OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55611
• Gene name: OTU deubiquitinase, ubiquitin aldehyde binding 1
• Gene symbol: OTUB1
• Synonyms (NCBI Gene): HSPC263, OTB1, OTU1
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitin

miRNA Show/Hide all (416)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006414	hsa-miR-28-5p	Luciferase reporter assay	20445018
MIRT006415	hsa-miR-708-3p	Luciferase reporter assay	20445018
MIRT006415	hsa-miR-708-3p	Luciferase reporter assay	20445018
MIRT006415	hsa-miR-708-3p	Luciferase reporter assay	20445018
MIRT051986	hsa-let-7b-5p	CLASH	23622248
MIRT051514	hsa-let-7e-5p	CLASH	23622248
MIRT038748	hsa-miR-93-3p	CLASH	23622248
MIRT471736	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT471735	hsa-miR-3154	PAR-CLIP	23592263
MIRT471734	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT471733	hsa-miR-4501	PAR-CLIP	23592263
MIRT471731	hsa-miR-3185	PAR-CLIP	23592263
MIRT471732	hsa-miR-3179	PAR-CLIP	23592263
MIRT471730	hsa-miR-3619-3p	PAR-CLIP	23592263
MIRT471729	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT471728	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT471727	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT471726	hsa-miR-4504	PAR-CLIP	23592263
MIRT471725	hsa-miR-583	PAR-CLIP	23592263
MIRT471724	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT471723	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT471722	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT471720	hsa-miR-4493	PAR-CLIP	23592263
MIRT471721	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT471719	hsa-miR-6132	PAR-CLIP	23592263
MIRT471718	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT471717	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT471716	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT471715	hsa-miR-4706	PAR-CLIP	23592263
MIRT471714	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT471713	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT471712	hsa-miR-663a	PAR-CLIP	23592263
MIRT471711	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT471710	hsa-miR-4271	PAR-CLIP	23592263
MIRT471709	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT471708	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT471707	hsa-miR-3180	PAR-CLIP	23592263
MIRT471706	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT471704	hsa-miR-3196	PAR-CLIP	23592263
MIRT471705	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT471703	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT471702	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT471701	hsa-miR-6126	PAR-CLIP	23592263
