
MIRT628981	hsa-miR-7977	HITS-CLIP	23313552
MIRT699086	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT699085	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT699084	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT699083	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT699082	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT699081	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT699080	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT699079	hsa-miR-3689c	HITS-CLIP	23313552
MIRT699078	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT699077	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT699076	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT699075	hsa-miR-3122	HITS-CLIP	23313552
MIRT699074	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT699073	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT699072	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT628985	hsa-miR-6749-5p	HITS-CLIP	23824327
MIRT628984	hsa-miR-4456	HITS-CLIP	23824327
MIRT628983	hsa-miR-4284	HITS-CLIP	23824327
MIRT030561	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT628982	hsa-miR-2861	HITS-CLIP	23824327
MIRT628981	hsa-miR-7977	HITS-CLIP	23824327
MIRT564534	hsa-miR-501-3p	PAR-CLIP	20371350
MIRT564533	hsa-miR-502-3p	PAR-CLIP	20371350
MIRT564532	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT564531	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT564530	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT564529	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT564528	hsa-miR-4470	PAR-CLIP	20371350
MIRT545739	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT545736	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT545737	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT545734	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545735	hsa-miR-454-5p	PAR-CLIP	21572407
MIRT545733	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT545732	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT545731	hsa-miR-6883-3p	PAR-CLIP	21572407
MIRT532721	hsa-miR-4418	PAR-CLIP	22012620
MIRT532720	hsa-miR-509-3-5p	PAR-CLIP	22012620
MIRT532719	hsa-miR-509-5p	PAR-CLIP	22012620
MIRT532718	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT532717	hsa-miR-6890-3p	PAR-CLIP	22012620
MIRT532716	hsa-miR-3155a	PAR-CLIP	22012620
MIRT532715	hsa-miR-3155b	PAR-CLIP	22012620
MIRT532714	hsa-miR-484	PAR-CLIP	22012620
MIRT532713	hsa-miR-1247-3p	PAR-CLIP	22012620
MIRT532712	hsa-miR-4532	PAR-CLIP	22012620
MIRT532711	hsa-miR-1205	PAR-CLIP	22012620
MIRT532710	hsa-miR-1206	PAR-CLIP	22012620
MIRT532709	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT532708	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT462700	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT462699	hsa-miR-649	PAR-CLIP	23592263
MIRT462698	hsa-miR-8080	PAR-CLIP	23592263
MIRT462697	hsa-miR-4330	PAR-CLIP	23592263
MIRT462696	hsa-miR-4766-5p	PAR-CLIP	23592263
MIRT462695	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT462694	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT462693	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT462692	hsa-miR-4459	PAR-CLIP	23592263
MIRT462691	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462690	hsa-miR-6077	PAR-CLIP	23592263
MIRT462689	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT462688	hsa-miR-4743-5p	PAR-CLIP	23592263
MIRT462687	hsa-miR-6721-5p	PAR-CLIP	23592263
MIRT462686	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT462685	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT462684	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT442672	hsa-miR-6858-3p	PAR-CLIP	22100165
MIRT442671	hsa-miR-4676-5p	PAR-CLIP	22100165
MIRT442670	hsa-miR-575	PAR-CLIP	22100165
MIRT442669	hsa-miR-6830-5p	PAR-CLIP	22100165
MIRT442668	hsa-let-7d-3p	PAR-CLIP	22100165
MIRT1376231	hsa-miR-2117	CLIP-seq
MIRT1376232	hsa-miR-3917	CLIP-seq
MIRT1376233	hsa-miR-4273	CLIP-seq
MIRT1376234	hsa-miR-4761-5p	CLIP-seq
MIRT1376235	hsa-miR-515-5p	CLIP-seq
MIRT2111854	hsa-miR-216a	CLIP-seq
MIRT2111855	hsa-miR-4668-3p	CLIP-seq
MIRT2335145	hsa-miR-105	CLIP-seq
MIRT2335146	hsa-miR-1256	CLIP-seq
MIRT2335147	hsa-miR-1278	CLIP-seq
MIRT2335148	hsa-miR-150	CLIP-seq
MIRT2335149	hsa-miR-1915	CLIP-seq
MIRT2335150	hsa-miR-193a-3p	CLIP-seq
MIRT2335151	hsa-miR-193b	CLIP-seq
MIRT2335152	hsa-miR-21	CLIP-seq
MIRT2335153	hsa-miR-3145-5p	CLIP-seq
MIRT2335154	hsa-miR-331-3p	CLIP-seq
MIRT2335155	hsa-miR-361-3p	CLIP-seq
MIRT2335156	hsa-miR-3646	CLIP-seq
MIRT2335157	hsa-miR-3671	CLIP-seq
MIRT2335158	hsa-miR-3679-3p	CLIP-seq
MIRT2335159	hsa-miR-3973	CLIP-seq
MIRT2335160	hsa-miR-4436a	CLIP-seq
MIRT2335161	hsa-miR-4713-5p	CLIP-seq
MIRT2335162	hsa-miR-4720-5p	CLIP-seq
MIRT2335163	hsa-miR-4726-3p	CLIP-seq
MIRT2335164	hsa-miR-4799-3p	CLIP-seq
MIRT2335165	hsa-miR-520g	CLIP-seq
MIRT2335166	hsa-miR-520h	CLIP-seq
MIRT2335167	hsa-miR-532-3p	CLIP-seq
MIRT2335168	hsa-miR-548k	CLIP-seq
MIRT2335169	hsa-miR-590-5p	CLIP-seq
MIRT2335170	hsa-miR-607	CLIP-seq
MIRT2335171	hsa-miR-892b	CLIP-seq

