RBM22 (RNA binding motif protein 22)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55696
• Gene name: RNA binding motif protein 22
• Gene symbol: RBM22
• Synonyms (NCBI Gene): Cwc2, ZC3H16, fSAP47
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

miRNA Show/Hide all (326)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020871	hsa-miR-155-5p	Proteomics	18668040
MIRT052325	hsa-let-7b-5p	CLASH	23622248
MIRT671019	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT671018	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT671017	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT671016	hsa-miR-5093	HITS-CLIP	23824327
MIRT671015	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT671014	hsa-miR-4284	HITS-CLIP	23824327
MIRT671013	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671012	hsa-miR-3178	HITS-CLIP	23824327
MIRT665218	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT665217	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT665216	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT665215	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT665214	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT665213	hsa-miR-4252	HITS-CLIP	23824327
MIRT665212	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT665211	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT665210	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT665209	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT665208	hsa-miR-7703	HITS-CLIP	23824327
MIRT519514	hsa-miR-4491	PAR-CLIP	21572407
MIRT519513	hsa-miR-4657	PAR-CLIP	21572407
MIRT519512	hsa-miR-299-3p	PAR-CLIP	21572407
MIRT519511	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT519509	hsa-miR-567	PAR-CLIP	21572407
MIRT519508	hsa-miR-7847-3p	PAR-CLIP	21572407
MIRT519507	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519506	hsa-miR-3924	PAR-CLIP	21572407
MIRT519503	hsa-miR-297	PAR-CLIP	21572407
MIRT532790	hsa-miR-580-5p	PAR-CLIP	22012620
MIRT532789	hsa-miR-3923	PAR-CLIP	22012620
MIRT532788	hsa-miR-1278	PAR-CLIP	22012620
MIRT532787	hsa-miR-101-5p	PAR-CLIP	22012620
MIRT519515	hsa-miR-4495	PAR-CLIP	23446348
MIRT519514	hsa-miR-4491	PAR-CLIP	23446348
MIRT519513	hsa-miR-4657	PAR-CLIP	23446348
MIRT519512	hsa-miR-299-3p	PAR-CLIP	23446348
MIRT519511	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT519510	hsa-miR-4683	PAR-CLIP	23446348
MIRT519509	hsa-miR-567	PAR-CLIP	23446348
MIRT519508	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519507	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519506	hsa-miR-3924	PAR-CLIP	23446348
MIRT519505	hsa-miR-1270	PAR-CLIP	23446348
