Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10450
Gene name	Peptidylprolyl isomerase E
Gene symbol	PPIE
Synonyms (NCBI Gene)	CYP-33CYP33CypE
Chromosome	1
Chromosome location	1p34.2
Summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein con

224 Show/Hide all (224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043678	hsa-miR-342-3p	CLASH	23622248
MIRT042995	hsa-miR-324-3p	CLASH	23622248
MIRT039021	hsa-miR-766-3p	CLASH	23622248
MIRT647526	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT647525	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT647524	hsa-miR-140-5p	HITS-CLIP	23824327
MIRT647523	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647522	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647521	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647520	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647519	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT663806	hsa-miR-1976	HITS-CLIP	23824327
MIRT647518	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647517	hsa-miR-4460	HITS-CLIP	23824327
MIRT647526	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT647525	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT647524	hsa-miR-140-5p	HITS-CLIP	23824327
MIRT647523	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647522	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647521	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647520	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647519	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT647518	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647517	hsa-miR-4460	HITS-CLIP	23824327
MIRT647526	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT647525	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT647524	hsa-miR-140-5p	HITS-CLIP	23824327
MIRT647523	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647522	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647521	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647520	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647519	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT663806	hsa-miR-1976	HITS-CLIP	23824327
MIRT647518	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647517	hsa-miR-4460	HITS-CLIP	23824327
MIRT647526	hsa-miR-203b-5p	HITS-CLIP	23824327
MIRT647525	hsa-miR-6718-5p	HITS-CLIP	23824327
MIRT647524	hsa-miR-140-5p	HITS-CLIP	23824327
MIRT647523	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT647522	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647521	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647520	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647519	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT647518	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647517	hsa-miR-4460	HITS-CLIP	23824327
MIRT1252910	hsa-miR-1289	CLIP-seq
MIRT1252911	hsa-miR-141	CLIP-seq
MIRT1252912	hsa-miR-185	CLIP-seq
MIRT1252913	hsa-miR-200a	CLIP-seq
MIRT1252914	hsa-miR-2682	CLIP-seq
MIRT1252915	hsa-miR-299-3p	CLIP-seq