Gene ontology (GO) Show/Hide all (67)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000243	Component	Commitment complex	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IBA
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161
GO:0000387	Process	Spliceosomal snRNP assembly	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346, 32494006, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	15564372, 30975767, 31744343, 33677607
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	IPI	18082603
GO:0005515	Function	Protein binding	IPI	10500148, 11714716, 11748230, 12065586, 15231747, 17332742, 18984161, 19325628, 21988832, 22101937, 22365833, 23236152, 30021884, 32296183, 32814053, 33961781, 35271311, 37248947
GO:0005634	Component	Nucleus	IDA	28076346
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21113136, 30975767, 31744343
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	30975767, 33677607
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005681	Component	Spliceosomal complex	TAS	7527560
GO:0005682	Component	U5 snRNP	IBA
GO:0005682	Component	U5 snRNP	NAS	15564372
GO:0005683	Component	U7 snRNP	IDA	11574479
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 36797247
GO:0005685	Component	U1 snRNP	IBA
GO:0005685	Component	U1 snRNP	IDA	21113136, 25555158
GO:0005685	Component	U1 snRNP	IPI	33677607
GO:0005685	Component	U1 snRNP	NAS	15564372
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	NAS	15564372, 31744343
GO:0005687	Component	U4 snRNP	IBA
GO:0005687	Component	U4 snRNP	IDA	21516107
GO:0005687	Component	U4 snRNP	NAS	15564372
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005697	Component	Telomerase holoenzyme complex	IDA	18082603
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18984161
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006479	Process	Protein methylation	IDA	18495660
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	1701240
GO:0016604	Component	Nuclear body	IDA
GO:0019899	Function	Enzyme binding	IPI	17709427
GO:0030532	Component	Small nuclear ribonucleoprotein complex	TAS	1701240
GO:0034709	Component	Methylosome	IDA	18984161
GO:0034715	Component	PICln-Sm protein complex	IDA	18984161
GO:0034719	Component	SMN-Sm protein complex	IBA
GO:0034719	Component	SMN-Sm protein complex	IDA	18984161
GO:0036261	Process	7-methylguanosine cap hypermethylation	NAS	15564372
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	26912367
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767
GO:0070034	Function	Telomerase RNA binding	IPI	18082603
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071011	Component	Precatalytic spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071208	Function	Histone pre-mRNA DCP binding	IEA
GO:0071208	Function	Histone pre-mRNA DCP binding	ISS
GO:0071209	Function	U7 snRNA binding	IPI	18082603
GO:0097526	Component	Spliceosomal tri-snRNP complex	IBA
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 601062
• HGNC: 11160
• e!Ensembl: ENSG00000100028

Protein

• UniProt ID: P62318
• Protein name: Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
• Protein function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, Pu
• PDB: 1D3B , 3CW1 , 3JCR , 3PGW , 3VRI , 4PJO , 4WZJ , 5MQF , 5O9Z , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6AH0 , 6AHD , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6QW6 , 6QX9 , 6V4X , 6Y53 , 6Y5Q , 7A5P , 7ABG , 7ABI , 7B0Y , 7DVQ , 7EVO , 7QTT , 7VPX , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01423	LSM	8 → 73	LSM domain	Domain

