PSAPL1 (prosaposin like 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 768239
• Gene name: Prosaposin like 1
• Gene symbol: PSAPL1
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4p16.1
• Summary: This gene encodes a protein that is related to the glycoprotein prosaposin. Based on sequence similarity between the encoded protein and prosaposin, it is predicted that the encoded protein is a preproprotein that is proteolytically processed to generate

miRNA Show/Hide all (199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718623	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT718622	hsa-miR-4783-3p	HITS-CLIP	19536157
MIRT718621	hsa-miR-6806-5p	HITS-CLIP	19536157
MIRT718619	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT530110	hsa-miR-216a-5p	PAR-CLIP	22012620
MIRT530109	hsa-miR-648	PAR-CLIP	22012620
MIRT530108	hsa-miR-1972	PAR-CLIP	22012620
MIRT530107	hsa-miR-4302	PAR-CLIP	22012620
MIRT530106	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT530105	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT530104	hsa-miR-3664-3p	PAR-CLIP	22012620
MIRT530103	hsa-miR-1266-5p	PAR-CLIP	22012620
MIRT530102	hsa-miR-4518	PAR-CLIP	22012620
MIRT530101	hsa-miR-214-5p	PAR-CLIP	22012620
MIRT530100	hsa-miR-6811-3p	PAR-CLIP	22012620
MIRT530099	hsa-miR-1271-3p	PAR-CLIP	22012620
MIRT530098	hsa-miR-550a-3-5p	PAR-CLIP	22012620
MIRT530097	hsa-miR-550a-5p	PAR-CLIP	22012620
MIRT530096	hsa-miR-124-5p	PAR-CLIP	22012620
MIRT530095	hsa-miR-6514-3p	PAR-CLIP	22012620
MIRT530094	hsa-miR-550b-2-5p	PAR-CLIP	22012620
MIRT718623	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT718622	hsa-miR-4783-3p	HITS-CLIP	19536157
MIRT718621	hsa-miR-6806-5p	HITS-CLIP	19536157
MIRT718619	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT530110	hsa-miR-216a-5p	PAR-CLIP	22012620
MIRT530109	hsa-miR-648	PAR-CLIP	22012620
MIRT530108	hsa-miR-1972	PAR-CLIP	22012620
MIRT530107	hsa-miR-4302	PAR-CLIP	22012620
MIRT530106	hsa-miR-199a-5p	PAR-CLIP	22012620
MIRT530105	hsa-miR-199b-5p	PAR-CLIP	22012620
MIRT530104	hsa-miR-3664-3p	PAR-CLIP	22012620
MIRT530103	hsa-miR-1266-5p	PAR-CLIP	22012620
MIRT530102	hsa-miR-4518	PAR-CLIP	22012620
MIRT530101	hsa-miR-214-5p	PAR-CLIP	22012620
MIRT530100	hsa-miR-6811-3p	PAR-CLIP	22012620
MIRT530099	hsa-miR-1271-3p	PAR-CLIP	22012620
MIRT530098	hsa-miR-550a-3-5p	PAR-CLIP	22012620
MIRT530097	hsa-miR-550a-5p	PAR-CLIP	22012620
MIRT530096	hsa-miR-124-5p	PAR-CLIP	22012620
MIRT530095	hsa-miR-6514-3p	PAR-CLIP	22012620
MIRT530094	hsa-miR-550b-2-5p	PAR-CLIP	22012620
MIRT1269096	hsa-miR-1207-5p	CLIP-seq
MIRT1269097	hsa-miR-1247	CLIP-seq
MIRT1269098	hsa-miR-1266	CLIP-seq
MIRT1269099	hsa-miR-1288	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269101	hsa-miR-1827	CLIP-seq
MIRT1269102	hsa-miR-198	CLIP-seq
MIRT1269103	hsa-miR-296-5p	CLIP-seq
MIRT1269104	hsa-miR-29a	CLIP-seq
MIRT1269105	hsa-miR-29b	CLIP-seq
MIRT1269106	hsa-miR-29c	CLIP-seq
MIRT1269107	hsa-miR-3065-3p	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT1269110	hsa-miR-3151	CLIP-seq
MIRT1269111	hsa-miR-3199	CLIP-seq
MIRT1269112	hsa-miR-3622a-5p	CLIP-seq
MIRT1269113	hsa-miR-3675-5p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT1269115	hsa-miR-3918	CLIP-seq
MIRT1269116	hsa-miR-4263	CLIP-seq
MIRT1269117	hsa-miR-4269	CLIP-seq
MIRT1269118	hsa-miR-4271	CLIP-seq
MIRT1269119	hsa-miR-4323	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269121	hsa-miR-4435	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269125	hsa-miR-4645-5p	CLIP-seq
