RHPN1 (rhophilin Rho GTPase binding protein 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 114822
• Gene name: Rhophilin Rho GTPase binding protein 1
• Gene symbol: RHPN1
• Synonyms (NCBI Gene): ODF5, RHOPHILIN, RHPN
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040941	hsa-miR-18a-3p	CLASH	23622248
MIRT1306179	hsa-miR-10a	CLIP-seq
MIRT1306180	hsa-miR-10b	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT1306182	hsa-miR-1233	CLIP-seq
MIRT1306183	hsa-miR-1237	CLIP-seq
MIRT1306184	hsa-miR-1248	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT1306186	hsa-miR-1273e	CLIP-seq
MIRT1306187	hsa-miR-1285	CLIP-seq
MIRT1306188	hsa-miR-1290	CLIP-seq
MIRT1306189	hsa-miR-1294	CLIP-seq
MIRT1306190	hsa-miR-1343	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306199	hsa-miR-2277-3p	CLIP-seq
MIRT1306200	hsa-miR-28-5p	CLIP-seq
MIRT1306201	hsa-miR-3126-5p	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306203	hsa-miR-3136-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306205	hsa-miR-3139	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT1306207	hsa-miR-3150b-3p	CLIP-seq
MIRT1306208	hsa-miR-3151	CLIP-seq
MIRT1306209	hsa-miR-3173-3p	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306211	hsa-miR-3182	CLIP-seq
MIRT1306212	hsa-miR-3187-5p	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306214	hsa-miR-3199	CLIP-seq
MIRT1306215	hsa-miR-331-3p	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306218	hsa-miR-3620	CLIP-seq
MIRT1306219	hsa-miR-3660	CLIP-seq
MIRT1306220	hsa-miR-3663-3p	CLIP-seq
MIRT1306221	hsa-miR-3665	CLIP-seq
MIRT1306222	hsa-miR-3672	CLIP-seq
MIRT1306223	hsa-miR-3940-3p	CLIP-seq
MIRT1306224	hsa-miR-3940-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT1306226	hsa-miR-4316	CLIP-seq
MIRT1306227	hsa-miR-4323	CLIP-seq
MIRT1306228	hsa-miR-4329	CLIP-seq
MIRT1306229	hsa-miR-4428	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306232	hsa-miR-4470	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT1306236	hsa-miR-4505	CLIP-seq
MIRT1306237	hsa-miR-4506	CLIP-seq
MIRT1306238	hsa-miR-4507	CLIP-seq
MIRT1306239	hsa-miR-4514	CLIP-seq
MIRT1306240	hsa-miR-4515	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306243	hsa-miR-4526	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT1306245	hsa-miR-4532	CLIP-seq
MIRT1306246	hsa-miR-4642	CLIP-seq
MIRT1306247	hsa-miR-4645-5p	CLIP-seq
MIRT1306248	hsa-miR-4663	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306250	hsa-miR-4673	CLIP-seq
MIRT1306251	hsa-miR-4677-3p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306253	hsa-miR-4687-3p	CLIP-seq
MIRT1306254	hsa-miR-4687-5p	CLIP-seq
MIRT1306255	hsa-miR-4689	CLIP-seq
MIRT1306256	hsa-miR-4690-5p	CLIP-seq
MIRT1306257	hsa-miR-4692	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT1306259	hsa-miR-4720-5p	CLIP-seq
MIRT1306260	hsa-miR-4721	CLIP-seq
MIRT1306261	hsa-miR-4728-5p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306263	hsa-miR-4733-3p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT1306265	hsa-miR-4784	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306267	hsa-miR-4787-5p	CLIP-seq
MIRT1306268	hsa-miR-4799-3p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306272	hsa-miR-612	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT1306274	hsa-miR-665	CLIP-seq
MIRT1306275	hsa-miR-708	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306278	hsa-miR-764	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT2090736	hsa-miR-3616-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT2090737	hsa-miR-4327	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT2090739	hsa-miR-636	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT2315396	hsa-miR-1272	CLIP-seq
MIRT2315397	hsa-miR-1286	CLIP-seq
MIRT2315398	hsa-miR-1296	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT2315399	hsa-miR-2278	CLIP-seq
MIRT2315400	hsa-miR-2909	CLIP-seq
MIRT2315401	hsa-miR-3120-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT2315402	hsa-miR-3169	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT2315403	hsa-miR-34b	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT2315404	hsa-miR-4436a	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT2315405	hsa-miR-4512	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT2315406	hsa-miR-4641	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT2315407	hsa-miR-4708-3p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT2315408	hsa-miR-647	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA

