Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5557
Gene name	DNA primase subunit 1
Gene symbol	PRIM1
Synonyms (NCBI Gene)	PDILp49
Chromosome	12
Chromosome location	12q13.3
Summary	The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, s

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000896	hsa-miR-15a-5p	Microarray	18362358
MIRT000895	hsa-miR-16-5p	Microarray	18362358
MIRT001604	hsa-let-7b-5p	pSILAC	18668040
MIRT016373	hsa-miR-193b-3p	Microarray	20304954
MIRT024825	hsa-miR-215-5p	Microarray	19074876
MIRT025399	hsa-miR-34a-5p	Proteomics	21566225
MIRT026411	hsa-miR-192-5p	Microarray	19074876
MIRT028506	hsa-miR-30a-5p	Proteomics	18668040
MIRT030386	hsa-miR-24-3p	Microarray	19748357
MIRT001604	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT048061	hsa-miR-197-3p	CLASH	23622248
MIRT517263	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT517262	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT517261	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT517260	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT517259	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT517258	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT517257	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT517256	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT517255	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT517254	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT517253	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT517252	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT517251	hsa-miR-302e	HITS-CLIP	23313552
MIRT517250	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT517249	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT517248	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT517247	hsa-miR-520b	HITS-CLIP	23313552
MIRT517246	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT517245	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT517244	hsa-miR-520e	HITS-CLIP	23313552
MIRT517243	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT517242	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT517241	hsa-miR-520h	HITS-CLIP	23313552
MIRT694052	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT694051	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT694050	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT694049	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT694048	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT517237	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT517236	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694047	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT517234	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT517233	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT517232	hsa-miR-4455	HITS-CLIP	23313552
MIRT517229	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT615746	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT615745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615744	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT615743	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT615748	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT615747	hsa-miR-4422	HITS-CLIP	23824327
MIRT615746	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT615745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615744	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT615743	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT569670	hsa-miR-21-3p	PAR-CLIP	20371350
MIRT569669	hsa-miR-3591-3p	PAR-CLIP	20371350
MIRT569668	hsa-miR-4438	PAR-CLIP	20371350
MIRT569667	hsa-miR-3130-5p	PAR-CLIP	20371350
MIRT569666	hsa-miR-4482-5p	PAR-CLIP	20371350
MIRT569665	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT569664	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT569663	hsa-miR-500b-3p	PAR-CLIP	20371350
MIRT569661	hsa-miR-4269	PAR-CLIP	20371350
MIRT569662	hsa-miR-6715b-5p	PAR-CLIP	20371350
MIRT569660	hsa-miR-5095	PAR-CLIP	20371350
MIRT569659	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT517227	hsa-miR-5197-5p	PAR-CLIP	21572407
MIRT517228	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT517226	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT517225	hsa-miR-940	PAR-CLIP	21572407
MIRT517224	hsa-miR-3929	PAR-CLIP	21572407
MIRT517223	hsa-miR-4419b	PAR-CLIP	21572407
MIRT517222	hsa-miR-4478	PAR-CLIP	21572407
MIRT517221	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT517220	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT517219	hsa-miR-2114-3p	PAR-CLIP	21572407
MIRT517217	hsa-miR-6823-3p	PAR-CLIP	21572407
MIRT517218	hsa-miR-1827	PAR-CLIP	21572407
MIRT517216	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT517215	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT517214	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT517213	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT517212	hsa-miR-3622b-5p	PAR-CLIP	21572407
MIRT517211	hsa-miR-665	PAR-CLIP	21572407
MIRT529697	hsa-miR-606	PAR-CLIP	22012620
MIRT529696	hsa-miR-888-3p	PAR-CLIP	22012620
MIRT529695	hsa-miR-125a-3p	PAR-CLIP	22012620
MIRT529694	hsa-miR-764	PAR-CLIP	22012620
MIRT529693	hsa-miR-3934-5p	PAR-CLIP	22012620
MIRT529692	hsa-miR-6790-3p	PAR-CLIP	22012620
MIRT529691	hsa-miR-6821-3p	PAR-CLIP	22012620
MIRT529690	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT529689	hsa-miR-8086	PAR-CLIP	22012620
MIRT529688	hsa-miR-4474-5p	PAR-CLIP	22012620
MIRT529687	hsa-miR-3157-5p	PAR-CLIP	22012620