MIRT1252916	hsa-miR-3127-5p	CLIP-seq
MIRT1252917	hsa-miR-3132	CLIP-seq
MIRT1252918	hsa-miR-3135b	CLIP-seq
MIRT1252919	hsa-miR-3144-5p	CLIP-seq
MIRT1252920	hsa-miR-3151	CLIP-seq
MIRT1252921	hsa-miR-3160-3p	CLIP-seq
MIRT1252922	hsa-miR-3165	CLIP-seq
MIRT1252923	hsa-miR-3191	CLIP-seq
MIRT1252924	hsa-miR-3192	CLIP-seq
MIRT1252925	hsa-miR-338-3p	CLIP-seq
MIRT1252926	hsa-miR-34a	CLIP-seq
MIRT1252927	hsa-miR-34c-5p	CLIP-seq
MIRT1252928	hsa-miR-3545-3p	CLIP-seq
MIRT1252929	hsa-miR-3622a-3p	CLIP-seq
MIRT1252930	hsa-miR-3622b-3p	CLIP-seq
MIRT1252931	hsa-miR-3622b-5p	CLIP-seq
MIRT1252932	hsa-miR-3652	CLIP-seq
MIRT1252933	hsa-miR-3663-3p	CLIP-seq
MIRT1252934	hsa-miR-370	CLIP-seq
MIRT1252935	hsa-miR-3913-3p	CLIP-seq
MIRT1252936	hsa-miR-3918	CLIP-seq
MIRT1252937	hsa-miR-3928	CLIP-seq
MIRT1252938	hsa-miR-3936	CLIP-seq
MIRT1252939	hsa-miR-4267	CLIP-seq
MIRT1252940	hsa-miR-4306	CLIP-seq
MIRT1252941	hsa-miR-4422	CLIP-seq
MIRT1252942	hsa-miR-4430	CLIP-seq
MIRT1252943	hsa-miR-4447	CLIP-seq
MIRT1252944	hsa-miR-4459	CLIP-seq
MIRT1252945	hsa-miR-4472	CLIP-seq
MIRT1252946	hsa-miR-449a	CLIP-seq
MIRT1252947	hsa-miR-449b	CLIP-seq
MIRT1252948	hsa-miR-449c	CLIP-seq
MIRT1252949	hsa-miR-4514	CLIP-seq
MIRT1252950	hsa-miR-4521	CLIP-seq
MIRT1252951	hsa-miR-4539	CLIP-seq
MIRT1252952	hsa-miR-4640-5p	CLIP-seq
MIRT1252953	hsa-miR-4641	CLIP-seq
MIRT1252954	hsa-miR-4644	CLIP-seq
MIRT1252955	hsa-miR-4652-5p	CLIP-seq
MIRT1252956	hsa-miR-4662a-5p	CLIP-seq
MIRT1252957	hsa-miR-4663	CLIP-seq
MIRT1252958	hsa-miR-4692	CLIP-seq
MIRT1252959	hsa-miR-4704-5p	CLIP-seq
MIRT1252960	hsa-miR-4716-3p	CLIP-seq
MIRT1252961	hsa-miR-4723-5p	CLIP-seq
MIRT1252962	hsa-miR-4726-5p	CLIP-seq
MIRT1252963	hsa-miR-4772-3p	CLIP-seq
MIRT1252964	hsa-miR-4777-5p	CLIP-seq
MIRT1252965	hsa-miR-4786-3p	CLIP-seq
MIRT1252966	hsa-miR-489	CLIP-seq
MIRT1252967	hsa-miR-491-5p	CLIP-seq
MIRT1252968	hsa-miR-516b	CLIP-seq
MIRT1252969	hsa-miR-548ac	CLIP-seq
MIRT1252970	hsa-miR-548ae	CLIP-seq
MIRT1252971	hsa-miR-548aj	CLIP-seq
MIRT1252972	hsa-miR-548am	CLIP-seq
MIRT1252973	hsa-miR-548d-3p	CLIP-seq
MIRT1252974	hsa-miR-548x	CLIP-seq
MIRT1252975	hsa-miR-548z	CLIP-seq
MIRT1252976	hsa-miR-576-3p	CLIP-seq
MIRT1252977	hsa-miR-591	CLIP-seq
MIRT1252978	hsa-miR-638	CLIP-seq
MIRT1252979	hsa-miR-939	CLIP-seq
MIRT1252929	hsa-miR-3622a-3p	CLIP-seq
MIRT1252930	hsa-miR-3622b-3p	CLIP-seq
MIRT1252935	hsa-miR-3913-3p	CLIP-seq
MIRT1252938	hsa-miR-3936	CLIP-seq
MIRT1252950	hsa-miR-4521	CLIP-seq
MIRT1252966	hsa-miR-489	CLIP-seq
MIRT1252978	hsa-miR-638	CLIP-seq
MIRT2074484	hsa-miR-1182	CLIP-seq
MIRT2074485	hsa-miR-1205	CLIP-seq
MIRT2074486	hsa-miR-1224-3p	CLIP-seq
MIRT2074487	hsa-miR-1237	CLIP-seq
MIRT2074488	hsa-miR-1254	CLIP-seq
MIRT2074489	hsa-miR-1260	CLIP-seq
MIRT2074490	hsa-miR-1260b	CLIP-seq
MIRT2074491	hsa-miR-1280	CLIP-seq
MIRT2074492	hsa-miR-1286	CLIP-seq
MIRT2074493	hsa-miR-1343	CLIP-seq
MIRT2074494	hsa-miR-214	CLIP-seq
MIRT2074495	hsa-miR-3116	CLIP-seq
MIRT1252918	hsa-miR-3135b	CLIP-seq
MIRT2074496	hsa-miR-3199	CLIP-seq
MIRT2074497	hsa-miR-3614-3p	CLIP-seq
