Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6169
Gene name	Ribosomal protein L38
Gene symbol	RPL38
Synonyms (NCBI Gene)	L38eL38
Chromosome	17
Chromosome location	17q25.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT345749	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT345749	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT735202	hsa-miR-374b-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	32617008
MIRT1316937	hsa-miR-369-3p	CLIP-seq
MIRT1316938	hsa-miR-374a	CLIP-seq
MIRT1316939	hsa-miR-374b	CLIP-seq
MIRT1316940	hsa-miR-374c	CLIP-seq
MIRT1316941	hsa-miR-4302	CLIP-seq
MIRT1316942	hsa-miR-4711-3p	CLIP-seq
MIRT1316943	hsa-miR-582-5p	CLIP-seq
MIRT1316944	hsa-miR-655	CLIP-seq
MIRT1316945	hsa-miR-889	CLIP-seq
MIRT1316946	hsa-miR-1231	CLIP-seq
MIRT1316937	hsa-miR-369-3p	CLIP-seq
MIRT1316938	hsa-miR-374a	CLIP-seq
MIRT1316939	hsa-miR-374b	CLIP-seq
MIRT1316940	hsa-miR-374c	CLIP-seq
MIRT1316941	hsa-miR-4302	CLIP-seq
MIRT1316942	hsa-miR-4711-3p	CLIP-seq
MIRT1316943	hsa-miR-582-5p	CLIP-seq
MIRT1316944	hsa-miR-655	CLIP-seq
MIRT1316945	hsa-miR-889	CLIP-seq
MIRT1316946	hsa-miR-1231	CLIP-seq
MIRT1316937	hsa-miR-369-3p	CLIP-seq
MIRT1316938	hsa-miR-374a	CLIP-seq
MIRT1316939	hsa-miR-374b	CLIP-seq
MIRT1316940	hsa-miR-374c	CLIP-seq
MIRT1316941	hsa-miR-4302	CLIP-seq
MIRT1316942	hsa-miR-4711-3p	CLIP-seq
MIRT1316943	hsa-miR-582-5p	CLIP-seq
MIRT1316944	hsa-miR-655	CLIP-seq
MIRT1316945	hsa-miR-889	CLIP-seq
MIRT1316946	hsa-miR-1231	CLIP-seq
MIRT1316937	hsa-miR-369-3p	CLIP-seq
MIRT1316938	hsa-miR-374a	CLIP-seq
MIRT1316939	hsa-miR-374b	CLIP-seq
MIRT1316940	hsa-miR-374c	CLIP-seq
MIRT1316941	hsa-miR-4302	CLIP-seq
MIRT1316942	hsa-miR-4711-3p	CLIP-seq
MIRT1316943	hsa-miR-582-5p	CLIP-seq
MIRT1316944	hsa-miR-655	CLIP-seq
MIRT1316945	hsa-miR-889	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IEA
GO:0001503	Process	Ossification	IEA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	TAS	9375793
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	9375793
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	9375793
GO:0006417	Process	Regulation of translation	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0022618	Process	Protein-RNA complex assembly	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	9375793
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0033291	Component	Eukaryotic 80S initiation complex	IEA
GO:0034463	Process	90S preribosome assembly	IEA
GO:0042474	Process	Middle ear morphogenesis	IEA
GO:0045202	Component	Synapse	IEA
GO:0048318	Process	Axial mesoderm development	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604182	10349	ENSG00000172809

P63173

Protein name

Large ribosomal subunit protein eL38 (60S ribosomal protein L38)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6SXO , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7XNX , 7XNY , 8A3D , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01781	Ribosomal_L38e	2 → 69	Ribosomal L38e protein family	Family

Sequence

MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSL
PPGLAVKELK

Sequence length

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPL35	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10L	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL22L1	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL13A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL36	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]

RPL38 (ribosomal protein L38)

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