POLM (DNA polymerase mu)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27434
• Gene name: DNA polymerase mu
• Gene symbol: POLM
• Synonyms (NCBI Gene): Pol Mu, Tdt-N
• Chromosome: 7
• Chromosome location: 7p13

miRNA Show/Hide all (303)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018681	hsa-miR-335-5p	Microarray	18185580
MIRT619848	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT619847	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT619846	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT619845	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT619844	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT619843	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT619842	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT619841	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT619840	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT619839	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT619838	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT619837	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT619836	hsa-miR-302e	HITS-CLIP	23313552
MIRT619835	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT619834	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT619833	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT619832	hsa-miR-520b	HITS-CLIP	23313552
MIRT619831	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT619830	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT619829	hsa-miR-520e	HITS-CLIP	23313552
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23313552
MIRT619827	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23313552
MIRT694176	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT619825	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT619824	hsa-miR-520h	HITS-CLIP	23313552
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT694175	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694174	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23313552
MIRT694173	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694172	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694171	hsa-miR-5095	HITS-CLIP	23313552
MIRT694170	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT619819	hsa-miR-4642	HITS-CLIP	23313552
MIRT694169	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT663653	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663652	hsa-miR-764	HITS-CLIP	23824327
MIRT663651	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT679271	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679270	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679269	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679268	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT679267	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT679266	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679265	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT663653	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663652	hsa-miR-764	HITS-CLIP	23824327
MIRT663651	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT663650	hsa-miR-640	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT619848	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT619847	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT619846	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT619845	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT619844	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT619843	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT619842	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT619841	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT619840	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT619839	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT619838	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT619837	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT619836	hsa-miR-302e	HITS-CLIP	23824327
MIRT619835	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT619834	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT619833	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT619832	hsa-miR-520b	HITS-CLIP	23824327
MIRT619831	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT619830	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT619829	hsa-miR-520e	HITS-CLIP	23824327
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619827	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT619825	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT619824	hsa-miR-520h	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT496420	hsa-miR-1324	PAR-CLIP	22291592
MIRT496419	hsa-miR-4645-3p	PAR-CLIP	22291592
MIRT496418	hsa-miR-4448	PAR-CLIP	22291592
MIRT489078	hsa-miR-500b-3p	PAR-CLIP	23592263
MIRT489077	hsa-miR-6773-3p	PAR-CLIP	23592263
MIRT489076	hsa-miR-6879-3p	PAR-CLIP	23592263
MIRT439936	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439936	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT018681	hsa-miR-335-5p	PAR-CLIP	27292025
MIRT018681	hsa-miR-335-5p	PAR-CLIP	27292025
MIRT018681	hsa-miR-335-5p	PAR-CLIP	27292025
MIRT619848	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT619847	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT619846	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT619845	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT619844	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT619843	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT619842	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT619841	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT619840	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT619839	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT619838	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT619837	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT619836	hsa-miR-302e	HITS-CLIP	23313552
MIRT619835	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT619834	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT619833	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT619832	hsa-miR-520b	HITS-CLIP	23313552
MIRT619831	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT619830	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT619829	hsa-miR-520e	HITS-CLIP	23313552
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23313552
MIRT619827	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23313552
MIRT694176	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT619825	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT619824	hsa-miR-520h	HITS-CLIP	23313552
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT694175	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694174	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23313552