MIRT727038	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727039	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727037	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727036	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT471736	hsa-miR-542-3p	Luciferase reporter assay, qRT-PCR, Western blot	28123857
MIRT471736	hsa-miR-542-3p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR	31939620
MIRT471736	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT471735	hsa-miR-3154	PAR-CLIP	23592263
MIRT471734	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT471733	hsa-miR-4501	PAR-CLIP	23592263
MIRT471731	hsa-miR-3185	PAR-CLIP	23592263
MIRT471732	hsa-miR-3179	PAR-CLIP	23592263
MIRT471730	hsa-miR-3619-3p	PAR-CLIP	23592263
MIRT471729	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT471728	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT471727	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT471726	hsa-miR-4504	PAR-CLIP	23592263
MIRT471725	hsa-miR-583	PAR-CLIP	23592263
MIRT471724	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT471723	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT471722	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT471720	hsa-miR-4493	PAR-CLIP	23592263
MIRT471721	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT471719	hsa-miR-6132	PAR-CLIP	23592263
MIRT471718	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT471717	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT471716	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT471715	hsa-miR-4706	PAR-CLIP	23592263
MIRT471714	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT471713	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT471712	hsa-miR-663a	PAR-CLIP	23592263
MIRT471711	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT471710	hsa-miR-4271	PAR-CLIP	23592263
MIRT471709	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT471708	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT471707	hsa-miR-3180	PAR-CLIP	23592263
MIRT471706	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT471704	hsa-miR-3196	PAR-CLIP	23592263
MIRT471705	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT471703	hsa-miR-3944-5p	PAR-CLIP	23592263
MIRT471702	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT471701	hsa-miR-6126	PAR-CLIP	23592263
MIRT1207254	hsa-miR-140-3p	CLIP-seq
MIRT1207255	hsa-miR-15a	CLIP-seq
MIRT1207256	hsa-miR-15b	CLIP-seq
MIRT1207257	hsa-miR-16	CLIP-seq
MIRT1207258	hsa-miR-195	CLIP-seq
MIRT1207259	hsa-miR-2110	CLIP-seq
MIRT1207260	hsa-miR-23a	CLIP-seq
MIRT1207261	hsa-miR-23b	CLIP-seq
MIRT1207262	hsa-miR-23c	CLIP-seq
MIRT1207263	hsa-miR-2467-3p	CLIP-seq
MIRT1207264	hsa-miR-3147	CLIP-seq
MIRT1207265	hsa-miR-3150a-3p	CLIP-seq
MIRT1207266	hsa-miR-3607-5p	CLIP-seq
MIRT1207267	hsa-miR-3616-3p	CLIP-seq
MIRT1207268	hsa-miR-3664-3p	CLIP-seq
MIRT1207269	hsa-miR-371-5p	CLIP-seq
MIRT1207270	hsa-miR-3935	CLIP-seq