MIRT2074498	hsa-miR-3619-5p	CLIP-seq
MIRT1252931	hsa-miR-3622b-5p	CLIP-seq
MIRT1252932	hsa-miR-3652	CLIP-seq
MIRT2074499	hsa-miR-3655	CLIP-seq
MIRT2074500	hsa-miR-3925-3p	CLIP-seq
MIRT2074501	hsa-miR-4254	CLIP-seq
MIRT1252939	hsa-miR-4267	CLIP-seq
MIRT2074502	hsa-miR-4291	CLIP-seq
MIRT2074503	hsa-miR-4300	CLIP-seq
MIRT2074504	hsa-miR-4303	CLIP-seq
MIRT1252942	hsa-miR-4430	CLIP-seq
MIRT2074505	hsa-miR-4645-5p	CLIP-seq
MIRT2074506	hsa-miR-4673	CLIP-seq
MIRT2074507	hsa-miR-4680-5p	CLIP-seq
MIRT2074508	hsa-miR-4682	CLIP-seq
MIRT2074509	hsa-miR-4722-5p	CLIP-seq
MIRT2074510	hsa-miR-498	CLIP-seq
MIRT2074511	hsa-miR-516a-3p	CLIP-seq
MIRT2074512	hsa-miR-532-3p	CLIP-seq
MIRT1252977	hsa-miR-591	CLIP-seq
MIRT2074513	hsa-miR-761	CLIP-seq
MIRT2074514	hsa-miR-766	CLIP-seq
MIRT2074515	hsa-miR-920	CLIP-seq
MIRT2074516	hsa-miR-922	CLIP-seq
MIRT2074486	hsa-miR-1224-3p	CLIP-seq
MIRT2074487	hsa-miR-1237	CLIP-seq
MIRT2074489	hsa-miR-1260	CLIP-seq
MIRT2074490	hsa-miR-1260b	CLIP-seq
MIRT2074491	hsa-miR-1280	CLIP-seq
MIRT2301480	hsa-miR-136	CLIP-seq
MIRT2301481	hsa-miR-15a	CLIP-seq
MIRT2301482	hsa-miR-15b	CLIP-seq
MIRT2301483	hsa-miR-16	CLIP-seq
MIRT2301484	hsa-miR-1915	CLIP-seq
MIRT2301485	hsa-miR-195	CLIP-seq
MIRT1252918	hsa-miR-3135b	CLIP-seq
MIRT2074496	hsa-miR-3199	CLIP-seq
MIRT2074497	hsa-miR-3614-3p	CLIP-seq
MIRT1252931	hsa-miR-3622b-5p	CLIP-seq
MIRT1252932	hsa-miR-3652	CLIP-seq
MIRT2301486	hsa-miR-3919	CLIP-seq
MIRT2301487	hsa-miR-424	CLIP-seq
MIRT1252939	hsa-miR-4267	CLIP-seq
MIRT2074504	hsa-miR-4303	CLIP-seq
MIRT1252942	hsa-miR-4430	CLIP-seq
MIRT2301488	hsa-miR-4530	CLIP-seq
MIRT1252956	hsa-miR-4662a-5p	CLIP-seq
MIRT2074508	hsa-miR-4682	CLIP-seq
MIRT2301489	hsa-miR-4693-3p	CLIP-seq
MIRT2301490	hsa-miR-4714-3p	CLIP-seq
MIRT2301491	hsa-miR-4726-3p	CLIP-seq
MIRT2301492	hsa-miR-497	CLIP-seq
MIRT2074510	hsa-miR-498	CLIP-seq
MIRT2074512	hsa-miR-532-3p	CLIP-seq
MIRT1252977	hsa-miR-591	CLIP-seq
MIRT2301493	hsa-miR-885-5p	CLIP-seq
MIRT2074494	hsa-miR-214	CLIP-seq
MIRT2074498	hsa-miR-3619-5p	CLIP-seq
MIRT2392890	hsa-miR-378g	CLIP-seq
MIRT2074502	hsa-miR-4291	CLIP-seq
MIRT2392891	hsa-miR-4679	CLIP-seq
MIRT2074513	hsa-miR-761	CLIP-seq
MIRT2074516	hsa-miR-922	CLIP-seq
MIRT2598194	hsa-miR-1250	CLIP-seq
MIRT2598195	hsa-miR-2467-5p	CLIP-seq
MIRT2598196	hsa-miR-3188	CLIP-seq
MIRT1252926	hsa-miR-34a	CLIP-seq
MIRT1252927	hsa-miR-34c-5p	CLIP-seq
MIRT2598197	hsa-miR-3921	CLIP-seq
MIRT2598198	hsa-miR-3975	CLIP-seq
MIRT1252946	hsa-miR-449a	CLIP-seq
MIRT1252947	hsa-miR-449b	CLIP-seq
MIRT2598199	hsa-miR-4649-3p	CLIP-seq
MIRT2598200	hsa-miR-4653-5p	CLIP-seq
MIRT2598201	hsa-miR-485-5p	CLIP-seq
MIRT2598194	hsa-miR-1250	CLIP-seq
MIRT2598195	hsa-miR-2467-5p	CLIP-seq
MIRT2598196	hsa-miR-3188	CLIP-seq
MIRT1252926	hsa-miR-34a	CLIP-seq
MIRT1252927	hsa-miR-34c-5p	CLIP-seq
MIRT2598197	hsa-miR-3921	CLIP-seq
MIRT2598198	hsa-miR-3975	CLIP-seq
MIRT1252946	hsa-miR-449a	CLIP-seq
MIRT1252947	hsa-miR-449b	CLIP-seq
MIRT2598199	hsa-miR-4649-3p	CLIP-seq
MIRT2598200	hsa-miR-4653-5p	CLIP-seq
MIRT2598201	hsa-miR-485-5p	CLIP-seq