MIRT519504	hsa-miR-620	PAR-CLIP	23446348
MIRT519503	hsa-miR-297	PAR-CLIP	23446348
MIRT671019	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT671018	hsa-miR-486-5p	HITS-CLIP	23824327
MIRT671017	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT671016	hsa-miR-5093	HITS-CLIP	23824327
MIRT671015	hsa-miR-4743-5p	HITS-CLIP	23824327
MIRT671014	hsa-miR-4284	HITS-CLIP	23824327
MIRT671013	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671012	hsa-miR-3178	HITS-CLIP	23824327
MIRT665218	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT665217	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT665216	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT665215	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT665214	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT665213	hsa-miR-4252	HITS-CLIP	23824327
MIRT665212	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT665211	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT665210	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT665209	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT665208	hsa-miR-7703	HITS-CLIP	23824327
MIRT519514	hsa-miR-4491	PAR-CLIP	21572407
MIRT519513	hsa-miR-4657	PAR-CLIP	21572407
MIRT519512	hsa-miR-299-3p	PAR-CLIP	21572407
MIRT519511	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT519509	hsa-miR-567	PAR-CLIP	21572407
MIRT519508	hsa-miR-7847-3p	PAR-CLIP	21572407
MIRT519507	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT519506	hsa-miR-3924	PAR-CLIP	21572407
MIRT519503	hsa-miR-297	PAR-CLIP	21572407
MIRT532790	hsa-miR-580-5p	PAR-CLIP	22012620
MIRT532789	hsa-miR-3923	PAR-CLIP	22012620
MIRT532788	hsa-miR-1278	PAR-CLIP	22012620
MIRT532787	hsa-miR-101-5p	PAR-CLIP	22012620
MIRT519515	hsa-miR-4495	PAR-CLIP	23446348
MIRT519514	hsa-miR-4491	PAR-CLIP	23446348
MIRT519513	hsa-miR-4657	PAR-CLIP	23446348
MIRT519512	hsa-miR-299-3p	PAR-CLIP	23446348
MIRT519511	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT519510	hsa-miR-4683	PAR-CLIP	23446348
MIRT519509	hsa-miR-567	PAR-CLIP	23446348
MIRT519508	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT519507	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT519506	hsa-miR-3924	PAR-CLIP	23446348
MIRT519505	hsa-miR-1270	PAR-CLIP	23446348
MIRT519504	hsa-miR-620	PAR-CLIP	23446348
MIRT519503	hsa-miR-297	PAR-CLIP	23446348
MIRT1295323	hsa-miR-101	CLIP-seq
MIRT1295324	hsa-miR-1205	CLIP-seq
MIRT1295325	hsa-miR-1252	CLIP-seq
MIRT1295326	hsa-miR-1257	CLIP-seq
MIRT1295327	hsa-miR-1295	CLIP-seq
MIRT1295328	hsa-miR-134	CLIP-seq
MIRT1295329	hsa-miR-144	CLIP-seq
MIRT1295330	hsa-miR-181a	CLIP-seq
MIRT1295331	hsa-miR-181b	CLIP-seq