MIRT1269126	hsa-miR-4649-3p	CLIP-seq
MIRT1269127	hsa-miR-4650-5p	CLIP-seq
MIRT1269128	hsa-miR-4651	CLIP-seq
MIRT1269129	hsa-miR-4652-5p	CLIP-seq
MIRT1269130	hsa-miR-4673	CLIP-seq
MIRT1269131	hsa-miR-4685-5p	CLIP-seq
MIRT1269132	hsa-miR-4722-3p	CLIP-seq
MIRT1269133	hsa-miR-4725-3p	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269135	hsa-miR-4730	CLIP-seq
MIRT1269136	hsa-miR-4755-3p	CLIP-seq
MIRT1269137	hsa-miR-4763-3p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269140	hsa-miR-486-3p	CLIP-seq
MIRT1269141	hsa-miR-495	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT1269143	hsa-miR-608	CLIP-seq
MIRT1269144	hsa-miR-636	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT1269146	hsa-miR-9	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT2079072	hsa-miR-3194-3p	CLIP-seq
MIRT2079073	hsa-miR-3545-3p	CLIP-seq
MIRT2079074	hsa-miR-3667-3p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT2079075	hsa-miR-4268	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT2079076	hsa-miR-4448	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT2079077	hsa-miR-558	CLIP-seq
MIRT2079078	hsa-miR-767-3p	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT2305358	hsa-miR-1224-3p	CLIP-seq
MIRT2305359	hsa-miR-1260	CLIP-seq
MIRT2305360	hsa-miR-1260b	CLIP-seq
MIRT2305361	hsa-miR-1280	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT2305362	hsa-miR-3665	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT2305363	hsa-miR-3690	CLIP-seq
MIRT2305364	hsa-miR-4254	CLIP-seq
MIRT2079075	hsa-miR-4268	CLIP-seq
MIRT2305365	hsa-miR-4283	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT2079076	hsa-miR-4448	CLIP-seq
MIRT2305366	hsa-miR-4455	CLIP-seq
MIRT2305367	hsa-miR-4512	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT1269100	hsa-miR-134	CLIP-seq
MIRT2393120	hsa-miR-148a	CLIP-seq
MIRT2393121	hsa-miR-148b	CLIP-seq
MIRT2393122	hsa-miR-152	CLIP-seq
MIRT2393123	hsa-miR-1976	CLIP-seq
MIRT1269108	hsa-miR-3118	CLIP-seq
MIRT1269109	hsa-miR-3136-5p	CLIP-seq
MIRT1269114	hsa-miR-3689d	CLIP-seq
MIRT2393124	hsa-miR-4264	CLIP-seq
MIRT1269120	hsa-miR-4329	CLIP-seq
MIRT1269122	hsa-miR-4439	CLIP-seq
MIRT1269123	hsa-miR-4513	CLIP-seq
MIRT1269124	hsa-miR-4534	CLIP-seq
MIRT1269134	hsa-miR-4725-5p	CLIP-seq
MIRT1269138	hsa-miR-4786-5p	CLIP-seq
MIRT2393125	hsa-miR-4797-3p	CLIP-seq
MIRT1269139	hsa-miR-4802-5p	CLIP-seq
MIRT1269142	hsa-miR-504	CLIP-seq
MIRT2393126	hsa-miR-512-3p	CLIP-seq
MIRT2393127	hsa-miR-622	CLIP-seq
MIRT1269145	hsa-miR-769-5p	CLIP-seq
MIRT2457290	hsa-miR-1470	CLIP-seq
MIRT2457291	hsa-miR-4469	CLIP-seq
MIRT2457292	hsa-miR-4667-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA
GO:0016020	Component	Membrane	IEA
GO:0019216	Process	Regulation of lipid metabolic process	IBA
GO:0060736	Process	Prostate gland growth	IBA
GO:0060742	Process	Epithelial cell differentiation involved in prostate gland development	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6NUJ1
• Protein name: Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like]
• Protein function: May activate the lysosomal degradation of sphingolipids.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02199	SapA	479 → 511	Saposin A-type domain	Family
  PF02199	SapA	23 → 55	Saposin A-type domain	Family
  PF03489	SapB_2	437 → 469	Saposin-like type B, region 2	Family
  PF03489	SapB_2	334 → 366	Saposin-like type B, region 2	Family
  PF05184	SapB_1	292 → 329	Saposin-like type B, region 1	Domain

