Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	8505
Gene name	Poly(ADP-ribose) glycohydrolase
Gene symbol	PARG
Synonyms (NCBI Gene)	PARG99
Chromosome	10
Chromosome location	10q11.23
Summary	Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smalle

146 Show/Hide all (146)

miRTarBase ID	miRNA	Experiments	Reference
MIRT644073	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT644072	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT644071	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT644070	hsa-miR-4635	HITS-CLIP	23824327
MIRT644068	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT644069	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT644073	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT644072	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT644071	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT644070	hsa-miR-4635	HITS-CLIP	23824327
MIRT644068	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT644069	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT1214214	hsa-miR-1298	CLIP-seq
MIRT1214215	hsa-miR-2392	CLIP-seq
MIRT1214216	hsa-miR-3125	CLIP-seq
MIRT1214217	hsa-miR-3134	CLIP-seq
MIRT1214218	hsa-miR-3148	CLIP-seq
MIRT1214219	hsa-miR-3167	CLIP-seq
MIRT1214220	hsa-miR-3663-3p	CLIP-seq
MIRT1214221	hsa-miR-383	CLIP-seq
MIRT1214222	hsa-miR-3916	CLIP-seq
MIRT1214223	hsa-miR-3919	CLIP-seq
MIRT1214224	hsa-miR-410	CLIP-seq
MIRT1214225	hsa-miR-4257	CLIP-seq
MIRT1214226	hsa-miR-4310	CLIP-seq
MIRT1214227	hsa-miR-4457	CLIP-seq
MIRT1214228	hsa-miR-4502	CLIP-seq
MIRT1214229	hsa-miR-4534	CLIP-seq
MIRT1214230	hsa-miR-4670-3p	CLIP-seq
MIRT1214231	hsa-miR-4772-5p	CLIP-seq
MIRT1214232	hsa-miR-4802-5p	CLIP-seq
MIRT1214233	hsa-miR-513b	CLIP-seq
MIRT1214234	hsa-miR-876-5p	CLIP-seq
MIRT1214235	hsa-miR-885-5p	CLIP-seq
MIRT2061571	hsa-miR-1276	CLIP-seq
MIRT2061572	hsa-miR-1283	CLIP-seq
MIRT2061573	hsa-miR-1290	CLIP-seq
MIRT1214214	hsa-miR-1298	CLIP-seq
MIRT2061574	hsa-miR-1305	CLIP-seq
MIRT2061575	hsa-miR-1343	CLIP-seq
MIRT2061576	hsa-miR-147	CLIP-seq
MIRT1214219	hsa-miR-3167	CLIP-seq
MIRT2061577	hsa-miR-3190	CLIP-seq
MIRT2061578	hsa-miR-3690	CLIP-seq
MIRT2061579	hsa-miR-3691-5p	CLIP-seq
MIRT2061580	hsa-miR-3911	CLIP-seq
MIRT1214223	hsa-miR-3919	CLIP-seq
MIRT2061581	hsa-miR-3924	CLIP-seq
MIRT1214224	hsa-miR-410	CLIP-seq
MIRT2061582	hsa-miR-4254	CLIP-seq
MIRT2061583	hsa-miR-4270	CLIP-seq
MIRT2061584	hsa-miR-4284	CLIP-seq
MIRT2061585	hsa-miR-4311	CLIP-seq
MIRT2061586	hsa-miR-4441	CLIP-seq
MIRT2061587	hsa-miR-4491	CLIP-seq
MIRT2061588	hsa-miR-4657	CLIP-seq
MIRT2061589	hsa-miR-4752	CLIP-seq
MIRT2061590	hsa-miR-4760-3p	CLIP-seq
MIRT2061591	hsa-miR-4766-3p	CLIP-seq
MIRT2061592	hsa-miR-513a-5p	CLIP-seq
MIRT2061593	hsa-miR-548p	CLIP-seq
MIRT2061594	hsa-miR-549	CLIP-seq
MIRT2061595	hsa-miR-583	CLIP-seq
MIRT2061596	hsa-miR-644	CLIP-seq
MIRT2061597	hsa-miR-664	CLIP-seq
MIRT1214234	hsa-miR-876-5p	CLIP-seq
MIRT2061598	hsa-miR-935	CLIP-seq
MIRT2061571	hsa-miR-1276	CLIP-seq
MIRT2061572	hsa-miR-1283	CLIP-seq
MIRT2061573	hsa-miR-1290	CLIP-seq
MIRT2061575	hsa-miR-1343	CLIP-seq
MIRT2061576	hsa-miR-147	CLIP-seq
MIRT2289978	hsa-miR-219-1-3p	CLIP-seq
MIRT2289979	hsa-miR-2277-3p	CLIP-seq
MIRT1214219	hsa-miR-3167	CLIP-seq
MIRT2061577	hsa-miR-3190	CLIP-seq
MIRT2289980	hsa-miR-3202	CLIP-seq
MIRT2289981	hsa-miR-326	CLIP-seq
MIRT2289982	hsa-miR-330-5p	CLIP-seq
MIRT2061578	hsa-miR-3690	CLIP-seq
MIRT2061579	hsa-miR-3691-5p	CLIP-seq
MIRT2289983	hsa-miR-3692	CLIP-seq
MIRT2289984	hsa-miR-371-5p	CLIP-seq
MIRT2289985	hsa-miR-371b-5p	CLIP-seq
MIRT2061580	hsa-miR-3911	CLIP-seq
MIRT2061582	hsa-miR-4254	CLIP-seq
MIRT2061583	hsa-miR-4270	CLIP-seq
MIRT2061584	hsa-miR-4284	CLIP-seq
MIRT2061585	hsa-miR-4311	CLIP-seq
MIRT2061586	hsa-miR-4441	CLIP-seq
MIRT2289986	hsa-miR-4481	CLIP-seq
MIRT2061587	hsa-miR-4491	CLIP-seq
MIRT2289987	hsa-miR-4533	CLIP-seq
MIRT2061588	hsa-miR-4657	CLIP-seq
MIRT2289988	hsa-miR-4658	CLIP-seq
MIRT2289989	hsa-miR-4700-3p	CLIP-seq
MIRT2289990	hsa-miR-4745-5p	CLIP-seq
MIRT2061589	hsa-miR-4752	CLIP-seq
MIRT2289991	hsa-miR-4758-5p	CLIP-seq
MIRT2061591	hsa-miR-4766-3p	CLIP-seq
MIRT2061592	hsa-miR-513a-5p	CLIP-seq
MIRT2061593	hsa-miR-548p	CLIP-seq
MIRT2061595	hsa-miR-583	CLIP-seq
MIRT2289992	hsa-miR-593	CLIP-seq
MIRT2289993	hsa-miR-603	CLIP-seq
MIRT2061596	hsa-miR-644	CLIP-seq
MIRT2289994	hsa-miR-7	CLIP-seq
MIRT1214234	hsa-miR-876-5p	CLIP-seq
MIRT2061598	hsa-miR-935	CLIP-seq
MIRT2587950	hsa-miR-1299	CLIP-seq
MIRT2289978	hsa-miR-219-1-3p	CLIP-seq
MIRT2061577	hsa-miR-3190	CLIP-seq
MIRT2289980	hsa-miR-3202	CLIP-seq
MIRT2587951	hsa-miR-3662	CLIP-seq
MIRT2289985	hsa-miR-371b-5p	CLIP-seq
MIRT2587952	hsa-miR-4477a	CLIP-seq
MIRT2289986	hsa-miR-4481	CLIP-seq
MIRT2289987	hsa-miR-4533	CLIP-seq
MIRT2289988	hsa-miR-4658	CLIP-seq
MIRT2289990	hsa-miR-4745-5p	CLIP-seq
MIRT2289991	hsa-miR-4758-5p	CLIP-seq
MIRT2587953	hsa-miR-4777-3p	CLIP-seq
MIRT2587954	hsa-miR-4782-5p	CLIP-seq
MIRT2587955	hsa-miR-516b	CLIP-seq
MIRT2587956	hsa-miR-548k	CLIP-seq
MIRT2587957	hsa-miR-548n	CLIP-seq
MIRT2587958	hsa-miR-577	CLIP-seq
MIRT2587959	hsa-miR-875-3p	CLIP-seq
MIRT2587960	hsa-miR-875-5p	CLIP-seq
MIRT1214235	hsa-miR-885-5p	CLIP-seq
MIRT2587961	hsa-miR-944	CLIP-seq
MIRT2587950	hsa-miR-1299	CLIP-seq
MIRT2687091	hsa-miR-186	CLIP-seq
MIRT2687092	hsa-miR-3133	CLIP-seq
MIRT2587951	hsa-miR-3662	CLIP-seq
MIRT2289985	hsa-miR-371b-5p	CLIP-seq
MIRT2587953	hsa-miR-4777-3p	CLIP-seq
MIRT2587954	hsa-miR-4782-5p	CLIP-seq
MIRT2587955	hsa-miR-516b	CLIP-seq
MIRT2587956	hsa-miR-548k	CLIP-seq
MIRT2587957	hsa-miR-548n	CLIP-seq
MIRT2587958	hsa-miR-577	CLIP-seq
MIRT2587959	hsa-miR-875-3p	CLIP-seq
MIRT2587960	hsa-miR-875-5p	CLIP-seq
MIRT1214235	hsa-miR-885-5p	CLIP-seq
MIRT2587961	hsa-miR-944	CLIP-seq

