Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10465
Gene name	Peptidylprolyl isomerase H
Gene symbol	PPIH
Synonyms (NCBI Gene)	CYP-20CYPHSnuCyp-20USA-CYP
Chromosome	1
Chromosome location	1p34.2
Summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is

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miRTarBase ID	miRNA	Experiments
MIRT2074590	hsa-miR-105	CLIP-seq
MIRT2074591	hsa-miR-1207-5p	CLIP-seq
MIRT2074592	hsa-miR-15a	CLIP-seq
MIRT2074593	hsa-miR-15b	CLIP-seq
MIRT2074594	hsa-miR-16	CLIP-seq
MIRT2074595	hsa-miR-195	CLIP-seq
MIRT2074596	hsa-miR-214	CLIP-seq
MIRT2074597	hsa-miR-3117-5p	CLIP-seq
MIRT2074598	hsa-miR-3619-5p	CLIP-seq
MIRT2074599	hsa-miR-3660	CLIP-seq
MIRT2074600	hsa-miR-3675-5p	CLIP-seq
MIRT2074601	hsa-miR-424	CLIP-seq
MIRT2074602	hsa-miR-4514	CLIP-seq
MIRT2074603	hsa-miR-4526	CLIP-seq
MIRT2074604	hsa-miR-4690-5p	CLIP-seq
MIRT2074605	hsa-miR-4692	CLIP-seq
MIRT2074606	hsa-miR-4763-3p	CLIP-seq
MIRT2074607	hsa-miR-483-5p	CLIP-seq
MIRT2074608	hsa-miR-486-3p	CLIP-seq
MIRT2074609	hsa-miR-497	CLIP-seq
MIRT2074610	hsa-miR-761	CLIP-seq
MIRT2074611	hsa-miR-940	CLIP-seq
MIRT2074590	hsa-miR-105	CLIP-seq
MIRT2074591	hsa-miR-1207-5p	CLIP-seq
MIRT2074592	hsa-miR-15a	CLIP-seq
MIRT2074593	hsa-miR-15b	CLIP-seq
MIRT2074594	hsa-miR-16	CLIP-seq
MIRT2074595	hsa-miR-195	CLIP-seq
MIRT2301530	hsa-miR-198	CLIP-seq
MIRT2074596	hsa-miR-214	CLIP-seq
MIRT2301531	hsa-miR-216b	CLIP-seq
MIRT2074597	hsa-miR-3117-5p	CLIP-seq
MIRT2301532	hsa-miR-3185	CLIP-seq
MIRT2301533	hsa-miR-3591-3p	CLIP-seq
MIRT2074598	hsa-miR-3619-5p	CLIP-seq
MIRT2074599	hsa-miR-3660	CLIP-seq
MIRT2074600	hsa-miR-3675-5p	CLIP-seq
MIRT2301534	hsa-miR-3921	CLIP-seq
MIRT2074601	hsa-miR-424	CLIP-seq
MIRT2301535	hsa-miR-4320	CLIP-seq
MIRT2301536	hsa-miR-4427	CLIP-seq
MIRT2074602	hsa-miR-4514	CLIP-seq
MIRT2074603	hsa-miR-4526	CLIP-seq
MIRT2301537	hsa-miR-455-3p	CLIP-seq
MIRT2301538	hsa-miR-4640-5p	CLIP-seq
MIRT2301539	hsa-miR-4653-5p	CLIP-seq
MIRT2301540	hsa-miR-4680-3p	CLIP-seq
MIRT2074604	hsa-miR-4690-5p	CLIP-seq
MIRT2074605	hsa-miR-4692	CLIP-seq
MIRT2301541	hsa-miR-4699-3p	CLIP-seq
MIRT2301542	hsa-miR-4726-5p	CLIP-seq
MIRT2074606	hsa-miR-4763-3p	CLIP-seq
MIRT2074607	hsa-miR-483-5p	CLIP-seq
MIRT2074608	hsa-miR-486-3p	CLIP-seq
MIRT2074609	hsa-miR-497	CLIP-seq
MIRT2301543	hsa-miR-548u	CLIP-seq
MIRT2301544	hsa-miR-570	CLIP-seq
MIRT2301545	hsa-miR-582-5p	CLIP-seq
MIRT2074610	hsa-miR-761	CLIP-seq
MIRT2301546	hsa-miR-888	CLIP-seq
MIRT2074611	hsa-miR-940	CLIP-seq
MIRT2074590	hsa-miR-105	CLIP-seq
MIRT2074591	hsa-miR-1207-5p	CLIP-seq
MIRT2074592	hsa-miR-15a	CLIP-seq
MIRT2074593	hsa-miR-15b	CLIP-seq
MIRT2074594	hsa-miR-16	CLIP-seq
MIRT2074595	hsa-miR-195	CLIP-seq
MIRT2074596	hsa-miR-214	CLIP-seq
MIRT2074598	hsa-miR-3619-5p	CLIP-seq
MIRT2074600	hsa-miR-3675-5p	CLIP-seq
MIRT2074601	hsa-miR-424	CLIP-seq
MIRT2074602	hsa-miR-4514	CLIP-seq
MIRT2074604	hsa-miR-4690-5p	CLIP-seq
MIRT2074605	hsa-miR-4692	CLIP-seq
MIRT2074606	hsa-miR-4763-3p	CLIP-seq
MIRT2074608	hsa-miR-486-3p	CLIP-seq
MIRT2074609	hsa-miR-497	CLIP-seq
MIRT2074610	hsa-miR-761	CLIP-seq
MIRT2074611	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9570313
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IBA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IDA	9570313, 20676357
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0005515	Function	Protein binding	IPI	9570313, 16723661, 19615732, 22046132, 22365833, 25383878, 25416956, 25959826, 27107012, 29997244, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IC	9570313
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	9570313
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0006457	Process	Protein folding	TAS	9570313
GO:0008380	Process	RNA splicing	IEA
GO:0016018	Function	Cyclosporin A binding	IBA
GO:0016018	Function	Cyclosporin A binding	TAS	9570313
GO:0016607	Component	Nuclear speck	IDA	9570313
GO:0016607	Component	Nuclear speck	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0043021	Function	Ribonucleoprotein complex binding	IDA	9570313
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0045070	Process	Positive regulation of viral genome replication	IMP	19932913
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	9570313
GO:0065003	Process	Protein-containing complex assembly	TAS	9570313
GO:0071001	Component	U4/U6 snRNP	IDA	9570313

MIM	HGNC	e!Ensembl
606095	14651	ENSG00000171960

O43447

Protein name

Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)

Protein function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri

PDB

1MZW , 1QOI , 5O9Z , 6AHD , 8H6K , 8H6L , 8QO9 , 8QZS , 8R09 , 8R0B , 8RM5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00160	Pro_isomerase	14 → 176	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Domain

Sequence

MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGY
KGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTN
GCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM

Sequence length

177

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	mRNA Splicing - Major Pathway

PPIH (peptidylprolyl isomerase H)

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