PRDX6 (peroxiredoxin 6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9588
• Gene name: Peroxiredoxin 6
• Gene symbol: PRDX6
• Synonyms (NCBI Gene): 1-Cys, AOP2, HEL-S-128m, LPCAT-5, NSGPx, PRX, aiPLA2, p29
• Chromosome: 1
• Chromosome location: 1q25.1
• Summary: The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain org

miRNA Show/Hide all (330)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004940	hsa-miR-632	qRT-PCR, Western blot	17980029
MIRT044389	hsa-miR-320a	CLASH	23622248
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assay, Western blot	27484502
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assay, Western blot	27484502
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260576	hsa-miR-1178	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260578	hsa-miR-122	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT1260587	hsa-miR-137	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260589	hsa-miR-183	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260604	hsa-miR-3134	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260607	hsa-miR-3171	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT1260611	hsa-miR-342-3p	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260613	hsa-miR-361-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260615	hsa-miR-3679-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260619	hsa-miR-3714	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT1260623	hsa-miR-3921	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260625	hsa-miR-4252	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT1260631	hsa-miR-4493	CLIP-seq
MIRT1260632	hsa-miR-4502	CLIP-seq
MIRT1260633	hsa-miR-4530	CLIP-seq
MIRT1260634	hsa-miR-4534	CLIP-seq
MIRT1260635	hsa-miR-4653-5p	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260642	hsa-miR-4727-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260646	hsa-miR-4769-3p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260648	hsa-miR-4790-3p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260655	hsa-miR-512-3p	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT1260658	hsa-miR-518a-3p	CLIP-seq
MIRT1260659	hsa-miR-518b	CLIP-seq
MIRT1260660	hsa-miR-518c	CLIP-seq
MIRT1260661	hsa-miR-518d-3p	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260663	hsa-miR-518f	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT1260671	hsa-miR-607	CLIP-seq
MIRT1260672	hsa-miR-628-5p	CLIP-seq
MIRT1260673	hsa-miR-634	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT1260675	hsa-miR-759	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260678	hsa-miR-922	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT2303390	hsa-miR-142-5p	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT2303394	hsa-miR-3065-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT2303395	hsa-miR-340	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT2303396	hsa-miR-4494	CLIP-seq
MIRT2303397	hsa-miR-4499	CLIP-seq
MIRT2303398	hsa-miR-4506	CLIP-seq
MIRT2303399	hsa-miR-4517	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT2303401	hsa-miR-505	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303402	hsa-miR-617	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT2688556	hsa-miR-1305	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004601	Function	Peroxidase activity	IBA
GO:0004601	Function	Peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IMP	10893423
GO:0004623	Function	Phospholipase A2 activity	IDA	26830860
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005515	Function	Protein binding	IPI	16186110, 19188445, 20849852, 21044950, 21911577, 26030842, 29128334, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	16186110
GO:0005737	Component	Cytoplasm	IDA	16186110, 19188445, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	NAS	9497358
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IMP	10893423
GO:0016020	Component	Membrane	HDA	19946888
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016209	Function	Antioxidant activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19725078
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IMP	9587003
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045454	Process	Cell redox homeostasis	IBA
GO:0046475	Process	Glycerophospholipid catabolic process	IMP	10893423
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IDA	26830860
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IEA
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IMP	10893423
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IGI	16186110
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16186110
GO:0051920	Function	Peroxiredoxin activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0098869	Process	Cellular oxidant detoxification	IMP	10893423

Other IDs

• MIM: 602316
• HGNC: 16753
• e!Ensembl: ENSG00000117592

Protein

• UniProt ID: P30041
• Protein name: Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylch
• Protein function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholip
• PDB: 1PRX , 5B6M , 5B6N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00578	AhpC-TSA	7 → 146	AhpC/TSA family	Domain
  PF10417	1-cysPrx_C	166 → 205	C-terminal domain of 1-Cys peroxiredoxin	Domain

• Sequence:

  MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
  FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
  EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
  WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

• Sequence length: 224

Pathways

KEGG Pathway	Reactome Pathway
Glutathione metabolism	Detoxification of Reactive Oxygen Species
Metabolic pathways	Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (18)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	21472284	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT	—	CTD	25724174	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DOWN SYNDROME	—	CTD, Disgenet CTD, Disgenet	11771762	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	23692979	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	16214533	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MMP10 2 shared diseasesContact dermatitis, Lung neoplasms 3 shared evidence sourcesDisgenet (Contact dermatitis), CTD (Contact dermatitis), CTD (Lung neoplasms) Related via 2 shared diseases including Contact dermatitis, Lung neoplasms — evidence mostly CTD. CXCL14 2 shared diseasesContact dermatitis, Lung neoplasms 3 shared evidence sourcesDisgenet (Contact dermatitis), CTD (Contact dermatitis), CTD (Lung neoplasms) Related via 2 shared diseases including Contact dermatitis, Lung neoplasms — evidence mostly CTD. GPX3 1 shared diseaseLung neoplasms 2 shared pathwaysGlutathione metabolism, Detoxification of Reactive Oxygen Species 1 shared evidence sourceCTD (Lung neoplasms) Related via 2 shared pathways including Glutathione metabolism, Detoxification of Reactive Oxygen Species — evidence mostly CTD. GPX6 2 shared pathwaysGlutathione metabolism, Detoxification of Reactive Oxygen Species Related via 2 shared pathways including Glutathione metabolism, Detoxification of Reactive Oxygen Species. GPX5 2 shared pathwaysGlutathione metabolism, Detoxification of Reactive Oxygen Species Related via 2 shared pathways including Glutathione metabolism, Detoxification of Reactive Oxygen Species.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MMP10	2	["Contact dermatitis","Lung neoplasms"]	0	[]	3	["Disgenet (Contact dermatitis)","CTD (Contact dermatitis)","CTD (Lung neoplasms)"]
CXCL14	2	["Contact dermatitis","Lung neoplasms"]	0	[]	3	["Disgenet (Contact dermatitis)","CTD (Contact dermatitis)","CTD (Lung neoplasms)"]
GPX3	1	["Lung neoplasms"]	2	["Glutathione metabolism","Detoxification of Reactive Oxygen Species"]	1	["CTD (Lung neoplasms)"]
GPX6	0	[]	2	["Glutathione metabolism","Detoxification of Reactive Oxygen Species"]	0	[]
GPX5	0	[]	2	["Glutathione metabolism","Detoxification of Reactive Oxygen Species"]	0	[]

Diseases Linked via Similar Genes

Bipolar disorder Linked via 3 of 5 related genesMMP10, GPX6, GPX5 Rheumatoid arthritis Linked via 2 of 5 related genesMMP10, GPX6 Asthma Linked via 2 of 5 related genesMMP10, CXCL14 Endometriosis Linked via 2 of 5 related genesCXCL14, GPX3 Autism Linked via 2 of 5 related genesGPX6, GPX5

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Bipolar disorder	3	["MMP10","GPX6","GPX5"]
Rheumatoid arthritis	2	["MMP10","GPX6"]
Asthma	2	["MMP10","CXCL14"]
Endometriosis	2	["CXCL14","GPX3"]
Autism	2	["GPX6","GPX5"]