MIRT517263	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT517262	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT517261	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT517260	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT517259	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT517258	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT517257	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT517256	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT517255	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT517254	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT517253	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT517252	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT517251	hsa-miR-302e	PAR-CLIP	23446348
MIRT517250	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT517249	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT517248	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT517247	hsa-miR-520b	PAR-CLIP	23446348
MIRT517246	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT517245	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT517244	hsa-miR-520e	PAR-CLIP	23446348
MIRT517243	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT517242	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT517241	hsa-miR-520h	PAR-CLIP	23446348
MIRT517240	hsa-miR-3614-5p	PAR-CLIP	23446348
MIRT517239	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT517238	hsa-miR-4793-3p	PAR-CLIP	23446348
MIRT517237	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT517236	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT517235	hsa-miR-4252	PAR-CLIP	23446348
MIRT517234	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT517233	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT517232	hsa-miR-4455	PAR-CLIP	23446348
MIRT517231	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT517230	hsa-miR-4325	PAR-CLIP	23446348
MIRT517229	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT517227	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT517228	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT517226	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT517225	hsa-miR-940	PAR-CLIP	23446348
MIRT517224	hsa-miR-3929	PAR-CLIP	23446348
MIRT517223	hsa-miR-4419b	PAR-CLIP	23446348
MIRT517222	hsa-miR-4478	PAR-CLIP	23446348
MIRT517221	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT517220	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT517219	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT517217	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT517218	hsa-miR-1827	PAR-CLIP	23446348
MIRT517216	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT517215	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT517214	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT517213	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT517212	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT517211	hsa-miR-665	PAR-CLIP	23446348
MIRT517221	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT517263	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT517262	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT517261	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT517260	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT517259	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT517258	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT517257	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT517256	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT517255	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT517254	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT517253	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT517252	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT517251	hsa-miR-302e	HITS-CLIP	23313552
MIRT517250	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT517249	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT517248	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT517247	hsa-miR-520b	HITS-CLIP	23313552
MIRT517246	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT517245	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT517244	hsa-miR-520e	HITS-CLIP	23313552
MIRT517243	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT517242	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT517241	hsa-miR-520h	HITS-CLIP	23313552
MIRT694052	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT694051	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT694050	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT694049	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT694048	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT517237	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT517236	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694047	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT517234	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT517233	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT517232	hsa-miR-4455	HITS-CLIP	23313552
MIRT517229	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT615746	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT615745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615744	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT615743	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT615748	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT615747	hsa-miR-4422	HITS-CLIP	23824327
MIRT615746	hsa-miR-3184-3p	HITS-CLIP	23824327
