In Drosophila melanogaster, the `Polycomb` group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein e
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Protein function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["Polycomb repressive complex","Oxidative Stress Induced Senescence","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of RNA binding proteins","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Regulation of PTEN gene transcription"]
["Polycomb repressive complex","Oxidative Stress Induced Senescence","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of RNA binding proteins","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Regulation of PTEN gene transcription"]
["Polycomb repressive complex","Oxidative Stress Induced Senescence","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of RNA binding proteins","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Regulation of PTEN gene transcription"]
["Polycomb repressive complex","Oxidative Stress Induced Senescence","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of RNA binding proteins","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Regulation of PTEN gene transcription"]
["Polycomb repressive complex","Oxidative Stress Induced Senescence","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of RNA binding proteins","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Regulation of PTEN gene transcription"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to PHC2 (see Related Genes above), that are NOT already directly curated for PHC2 itself -- a lead worth checking, not a confirmed association.