Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	25873
Gene name	Ribosomal protein L36
Gene symbol	RPL36
Synonyms (NCBI Gene)	L36eL36
Chromosome	19
Chromosome location	19p13.3
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044992	hsa-miR-186-5p	CLASH	23622248
MIRT044707	hsa-miR-320a	CLASH	23622248
MIRT042307	hsa-miR-484	CLASH	23622248
MIRT039808	hsa-miR-615-3p	CLASH	23622248
MIRT457418	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457417	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT457416	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457415	hsa-miR-4270	PAR-CLIP	23592263
MIRT457414	hsa-miR-4441	PAR-CLIP	23592263
MIRT457413	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT457412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT457411	hsa-miR-8085	PAR-CLIP	23592263
MIRT457410	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT726685	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726683	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726684	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726682	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT457418	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457417	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT457416	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457415	hsa-miR-4270	PAR-CLIP	23592263
MIRT457414	hsa-miR-4441	PAR-CLIP	23592263
MIRT457413	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT457412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT457411	hsa-miR-8085	PAR-CLIP	23592263
MIRT457410	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT1316763	hsa-miR-2116	CLIP-seq
MIRT1316764	hsa-miR-4677-5p	CLIP-seq
MIRT1316765	hsa-miR-1207-5p	CLIP-seq
MIRT1316766	hsa-miR-1909	CLIP-seq
MIRT1316763	hsa-miR-2116	CLIP-seq
MIRT1316767	hsa-miR-3184	CLIP-seq
MIRT1316768	hsa-miR-3616-3p	CLIP-seq
MIRT1316769	hsa-miR-423-5p	CLIP-seq
MIRT1316770	hsa-miR-4436b-3p	CLIP-seq
MIRT1316764	hsa-miR-4677-5p	CLIP-seq
MIRT1316771	hsa-miR-4728-5p	CLIP-seq
MIRT1316772	hsa-miR-4763-3p	CLIP-seq
MIRT1316765	hsa-miR-1207-5p	CLIP-seq
MIRT1316766	hsa-miR-1909	CLIP-seq
MIRT1316768	hsa-miR-3616-3p	CLIP-seq
MIRT1316770	hsa-miR-4436b-3p	CLIP-seq
MIRT1316772	hsa-miR-4763-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	30021884, 33961781
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045202	Component	Synapse	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
617893	13631	ENSG00000130255

Q9Y3U8

Protein name

Large ribosomal subunit protein eL36 (60S ribosomal protein L36)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QGG , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01158	Ribosomal_L36e	4 → 99	Ribosomal protein L36e	Family

Sequence

MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMEL
LKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD

Sequence length

105

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Myoepithelial tumor	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anemia, Diamond-Blackfan	Anemia	GENOMICS_ENGLAND_DG	28297620	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28922548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22029674	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22029674	★★★★★ ★☆☆☆☆ Found in Text Mining only
Portal Vein Thrombosis	Portal Vein Thrombosis	BEFREE	22029674	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPL35	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10L	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL22L1	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL13A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]

RPL36 (ribosomal protein L36)

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