Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6170
Gene name	Ribosomal protein L39
Gene symbol	RPL39
Synonyms (NCBI Gene)	L39RPL39P42RPL39_23_1806eL39
Chromosome	X
Chromosome location	Xq24
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

93 Show/Hide all (93)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020677	hsa-miR-155-5p	Proteomics	18668040
MIRT029161	hsa-miR-26b-5p	Microarray	19088304
MIRT048919	hsa-miR-92a-3p	CLASH	23622248
MIRT047878	hsa-miR-30c-5p	CLASH	23622248
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316948	hsa-miR-1227	CLIP-seq
MIRT1316949	hsa-miR-1245b-5p	CLIP-seq
MIRT1316950	hsa-miR-1324	CLIP-seq
MIRT1316951	hsa-miR-140-5p	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316954	hsa-miR-19a	CLIP-seq
MIRT1316955	hsa-miR-19b	CLIP-seq
MIRT1316956	hsa-miR-3125	CLIP-seq
MIRT1316957	hsa-miR-3142	CLIP-seq
MIRT1316958	hsa-miR-3545-5p	CLIP-seq
MIRT1316959	hsa-miR-3607-5p	CLIP-seq
MIRT1316960	hsa-miR-3916	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316962	hsa-miR-3925-3p	CLIP-seq
MIRT1316963	hsa-miR-4460	CLIP-seq
MIRT1316964	hsa-miR-4724-5p	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316966	hsa-miR-556-3p	CLIP-seq
MIRT1316967	hsa-miR-570	CLIP-seq
MIRT1316968	hsa-miR-766	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316948	hsa-miR-1227	CLIP-seq
MIRT1316950	hsa-miR-1324	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316954	hsa-miR-19a	CLIP-seq
MIRT1316955	hsa-miR-19b	CLIP-seq
MIRT1316956	hsa-miR-3125	CLIP-seq
MIRT1316959	hsa-miR-3607-5p	CLIP-seq
MIRT1316960	hsa-miR-3916	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316964	hsa-miR-4724-5p	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316967	hsa-miR-570	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316950	hsa-miR-1324	CLIP-seq
MIRT1316951	hsa-miR-140-5p	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316956	hsa-miR-3125	CLIP-seq
MIRT1316958	hsa-miR-3545-5p	CLIP-seq
MIRT1316960	hsa-miR-3916	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316962	hsa-miR-3925-3p	CLIP-seq
MIRT1316963	hsa-miR-4460	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316967	hsa-miR-570	CLIP-seq
MIRT1316968	hsa-miR-766	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316948	hsa-miR-1227	CLIP-seq
MIRT1316950	hsa-miR-1324	CLIP-seq
MIRT1316951	hsa-miR-140-5p	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316954	hsa-miR-19a	CLIP-seq
MIRT1316955	hsa-miR-19b	CLIP-seq
MIRT1316956	hsa-miR-3125	CLIP-seq
MIRT1316958	hsa-miR-3545-5p	CLIP-seq
MIRT1316959	hsa-miR-3607-5p	CLIP-seq
MIRT1316960	hsa-miR-3916	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316962	hsa-miR-3925-3p	CLIP-seq
MIRT1316963	hsa-miR-4460	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316967	hsa-miR-570	CLIP-seq
MIRT1316968	hsa-miR-766	CLIP-seq
MIRT1316947	hsa-miR-1206	CLIP-seq
MIRT1316948	hsa-miR-1227	CLIP-seq
MIRT1316950	hsa-miR-1324	CLIP-seq
MIRT1316952	hsa-miR-190	CLIP-seq
MIRT1316953	hsa-miR-190b	CLIP-seq
MIRT1316954	hsa-miR-19a	CLIP-seq
MIRT1316955	hsa-miR-19b	CLIP-seq
MIRT1316956	hsa-miR-3125	CLIP-seq
MIRT1316959	hsa-miR-3607-5p	CLIP-seq
MIRT1316960	hsa-miR-3916	CLIP-seq
MIRT1316961	hsa-miR-3919	CLIP-seq
MIRT1316965	hsa-miR-4756-3p	CLIP-seq
MIRT1316967	hsa-miR-570	CLIP-seq

26 Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	IEA
GO:0002227	Process	Innate immune response in mucosa	IDA	12860195
GO:0003723	Function	RNA binding	TAS	8764829
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	8764829
GO:0005615	Component	Extracellular space	IDA	12860195
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	8764829
GO:0019731	Process	Antibacterial humoral response	IDA	12860195
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	8764829
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	12860195
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	12860195
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
300899	10350	ENSG00000198918

P62891

Protein name

Large ribosomal subunit protein eL39 (60S ribosomal protein L39)

Protein function

RNA-binding component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:8764829}

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7XNX , 7XNY , 8A3D , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD , 8FLE , 8FLF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00832	Ribosomal_L39	9 → 50	Ribosomal L39 protein	Family

Sequence

MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL

Sequence length

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPL35	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10L	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL22L1	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL13A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL36	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]

RPL39 (ribosomal protein L39)

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