Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5778
Gene name	Protein tyrosine phosphatase non-receptor type 7
Gene symbol	PTPN7
Synonyms (NCBI Gene)	BPTP-4HEPTPLC-PTPLPTPPTPNI
Chromosome	1
Chromosome location	1q32.1
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005727	hsa-miR-126-3p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT005727	hsa-miR-126-3p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT005727	hsa-miR-126-3p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT005728	hsa-miR-126-5p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT005728	hsa-miR-126-5p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT005728	hsa-miR-126-5p	FlowImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	21163928
MIRT018524	hsa-miR-335-5p	Microarray	18185580
MIRT1275742	hsa-miR-2116	CLIP-seq
MIRT1275743	hsa-miR-3692	CLIP-seq
MIRT1275744	hsa-miR-4273	CLIP-seq
MIRT1275745	hsa-miR-4487	CLIP-seq
MIRT1275746	hsa-miR-4677-5p	CLIP-seq
MIRT1275747	hsa-miR-4774-5p	CLIP-seq
MIRT1275748	hsa-miR-4787-5p	CLIP-seq
MIRT1275749	hsa-miR-1273f	CLIP-seq
MIRT1275750	hsa-miR-1275	CLIP-seq
MIRT1275751	hsa-miR-143	CLIP-seq
MIRT1275752	hsa-miR-2114	CLIP-seq
MIRT1275753	hsa-miR-3152-5p	CLIP-seq
MIRT1275754	hsa-miR-3170	CLIP-seq
MIRT1275755	hsa-miR-3661	CLIP-seq
MIRT1275756	hsa-miR-3921	CLIP-seq
MIRT1275757	hsa-miR-4251	CLIP-seq
MIRT1275758	hsa-miR-4268	CLIP-seq
MIRT1275759	hsa-miR-4329	CLIP-seq
MIRT1275760	hsa-miR-4653-5p	CLIP-seq
MIRT1275761	hsa-miR-4665-5p	CLIP-seq
MIRT1275762	hsa-miR-4682	CLIP-seq
MIRT1275763	hsa-miR-4708-5p	CLIP-seq
MIRT1275764	hsa-miR-4709-3p	CLIP-seq
MIRT1275765	hsa-miR-4770	CLIP-seq
MIRT1275766	hsa-miR-4774-3p	CLIP-seq
MIRT1275767	hsa-miR-619	CLIP-seq
MIRT1275768	hsa-miR-631	CLIP-seq
MIRT1275769	hsa-miR-653	CLIP-seq
MIRT1275745	hsa-miR-4487	CLIP-seq
MIRT1275747	hsa-miR-4774-5p	CLIP-seq
MIRT2307071	hsa-miR-3714	CLIP-seq
MIRT2307072	hsa-miR-3922-5p	CLIP-seq
MIRT1275745	hsa-miR-4487	CLIP-seq
MIRT1275747	hsa-miR-4774-5p	CLIP-seq
MIRT2393255	hsa-miR-4755-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	1530918
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	TAS
GO:0005515	Function	Protein binding	IPI	10415025, 12583813, 12592337, 25241761, 25416956, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	10940933, 14613483
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	7545170
GO:0005829	Component	Cytosol	IDA	10940933
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006470	Process	Protein dephosphorylation	TAS	1530918
GO:0007165	Process	Signal transduction	IBA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	10940933
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0072686	Component	Mitotic spindle	IDA

MIM	HGNC	e!Ensembl
176889	9659	ENSG00000143851

P35236

Protein name

Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP)

Protein function

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMe

PDB

1ZC0 , 2A3K , 2GP0 , 2GPH , 2HVL , 2QDC , 2QDM , 2QDP , 3D42 , 3D44 , 3O4S , 3O4T , 3O4U

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00102	Y_phosphatase	119 → 349	Protein-tyrosine phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen. {ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918}.

Sequence

MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEP
ICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHA
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFW
EMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQY
QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGC
FIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP

Sequence length

360

Interactions

View interactions

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	Interleukin-37 signaling

PTPN7 (protein tyrosine phosphatase non-receptor type 7)

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