RXFP4 (relaxin family peptide/INSL5 receptor 4)

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Gene Gene information from NCBI Gene database.
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Entrez ID 339403
Gene name Relaxin family peptide/INSL5 receptor 4
Gene symbol RXFP4
Synonyms (NCBI Gene)
GPCR142GPR100RLN3R2RXFPR4
Chromosome 1
Chromosome location 1q22
Summary GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT722453 hsa-miR-3943 HITS-CLIP 19536157
MIRT722452 hsa-miR-361-3p HITS-CLIP 19536157
MIRT722451 hsa-miR-1281 HITS-CLIP 19536157
MIRT722450 hsa-miR-1199-5p HITS-CLIP 19536157
MIRT722448 hsa-miR-6751-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004966 Function Galanin receptor activity IBA
GO:0005515 Function Protein binding IPI 24802387, 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
609043 14666 ENSG00000173080
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TDU9
Protein name Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (G-protein coupled receptor GPCR142) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4)
Protein function High affinity receptor for INSL5. Also acts as a receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.
PDB 7YJ4 , 7YK6 , 7YK7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 56 → 309 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon. {ECO:0000269|PubMed:14530218}.
Sequence
Sequence length 374
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Neuroactive ligand-receptor interaction G alpha (i) signalling events
Relaxin signaling pathway Relaxin receptors
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INSL5 3 shared pathwaysRelaxin signaling pathway, G alpha (i) signalling events, Relaxin receptors Related via 3 shared pathways including Relaxin signaling pathway, G alpha (i) signalling events. RXFP3 3 shared pathwaysRelaxin signaling pathway, G alpha (i) signalling events, Relaxin receptors Related via 3 shared pathways including Relaxin signaling pathway, G alpha (i) signalling events. RLN3 3 shared pathwaysRelaxin signaling pathway, G alpha (i) signalling events, Relaxin receptors Related via 3 shared pathways including Relaxin signaling pathway, G alpha (i) signalling events. RXFP2 2 shared pathwaysRelaxin signaling pathway, Relaxin receptors Related via 2 shared pathways including Relaxin signaling pathway, Relaxin receptors. INSL3 2 shared pathwaysRelaxin signaling pathway, Relaxin receptors Related via 2 shared pathways including Relaxin signaling pathway, Relaxin receptors.
Hyperplasia Linked via 2 of 5 related genesRLN3, RXFP2 Cryptorchidism Linked via 2 of 5 related genesRXFP2, INSL3 Amblyopia Linked via 1 of 5 related genesINSL5 Basal cell carcinoma Linked via 1 of 5 related genesRXFP3 Melanoma Linked via 1 of 5 related genesRXFP3