MIRT1207271	hsa-miR-424	CLIP-seq
MIRT1207272	hsa-miR-4268	CLIP-seq
MIRT1207273	hsa-miR-4425	CLIP-seq
MIRT1207274	hsa-miR-4433	CLIP-seq
MIRT1207275	hsa-miR-4448	CLIP-seq
MIRT1207276	hsa-miR-4459	CLIP-seq
MIRT1207277	hsa-miR-4461	CLIP-seq
MIRT1207278	hsa-miR-4512	CLIP-seq
MIRT1207279	hsa-miR-4666-5p	CLIP-seq
MIRT1207280	hsa-miR-4721	CLIP-seq
MIRT1207281	hsa-miR-4729	CLIP-seq
MIRT1207282	hsa-miR-4749-3p	CLIP-seq
MIRT1207283	hsa-miR-4768-3p	CLIP-seq
MIRT1207284	hsa-miR-497	CLIP-seq
MIRT1207285	hsa-miR-548ac	CLIP-seq
MIRT1207286	hsa-miR-548d-3p	CLIP-seq
MIRT1207287	hsa-miR-548z	CLIP-seq
MIRT2059529	hsa-miR-1204	CLIP-seq
MIRT2059530	hsa-miR-1224-5p	CLIP-seq
MIRT2059531	hsa-miR-1245b-3p	CLIP-seq
MIRT2059532	hsa-miR-125a-5p	CLIP-seq
MIRT2059533	hsa-miR-125b	CLIP-seq
MIRT2059534	hsa-miR-214	CLIP-seq
MIRT2059535	hsa-miR-2278	CLIP-seq
MIRT1207263	hsa-miR-2467-3p	CLIP-seq
MIRT2059536	hsa-miR-2861	CLIP-seq
MIRT2059537	hsa-miR-3126-5p	CLIP-seq
MIRT2059538	hsa-miR-3135	CLIP-seq
MIRT2059539	hsa-miR-3136-3p	CLIP-seq
MIRT1207265	hsa-miR-3150a-3p	CLIP-seq
MIRT2059540	hsa-miR-3151	CLIP-seq
MIRT2059541	hsa-miR-3169	CLIP-seq
MIRT2059542	hsa-miR-3173-5p	CLIP-seq
MIRT2059543	hsa-miR-3175	CLIP-seq
MIRT2059544	hsa-miR-320e	CLIP-seq
MIRT2059545	hsa-miR-342-5p	CLIP-seq
MIRT1207267	hsa-miR-3616-3p	CLIP-seq
MIRT2059546	hsa-miR-3616-5p	CLIP-seq
MIRT2059547	hsa-miR-3619-5p	CLIP-seq
MIRT2059548	hsa-miR-3647-5p	CLIP-seq
MIRT2059549	hsa-miR-3678-3p	CLIP-seq
MIRT2059550	hsa-miR-3684	CLIP-seq
MIRT2059551	hsa-miR-3689d	CLIP-seq
MIRT2059552	hsa-miR-3937	CLIP-seq
MIRT1207272	hsa-miR-4268	CLIP-seq
MIRT2059553	hsa-miR-4319	CLIP-seq
MIRT2059554	hsa-miR-4419a	CLIP-seq
MIRT2059555	hsa-miR-4434	CLIP-seq
MIRT2059556	hsa-miR-4436b-3p	CLIP-seq
MIRT2059557	hsa-miR-4468	CLIP-seq
MIRT2059558	hsa-miR-4492	CLIP-seq
MIRT2059559	hsa-miR-4498	CLIP-seq
MIRT2059560	hsa-miR-4510	CLIP-seq
MIRT2059561	hsa-miR-4516	CLIP-seq
MIRT2059562	hsa-miR-4531	CLIP-seq
MIRT2059563	hsa-miR-4664-5p	CLIP-seq
MIRT2059564	hsa-miR-4667-5p	CLIP-seq
MIRT2059565	hsa-miR-4691-5p	CLIP-seq
MIRT2059566	hsa-miR-4700-5p	CLIP-seq
MIRT2059567	hsa-miR-4708-3p	CLIP-seq
MIRT2059568	hsa-miR-4719	CLIP-seq
MIRT2059569	hsa-miR-4731-5p	CLIP-seq
MIRT1207282	hsa-miR-4749-3p	CLIP-seq
MIRT2059570	hsa-miR-4751	CLIP-seq
MIRT2059571	hsa-miR-4755-3p	CLIP-seq
MIRT2059572	hsa-miR-4795-5p	CLIP-seq
MIRT2059573	hsa-miR-486-3p	CLIP-seq
MIRT2059574	hsa-miR-503	CLIP-seq
MIRT2059575	hsa-miR-544b	CLIP-seq
MIRT2059576	hsa-miR-573	CLIP-seq
MIRT2059577	hsa-miR-589	CLIP-seq
MIRT2059578	hsa-miR-615-5p	CLIP-seq
MIRT2059579	hsa-miR-637	CLIP-seq
MIRT2059580	hsa-miR-663b	CLIP-seq
MIRT2059581	hsa-miR-761	CLIP-seq
MIRT2059582	hsa-miR-762	CLIP-seq
MIRT2059583	hsa-miR-922	CLIP-seq
MIRT2059584	hsa-miR-939	CLIP-seq