Other IDs

• MIM: 601031
• HGNC: 19973
• e!Ensembl: ENSG00000158106

Protein

• UniProt ID: Q8TCX5
• Protein name: Rhophilin-1 (GTP-Rho-binding protein 1)
• Protein function: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	513 → 590	PDZ domain	Domain
  PF02185	HR1	36 → 97	Hr1 repeat	Family
  PF03097	BRO1	109 → 510	BRO1-like domain	Domain

• Sequence:

  MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA
  TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL
  DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA
  RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR
  RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP
  QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA
  MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA
  LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR
  MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP
  GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG
  DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP
  PSSLKHPGWP

• Sequence length: 670

Pathways

Reactome Pathway:

RHO GTPases Activate Rhotekin and Rhophilins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	40050429	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERALDOSTERONISM	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	21411543	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (21)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	31089812		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31285391	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32910747, 34095306, 37478241	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	32163372	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	32910747	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	39233606	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31089812		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31285391		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28124977, 31417644		★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	33907841, 34414458	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32163372, 33907841, 34414458	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31285391	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	32953881	Associate	★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	33426053	Associate	★☆☆☆☆ Found in Text Mining only
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	31417644		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31982726	Stimulate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	39233606	Associate	★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	28124977	Associate	★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	BEFREE	28124977		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ARHGAP30 1 shared diseasePolycystic ovary syndrome 2 shared evidence sourcesCTD (Polycystic ovary syndrome), Disgenet (Polycystic ovary syndrome) Related via 1 shared disease including Polycystic ovary syndrome — evidence mostly CTD. CARMIL3 1 shared diseasePolycystic ovary syndrome 2 shared evidence sourcesCTD (Polycystic ovary syndrome), Disgenet (Polycystic ovary syndrome) Related via 1 shared disease including Polycystic ovary syndrome — evidence mostly CTD. DACT3 1 shared diseasePolycystic ovary syndrome 2 shared evidence sourcesCTD (Polycystic ovary syndrome), Disgenet (Polycystic ovary syndrome) Related via 1 shared disease including Polycystic ovary syndrome — evidence mostly CTD. DCBLD2 1 shared diseasePolycystic ovary syndrome 2 shared evidence sourcesCTD (Polycystic ovary syndrome), Disgenet (Polycystic ovary syndrome) Related via 1 shared disease including Polycystic ovary syndrome — evidence mostly CTD. ELAVL3 1 shared diseasePolycystic ovary syndrome 2 shared evidence sourcesCTD (Polycystic ovary syndrome), Disgenet (Polycystic ovary syndrome) Related via 1 shared disease including Polycystic ovary syndrome — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ARHGAP30	1	["Polycystic ovary syndrome"]	0	[]	2	["CTD (Polycystic ovary syndrome)","Disgenet (Polycystic ovary syndrome)"]
CARMIL3	1	["Polycystic ovary syndrome"]	0	[]	2	["CTD (Polycystic ovary syndrome)","Disgenet (Polycystic ovary syndrome)"]
DACT3	1	["Polycystic ovary syndrome"]	0	[]	2	["CTD (Polycystic ovary syndrome)","Disgenet (Polycystic ovary syndrome)"]
DCBLD2	1	["Polycystic ovary syndrome"]	0	[]	2	["CTD (Polycystic ovary syndrome)","Disgenet (Polycystic ovary syndrome)"]
ELAVL3	1	["Polycystic ovary syndrome"]	0	[]	2	["CTD (Polycystic ovary syndrome)","Disgenet (Polycystic ovary syndrome)"]

Diseases Linked via Similar Genes

Intellectual developmental disorder Linked via 1 of 5 related genesDACT3 Stomach neoplasms Linked via 1 of 5 related genesDCBLD2 Alzheimer disease Linked via 1 of 5 related genesELAVL3 Oligodendroglioma Linked via 1 of 5 related genesELAVL3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Intellectual developmental disorder	1	["DACT3"]
Stomach neoplasms	1	["DCBLD2"]
Alzheimer disease	1	["ELAVL3"]
Oligodendroglioma	1	["ELAVL3"]