OSCAR (osteoclast associated Ig-like receptor)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 126014
• Gene name: Osteoclast associated Ig-like receptor
• Gene symbol: OSCAR
• Synonyms (NCBI Gene): PIGR3, PIgR-3
• Chromosome: 19
• Chromosome location: 19q13.42
• Summary: Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the

miRNA Show/Hide all (216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT691857	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT691856	hsa-miR-6736-3p	HITS-CLIP	23313552
MIRT691855	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT691854	hsa-miR-345-3p	HITS-CLIP	23313552
MIRT691853	hsa-miR-4539	HITS-CLIP	23313552
MIRT691852	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT691851	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT691850	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT691849	hsa-miR-612	HITS-CLIP	23313552
MIRT691848	hsa-miR-6860	HITS-CLIP	23313552
MIRT691847	hsa-miR-4486	HITS-CLIP	23313552
MIRT691846	hsa-miR-378g	HITS-CLIP	23313552
MIRT691845	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT691844	hsa-miR-7976	HITS-CLIP	23313552
MIRT691843	hsa-miR-1291	HITS-CLIP	23313552
MIRT691842	hsa-miR-6775-3p	HITS-CLIP	23313552
MIRT691841	hsa-miR-296-5p	HITS-CLIP	23313552
MIRT691840	hsa-miR-6724-5p	HITS-CLIP	23313552
MIRT691839	hsa-miR-6773-5p	HITS-CLIP	23313552
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550472	hsa-miR-2278	PAR-CLIP	21572407
MIRT550471	hsa-miR-451b	PAR-CLIP	21572407
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT550468	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT550467	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT550466	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT550465	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT550464	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT550462	hsa-miR-646	PAR-CLIP	21572407
MIRT550461	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT550459	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT550457	hsa-miR-5701	PAR-CLIP	21572407
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT550454	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT691857	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT691856	hsa-miR-6736-3p	HITS-CLIP	23313552
MIRT691855	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT691854	hsa-miR-345-3p	HITS-CLIP	23313552
MIRT691853	hsa-miR-4539	HITS-CLIP	23313552
MIRT691852	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT691851	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT691850	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT691849	hsa-miR-612	HITS-CLIP	23313552
MIRT691848	hsa-miR-6860	HITS-CLIP	23313552
MIRT691847	hsa-miR-4486	HITS-CLIP	23313552
MIRT691846	hsa-miR-378g	HITS-CLIP	23313552
MIRT691845	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT691844	hsa-miR-7976	HITS-CLIP	23313552
MIRT691843	hsa-miR-1291	HITS-CLIP	23313552
MIRT691842	hsa-miR-6775-3p	HITS-CLIP	23313552
MIRT691841	hsa-miR-296-5p	HITS-CLIP	23313552
MIRT691840	hsa-miR-6724-5p	HITS-CLIP	23313552
MIRT691839	hsa-miR-6773-5p	HITS-CLIP	23313552
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550471	hsa-miR-451b	PAR-CLIP	20371350
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT550468	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT550467	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT550466	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT550465	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT550464	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT550462	hsa-miR-646	PAR-CLIP	20371350
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT550457	hsa-miR-5701	PAR-CLIP	20371350
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT550472	hsa-miR-2278	PAR-CLIP	21572407
MIRT550471	hsa-miR-451b	PAR-CLIP	21572407
MIRT550470	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT550469	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT550468	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT550467	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT550466	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT550465	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT550463	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT550464	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT550462	hsa-miR-646	PAR-CLIP	21572407
MIRT550461	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT550459	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT550460	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT550458	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT550457	hsa-miR-5701	PAR-CLIP	21572407
MIRT550456	hsa-miR-374b-3p	PAR-CLIP	21572407
MIRT550454	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT1206549	hsa-miR-133a	CLIP-seq
MIRT1206550	hsa-miR-133b	CLIP-seq
MIRT1206551	hsa-miR-4797-5p	CLIP-seq
MIRT1206552	hsa-miR-509-3p	CLIP-seq
MIRT1206553	hsa-miR-512-3p	CLIP-seq
MIRT1206554	hsa-miR-600	CLIP-seq
MIRT1206555	hsa-miR-759	CLIP-seq
MIRT1206556	hsa-miR-3120-3p	CLIP-seq
MIRT1206557	hsa-miR-3978	CLIP-seq
MIRT1206558	hsa-miR-548v	CLIP-seq
MIRT1206559	hsa-miR-875-3p	CLIP-seq
MIRT1206560	hsa-miR-1321	CLIP-seq
MIRT1206561	hsa-miR-1538	CLIP-seq
MIRT1206562	hsa-miR-3126-5p	CLIP-seq
MIRT1206563	hsa-miR-3162-5p	CLIP-seq
MIRT1206564	hsa-miR-342-5p	CLIP-seq
MIRT1206565	hsa-miR-345	CLIP-seq
MIRT1206566	hsa-miR-3617	CLIP-seq
MIRT1206567	hsa-miR-3648	CLIP-seq
MIRT1206568	hsa-miR-3649	CLIP-seq
MIRT1206569	hsa-miR-4299	CLIP-seq
MIRT1206570	hsa-miR-4419a	CLIP-seq
MIRT1206571	hsa-miR-4456	CLIP-seq
MIRT1206572	hsa-miR-4510	CLIP-seq
MIRT1206573	hsa-miR-4522	CLIP-seq
MIRT1206574	hsa-miR-4649-3p	CLIP-seq
MIRT1206575	hsa-miR-4651	CLIP-seq
MIRT1206576	hsa-miR-4664-5p	CLIP-seq
MIRT1206577	hsa-miR-4739	CLIP-seq
MIRT1206578	hsa-miR-4745-3p	CLIP-seq
MIRT1206579	hsa-miR-4756-5p	CLIP-seq
MIRT1206580	hsa-miR-4771	CLIP-seq
MIRT1206581	hsa-miR-492	CLIP-seq
MIRT1206582	hsa-miR-515-5p	CLIP-seq
MIRT1206583	hsa-miR-541	CLIP-seq
MIRT1206584	hsa-miR-548q	CLIP-seq
MIRT1206585	hsa-miR-608	CLIP-seq
MIRT1206586	hsa-miR-641	CLIP-seq
MIRT1206587	hsa-miR-643	CLIP-seq
MIRT1206588	hsa-miR-654-5p	CLIP-seq
MIRT1206589	hsa-miR-765	CLIP-seq
MIRT1206560	hsa-miR-1321	CLIP-seq
MIRT1206577	hsa-miR-4739	CLIP-seq
MIRT1206579	hsa-miR-4756-5p	CLIP-seq
MIRT2585940	hsa-miR-1254	CLIP-seq
MIRT2585941	hsa-miR-3116	CLIP-seq
MIRT2585942	hsa-miR-3153	CLIP-seq
MIRT2585943	hsa-miR-3189-3p	CLIP-seq
MIRT1206557	hsa-miR-3978	CLIP-seq
MIRT2585944	hsa-miR-4668-5p	CLIP-seq
MIRT1206559	hsa-miR-875-3p	CLIP-seq
MIRT2585940	hsa-miR-1254	CLIP-seq
MIRT2585941	hsa-miR-3116	CLIP-seq
MIRT2585942	hsa-miR-3153	CLIP-seq
MIRT2585943	hsa-miR-3189-3p	CLIP-seq
MIRT1206557	hsa-miR-3978	CLIP-seq
MIRT2585944	hsa-miR-4668-5p	CLIP-seq
MIRT1206559	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002764	Process	Immune response-regulating signaling pathway	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030316	Process	Osteoclast differentiation	IMP	21841309
GO:0035580	Component	Specific granule lumen	TAS
GO:0038064	Function	Collagen receptor activity	IBA
GO:0038064	Function	Collagen receptor activity	IDA	21841309
GO:0038064	Function	Collagen receptor activity	IMP	21841309
GO:0038065	Process	Collagen-activated signaling pathway	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 606862
• HGNC: 29960
• e!Ensembl: ENSG00000170909