MIRT2287960	hsa-miR-10a	CLIP-seq
MIRT2287961	hsa-miR-10b	CLIP-seq
MIRT2287962	hsa-miR-1183	CLIP-seq
MIRT2059529	hsa-miR-1204	CLIP-seq
MIRT2287963	hsa-miR-1207-5p	CLIP-seq
MIRT2059530	hsa-miR-1224-5p	CLIP-seq
MIRT2287964	hsa-miR-1226	CLIP-seq
MIRT2059531	hsa-miR-1245b-3p	CLIP-seq
MIRT2287965	hsa-miR-1252	CLIP-seq
MIRT2059532	hsa-miR-125a-5p	CLIP-seq
MIRT2059533	hsa-miR-125b	CLIP-seq
MIRT2287966	hsa-miR-1291	CLIP-seq
MIRT2287967	hsa-miR-1293	CLIP-seq
MIRT2287968	hsa-miR-1324	CLIP-seq
MIRT2287969	hsa-miR-146b-3p	CLIP-seq
MIRT2287970	hsa-miR-150	CLIP-seq
MIRT1207255	hsa-miR-15a	CLIP-seq
MIRT1207256	hsa-miR-15b	CLIP-seq
MIRT1207257	hsa-miR-16	CLIP-seq
MIRT2287971	hsa-miR-1908	CLIP-seq
MIRT2287972	hsa-miR-1909	CLIP-seq
MIRT2287973	hsa-miR-1913	CLIP-seq
MIRT1207258	hsa-miR-195	CLIP-seq
MIRT2287974	hsa-miR-197	CLIP-seq
MIRT2059534	hsa-miR-214	CLIP-seq
MIRT2059535	hsa-miR-2278	CLIP-seq
MIRT1207260	hsa-miR-23a	CLIP-seq
MIRT1207261	hsa-miR-23b	CLIP-seq
MIRT1207262	hsa-miR-23c	CLIP-seq
MIRT1207263	hsa-miR-2467-3p	CLIP-seq
MIRT2059536	hsa-miR-2861	CLIP-seq
MIRT2287975	hsa-miR-3065-3p	CLIP-seq
MIRT2059537	hsa-miR-3126-5p	CLIP-seq
MIRT2059538	hsa-miR-3135	CLIP-seq
MIRT2059539	hsa-miR-3136-3p	CLIP-seq
MIRT2287976	hsa-miR-3139	CLIP-seq
MIRT1207265	hsa-miR-3150a-3p	CLIP-seq
MIRT2059540	hsa-miR-3151	CLIP-seq
MIRT2287977	hsa-miR-3166	CLIP-seq
MIRT2059541	hsa-miR-3169	CLIP-seq
MIRT2059542	hsa-miR-3173-5p	CLIP-seq
MIRT2059543	hsa-miR-3175	CLIP-seq
MIRT2059544	hsa-miR-320e	CLIP-seq
MIRT2287978	hsa-miR-324-3p	CLIP-seq
MIRT2287979	hsa-miR-328	CLIP-seq
MIRT2059545	hsa-miR-342-5p	CLIP-seq
MIRT1207266	hsa-miR-3607-5p	CLIP-seq
MIRT1207267	hsa-miR-3616-3p	CLIP-seq
MIRT2059547	hsa-miR-3619-5p	CLIP-seq
MIRT2287980	hsa-miR-3620	CLIP-seq
MIRT2287981	hsa-miR-3649	CLIP-seq
MIRT2287982	hsa-miR-3653	CLIP-seq
MIRT2287983	hsa-miR-3670	CLIP-seq
MIRT2059549	hsa-miR-3678-3p	CLIP-seq
MIRT2059550	hsa-miR-3684	CLIP-seq
MIRT2287984	hsa-miR-3689a-3p	CLIP-seq
MIRT2287985	hsa-miR-3689c	CLIP-seq
MIRT2059551	hsa-miR-3689d	CLIP-seq
MIRT2287986	hsa-miR-3714	CLIP-seq
MIRT2059552	hsa-miR-3937	CLIP-seq
MIRT1207271	hsa-miR-424	CLIP-seq
MIRT2287987	hsa-miR-4267	CLIP-seq
MIRT1207272	hsa-miR-4268	CLIP-seq
MIRT2287988	hsa-miR-4269	CLIP-seq
MIRT2287989	hsa-miR-4284	CLIP-seq
MIRT2287990	hsa-miR-4292	CLIP-seq
MIRT2287991	hsa-miR-4313	CLIP-seq
MIRT2059553	hsa-miR-4319	CLIP-seq
MIRT2287992	hsa-miR-4329	CLIP-seq
MIRT2059554	hsa-miR-4419a	CLIP-seq
MIRT2059555	hsa-miR-4434	CLIP-seq
MIRT2059556	hsa-miR-4436b-3p	CLIP-seq
MIRT1207277	hsa-miR-4461	CLIP-seq
MIRT2059557	hsa-miR-4468	CLIP-seq
MIRT2287993	hsa-miR-4483	CLIP-seq
MIRT2287994	hsa-miR-4488	CLIP-seq
MIRT2059560	hsa-miR-4510	CLIP-seq
MIRT1207278	hsa-miR-4512	CLIP-seq
MIRT2287995	hsa-miR-4514	CLIP-seq
MIRT2059561	hsa-miR-4516	CLIP-seq
