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Gene Gene information from NCBI Gene database.
Entrez ID 54107
Gene name DNA polymerase epsilon 3, accessory subunit
Gene symbol POLE3
Synonyms (NCBI Gene)
CHARAC17CHRAC17CHRAC2YBL1p17
Chromosome 9
Chromosome location 9q32
Summary POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[su
miRNA miRNA information provided by mirtarbase database.
703 Show/Hide all (703)
miRTarBase ID miRNA Experiments Reference
MIRT001521 hsa-miR-155-5p pSILAC 18668040
MIRT001521 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT001521 hsa-miR-155-5p Proteomics 18668040
MIRT025939 hsa-miR-7-5p Microarray 19073608
MIRT030344 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26 Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 18838386
GO:0000785 Component Chromatin IEA
GO:0003677 Function DNA binding IEA
GO:0003887 Function DNA-directed DNA polymerase activity TAS 10801849
GO:0005515 Function Protein binding IPI 10801849, 16189514, 21516116, 22190034, 25416956, 31515488, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607267 13546 ENSG00000148229
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NRF9
Protein name DNA polymerase epsilon subunit 3 (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)
Protein function Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromati
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00808 CBFD_NFYB_HMF 8 → 73 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10880450}.
Sequence
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAM
EEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
Sequence length 147
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
DNA replication Recognition of DNA damage by PCNA-containing replication complex
ATP-dependent chromatin remodeling PCNA-Dependent Long Patch Base Excision Repair
Base excision repair Termination of translesion DNA synthesis
Nucleotide excision repair HDR through Homologous Recombination (HRR)
  Gap-filling DNA repair synthesis and ligation in GG-NER
  Dual Incision in GG-NER
  Dual incision in TC-NER
  Gap-filling DNA repair synthesis and ligation in TC-NER
  DNA replication initiation
  Activation of the pre-replicative complex