This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)
Protein function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric compone
["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]
["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]
["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]
["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]
["RNA polymerase","Cytosolic DNA-sensing pathway","RNA Polymerase III Transcription Initiation From Type 3 Promoter","Cytosolic sensors of pathogen-associated DNA ","RNA Polymerase III Transcription Initiation From Type 1 Promoter","RNA Polymerase III Transcription Initiation From Type 2 Promoter"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to POLR3D (see Related Genes above), that are NOT already directly curated for POLR3D itself -- a lead worth checking, not a confirmed association.