MIRT1295332	hsa-miR-181c	CLIP-seq
MIRT1295333	hsa-miR-181d	CLIP-seq
MIRT1295334	hsa-miR-186	CLIP-seq
MIRT1295335	hsa-miR-2053	CLIP-seq
MIRT1295336	hsa-miR-214	CLIP-seq
MIRT1295337	hsa-miR-217	CLIP-seq
MIRT1295338	hsa-miR-300	CLIP-seq
MIRT1295339	hsa-miR-3118	CLIP-seq
MIRT1295340	hsa-miR-3120-3p	CLIP-seq
MIRT1295341	hsa-miR-3125	CLIP-seq
MIRT1295342	hsa-miR-3133	CLIP-seq
MIRT1295343	hsa-miR-3148	CLIP-seq
MIRT1295344	hsa-miR-3152-3p	CLIP-seq
MIRT1295345	hsa-miR-3164	CLIP-seq
MIRT1295346	hsa-miR-3200-5p	CLIP-seq
MIRT1295347	hsa-miR-335	CLIP-seq
MIRT1295348	hsa-miR-3613-3p	CLIP-seq
MIRT1295349	hsa-miR-3619-5p	CLIP-seq
MIRT1295350	hsa-miR-3646	CLIP-seq
MIRT1295351	hsa-miR-3662	CLIP-seq
MIRT1295352	hsa-miR-3663-3p	CLIP-seq
MIRT1295353	hsa-miR-3665	CLIP-seq
MIRT1295354	hsa-miR-3676	CLIP-seq
MIRT1295355	hsa-miR-3679-3p	CLIP-seq
MIRT1295356	hsa-miR-3688-3p	CLIP-seq
MIRT1295357	hsa-miR-381	CLIP-seq
MIRT1295358	hsa-miR-3915	CLIP-seq
MIRT1295359	hsa-miR-3916	CLIP-seq
MIRT1295360	hsa-miR-3928	CLIP-seq
MIRT1295361	hsa-miR-4261	CLIP-seq
MIRT1295362	hsa-miR-4262	CLIP-seq
MIRT1295363	hsa-miR-4303	CLIP-seq
MIRT1295364	hsa-miR-4328	CLIP-seq
MIRT1295365	hsa-miR-4418	CLIP-seq
MIRT1295366	hsa-miR-4424	CLIP-seq
MIRT1295367	hsa-miR-4428	CLIP-seq
MIRT1295368	hsa-miR-4446-5p	CLIP-seq
MIRT1295369	hsa-miR-4459	CLIP-seq
MIRT1295370	hsa-miR-4530	CLIP-seq
MIRT1295371	hsa-miR-4533	CLIP-seq
MIRT1295372	hsa-miR-4659a-3p	CLIP-seq
MIRT1295373	hsa-miR-4659b-3p	CLIP-seq
MIRT1295374	hsa-miR-4666-3p	CLIP-seq
MIRT1295375	hsa-miR-4698	CLIP-seq
MIRT1295376	hsa-miR-4700-3p	CLIP-seq
MIRT1295377	hsa-miR-4717-5p	CLIP-seq
MIRT1295378	hsa-miR-4722-5p	CLIP-seq
MIRT1295379	hsa-miR-4728-3p	CLIP-seq
MIRT1295380	hsa-miR-4733-3p	CLIP-seq
MIRT1295381	hsa-miR-4747-5p	CLIP-seq
MIRT1295382	hsa-miR-509-3-5p	CLIP-seq
MIRT1295383	hsa-miR-5095	CLIP-seq
MIRT1295384	hsa-miR-509-5p	CLIP-seq
MIRT1295385	hsa-miR-569	CLIP-seq
MIRT1295386	hsa-miR-576-3p	CLIP-seq
MIRT1295387	hsa-miR-582-5p	CLIP-seq
MIRT1295388	hsa-miR-617	CLIP-seq
MIRT1295389	hsa-miR-624	CLIP-seq
MIRT1295390	hsa-miR-657	CLIP-seq
MIRT1295391	hsa-miR-759	CLIP-seq
MIRT1295392	hsa-miR-761	CLIP-seq
MIRT1295326	hsa-miR-1257	CLIP-seq
MIRT2087762	hsa-miR-1298	CLIP-seq
MIRT1295330	hsa-miR-181a	CLIP-seq
MIRT1295331	hsa-miR-181b	CLIP-seq
MIRT1295332	hsa-miR-181c	CLIP-seq
MIRT1295333	hsa-miR-181d	CLIP-seq
MIRT1295335	hsa-miR-2053	CLIP-seq
MIRT2087763	hsa-miR-21	CLIP-seq
MIRT1295336	hsa-miR-214	CLIP-seq
MIRT1295340	hsa-miR-3120-3p	CLIP-seq
MIRT1295344	hsa-miR-3152-3p	CLIP-seq
MIRT1295346	hsa-miR-3200-5p	CLIP-seq
MIRT1295347	hsa-miR-335	CLIP-seq
MIRT1295349	hsa-miR-3619-5p	CLIP-seq