• Sequence:

  MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQ
  VYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGN
  IFQKRR

• Sequence length: 126

Pathways

KEGG Pathway	Reactome Pathway
Spliceosome	SLBP independent Processing of Histone Pre-mRNAs
Systemic lupus erythematosus	snRNP Assembly
	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway
	RNA Polymerase II Transcription Termination
	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CARCINOMA	—	CTD	16316942	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS ERYTHEMATOSUS, SYSTEMIC	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	38049564	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	16316942		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma of lung	Lung carcinoma	BEFREE	28806746		★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	33049985	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	22363785	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28806746		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	38049564	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28296343		★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	16316942		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SNRPB 8 shared pathwaysSpliceosome, Systemic lupus erythematosus, mRNA Splicing - Major Pathway, snRNP Assembly, mRNA Splicing - Minor Pathway, RNA Polymerase II Transcription Termination, SLBP independent Processing of Histone Pre-mRNAs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Related via 8 shared pathways including Spliceosome, Systemic lupus erythematosus. SNRPE 7 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway, snRNP Assembly, mRNA Splicing - Minor Pathway, RNA Polymerase II Transcription Termination, SLBP independent Processing of Histone Pre-mRNAs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Related via 7 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SNRPF 7 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway, snRNP Assembly, mRNA Splicing - Minor Pathway, RNA Polymerase II Transcription Termination, SLBP independent Processing of Histone Pre-mRNAs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Related via 7 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SNRPG 7 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway, snRNP Assembly, mRNA Splicing - Minor Pathway, RNA Polymerase II Transcription Termination, SLBP independent Processing of Histone Pre-mRNAs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Related via 7 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SNRPD1 5 shared pathwaysSpliceosome, Systemic lupus erythematosus, mRNA Splicing - Major Pathway, snRNP Assembly, mRNA Splicing - Minor Pathway 1 shared evidence sourceDisgenet (Systemic lupus erythematosus) Related via 5 shared pathways including Spliceosome, Systemic lupus erythematosus — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SNRPB	0	[]	8	["Spliceosome","Systemic lupus erythematosus","mRNA Splicing - Major Pathway","snRNP Assembly","mRNA Splicing - Minor Pathway","RNA Polymerase II Transcription Termination","SLBP independent Processing of Histone Pre-mRNAs","SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"]	0	[]
SNRPE	0	[]	7	["Spliceosome","mRNA Splicing - Major Pathway","snRNP Assembly","mRNA Splicing - Minor Pathway","RNA Polymerase II Transcription Termination","SLBP independent Processing of Histone Pre-mRNAs","SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"]	0	[]
SNRPF	0	[]	7	["Spliceosome","mRNA Splicing - Major Pathway","snRNP Assembly","mRNA Splicing - Minor Pathway","RNA Polymerase II Transcription Termination","SLBP independent Processing of Histone Pre-mRNAs","SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"]	0	[]
SNRPG	0	[]	7	["Spliceosome","mRNA Splicing - Major Pathway","snRNP Assembly","mRNA Splicing - Minor Pathway","RNA Polymerase II Transcription Termination","SLBP independent Processing of Histone Pre-mRNAs","SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"]	0	[]
SNRPD1	0	[]	5	["Spliceosome","Systemic lupus erythematosus","mRNA Splicing - Major Pathway","snRNP Assembly","mRNA Splicing - Minor Pathway"]	1	["Disgenet (Systemic lupus erythematosus)"]

Diseases Linked via Similar Genes

Lupus nephritis Linked via 2 of 5 related genesSNRPE, SNRPF Cerebrocostomandibular syndrome Linked via 1 of 5 related genesSNRPB Desbuquois syndrome Linked via 1 of 5 related genesSNRPB Intellectual developmental disorder Linked via 1 of 5 related genesSNRPB Mixed connective tissue disease Linked via 1 of 5 related genesSNRPB

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Lupus nephritis	2	["SNRPE","SNRPF"]
Cerebrocostomandibular syndrome	1	["SNRPB"]
Desbuquois syndrome	1	["SNRPB"]
Intellectual developmental disorder	1	["SNRPB"]
Mixed connective tissue disease	1	["SNRPB"]