RPL30 (ribosomal protein L30)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6156
• Gene name: Ribosomal protein L30
• Gene symbol: RPL30
• Synonyms (NCBI Gene): L30, eL30
• Chromosome: 8
• Chromosome location: 8q22.2
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031874	hsa-miR-16-5p	Proteomics	18668040
MIRT052419	hsa-let-7a-5p	CLASH	23622248
MIRT050530	hsa-miR-20a-5p	CLASH	23622248
MIRT048773	hsa-miR-93-5p	CLASH	23622248
MIRT044397	hsa-miR-320a	CLASH	23622248
MIRT042716	hsa-miR-346	CLASH	23622248
MIRT452271	hsa-miR-4464	PAR-CLIP	23592263
MIRT452270	hsa-miR-4748	PAR-CLIP	23592263
MIRT452269	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT452268	hsa-miR-3665	PAR-CLIP	23592263
MIRT452267	hsa-miR-657	PAR-CLIP	23592263
MIRT452266	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT452264	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT452265	hsa-miR-4477b	PAR-CLIP	23592263
MIRT452263	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT452261	hsa-miR-7856-5p	PAR-CLIP	23592263
MIRT452262	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT452260	hsa-miR-507	PAR-CLIP	23592263
MIRT452259	hsa-miR-557	PAR-CLIP	23592263
MIRT452258	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT452257	hsa-miR-19b-1-5p	PAR-CLIP	23592263
MIRT452256	hsa-miR-19b-2-5p	PAR-CLIP	23592263
MIRT452271	hsa-miR-4464	PAR-CLIP	23592263
MIRT452270	hsa-miR-4748	PAR-CLIP	23592263
MIRT452269	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT452268	hsa-miR-3665	PAR-CLIP	23592263
MIRT452267	hsa-miR-657	PAR-CLIP	23592263
MIRT452266	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT452264	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT452265	hsa-miR-4477b	PAR-CLIP	23592263
MIRT452263	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT452261	hsa-miR-7856-5p	PAR-CLIP	23592263
MIRT452262	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT452260	hsa-miR-507	PAR-CLIP	23592263
MIRT452259	hsa-miR-557	PAR-CLIP	23592263
MIRT452258	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT452257	hsa-miR-19b-1-5p	PAR-CLIP	23592263
MIRT452256	hsa-miR-19b-2-5p	PAR-CLIP	23592263
MIRT2318699	hsa-miR-3647-3p	CLIP-seq
MIRT2318700	hsa-miR-3674	CLIP-seq
MIRT2318701	hsa-miR-4282	CLIP-seq

Gene ontology (GO) Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	1577483
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	1577483
GO:0005515	Function	Protein binding	IPI	22720776, 24725412, 31046837
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	1577483
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	1577483
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0031640	Process	Killing of cells of another organism	IDA	15019208
GO:0045202	Component	Synapse	IEA
GO:0050829	Process	Defense response to Gram-negative bacterium	IDA	15019208
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	15019208
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 180467
• HGNC: 10333
• e!Ensembl: ENSG00000156482

Protein

• UniProt ID: P62888
• Protein name: Large ribosomal subunit protein eL30 (60S ribosomal protein L30)
• Protein function: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399
• PDB: 3VI6 , 4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKY , 8FKZ , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01248	Ribosomal_L7Ae	12 → 106	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	Domain

• Sequence:

  MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEI
  EYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK

• Sequence length: 115

Pathways

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RPL35 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPL10L 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPL22L1 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPL13A 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPL36 10 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Related via 10 shared pathways including Ribosome, Coronavirus disease - COVID-19.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RPL35	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL10L	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL22L1	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL13A	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]
RPL36	0	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesRPL10L, RPL22L1 Diamond-blackfan anemia Linked via 1 of 5 related genesRPL35 Anorexia nervosa Linked via 1 of 5 related genesRPL10L Attention deficit hyperactivity disorder Linked via 1 of 5 related genesRPL10L Central nervous system cancer Linked via 1 of 5 related genesRPL10L

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["RPL10L","RPL22L1"]
Diamond-blackfan anemia	1	["RPL35"]
Anorexia nervosa	1	["RPL10L"]
Attention deficit hyperactivity disorder	1	["RPL10L"]
Central nervous system cancer	1	["RPL10L"]