MIRT1295352	hsa-miR-3663-3p	CLIP-seq
MIRT1295356	hsa-miR-3688-3p	CLIP-seq
MIRT1295362	hsa-miR-4262	CLIP-seq
MIRT1295363	hsa-miR-4303	CLIP-seq
MIRT1295366	hsa-miR-4424	CLIP-seq
MIRT1295369	hsa-miR-4459	CLIP-seq
MIRT1295370	hsa-miR-4530	CLIP-seq
MIRT1295372	hsa-miR-4659a-3p	CLIP-seq
MIRT1295373	hsa-miR-4659b-3p	CLIP-seq
MIRT2087764	hsa-miR-4699-3p	CLIP-seq
MIRT1295378	hsa-miR-4722-5p	CLIP-seq
MIRT1295379	hsa-miR-4728-3p	CLIP-seq
MIRT1295385	hsa-miR-569	CLIP-seq
MIRT1295386	hsa-miR-576-3p	CLIP-seq
MIRT2087765	hsa-miR-590-5p	CLIP-seq
MIRT1295391	hsa-miR-759	CLIP-seq
MIRT1295392	hsa-miR-761	CLIP-seq
MIRT2087766	hsa-miR-885-3p	CLIP-seq
MIRT2312640	hsa-miR-1178	CLIP-seq
MIRT1295325	hsa-miR-1252	CLIP-seq
MIRT2312641	hsa-miR-1253	CLIP-seq
MIRT2312642	hsa-miR-1285	CLIP-seq
MIRT1295327	hsa-miR-1295	CLIP-seq
MIRT2312643	hsa-miR-138	CLIP-seq
MIRT2312644	hsa-miR-1587	CLIP-seq
MIRT1295330	hsa-miR-181a	CLIP-seq
MIRT1295331	hsa-miR-181b	CLIP-seq
MIRT1295332	hsa-miR-181c	CLIP-seq
MIRT1295333	hsa-miR-181d	CLIP-seq
MIRT1295335	hsa-miR-2053	CLIP-seq
MIRT2087763	hsa-miR-21	CLIP-seq
MIRT1295336	hsa-miR-214	CLIP-seq
MIRT2312645	hsa-miR-223	CLIP-seq
MIRT1295340	hsa-miR-3120-3p	CLIP-seq
MIRT1295343	hsa-miR-3148	CLIP-seq
MIRT1295344	hsa-miR-3152-3p	CLIP-seq
MIRT2312646	hsa-miR-3156-5p	CLIP-seq
MIRT2312647	hsa-miR-3187-5p	CLIP-seq
MIRT1295346	hsa-miR-3200-5p	CLIP-seq
MIRT1295347	hsa-miR-335	CLIP-seq
MIRT2312648	hsa-miR-345	CLIP-seq
MIRT1295349	hsa-miR-3619-5p	CLIP-seq
MIRT1295352	hsa-miR-3663-3p	CLIP-seq
MIRT2312649	hsa-miR-3667-5p	CLIP-seq
MIRT1295356	hsa-miR-3688-3p	CLIP-seq
MIRT2312650	hsa-miR-378g	CLIP-seq
MIRT2312651	hsa-miR-3921	CLIP-seq
MIRT1295361	hsa-miR-4261	CLIP-seq
MIRT1295362	hsa-miR-4262	CLIP-seq
MIRT1295363	hsa-miR-4303	CLIP-seq
MIRT2312652	hsa-miR-4422	CLIP-seq
MIRT1295366	hsa-miR-4424	CLIP-seq
MIRT1295369	hsa-miR-4459	CLIP-seq
MIRT2312653	hsa-miR-4486	CLIP-seq
MIRT2312654	hsa-miR-4492	CLIP-seq
MIRT2312655	hsa-miR-4498	CLIP-seq
MIRT1295370	hsa-miR-4530	CLIP-seq
MIRT1295371	hsa-miR-4533	CLIP-seq
MIRT2312656	hsa-miR-4653-5p	CLIP-seq
MIRT2312657	hsa-miR-4656	CLIP-seq
MIRT2312658	hsa-miR-4675	CLIP-seq
MIRT2312659	hsa-miR-4687-3p	CLIP-seq
MIRT2312660	hsa-miR-4697-3p	CLIP-seq
MIRT2087764	hsa-miR-4699-3p	CLIP-seq
MIRT1295377	hsa-miR-4717-5p	CLIP-seq
MIRT1295378	hsa-miR-4722-5p	CLIP-seq
MIRT1295380	hsa-miR-4733-3p	CLIP-seq
MIRT2312661	hsa-miR-4741	CLIP-seq
MIRT1295381	hsa-miR-4747-5p	CLIP-seq
MIRT2312662	hsa-miR-548l	CLIP-seq
MIRT1295385	hsa-miR-569	CLIP-seq
MIRT1295386	hsa-miR-576-3p	CLIP-seq
MIRT2087765	hsa-miR-590-5p	CLIP-seq
MIRT2312663	hsa-miR-593	CLIP-seq