38 Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	11313484
GO:0003729	Function	MRNA binding	IDA	18258190
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IBA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IDA	18258190, 20676357
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	TAS	11313484
GO:0005515	Function	Protein binding	IPI	11313484, 16189514, 20541251, 22365833, 24981860, 25416956, 25599396, 32296183, 32814053, 33961781, 34799561, 37100772
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	11313484, 28076346
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	11313484
GO:0006397	Process	MRNA processing	IEA
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IEA
GO:0008143	Function	Poly(A) binding	IDA	18258190
GO:0008380	Process	RNA splicing	IEA
GO:0016018	Function	Cyclosporin A binding	IBA
GO:0016018	Function	Cyclosporin A binding	TAS	9747881
GO:0016607	Component	Nuclear speck	IDA
GO:0016853	Function	Isomerase activity	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0045070	Process	Positive regulation of viral genome replication	IMP	19932913
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
602435	9258	ENSG00000084072

Q9UNP9

Protein name

Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)

Protein function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for

PDB

1ZMF , 2CQB , 2KU7 , 2KYX , 2R99 , 3LPY , 3MDF , 3UCH , 5MQF , 5YZG , 5Z56 , 5Z57 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 7A5P , 7ABI , 7W59 , 7W5A , 7W5B , 7ZEV , 7ZEW , 7ZEX , 7ZEY , 7ZEZ , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	8 → 78	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00160	Pro_isomerase	143 → 299	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Sequence

MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDA
AAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENKEEEGSE
PPKAETQEGEPIAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEK
GFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSG
PNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEAQGSKDGKPKQKVIIADCGEY
V

Sequence length

301

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	Formation of TC-NER Pre-Incision Complex
	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	Neutrophil degranulation
	mRNA Splicing - Major Pathway

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
ISY1-RAB43	[]	6	["Spliceosome","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway"]	[]
XAB2	[]	6	["Spliceosome","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway"]	[]
ISY1	[]	6	["Spliceosome","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway"]	[]
AQR	[]	6	["Spliceosome","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway"]	[]
PRPF19	[]	6	["Spliceosome","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway"]	[]

PPIE (peptidylprolyl isomerase E)

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