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Gene Gene information from NCBI Gene database.
Entrez ID 661
Gene name RNA polymerase III subunit D
Gene symbol POLR3D
Synonyms (NCBI Gene)
BN51TC53RPC4RPC53TSBN51
Chromosome 8
Chromosome location 8p21.3
Summary This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
316 Show/Hide all (316)
miRTarBase ID miRNA Experiments Reference
MIRT001964 hsa-miR-320a TaqMan miRNA assay/RT-PCR 18852463
MIRT001964 hsa-miR-320a TaqMan miRNA assayqRT-PCR 18852463
MIRT051623 hsa-let-7e-5p CLASH 23622248
MIRT045444 hsa-miR-149-5p CLASH 23622248
MIRT123972 hsa-let-7a-5p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
EZH2 Unknown 18852463
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0000428 Component DNA-directed RNA polymerase complex IEA
GO:0002376 Process Immune system process IEA
GO:0003677 Function DNA binding IEA
GO:0003682 Function Chromatin binding IDA 24107381
GO:0003682 Function Chromatin binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
187280 1080 ENSG00000168495
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05423
Protein name DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)
Protein function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric compone
PDB 7A6H , 7AE1 , 7AE3 , 7AEA , 7AST , 7D58 , 7D59 , 7DN3 , 7DU2 , 7FJI , 7FJJ , 8ITY , 8IUE , 8IUH , 9FSO , 9FSP , 9FSQ , 9FSR , 9FSS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05132 RNA_pol_Rpc4 263 → 389 RNA polymerase III RPC4 Family
Sequence
MSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTP
NIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKK
GNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQL
PLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAAR
KTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQVVL
IKQEKDREAKLAENACTLADLTEGQVGKLLIRKSGRVQLLLGKVTLDVTMGTACSFLQEL
VSVGLGDSRTGEMTVLGHVKHKLVCSPDF
ESLLDHKHR
Sequence length 398
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
RNA polymerase Cytosolic sensors of pathogen-associated DNA
Cytosolic DNA-sensing pathway RNA Polymerase III Transcription Initiation From Type 1 Promoter
  RNA Polymerase III Transcription Initiation From Type 2 Promoter
  RNA Polymerase III Transcription Initiation From Type 3 Promoter