Transcription factor	Regulation	Reference
SPI1	Repression	19076642

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004649	Function	Poly(ADP-ribose) glycohydrolase activity	IBA
GO:0004649	Function	Poly(ADP-ribose) glycohydrolase activity	IDA	9074616, 15450800, 22673905, 23474714, 33186521, 34019811, 34321462, 37268618
GO:0004649	Function	Poly(ADP-ribose) glycohydrolase activity	IEA
GO:0004649	Function	Poly(ADP-ribose) glycohydrolase activity	TAS	9925755
GO:0005515	Function	Protein binding	IPI	27257257
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9074616
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9925755
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006282	Process	Regulation of DNA repair	IBA
GO:0006282	Process	Regulation of DNA repair	IEA
GO:0006287	Process	Base-excision repair, gap-filling	TAS
GO:0006974	Process	DNA damage response	IEA
GO:0009225	Process	Nucleotide-sugar metabolic process	IBA
GO:0016604	Component	Nuclear body	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:1990966	Process	ATP generation from poly-ADP-D-ribose	IBA
GO:1990966	Process	ATP generation from poly-ADP-D-ribose	IDA	27257257

MIM	HGNC	e!Ensembl
603501	8605	ENSG00000227345

Q86W56

Protein name

Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)

Protein function

Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321

PDB

4A0D , 4B1G , 4B1H , 4B1I , 4B1J , 5A7R , 5LHB , 6HH6 , 6HMK , 6HML , 6HMM , 6HMN , 6O9X , 6O9Y , 6OA0 , 6OA1 , 6OA3 , 6OAK , 6OAL , 7KFP , 7KG0 , 7KG1 , 7KG6 , 7KG7 , 7KG8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05028	PARG_cat	581 → 909	Poly (ADP-ribose) glycohydrolase (PARG)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:14527731}.

Sequence

MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT

Sequence length

976

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Base excision repair	POLB-Dependent Long Patch Base Excision Repair

PARG (poly(ADP-ribose) glycohydrolase)

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