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Gene Gene information from NCBI Gene database.
Entrez ID 51246
Gene name Shisa family member 5
Gene symbol SHISA5
Synonyms (NCBI Gene)
SCOTIN
Chromosome 3
Chromosome location 3p21.31
Summary This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pse
miRNA miRNA information provided by mirtarbase database.
770 Show/Hide all (770)
miRTarBase ID miRNA Experiments Reference
MIRT025901 hsa-miR-7-5p Microarray 19073608
MIRT048940 hsa-miR-92a-3p CLASH 23622248
MIRT037247 hsa-miR-877-5p CLASH 23622248
MIRT036083 hsa-miR-1296-5p CLASH 23622248
MIRT459966 hsa-miR-885-3p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15064722, 17889823, 32296183
GO:0005634 Component Nucleus IEA
GO:0005635 Component Nuclear envelope IEA
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607290 30376 ENSG00000164054
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N114
Protein name Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin)
Protein function Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13908 Shisa 28 → 197 Wnt and FGF inhibitory regulator Family
Sequence
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
p53 signaling pathway Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  Post-translational protein phosphorylation