MIRT694173	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694172	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694171	hsa-miR-5095	HITS-CLIP	23313552
MIRT694170	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT619819	hsa-miR-4642	HITS-CLIP	23313552
MIRT694169	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT663653	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663652	hsa-miR-764	HITS-CLIP	23824327
MIRT663651	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT679271	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679270	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679269	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679268	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT679267	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT679266	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679265	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT663653	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT663652	hsa-miR-764	HITS-CLIP	23824327
MIRT663651	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT663650	hsa-miR-640	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT619848	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT619847	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT619846	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT619845	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT619844	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT619843	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT619842	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT619841	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT619840	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT619839	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT619838	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT619837	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT619836	hsa-miR-302e	HITS-CLIP	23824327
MIRT619835	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT619834	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT619833	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT619832	hsa-miR-520b	HITS-CLIP	23824327
MIRT619831	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT619830	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT619829	hsa-miR-520e	HITS-CLIP	23824327
MIRT619828	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT619827	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT619826	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT619825	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT619824	hsa-miR-520h	HITS-CLIP	23824327
MIRT619823	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT619822	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT619821	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT619820	hsa-miR-324-5p	HITS-CLIP	23824327
MIRT619819	hsa-miR-4642	HITS-CLIP	23824327
MIRT496420	hsa-miR-1324	PAR-CLIP	22291592
MIRT496419	hsa-miR-4645-3p	PAR-CLIP	22291592
MIRT496418	hsa-miR-4448	PAR-CLIP	22291592
MIRT489078	hsa-miR-500b-3p	PAR-CLIP	23592263
MIRT489077	hsa-miR-6773-3p	PAR-CLIP	23592263
MIRT489076	hsa-miR-6879-3p	PAR-CLIP	23592263
MIRT1248046	hsa-miR-1205	CLIP-seq
MIRT1248047	hsa-miR-1275	CLIP-seq
MIRT1248048	hsa-miR-1286	CLIP-seq
MIRT1248049	hsa-miR-2467-5p	CLIP-seq
MIRT1248050	hsa-miR-3188	CLIP-seq
MIRT1248051	hsa-miR-3190	CLIP-seq
MIRT1248052	hsa-miR-3616-3p	CLIP-seq
MIRT1248053	hsa-miR-3975	CLIP-seq
MIRT1248054	hsa-miR-4418	CLIP-seq
MIRT1248055	hsa-miR-4447	CLIP-seq
MIRT1248056	hsa-miR-4472	CLIP-seq
MIRT1248057	hsa-miR-4481	CLIP-seq
MIRT1248058	hsa-miR-4514	CLIP-seq
MIRT1248059	hsa-miR-4525	CLIP-seq
MIRT1248060	hsa-miR-4665-5p	CLIP-seq
MIRT1248061	hsa-miR-4692	CLIP-seq
MIRT1248062	hsa-miR-4721	CLIP-seq
MIRT1248063	hsa-miR-4722-5p	CLIP-seq
MIRT1248064	hsa-miR-4723-5p	CLIP-seq
MIRT1248065	hsa-miR-4745-5p	CLIP-seq
MIRT1248066	hsa-miR-4758-5p	CLIP-seq
MIRT1248067	hsa-miR-4795-5p	CLIP-seq
MIRT1248068	hsa-miR-485-5p	CLIP-seq
MIRT1248069	hsa-miR-509-3-5p	CLIP-seq
MIRT1248070	hsa-miR-509-5p	CLIP-seq
MIRT1248071	hsa-miR-625	CLIP-seq
MIRT2073214	hsa-miR-105	CLIP-seq
MIRT1248047	hsa-miR-1275	CLIP-seq
MIRT1248048	hsa-miR-1286	CLIP-seq
MIRT2073215	hsa-miR-130a	CLIP-seq
MIRT2073216	hsa-miR-130b	CLIP-seq
MIRT2073217	hsa-miR-148a	CLIP-seq
MIRT2073218	hsa-miR-148b	CLIP-seq
MIRT2073219	hsa-miR-152	CLIP-seq
MIRT2073220	hsa-miR-301a	CLIP-seq
MIRT2073221	hsa-miR-301b	CLIP-seq
MIRT2073222	hsa-miR-3154	CLIP-seq
MIRT2073223	hsa-miR-3179	CLIP-seq
MIRT1248051	hsa-miR-3190	CLIP-seq
MIRT2073224	hsa-miR-3665	CLIP-seq
MIRT2073225	hsa-miR-3666	CLIP-seq
MIRT2073226	hsa-miR-3677-5p	CLIP-seq
MIRT2073227	hsa-miR-371-5p	CLIP-seq
MIRT2073228	hsa-miR-371b-5p	CLIP-seq
MIRT2073229	hsa-miR-4295	CLIP-seq
MIRT1248054	hsa-miR-4418	CLIP-seq
MIRT2073230	hsa-miR-4435	CLIP-seq
MIRT1248057	hsa-miR-4481	CLIP-seq
MIRT2073231	hsa-miR-4488	CLIP-seq
MIRT2073232	hsa-miR-454	CLIP-seq
MIRT1248060	hsa-miR-4665-5p	CLIP-seq
MIRT2073233	hsa-miR-4690-3p	CLIP-seq
MIRT2073234	hsa-miR-4697-5p	CLIP-seq
MIRT1248063	hsa-miR-4722-5p	CLIP-seq
MIRT2073235	hsa-miR-4728-5p	CLIP-seq
MIRT1248065	hsa-miR-4745-5p	CLIP-seq
MIRT1248066	hsa-miR-4758-5p	CLIP-seq
MIRT2073236	hsa-miR-486-3p	CLIP-seq
MIRT1248069	hsa-miR-509-3-5p	CLIP-seq
MIRT1248070	hsa-miR-509-5p	CLIP-seq
MIRT2073237	hsa-miR-544b	CLIP-seq
MIRT2073238	hsa-miR-657	CLIP-seq
MIRT2073239	hsa-miR-760	CLIP-seq
MIRT2073240	hsa-miR-891b	CLIP-seq
MIRT2300342	hsa-miR-103a	CLIP-seq
MIRT2300343	hsa-miR-107	CLIP-seq
MIRT2300344	hsa-miR-140-3p	CLIP-seq
MIRT2300345	hsa-miR-2278	CLIP-seq
MIRT2300346	hsa-miR-3150a-3p	CLIP-seq
MIRT2300347	hsa-miR-3175	CLIP-seq
MIRT1248052	hsa-miR-3616-3p	CLIP-seq
MIRT1248053	hsa-miR-3975	CLIP-seq
MIRT2300348	hsa-miR-4419a	CLIP-seq
MIRT2073230	hsa-miR-4435	CLIP-seq
MIRT2300349	hsa-miR-4510	CLIP-seq
MIRT2300350	hsa-miR-4640-5p	CLIP-seq
MIRT2300351	hsa-miR-4726-5p	CLIP-seq
MIRT2300352	hsa-miR-766	CLIP-seq
MIRT2300353	hsa-miR-873	CLIP-seq
MIRT2300354	hsa-miR-939	CLIP-seq
MIRT2392813	hsa-miR-185	CLIP-seq
MIRT2392814	hsa-miR-3135b	CLIP-seq
MIRT2392815	hsa-miR-3151	CLIP-seq
MIRT2392816	hsa-miR-3652	CLIP-seq
MIRT2392817	hsa-miR-4283	CLIP-seq
MIRT2392818	hsa-miR-4306	CLIP-seq
MIRT2392819	hsa-miR-4430	CLIP-seq
MIRT2392820	hsa-miR-4489	CLIP-seq
MIRT2392821	hsa-miR-4492	CLIP-seq
MIRT2392822	hsa-miR-4498	CLIP-seq
MIRT2392823	hsa-miR-4644	CLIP-seq
MIRT2392824	hsa-miR-4708-5p	CLIP-seq
MIRT2392825	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS
GO:0005515	Function	Protein binding	IPI	22458338
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IBA
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	TAS
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0030183	Process	B cell differentiation	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0071897	Process	DNA biosynthetic process	IEA