MIRT615745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT615744	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT615743	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT569670	hsa-miR-21-3p	PAR-CLIP	20371350
MIRT569669	hsa-miR-3591-3p	PAR-CLIP	20371350
MIRT569668	hsa-miR-4438	PAR-CLIP	20371350
MIRT569667	hsa-miR-3130-5p	PAR-CLIP	20371350
MIRT569666	hsa-miR-4482-5p	PAR-CLIP	20371350
MIRT569665	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT569664	hsa-miR-5003-5p	PAR-CLIP	20371350
MIRT569663	hsa-miR-500b-3p	PAR-CLIP	20371350
MIRT569661	hsa-miR-4269	PAR-CLIP	20371350
MIRT569662	hsa-miR-6715b-5p	PAR-CLIP	20371350
MIRT569660	hsa-miR-5095	PAR-CLIP	20371350
MIRT569659	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT517227	hsa-miR-5197-5p	PAR-CLIP	21572407
MIRT517228	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT517226	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT517225	hsa-miR-940	PAR-CLIP	21572407
MIRT517224	hsa-miR-3929	PAR-CLIP	21572407
MIRT517223	hsa-miR-4419b	PAR-CLIP	21572407
MIRT517222	hsa-miR-4478	PAR-CLIP	21572407
MIRT517221	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT517220	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT517219	hsa-miR-2114-3p	PAR-CLIP	21572407
MIRT517217	hsa-miR-6823-3p	PAR-CLIP	21572407
MIRT517218	hsa-miR-1827	PAR-CLIP	21572407
MIRT517216	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT517215	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT517214	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT517213	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT517212	hsa-miR-3622b-5p	PAR-CLIP	21572407
MIRT517211	hsa-miR-665	PAR-CLIP	21572407
MIRT529697	hsa-miR-606	PAR-CLIP	22012620
MIRT529696	hsa-miR-888-3p	PAR-CLIP	22012620
MIRT529695	hsa-miR-125a-3p	PAR-CLIP	22012620
MIRT529694	hsa-miR-764	PAR-CLIP	22012620
MIRT529693	hsa-miR-3934-5p	PAR-CLIP	22012620
MIRT529692	hsa-miR-6790-3p	PAR-CLIP	22012620
MIRT529691	hsa-miR-6821-3p	PAR-CLIP	22012620
MIRT529690	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT529689	hsa-miR-8086	PAR-CLIP	22012620
MIRT529688	hsa-miR-4474-5p	PAR-CLIP	22012620
MIRT529687	hsa-miR-3157-5p	PAR-CLIP	22012620
MIRT517263	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT517262	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT517261	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT517260	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT517259	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT517258	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT517257	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT517256	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT517255	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT517254	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT517253	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT517252	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT517251	hsa-miR-302e	PAR-CLIP	23446348
MIRT517250	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT517249	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT517248	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT517247	hsa-miR-520b	PAR-CLIP	23446348
MIRT517246	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT517245	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT517244	hsa-miR-520e	PAR-CLIP	23446348
MIRT517243	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT517242	hsa-miR-520g-3p	PAR-CLIP	23446348
MIRT517241	hsa-miR-520h	PAR-CLIP	23446348
MIRT517240	hsa-miR-3614-5p	PAR-CLIP	23446348
MIRT517239	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT517238	hsa-miR-4793-3p	PAR-CLIP	23446348
MIRT517237	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT517236	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT517235	hsa-miR-4252	PAR-CLIP	23446348
MIRT517234	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT517233	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT517232	hsa-miR-4455	PAR-CLIP	23446348
MIRT517231	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT517230	hsa-miR-4325	PAR-CLIP	23446348
MIRT517229	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT517227	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT517228	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT517226	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT517225	hsa-miR-940	PAR-CLIP	23446348
MIRT517224	hsa-miR-3929	PAR-CLIP	23446348
MIRT517223	hsa-miR-4419b	PAR-CLIP	23446348
MIRT517222	hsa-miR-4478	PAR-CLIP	23446348
MIRT517221	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT517220	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT517219	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT517217	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT517218	hsa-miR-1827	PAR-CLIP	23446348
MIRT517216	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT517215	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT517214	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT517213	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT517212	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT517211	hsa-miR-665	PAR-CLIP	23446348
MIRT1261645	hsa-miR-1224-5p	CLIP-seq
MIRT1261646	hsa-miR-1304	CLIP-seq
MIRT1261647	hsa-miR-28-5p	CLIP-seq
MIRT1261648	hsa-miR-3120-5p	CLIP-seq
MIRT1261649	hsa-miR-3139	CLIP-seq
MIRT1261650	hsa-miR-3150b-3p	CLIP-seq
MIRT1261651	hsa-miR-3915	CLIP-seq
MIRT1261652	hsa-miR-4689	CLIP-seq
MIRT1261653	hsa-miR-4784	CLIP-seq
MIRT1261654	hsa-miR-708	CLIP-seq

