Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4969
Gene name	Osteoglycin
Gene symbol	OGN
Synonyms (NCBI Gene)	OGOIFSLRR3A
Chromosome	9
Chromosome location	9q22.31
Summary	This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expressio

34 Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT447694	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT447694	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT756060	hsa-miR-548i	Luciferase reporter assayqRT-PCR	36926413
MIRT1202778	hsa-miR-514	CLIP-seq
MIRT1202779	hsa-miR-514b-3p	CLIP-seq
MIRT1202780	hsa-miR-526b	CLIP-seq
MIRT2058595	hsa-miR-3685	CLIP-seq
MIRT2058596	hsa-miR-384	CLIP-seq
MIRT2058597	hsa-miR-3978	CLIP-seq
MIRT2058598	hsa-miR-4729	CLIP-seq
MIRT2058599	hsa-miR-561	CLIP-seq
MIRT2286779	hsa-miR-1827	CLIP-seq
MIRT2431796	hsa-miR-1245b-3p	CLIP-seq
MIRT2431797	hsa-miR-4330	CLIP-seq
MIRT2585115	hsa-miR-140-3p	CLIP-seq
MIRT2585116	hsa-miR-3129-3p	CLIP-seq
MIRT2585117	hsa-miR-4652-3p	CLIP-seq
MIRT2585118	hsa-miR-4735-5p	CLIP-seq
MIRT2585119	hsa-miR-4778-5p	CLIP-seq
MIRT2686795	hsa-miR-141	CLIP-seq
MIRT2686796	hsa-miR-200a	CLIP-seq
MIRT2686797	hsa-miR-2113	CLIP-seq
MIRT2686798	hsa-miR-3687	CLIP-seq
MIRT2686799	hsa-miR-3941	CLIP-seq
MIRT2686800	hsa-miR-4263	CLIP-seq
MIRT2686801	hsa-miR-4442	CLIP-seq
MIRT2686802	hsa-miR-466	CLIP-seq
MIRT2686803	hsa-miR-4672	CLIP-seq
MIRT2686804	hsa-miR-4775	CLIP-seq
MIRT2585119	hsa-miR-4778-5p	CLIP-seq
MIRT2686805	hsa-miR-4799-5p	CLIP-seq
MIRT2686806	hsa-miR-576-5p	CLIP-seq
MIRT2686807	hsa-miR-590-3p	CLIP-seq
MIRT2686808	hsa-miR-599	CLIP-seq

Transcription factor	Regulation	Reference
IRF1	Unknown	12835654

18 Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	20551380
GO:0005796	Component	Golgi lumen	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0030021	Function	Extracellular matrix structural constituent conferring compression resistance	RCA	20551380, 25037231, 27559042, 28675934
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	HDA	25037231, 27559042, 28675934
GO:0031012	Component	Extracellular matrix	IBA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	ISS
GO:0060348	Process	Bone development	IBA
GO:0061975	Process	Articular cartilage development	IBA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
602383	8126	ENSG00000106809

P20774

Protein name

Mimecan (Osteoglycin) (Osteoinductive factor) (OIF)

Protein function

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	122 → 179	Leucine rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Bone.

Sequence

MKTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFSQDYEDKYLDGKNIKEK
ETVIIPNEKSLQLQKDEAITPLPPKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKE
SAYLYARFNKIKKLTAKDFADIPNLRRLDFTGNLIEDIEDGTFSKLSLLEELSLAENQLL
KLPVLPPKLTLFNAKYNKIKSRGIKANAFKKLNNLTFLYLDHNALESVPLNLPESLRVIH
LQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGNPIVLGKHPNSFICLKRLPIGSYF

Sequence length

298

Interactions

View interactions

Reactome Pathway
Keratan sulfate biosynthesis
Keratan sulfate degradation
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

OGN (osteoglycin)

Save This Analysis