Other IDs

• MIM: 606344
• HGNC: 9185
• e!Ensembl: ENSG00000122678

Protein

• UniProt ID: Q9NP87
• Protein name: DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase)
• Protein function: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269|PubMed:12640116, ECO:0000269|PubM
• PDB: 2DUN , 2HTF , 4LZD , 4LZG , 4M04 , 4M0A , 4YCX , 4YD1 , 4YD2 , 5TWP , 5TWQ , 5TWR , 5TWS , 5TXX , 5TXZ , 5TYB , 5TYC , 5TYD , 5TYE , 5TYF , 5TYG , 5TYU , 5TYV , 5TYW , 5TYX , 5TYY , 5TYZ , 5VZ7 , 5VZ8 , 5VZ9 , 5VZA , 5VZB , 5VZC , 5VZD , 5VZE , 5VZF , 5VZG , 5VZH , 5VZI , 5W4F , 5ZLC , 6AEC , 6AEH , 6AK5 , 6AK6 , 6AK8 , 6AK9 , 6AKH , 6IPD , 6IPE , 6IPF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10391	DNA_pol_lambd_f	238 → 287	Fingers domain of DNA polymerase lambda	Domain
  PF14716	HHH_8	153 → 218	Helix-hairpin-helix domain	Domain
  PF14791	DNA_pol_B_thumb	430 → 493	DNA polymerase beta thumb	Family
  PF14792	DNA_pol_B_palm	290 → 386	DNA polymerase beta palm	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a number of tissues. Abundant in thymus.
• Sequence:

  MLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLD
  ACSSEATHVVMEETSAEEAVSWQERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECR
  HRLEVAGPRKGPLSPAWMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFC
  RAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTMKLF
  TQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDALQQ
  VVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITHPKEGQEAGLLPRVMCRLQDQGLI
  LYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLV
  VAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFR
  HLGLEYLPPEQRNA

• Sequence length: 494

Pathways

KEGG Pathway:

Non-homologous end-joining

Reactome Pathway:

Nonhomologous End-Joining (NHEJ)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of esophagus	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (26)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	40033250	Associate	★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	28959900		★☆☆☆☆ Found in Text Mining only
Blast Phase	Blast phase chronic myelogenous leukemia	BEFREE	283875, 62904		★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	12368208, 18586118	Associate	★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	LHGDN	15520469		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23922701	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	22509890		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	15026325, 30060029		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	22509890, 26097541	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	22509890, 28905458	Associate	★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	33376220	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20164241		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	20164241	Associate	★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	12368208		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	283875		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	15026325		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30060029	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	26097541	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	LHGDN	12368208		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	28460268		★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	12368208	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	15026325, 30060029		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22509890, 26097541		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	28460268		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	22509890, 26097541		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	23922701	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NHEJ1 2 shared pathwaysNon-homologous end-joining, Nonhomologous End-Joining (NHEJ) Related via 2 shared pathways including Non-homologous end-joining, Nonhomologous End-Joining (NHEJ). POLL 2 shared pathwaysNon-homologous end-joining, Nonhomologous End-Joining (NHEJ) Related via 2 shared pathways including Non-homologous end-joining, Nonhomologous End-Joining (NHEJ). LIG4 2 shared pathwaysNon-homologous end-joining, Nonhomologous End-Joining (NHEJ) Related via 2 shared pathways including Non-homologous end-joining, Nonhomologous End-Joining (NHEJ). DCLRE1C 2 shared pathwaysNon-homologous end-joining, Nonhomologous End-Joining (NHEJ) Related via 2 shared pathways including Non-homologous end-joining, Nonhomologous End-Joining (NHEJ). XRCC4 2 shared pathwaysNon-homologous end-joining, Nonhomologous End-Joining (NHEJ) Related via 2 shared pathways including Non-homologous end-joining, Nonhomologous End-Joining (NHEJ).

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NHEJ1	0	[]	2	["Non-homologous end-joining","Nonhomologous End-Joining (NHEJ)"]	0	[]
POLL	0	[]	2	["Non-homologous end-joining","Nonhomologous End-Joining (NHEJ)"]	0	[]
LIG4	0	[]	2	["Non-homologous end-joining","Nonhomologous End-Joining (NHEJ)"]	0	[]
DCLRE1C	0	[]	2	["Non-homologous end-joining","Nonhomologous End-Joining (NHEJ)"]	0	[]
XRCC4	0	[]	2	["Non-homologous end-joining","Nonhomologous End-Joining (NHEJ)"]	0	[]

Diseases Linked via Similar Genes

Severe combined immunodeficiency Linked via 3 of 5 related genesNHEJ1, LIG4, DCLRE1C Desbuquois syndrome Linked via 2 of 5 related genesPOLL, XRCC4 Lig4 syndrome Linked via 2 of 5 related genesLIG4, XRCC4 Omenn syndrome Linked via 2 of 5 related genesLIG4, DCLRE1C Schizophrenia Linked via 2 of 5 related genesLIG4, XRCC4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Severe combined immunodeficiency	3	["NHEJ1","LIG4","DCLRE1C"]
Desbuquois syndrome	2	["POLL","XRCC4"]
Lig4 syndrome	2	["LIG4","XRCC4"]
Omenn syndrome	2	["LIG4","DCLRE1C"]
Schizophrenia	2	["LIG4","XRCC4"]