Protein

• UniProt ID: Q8IYS5
• Protein name: Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3)
• Protein function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
• PDB: 5CJ8 , 5CJB , 5EIQ , 5EIV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	32 → 123	Immunoglobulin domain	Domain

• Sequence:

  MALVLILQLLTLWPLCHTDITPSVPPASYHPKPWLGAQPATVVTPGVNVTLRCRAPQPAW
  RFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGIYRCCYRRPDWGPGVWSQPSDVLE
  LLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFVLYREGVAAPLQYRHSAQPWA
  DFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWEGEGPEARPASSAPGMQAPGPPP
  SDPGAQAPSLSSFRPRGLVLQPLLPQTQDSWDPAPPPSDPGV

• Sequence length: 282

Pathways

KEGG Pathway	Reactome Pathway
Osteoclast differentiation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Neutrophil degranulation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

LOC102725035 2 shared pathwaysOsteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Osteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. LOC107987462 2 shared pathwaysOsteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Osteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. LILRB1 2 shared pathwaysOsteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Osteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. LILRB5 2 shared pathwaysOsteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Osteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. LILRB4 2 shared pathwaysOsteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Osteoclast differentiation, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
LOC102725035	0	[]	2	["Osteoclast differentiation","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]	0	[]
LOC107987462	0	[]	2	["Osteoclast differentiation","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]	0	[]
LILRB1	0	[]	2	["Osteoclast differentiation","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]	0	[]
LILRB5	0	[]	2	["Osteoclast differentiation","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]	0	[]
LILRB4	0	[]	2	["Osteoclast differentiation","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]	0	[]

Diseases Linked via Similar Genes

Schizophrenia Linked via 1 of 5 related genesLILRB1 Hepatocellular carcinoma Linked via 1 of 5 related genesLILRB5 Colorectal cancer Linked via 1 of 5 related genesLILRB4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Schizophrenia	1	["LILRB1"]
Hepatocellular carcinoma	1	["LILRB5"]
Colorectal cancer	1	["LILRB4"]