POLR3E (RNA polymerase III subunit E)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55718
• Gene name: RNA polymerase III subunit E
• Gene symbol: POLR3E
• Synonyms (NCBI Gene): C37, RPC5, SIN
• Chromosome: 16
• Chromosome location: 16p12.2

miRNA Show/Hide all (49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027727	hsa-miR-98-5p	Microarray	19088304
MIRT047349	hsa-miR-34a-5p	CLASH	23622248
MIRT044787	hsa-miR-320a	CLASH	23622248
MIRT492612	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT492611	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT492610	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT492609	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT492608	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT492607	hsa-miR-218-2-3p	PAR-CLIP	23592263
MIRT492606	hsa-miR-758-5p	PAR-CLIP	23592263
MIRT492605	hsa-miR-4495	PAR-CLIP	23592263
MIRT492604	hsa-miR-873-3p	PAR-CLIP	23592263
MIRT492603	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT492602	hsa-miR-1206	PAR-CLIP	23592263
MIRT492601	hsa-miR-584-5p	PAR-CLIP	23592263
MIRT492600	hsa-miR-6516-3p	PAR-CLIP	23592263
MIRT492599	hsa-miR-3672	PAR-CLIP	23592263
MIRT492598	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT492612	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT492611	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT492610	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT492609	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT492608	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT492607	hsa-miR-218-2-3p	PAR-CLIP	23592263
MIRT492606	hsa-miR-758-5p	PAR-CLIP	23592263
MIRT492605	hsa-miR-4495	PAR-CLIP	23592263
MIRT492604	hsa-miR-873-3p	PAR-CLIP	23592263
MIRT492603	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT492602	hsa-miR-1206	PAR-CLIP	23592263
MIRT492601	hsa-miR-584-5p	PAR-CLIP	23592263
MIRT492600	hsa-miR-6516-3p	PAR-CLIP	23592263
MIRT492599	hsa-miR-3672	PAR-CLIP	23592263
MIRT492598	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1249235	hsa-miR-217	CLIP-seq
MIRT1249236	hsa-miR-3671	CLIP-seq
MIRT1249237	hsa-miR-4418	CLIP-seq
MIRT1249238	hsa-miR-4641	CLIP-seq
MIRT1249239	hsa-miR-4722-3p	CLIP-seq
MIRT1249240	hsa-miR-4793-5p	CLIP-seq
MIRT1249241	hsa-miR-509-3-5p	CLIP-seq
MIRT1249242	hsa-miR-509-5p	CLIP-seq
MIRT1249243	hsa-miR-518a-5p	CLIP-seq
MIRT1249244	hsa-miR-527	CLIP-seq
MIRT1249245	hsa-miR-607	CLIP-seq
MIRT1249246	hsa-miR-873	CLIP-seq
MIRT2073620	hsa-miR-1237	CLIP-seq
MIRT2073621	hsa-miR-188-5p	CLIP-seq
MIRT2073622	hsa-miR-3182	CLIP-seq
MIRT2597417	hsa-miR-548p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005666	Component	RNA polymerase III complex	IBA
GO:0005666	Component	RNA polymerase III complex	IDA	24107381, 33335104, 34675218
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	DNA-templated transcription	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0051607	Process	Defense response to virus	IEA

Other IDs

• MIM: 617815
• HGNC: 30347
• e!Ensembl: ENSG00000058600

Protein

• UniProt ID: Q9NVU0
• Protein name: DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
• Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III)
• PDB: 7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7ASU , 7ASV , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04801	Sin_N	5 → 432	Sin-like protein conserved region	Family

• Sequence:

  MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEM
  AIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYR
  QGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRP
  ESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVK
  SPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSL
  LGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKF
  TQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQH
  MLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQ
  RRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAA
  GTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFS
  GISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKN
  YRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS

• Sequence length: 708

Pathways

KEGG Pathway	Reactome Pathway
RNA polymerase	Cytosolic sensors of pathogen-associated DNA
Cytosolic DNA-sensing pathway	RNA Polymerase III Transcription Initiation From Type 1 Promoter
	RNA Polymerase III Transcription Initiation From Type 2 Promoter
	RNA Polymerase III Transcription Initiation From Type 3 Promoter

Related Genes

Sort by: Blended Diseases Pathways Evidence source

POLR3F 6 shared pathwaysRNA polymerase, Cytosolic DNA-sensing pathway, RNA Polymerase III Transcription Initiation From Type 3 Promoter, Cytosolic sensors of pathogen-associated DNA , RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter Related via 6 shared pathways including RNA polymerase, Cytosolic DNA-sensing pathway. POLR3G 6 shared pathwaysRNA polymerase, Cytosolic DNA-sensing pathway, RNA Polymerase III Transcription Initiation From Type 3 Promoter, Cytosolic sensors of pathogen-associated DNA , RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter Related via 6 shared pathways including RNA polymerase, Cytosolic DNA-sensing pathway. POLR3C 6 shared pathwaysRNA polymerase, Cytosolic DNA-sensing pathway, RNA Polymerase III Transcription Initiation From Type 3 Promoter, Cytosolic sensors of pathogen-associated DNA , RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter Related via 6 shared pathways including RNA polymerase, Cytosolic DNA-sensing pathway. POLR3A 6 shared pathwaysRNA polymerase, Cytosolic DNA-sensing pathway, RNA Polymerase III Transcription Initiation From Type 3 Promoter, Cytosolic sensors of pathogen-associated DNA , RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter Related via 6 shared pathways including RNA polymerase, Cytosolic DNA-sensing pathway. POLR3H 6 shared pathwaysRNA polymerase, Cytosolic DNA-sensing pathway, RNA Polymerase III Transcription Initiation From Type 3 Promoter, Cytosolic sensors of pathogen-associated DNA , RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter Related via 6 shared pathways including RNA polymerase, Cytosolic DNA-sensing pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
POLR3F	0	[]	6	["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]	0	[]
POLR3G	0	[]	6	["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]	0	[]
POLR3C	0	[]	6	["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]	0	[]
POLR3A	0	[]	6	["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]	0	[]
POLR3H	0	[]	6	["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]	0	[]

Diseases Linked via Similar Genes

Immunodeficiency Linked via 1 of 5 related genesPOLR3F Autism Linked via 1 of 5 related genesPOLR3G Gout Linked via 1 of 5 related genesPOLR3C Bipolar disorder Linked via 1 of 5 related genesPOLR3A Cerebellar ataxia Linked via 1 of 5 related genesPOLR3A

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Immunodeficiency	1	["POLR3F"]
Autism	1	["POLR3G"]
Gout	1	["POLR3C"]
Bipolar disorder	1	["POLR3A"]
Cerebellar ataxia	1	["POLR3A"]