Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4736
Gene name	Ribosomal protein L10a
Gene symbol	RPL10A
Synonyms (NCBI Gene)	CSA19Csa-19L10ANEDD6uL1
Chromosome	6
Chromosome location	6p21.31
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048513	hsa-miR-100-5p	CLASH	23622248
MIRT042813	hsa-miR-324-3p	CLASH	23622248
MIRT038179	hsa-miR-339-3p	CLASH	23622248
MIRT052719	hsa-miR-1260b	CLASH	23622248
MIRT714264	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT714263	hsa-miR-6776-3p	HITS-CLIP	19536157
MIRT714262	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT714261	hsa-miR-4705	HITS-CLIP	19536157
MIRT714259	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT714260	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT684999	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT684998	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT684997	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT684996	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT684995	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT684994	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT684993	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT684992	hsa-miR-7844-5p	HITS-CLIP	23313552
MIRT684991	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT714264	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT714263	hsa-miR-6776-3p	HITS-CLIP	19536157
MIRT714262	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT714261	hsa-miR-4705	HITS-CLIP	19536157
MIRT714259	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT714260	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT684999	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT684998	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT684997	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT684996	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT684995	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT684994	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT684993	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT684992	hsa-miR-7844-5p	HITS-CLIP	23313552
MIRT684991	hsa-miR-3613-3p	HITS-CLIP	23313552

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	24725412, 25416956, 30021884, 31046837, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0014069	Component	Postsynaptic density	IEA
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045471	Process	Response to ethanol	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
615660	10299	ENSG00000198755

P62906

Protein name

Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6LQM , 6LSR , 6LU8 , 6OLG , 6QZP , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FL2 , 8FL3 , 8FL4 , 8G5Y , 8G60 , 8G61 , 8G6J , 8IDY , 8IFD , 8IFE , 8INF , 8K2C , 8OHD , 8OJ0 , 8OJ5 , 8OJ8 , 8QFC , 8UKB , 8XSX , 8XSY , 8Y0W , 8YOP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00687	Ribosomal_L1	18 → 212	Ribosomal protein L1p/L10e family	Domain

Sequence

MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPR
PKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQI
PRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELV
YNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY

Sequence length

217

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	30804565	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (11)
Adenocarcinoma	Adenocarcinoma	BEFREE	17184759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	17184759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	35766008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	31792295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29081411	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Focal glomerulosclerosis	Glomerulosclerosis	BEFREE	24940801		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	36450729	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	2734299		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	17184759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	34434692	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPL35	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10L	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL22L1	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL13A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL36	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]

RPL10A (ribosomal protein L10a)

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