MIRT2287996	hsa-miR-4521	CLIP-seq
MIRT2059562	hsa-miR-4531	CLIP-seq
MIRT2287997	hsa-miR-4533	CLIP-seq
MIRT2287998	hsa-miR-4537	CLIP-seq
MIRT2287999	hsa-miR-4640-3p	CLIP-seq
MIRT2288000	hsa-miR-4648	CLIP-seq
MIRT2288001	hsa-miR-4654	CLIP-seq
MIRT2288002	hsa-miR-4656	CLIP-seq
MIRT2288003	hsa-miR-4661-3p	CLIP-seq
MIRT2059563	hsa-miR-4664-5p	CLIP-seq
MIRT1207279	hsa-miR-4666-5p	CLIP-seq
MIRT2059564	hsa-miR-4667-5p	CLIP-seq
MIRT2059565	hsa-miR-4691-5p	CLIP-seq
MIRT2288004	hsa-miR-4692	CLIP-seq
MIRT2288005	hsa-miR-4697-5p	CLIP-seq
MIRT2059566	hsa-miR-4700-5p	CLIP-seq
MIRT2059567	hsa-miR-4708-3p	CLIP-seq
MIRT2059568	hsa-miR-4719	CLIP-seq
MIRT1207280	hsa-miR-4721	CLIP-seq
MIRT2288006	hsa-miR-4725-5p	CLIP-seq
MIRT2288007	hsa-miR-4728-5p	CLIP-seq
MIRT1207281	hsa-miR-4729	CLIP-seq
MIRT2059569	hsa-miR-4731-5p	CLIP-seq
MIRT2288008	hsa-miR-4742-5p	CLIP-seq
MIRT2288009	hsa-miR-4747-5p	CLIP-seq
MIRT1207282	hsa-miR-4749-3p	CLIP-seq
MIRT2059570	hsa-miR-4751	CLIP-seq
MIRT2059571	hsa-miR-4755-3p	CLIP-seq
MIRT2288010	hsa-miR-4763-3p	CLIP-seq
MIRT2288011	hsa-miR-4763-5p	CLIP-seq
MIRT2288012	hsa-miR-4769-5p	CLIP-seq
MIRT2288013	hsa-miR-4783-3p	CLIP-seq
MIRT2288014	hsa-miR-4786-5p	CLIP-seq
MIRT2059573	hsa-miR-486-3p	CLIP-seq
MIRT1207284	hsa-miR-497	CLIP-seq
MIRT2059574	hsa-miR-503	CLIP-seq
MIRT2288015	hsa-miR-504	CLIP-seq
MIRT2059575	hsa-miR-544b	CLIP-seq
MIRT2288016	hsa-miR-548an	CLIP-seq
MIRT2059577	hsa-miR-589	CLIP-seq
MIRT2059578	hsa-miR-615-5p	CLIP-seq
MIRT2288017	hsa-miR-634	CLIP-seq
MIRT2059579	hsa-miR-637	CLIP-seq
MIRT2288018	hsa-miR-661	CLIP-seq
MIRT2288019	hsa-miR-663	CLIP-seq
MIRT2059580	hsa-miR-663b	CLIP-seq
MIRT2288020	hsa-miR-665	CLIP-seq
MIRT2288021	hsa-miR-708	CLIP-seq
MIRT2059581	hsa-miR-761	CLIP-seq
MIRT2288022	hsa-miR-769-5p	CLIP-seq
MIRT2288023	hsa-miR-874	CLIP-seq
MIRT2059583	hsa-miR-922	CLIP-seq
MIRT2059584	hsa-miR-939	CLIP-seq
MIRT2288024	hsa-miR-940	CLIP-seq
MIRT2059529	hsa-miR-1204	CLIP-seq
MIRT2287963	hsa-miR-1207-5p	CLIP-seq
MIRT2287968	hsa-miR-1324	CLIP-seq
MIRT2059535	hsa-miR-2278	CLIP-seq
MIRT1207263	hsa-miR-2467-3p	CLIP-seq
MIRT2059539	hsa-miR-3136-3p	CLIP-seq
MIRT2287977	hsa-miR-3166	CLIP-seq
MIRT2059545	hsa-miR-342-5p	CLIP-seq
MIRT2287986	hsa-miR-3714	CLIP-seq
MIRT2059552	hsa-miR-3937	CLIP-seq
MIRT2287995	hsa-miR-4514	CLIP-seq
MIRT2059563	hsa-miR-4664-5p	CLIP-seq
MIRT2288004	hsa-miR-4692	CLIP-seq
MIRT2059567	hsa-miR-4708-3p	CLIP-seq
MIRT2059571	hsa-miR-4755-3p	CLIP-seq
MIRT2288010	hsa-miR-4763-3p	CLIP-seq
MIRT2059580	hsa-miR-663b	CLIP-seq
MIRT2059583	hsa-miR-922	CLIP-seq
MIRT2288024	hsa-miR-940	CLIP-seq
MIRT2287960	hsa-miR-10a	CLIP-seq
MIRT2287961	hsa-miR-10b	CLIP-seq
MIRT2059532	hsa-miR-125a-5p	CLIP-seq
MIRT2059533	hsa-miR-125b	CLIP-seq
MIRT2287969	hsa-miR-146b-3p	CLIP-seq