MIRT2312664	hsa-miR-612	CLIP-seq
MIRT2312665	hsa-miR-622	CLIP-seq
MIRT1295389	hsa-miR-624	CLIP-seq
MIRT1295392	hsa-miR-761	CLIP-seq
MIRT2312666	hsa-miR-762	CLIP-seq
MIRT2312667	hsa-miR-767-3p	CLIP-seq
MIRT2087766	hsa-miR-885-3p	CLIP-seq
MIRT1295340	hsa-miR-3120-3p	CLIP-seq
MIRT1295372	hsa-miR-4659a-3p	CLIP-seq
MIRT1295373	hsa-miR-4659b-3p	CLIP-seq
MIRT2393541	hsa-miR-4672	CLIP-seq
MIRT1295380	hsa-miR-4733-3p	CLIP-seq
MIRT1295348	hsa-miR-3613-3p	CLIP-seq
MIRT2457869	hsa-miR-548ac	CLIP-seq
MIRT2457870	hsa-miR-548ae	CLIP-seq
MIRT2457871	hsa-miR-548aj	CLIP-seq
MIRT2457872	hsa-miR-548am	CLIP-seq
MIRT2457873	hsa-miR-548d-3p	CLIP-seq
MIRT2457874	hsa-miR-548x	CLIP-seq
MIRT2457875	hsa-miR-548z	CLIP-seq
MIRT2457876	hsa-miR-944	CLIP-seq
MIRT2312641	hsa-miR-1253	CLIP-seq
MIRT2312642	hsa-miR-1285	CLIP-seq
MIRT2609000	hsa-miR-129-5p	CLIP-seq
MIRT2312643	hsa-miR-138	CLIP-seq
MIRT2609001	hsa-miR-145	CLIP-seq
MIRT2312644	hsa-miR-1587	CLIP-seq
MIRT1295341	hsa-miR-3125	CLIP-seq
MIRT2312647	hsa-miR-3187-5p	CLIP-seq
MIRT1295350	hsa-miR-3646	CLIP-seq
MIRT1295351	hsa-miR-3662	CLIP-seq
MIRT2312650	hsa-miR-378g	CLIP-seq
MIRT2609002	hsa-miR-3907	CLIP-seq
MIRT1295358	hsa-miR-3915	CLIP-seq
MIRT1295359	hsa-miR-3916	CLIP-seq
MIRT1295360	hsa-miR-3928	CLIP-seq
MIRT2609003	hsa-miR-4311	CLIP-seq
MIRT1295367	hsa-miR-4428	CLIP-seq
MIRT2312653	hsa-miR-4486	CLIP-seq
MIRT2312654	hsa-miR-4492	CLIP-seq
MIRT2312655	hsa-miR-4498	CLIP-seq
MIRT2312657	hsa-miR-4656	CLIP-seq
MIRT1295372	hsa-miR-4659a-3p	CLIP-seq
MIRT1295373	hsa-miR-4659b-3p	CLIP-seq
MIRT2393541	hsa-miR-4672	CLIP-seq
MIRT2312658	hsa-miR-4675	CLIP-seq
MIRT1295380	hsa-miR-4733-3p	CLIP-seq
MIRT2312661	hsa-miR-4741	CLIP-seq
MIRT2609004	hsa-miR-511	CLIP-seq
MIRT2609005	hsa-miR-522	CLIP-seq
MIRT2609006	hsa-miR-548q	CLIP-seq
MIRT2609007	hsa-miR-587	CLIP-seq
MIRT2609008	hsa-miR-599	CLIP-seq
MIRT2312664	hsa-miR-612	CLIP-seq
MIRT2609009	hsa-miR-651	CLIP-seq
MIRT2312666	hsa-miR-762	CLIP-seq
MIRT2312641	hsa-miR-1253	CLIP-seq
MIRT2609000	hsa-miR-129-5p	CLIP-seq
MIRT2609001	hsa-miR-145	CLIP-seq
MIRT1295341	hsa-miR-3125	CLIP-seq
MIRT1295350	hsa-miR-3646	CLIP-seq
MIRT1295351	hsa-miR-3662	CLIP-seq
MIRT1295358	hsa-miR-3915	CLIP-seq
MIRT1295359	hsa-miR-3916	CLIP-seq
MIRT1295360	hsa-miR-3928	CLIP-seq
MIRT2609003	hsa-miR-4311	CLIP-seq
MIRT1295367	hsa-miR-4428	CLIP-seq
MIRT1295372	hsa-miR-4659a-3p	CLIP-seq
MIRT1295373	hsa-miR-4659b-3p	CLIP-seq
MIRT2393541	hsa-miR-4672	CLIP-seq
MIRT1295380	hsa-miR-4733-3p	CLIP-seq
MIRT2609004	hsa-miR-511	CLIP-seq
MIRT2609005	hsa-miR-522	CLIP-seq
MIRT2609007	hsa-miR-587	CLIP-seq
MIRT2609008	hsa-miR-599	CLIP-seq
MIRT2609009	hsa-miR-651	CLIP-seq

