Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9410
Gene name	Small nuclear ribonucleoprotein U5 subunit 40
Gene symbol	SNRNP40
Synonyms (NCBI Gene)	40KHPRP8BPPRP8BPPRPF8BPSPF38WDR57
Chromosome	1
Chromosome location	1p35.2
Summary	This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047943	hsa-miR-30c-5p	CLASH	23622248
MIRT045102	hsa-miR-186-5p	CLASH	23622248
MIRT1375975	hsa-miR-1303	CLIP-seq
MIRT1375976	hsa-miR-3119	CLIP-seq
MIRT1375977	hsa-miR-3123	CLIP-seq
MIRT1375978	hsa-miR-3662	CLIP-seq
MIRT1375979	hsa-miR-3665	CLIP-seq
MIRT1375980	hsa-miR-374c	CLIP-seq
MIRT1375981	hsa-miR-3925-5p	CLIP-seq
MIRT1375982	hsa-miR-3976	CLIP-seq
MIRT1375983	hsa-miR-4649-3p	CLIP-seq
MIRT1375984	hsa-miR-4698	CLIP-seq
MIRT1375985	hsa-miR-4717-5p	CLIP-seq
MIRT1375986	hsa-miR-4736	CLIP-seq
MIRT1375987	hsa-miR-487a	CLIP-seq
MIRT1375988	hsa-miR-491-3p	CLIP-seq
MIRT1375989	hsa-miR-539	CLIP-seq
MIRT1375990	hsa-miR-622	CLIP-seq
MIRT1375991	hsa-miR-655	CLIP-seq
MIRT1375992	hsa-miR-876-3p	CLIP-seq
MIRT1375993	hsa-miR-877	CLIP-seq
MIRT2111772	hsa-miR-203	CLIP-seq
MIRT2111773	hsa-miR-4270	CLIP-seq
MIRT2111774	hsa-miR-4299	CLIP-seq
MIRT2111775	hsa-miR-4300	CLIP-seq
MIRT2111776	hsa-miR-4441	CLIP-seq
MIRT2111777	hsa-miR-4793-5p	CLIP-seq
MIRT2111778	hsa-miR-920	CLIP-seq
MIRT2335052	hsa-miR-1289	CLIP-seq
MIRT2335053	hsa-miR-145	CLIP-seq
MIRT2335054	hsa-miR-3198	CLIP-seq
MIRT2335055	hsa-miR-371-5p	CLIP-seq
MIRT2335056	hsa-miR-371b-5p	CLIP-seq
MIRT2335057	hsa-miR-4294	CLIP-seq
MIRT2335058	hsa-miR-4309	CLIP-seq
MIRT2335059	hsa-miR-432	CLIP-seq
MIRT2335060	hsa-miR-455-3p	CLIP-seq
MIRT1375983	hsa-miR-4649-3p	CLIP-seq
MIRT2335061	hsa-miR-924	CLIP-seq
MIRT2629111	hsa-miR-23a	CLIP-seq
MIRT2629112	hsa-miR-23b	CLIP-seq
MIRT2629113	hsa-miR-23c	CLIP-seq
MIRT2629114	hsa-miR-2861	CLIP-seq
MIRT2629115	hsa-miR-3148	CLIP-seq
MIRT2629116	hsa-miR-570	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000375	Process	RNA splicing, via transesterification reactions	IEA
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	9774689
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	30975767
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9774689, 28514442, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	30975767
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	30975767
GO:0005682	Component	U5 snRNP	IEA
GO:0005682	Component	U5 snRNP	TAS	9774689
GO:0005732	Component	Sno(s)RNA-containing ribonucleoprotein complex	NAS	9774689
GO:0005829	Component	Cytosol	IDA
GO:0006396	Process	RNA processing	TAS	9774689
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	9774689
GO:0016607	Component	Nuclear speck	IDA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
607797	30857	ENSG00000060688

Q96DI7

Protein name

U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)

Protein function

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:30315277, PubMed:30705154). Component of the U5 small nuclear

PDB

3JCR , 5MQF , 5O9Z , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6AH0 , 6AHD , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6QW6 , 6QX9 , 6ZYM , 7ABG , 7ABI , 7DVQ , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8Q7Q , 8Q7V , 8Q7W , 8Q7X , 8QO9 , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A , 8R0B , 8RC0 , 8RM5 , 8RO2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	56 → 94	WD domain, G-beta repeat	Repeat
PF00400	WD40	224 → 263	WD domain, G-beta repeat	Repeat
PF00400	WD40	141 → 180	WD domain, G-beta repeat	Repeat
PF00400	WD40	271 → 313	WD domain, G-beta repeat	Repeat
PF00400	WD40	99 → 137	WD domain, G-beta repeat	Repeat
PF00400	WD40	317 → 353	WD domain, G-beta repeat	Repeat
PF00400	WD40	186 → 221	WD domain, G-beta repeat	Repeat

Sequence

MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ

Sequence length

357

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway

SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)

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