MIRT2287970	hsa-miR-150	CLIP-seq
MIRT2287971	hsa-miR-1908	CLIP-seq
MIRT2287972	hsa-miR-1909	CLIP-seq
MIRT1207263	hsa-miR-2467-3p	CLIP-seq
MIRT2287977	hsa-miR-3166	CLIP-seq
MIRT2059542	hsa-miR-3173-5p	CLIP-seq
MIRT2059544	hsa-miR-320e	CLIP-seq
MIRT1207267	hsa-miR-3616-3p	CLIP-seq
MIRT2287980	hsa-miR-3620	CLIP-seq
MIRT2059549	hsa-miR-3678-3p	CLIP-seq
MIRT2287984	hsa-miR-3689a-3p	CLIP-seq
MIRT2287985	hsa-miR-3689c	CLIP-seq
MIRT2287986	hsa-miR-3714	CLIP-seq
MIRT2287987	hsa-miR-4267	CLIP-seq
MIRT1207272	hsa-miR-4268	CLIP-seq
MIRT2059553	hsa-miR-4319	CLIP-seq
MIRT2059556	hsa-miR-4436b-3p	CLIP-seq
MIRT2287994	hsa-miR-4488	CLIP-seq
MIRT2287998	hsa-miR-4537	CLIP-seq
MIRT2288000	hsa-miR-4648	CLIP-seq
MIRT2288001	hsa-miR-4654	CLIP-seq
MIRT2059564	hsa-miR-4667-5p	CLIP-seq
MIRT2059565	hsa-miR-4691-5p	CLIP-seq
MIRT2288005	hsa-miR-4697-5p	CLIP-seq
MIRT2059566	hsa-miR-4700-5p	CLIP-seq
MIRT2059568	hsa-miR-4719	CLIP-seq
MIRT2288007	hsa-miR-4728-5p	CLIP-seq
MIRT2059569	hsa-miR-4731-5p	CLIP-seq
MIRT2288008	hsa-miR-4742-5p	CLIP-seq
MIRT1207282	hsa-miR-4749-3p	CLIP-seq
MIRT2288012	hsa-miR-4769-5p	CLIP-seq
MIRT2586143	hsa-miR-4771	CLIP-seq
MIRT2288013	hsa-miR-4783-3p	CLIP-seq
MIRT2288014	hsa-miR-4786-5p	CLIP-seq
MIRT2288016	hsa-miR-548an	CLIP-seq
MIRT2059578	hsa-miR-615-5p	CLIP-seq
MIRT2059579	hsa-miR-637	CLIP-seq
MIRT2288019	hsa-miR-663	CLIP-seq
MIRT2288022	hsa-miR-769-5p	CLIP-seq
MIRT2288023	hsa-miR-874	CLIP-seq
MIRT2288024	hsa-miR-940	CLIP-seq
MIRT2287960	hsa-miR-10a	CLIP-seq
MIRT2287961	hsa-miR-10b	CLIP-seq
MIRT2059532	hsa-miR-125a-5p	CLIP-seq
MIRT2059533	hsa-miR-125b	CLIP-seq
MIRT2287969	hsa-miR-146b-3p	CLIP-seq
MIRT2287970	hsa-miR-150	CLIP-seq
MIRT2287971	hsa-miR-1908	CLIP-seq
MIRT2287972	hsa-miR-1909	CLIP-seq
MIRT2287977	hsa-miR-3166	CLIP-seq
MIRT2059542	hsa-miR-3173-5p	CLIP-seq
MIRT2059544	hsa-miR-320e	CLIP-seq
MIRT1207267	hsa-miR-3616-3p	CLIP-seq
MIRT2287980	hsa-miR-3620	CLIP-seq
MIRT2287984	hsa-miR-3689a-3p	CLIP-seq
MIRT2287985	hsa-miR-3689c	CLIP-seq
MIRT2287987	hsa-miR-4267	CLIP-seq
MIRT1207272	hsa-miR-4268	CLIP-seq
MIRT2059553	hsa-miR-4319	CLIP-seq
MIRT2059556	hsa-miR-4436b-3p	CLIP-seq
MIRT2287994	hsa-miR-4488	CLIP-seq
MIRT2287998	hsa-miR-4537	CLIP-seq
MIRT2288000	hsa-miR-4648	CLIP-seq
MIRT2288001	hsa-miR-4654	CLIP-seq
MIRT2059565	hsa-miR-4691-5p	CLIP-seq
MIRT2288005	hsa-miR-4697-5p	CLIP-seq
MIRT2059568	hsa-miR-4719	CLIP-seq
MIRT2288007	hsa-miR-4728-5p	CLIP-seq
MIRT2059569	hsa-miR-4731-5p	CLIP-seq
MIRT1207282	hsa-miR-4749-3p	CLIP-seq
MIRT2288012	hsa-miR-4769-5p	CLIP-seq
MIRT2586143	hsa-miR-4771	CLIP-seq
MIRT2288013	hsa-miR-4783-3p	CLIP-seq
MIRT2288014	hsa-miR-4786-5p	CLIP-seq
MIRT2059578	hsa-miR-615-5p	CLIP-seq
MIRT2288019	hsa-miR-663	CLIP-seq
MIRT2288022	hsa-miR-769-5p	CLIP-seq
MIRT2288023	hsa-miR-874	CLIP-seq