24 Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	24043831
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IBA
GO:0003899	Function	DNA-directed RNA polymerase activity	IDA	24043831, 26975377
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	ISS	8026492
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 32814053, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0005658	Component	Alpha DNA polymerase:primase complex	IBA
GO:0005658	Component	Alpha DNA polymerase:primase complex	IDA	8026492, 26975377
GO:0005658	Component	Alpha DNA polymerase:primase complex	IEA
GO:0005658	Component	Alpha DNA polymerase:primase complex	IPI	26975377
GO:0006260	Process	DNA replication	IEA
GO:0006269	Process	DNA replication, synthesis of primer	IBA
GO:0006269	Process	DNA replication, synthesis of primer	IDA	8026492, 26975377
GO:0006269	Process	DNA replication, synthesis of primer	IEA
GO:0006270	Process	DNA replication initiation	IDA	26975377
GO:0006270	Process	DNA replication initiation	IEA
GO:0008270	Function	Zinc ion binding	IDA	24043831, 25550159, 26975377
GO:0016020	Component	Membrane	HDA	19946888
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0032553	Function	Ribonucleotide binding	IDA	24043831
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
176635	9369	ENSG00000198056

P49642

Protein name

DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49)

Protein function

Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed

PDB

4BPU , 4BPW , 4BPX , 4LIK , 4LIL , 4MHQ , 4RR2 , 5EXR , 6R4S , 6R4T , 6R4U , 6R5D , 6R5E , 6RB4 , 7OPL , 7U5C , 8B9D , 8D0B , 8D0K , 8D9D , 8QJ7 , 8VY3 , 9C8V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01896	DNA_primase_S	108 → 336	DNA primase small subunit	Family

Sequence

METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSF
NNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRR
CCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSA
VRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESW
DKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQY
CFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAI
STNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSDLQKDF

Sequence length

420

Interactions

View interactions

KEGG Pathway	Reactome Pathway
DNA replication	Inhibition of replication initiation of damaged DNA by RB1/E2F1
	Polymerase switching on the C-strand of the telomere
	Telomere C-strand synthesis initiation
	DNA replication initiation
	Activation of the pre-replicative complex
	Polymerase switching
	Removal of the Flap Intermediate
	Processive synthesis on the lagging strand

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Pathogenic	rs1953871835, rs1487483670, rs762016916	RCV002274169 RCV002274167 RCV002274168	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Seckel syndrome	Pathogenic	rs1953871835, rs1487483670, rs762016916	RCV006449385 RCV006449383 RCV006449384	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (9)
BREAST CANCER	—	GWAS catalog	37380357	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	36989840	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN FAILURE, PREMATURE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Premature ovarian failure	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	32514122, 32541925, 38374256	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	34594039, 40050615	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE POLYP	—	GWAS catalog	40069456	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (12)
Breast Carcinoma	Breast Carcinoma	BEFREE	30097999		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	32908930	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32908930	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	31797865	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30097999		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30257222		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	30097999		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30097999, 30257222		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	BEFREE	27599756		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pituitary dwarfism 1	Pituitary dwarfism	Pubtator	33060134	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	27599756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sleep Apnea Obstructive	Sleep apnea	Pubtator	36574455	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
HSD17B6	2	["Obstructive sleep apnea syndrome","Uterine polyp"]	0	[]	2	["GWAS catalog (Obstructive sleep apnea syndrome)","GWAS catalog (Uterine polyp)"]
POLA2	0	[]	9	["DNA replication","Telomere C-strand synthesis initiation","Activation of the pre-replicative complex","Polymerase switching on the C-strand of the telomere","Polymerase switching","Removal of the Flap Intermediate","Processive synthesis on the lagging strand","Inhibition of replication initiation of damaged DNA by RB1\/E2F1","DNA replication initiation"]	0	[]
PRIM2	0	[]	9	["DNA replication","Telomere C-strand synthesis initiation","Activation of the pre-replicative complex","Polymerase switching on the C-strand of the telomere","Polymerase switching","Removal of the Flap Intermediate","Processive synthesis on the lagging strand","Inhibition of replication initiation of damaged DNA by RB1\/E2F1","DNA replication initiation"]	0	[]
POLA1	0	[]	9	["DNA replication","Telomere C-strand synthesis initiation","Activation of the pre-replicative complex","Polymerase switching on the C-strand of the telomere","Polymerase switching","Removal of the Flap Intermediate","Processive synthesis on the lagging strand","Inhibition of replication initiation of damaged DNA by RB1\/E2F1","DNA replication initiation"]	0	[]
POLD3	0	[]	5	["DNA replication","Polymerase switching on the C-strand of the telomere","Polymerase switching","Removal of the Flap Intermediate","Processive synthesis on the lagging strand"]	0	[]

PRIM1 (DNA primase subunit 1)

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