Gene ontology (GO) Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000974	Component	Prp19 complex	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33220177
GO:0005634	Component	Nucleus	IDA	17045351, 21122810
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IDA	21122810
GO:0005737	Component	Cytoplasm	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0017070	Function	U6 snRNA binding	IBA
GO:0017070	Function	U6 snRNA binding	IDA	22246180
GO:0033120	Process	Positive regulation of RNA splicing	IDA	22246180
GO:0036002	Function	Pre-mRNA binding	IBA
GO:0036002	Function	Pre-mRNA binding	IDA	22246180
GO:0042307	Process	Positive regulation of protein import into nucleus	IDA	21122810
GO:0045292	Process	MRNA cis splicing, via spliceosome	IDA	22246180
GO:0046827	Process	Positive regulation of protein export from nucleus	IDA	21122810
GO:0046872	Function	Metal ion binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	17045351
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IBA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IBA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071466	Process	Cellular response to xenobiotic stimulus	IDA	21122810

Other IDs

• MIM: 612430
• HGNC: 25503
• e!Ensembl: ENSG00000086589

Protein

• UniProt ID: Q9NW64
• Protein name: Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)
• Protein function: Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to t
• PDB: 2YTC , 5MQF , 5XJC , 5YZG , 5Z56 , 5Z57 , 6FF4 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6ZYM , 7A5P , 7AAV , 7ABG , 7ABI , 7QTT , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8RO2 , 9FMD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	234 → 299	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPG
  VRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQN
  MEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECP
  YRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLG
  DTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNV
  KWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAV
  VNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
  

• Sequence length: 420

Pathways

KEGG Pathway:

Spliceosome

Reactome Pathway:

mRNA Splicing - Major Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RBM22-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bohring syndrome	Bohring syndrome	Pubtator	33141183	Associate	★☆☆☆☆ Found in Text Mining only
Chromosome 5q Deletion Syndrome	Chromosome 5q deletion syndrome	Pubtator	17916100	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	33141183	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	40268057	Associate	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	40268057	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PQBP1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SMNDC1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. BCAS2 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. SF3A1 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway. PPIH 2 shared pathwaysSpliceosome, mRNA Splicing - Major Pathway Related via 2 shared pathways including Spliceosome, mRNA Splicing - Major Pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PQBP1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
SMNDC1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
BCAS2	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
SF3A1	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]
PPIH	0	[]	2	["Spliceosome","mRNA Splicing - Major Pathway"]	0	[]

Diseases Linked via Similar Genes

Autism Linked via 2 of 5 related genesPQBP1, BCAS2 Atrial septal defect Linked via 1 of 5 related genesPQBP1 Growth disorder Linked via 1 of 5 related genesPQBP1 Congenital heart septal defect Linked via 1 of 5 related genesPQBP1 Intellectual developmental disorder Linked via 1 of 5 related genesPQBP1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Autism	2	["PQBP1","BCAS2"]
Atrial septal defect	1	["PQBP1"]
Growth disorder	1	["PQBP1"]
Congenital heart septal defect	1	["PQBP1"]
Intellectual developmental disorder	1	["PQBP1"]