Gene ontology (GO) Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	18954305, 19211026, 23827681
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	16364312, 18954305, 19549727, 19615732, 20553488, 21900206, 22124327, 22367539, 23524849, 25416956, 26752685, 28514442, 31515488, 32296183, 32814053, 33421002, 33961781
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006281	Process	DNA repair	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IDA	20725033
GO:0006974	Process	DNA damage response	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	IDA	35927303
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019784	Function	DeNEDDylase activity	IDA	18954305
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	20725033
GO:0031669	Process	Cellular response to nutrient levels	IDA	12747827, 29750193
GO:0038202	Process	TORC1 signaling	IDA	12747827, 29750193
GO:0043130	Function	Ubiquitin binding	IBA
GO:0043130	Function	Ubiquitin binding	IDA	19211026
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	35927303
GO:0055105	Function	Ubiquitin-protein transferase inhibitor activity	IDA	35927303
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071108	Process	Protein K48-linked deubiquitination	IDA	18954305, 19211026, 23827681
GO:0071108	Process	Protein K48-linked deubiquitination	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	35927303
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	35927303
GO:2000780	Process	Negative regulation of double-strand break repair	IMP	20725033

Other IDs

• MIM: 608337
• HGNC: 23077
• e!Ensembl: ENSG00000167770

Protein

• UniProt ID: Q96FW1
• Protein name: Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
• Protein function: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMe
• PDB: 2ZFY , 3VON , 4DDG , 4DDI , 4DHZ , 4I6L , 4LDT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10275	Peptidase_C65	40 → 271	Peptidase C65 Otubain	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020}.
• Sequence:

  MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKE
  YAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAK
  SKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTS
  GYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQVEYMDRGE
  GGTTNPHIFPEGSEPKVYLLYRPGHYDILYK

• Sequence length: 271

Pathways

Reactome Pathway

Ub-specific processing proteases

Ovarian tumor domain proteases

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RNF128 2 shared pathwaysUb-specific processing proteases, Ovarian tumor domain proteases Related via 2 shared pathways including Ub-specific processing proteases, Ovarian tumor domain proteases. IFIH1 2 shared pathwaysUb-specific processing proteases, Ovarian tumor domain proteases Related via 2 shared pathways including Ub-specific processing proteases, Ovarian tumor domain proteases. DDX58 2 shared pathwaysUb-specific processing proteases, Ovarian tumor domain proteases Related via 2 shared pathways including Ub-specific processing proteases, Ovarian tumor domain proteases. PTEN 2 shared pathwaysUb-specific processing proteases, Ovarian tumor domain proteases Related via 2 shared pathways including Ub-specific processing proteases, Ovarian tumor domain proteases. RIPK1 2 shared pathwaysUb-specific processing proteases, Ovarian tumor domain proteases Related via 2 shared pathways including Ub-specific processing proteases, Ovarian tumor domain proteases.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RNF128	0	[]	2	["Ub-specific processing proteases","Ovarian tumor domain proteases"]	0	[]
IFIH1	0	[]	2	["Ub-specific processing proteases","Ovarian tumor domain proteases"]	0	[]
DDX58	0	[]	2	["Ub-specific processing proteases","Ovarian tumor domain proteases"]	0	[]
PTEN	0	[]	2	["Ub-specific processing proteases","Ovarian tumor domain proteases"]	0	[]
RIPK1	0	[]	2	["Ub-specific processing proteases","Ovarian tumor domain proteases"]	0	[]

Diseases Linked via Similar Genes

Immunodeficiency Linked via 2 of 5 related genesIFIH1, RIPK1 Diabetes mellitus type 2 Linked via 2 of 5 related genesIFIH1, PTEN Pancreatitis Linked via 1 of 5 related genesRNF128 Aicardi goutieres syndrome Linked via 1 of 5 related genesIFIH1 Ankylosing spondylitis Linked via 1 of 5 related genesIFIH1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Immunodeficiency	2	["IFIH1","RIPK1"]
Diabetes mellitus type 2	2	["IFIH1","PTEN"]
Pancreatitis	1	["RNF128"]
Aicardi goutieres syndrome	1	["IFIH1"]
Ankylosing spondylitis	1	["IFIH1"]