• Sequence:

  MLCALLLLPSLLGATRASPTSGPQECAKGSTVWCQDLQTAARCGAVGYCQGAVWNKPTAK
  SLPCDVCQDIAAAAGNGLNPDATESDILALVMKTCEWLPSQESSAGCKWMVDAHSSAILS
  MLRGAPDSAPAQVCTALSLCEPLQRHLATLRPLSKEDTFEAVAPFMANGPLTFHPRQAPE
  GALCQDCVRQVSRLQEAVRSNLTLADLNIQEQCESLGPGLAVLCKNYLFQFFVPADQALR
  LLPPQELCRKGGFCEELGAPARLTQVVAMDGVPSLELGLPRKQSEMQMKAGVTCEVCMNV
  VQKLDHWLMSNSSELMITHALERVCSVMPASITKECIILVDTYSPSLVQLVAKITPEKVC
  KFIRLCGNRRRARAVHDAYAIVPSPEWDAENQGSFCNGCKRLLTVSSHNLESKSTKRDIL
  VAFKGGCSILPLPYMIQCKHFVTQYEPVLIESLKDMMDPVAVCKKVGACHGPRTPLLGTD
  QCALGPSFWCRSQEAAKLCNAVQHCQKHVWKEMHLHAGEHA

• Sequence length: 521

Pathways

KEGG Pathway

Sphingolipid metabolism

Lysosome

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GALC 2 shared pathwaysSphingolipid metabolism, Lysosome Related via 2 shared pathways including Sphingolipid metabolism, Lysosome. GM2A 2 shared pathwaysSphingolipid metabolism, Lysosome Related via 2 shared pathways including Sphingolipid metabolism, Lysosome. GBA 2 shared pathwaysSphingolipid metabolism, Lysosome Related via 2 shared pathways including Sphingolipid metabolism, Lysosome. ARSA 2 shared pathwaysSphingolipid metabolism, Lysosome Related via 2 shared pathways including Sphingolipid metabolism, Lysosome. ASAH1 2 shared pathwaysSphingolipid metabolism, Lysosome Related via 2 shared pathways including Sphingolipid metabolism, Lysosome.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GALC	0	[]	2	["Sphingolipid metabolism","Lysosome"]	0	[]
GM2A	0	[]	2	["Sphingolipid metabolism","Lysosome"]	0	[]
GBA	0	[]	2	["Sphingolipid metabolism","Lysosome"]	0	[]
ARSA	0	[]	2	["Sphingolipid metabolism","Lysosome"]	0	[]
ASAH1	0	[]	2	["Sphingolipid metabolism","Lysosome"]	0	[]

Diseases Linked via Similar Genes

Congenital neurologic anomalies Linked via 3 of 5 related genesGALC, ARSA, ASAH1 Intellectual developmental disorder Linked via 2 of 5 related genesGALC, ARSA Leukodystrophy Linked via 2 of 5 related genesGALC, ARSA Oligodendroglioma Linked via 2 of 5 related genesGALC, ASAH1 Spastic ataxia Linked via 2 of 5 related genesGALC, ARSA

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Congenital neurologic anomalies	3	["GALC","ARSA","ASAH1"]
Intellectual developmental disorder	2	["GALC","ARSA"]
Leukodystrophy	2	["GALC","ARSA"]
Oligodendroglioma	2	["GALC","ASAH1"]
Spastic ataxia	2	["GALC","ARSA"]