Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6142
Gene name	Ribosomal protein L18a
Gene symbol	RPL18A
Synonyms (NCBI Gene)	L18AeL20
Chromosome	19
Chromosome location	19p13.11
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the

100 Show/Hide all (100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052313	hsa-let-7b-5p	CLASH	23622248
MIRT051763	hsa-let-7c-5p	CLASH	23622248
MIRT050561	hsa-miR-20a-5p	CLASH	23622248
MIRT049166	hsa-miR-92a-3p	CLASH	23622248
MIRT047248	hsa-miR-181b-5p	CLASH	23622248
MIRT045556	hsa-miR-149-5p	CLASH	23622248
MIRT044981	hsa-miR-186-5p	CLASH	23622248
MIRT044376	hsa-miR-106b-5p	CLASH	23622248
MIRT044219	hsa-miR-301a-3p	CLASH	23622248
MIRT041123	hsa-miR-503-5p	CLASH	23622248
MIRT039488	hsa-miR-652-3p	CLASH	23622248
MIRT039363	hsa-miR-421	CLASH	23622248
MIRT038096	hsa-miR-423-5p	CLASH	23622248
MIRT037405	hsa-miR-744-5p	CLASH	23622248
MIRT661064	hsa-miR-8485	HITS-CLIP	23824327
MIRT661063	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT661062	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT661061	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT661060	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT661059	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT661058	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT661057	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT661056	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT661055	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT661054	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT661052	hsa-miR-4290	HITS-CLIP	23824327
MIRT661053	hsa-miR-1262	HITS-CLIP	23824327
MIRT661051	hsa-miR-4701-3p	HITS-CLIP	23824327
MIRT661050	hsa-miR-6736-5p	HITS-CLIP	23824327
MIRT573422	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT573423	hsa-miR-6784-5p	PAR-CLIP	20371350
MIRT573421	hsa-miR-4324	PAR-CLIP	20371350
MIRT573420	hsa-miR-544b	PAR-CLIP	20371350
MIRT573419	hsa-miR-4682	PAR-CLIP	20371350
MIRT573418	hsa-miR-486-3p	PAR-CLIP	20371350
MIRT573417	hsa-miR-378a-5p	PAR-CLIP	20371350
MIRT573416	hsa-miR-1200	PAR-CLIP	20371350
MIRT573415	hsa-miR-1227-5p	PAR-CLIP	20371350
MIRT573414	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT573413	hsa-miR-4260	PAR-CLIP	20371350
MIRT573412	hsa-miR-5572	PAR-CLIP	20371350
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT482641	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT482640	hsa-miR-4444	PAR-CLIP	23592263
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	26701625
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	26701625
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	26701625
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT482640	hsa-miR-4444	PAR-CLIP	26701625
MIRT482640	hsa-miR-4444	PAR-CLIP	26701625
MIRT482640	hsa-miR-4444	PAR-CLIP	26701625
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	26701625
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	26701625
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	26701625
MIRT482641	hsa-miR-525-5p	PAR-CLIP	26701625
MIRT482641	hsa-miR-525-5p	PAR-CLIP	26701625
MIRT482641	hsa-miR-525-5p	PAR-CLIP	26701625
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	27292025
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	27292025
MIRT482640	hsa-miR-4444	PAR-CLIP	27292025
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	27292025
MIRT482641	hsa-miR-525-5p	PAR-CLIP	27292025
MIRT661064	hsa-miR-8485	HITS-CLIP	23824327
MIRT661063	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT661062	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT661061	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT661060	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT661059	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT661058	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT661057	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT661056	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT661055	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT661054	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT661052	hsa-miR-4290	HITS-CLIP	23824327
MIRT661053	hsa-miR-1262	HITS-CLIP	23824327
MIRT661051	hsa-miR-4701-3p	HITS-CLIP	23824327
MIRT661050	hsa-miR-6736-5p	HITS-CLIP	23824327
MIRT573422	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT573423	hsa-miR-6784-5p	PAR-CLIP	20371350
MIRT573421	hsa-miR-4324	PAR-CLIP	20371350
MIRT573420	hsa-miR-544b	PAR-CLIP	20371350
MIRT573419	hsa-miR-4682	PAR-CLIP	20371350
MIRT573418	hsa-miR-486-3p	PAR-CLIP	20371350
MIRT573417	hsa-miR-378a-5p	PAR-CLIP	20371350
MIRT573416	hsa-miR-1200	PAR-CLIP	20371350
MIRT573415	hsa-miR-1227-5p	PAR-CLIP	20371350
MIRT573414	hsa-miR-450a-2-3p	PAR-CLIP	20371350
MIRT573413	hsa-miR-4260	PAR-CLIP	20371350
MIRT573412	hsa-miR-5572	PAR-CLIP	20371350
MIRT482643	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT482642	hsa-miR-520a-5p	PAR-CLIP	23592263
MIRT482641	hsa-miR-525-5p	PAR-CLIP	23592263
MIRT482640	hsa-miR-4444	PAR-CLIP	23592263
MIRT482639	hsa-miR-3180-5p	PAR-CLIP	23592263
MIRT1316210	hsa-miR-1291	CLIP-seq
MIRT1316211	hsa-miR-4655-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	TAS	9582194
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0003735	Function	Structural constituent of ribosome	TAS	9582194
GO:0005515	Function	Protein binding	IPI	24965446, 28514442, 30021884, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0006412	Process	Translation	TAS	9582194
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022625	Component	Cytosolic large ribosomal subunit	TAS	9582194
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604178	10311	ENSG00000105640

Q02543

Protein name

Large ribosomal subunit protein eL20 (60S ribosomal protein L18a)

Protein function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7OW7 , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01775	Ribosomal_L18A	7 → 130	Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A	Domain

Sequence

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGE
IVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRAR
AHSIQIMKVEEIAASKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF

Sequence length

176

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Formation of a pool of free 40S subunits
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPL35	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL10L	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL22L1	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL13A	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]
RPL36	[]	10	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Formation of a pool of free 40S subunits","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]	[]

RPL18A (ribosomal protein L18a)

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