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Gene Gene information from NCBI Gene database.
Entrez ID 10482
Gene name Nuclear RNA export factor 1
Gene symbol NXF1
Synonyms (NCBI Gene)
MEX67TAP
Chromosome 11
Chromosome location 11q12.3
Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT039654 hsa-miR-615-3p CLASH 23622248
MIRT440067 hsa-miR-487b-3p HITS-CLIP 24374217
MIRT440067 hsa-miR-487b-3p HITS-CLIP 24374217
MIRT737789 hsa-miR-103b CLIP-seq
MIRT1200394 hsa-miR-1253 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33 Show/Hide all (33)
GO ID Ontology Definition Evidence Reference
GO:0000346 Component Transcription export complex IDA 23299939
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602647 8071 ENSG00000162231
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UBU9
Protein name Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)
Protein function Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in th
PDB 1FO1 , 1FT8 , 1GO5 , 1JKG , 1JN5 , 1KOH , 1KOO , 1OAI , 2Z5K , 2Z5M , 3RW6 , 3RW7 , 4WYK , 6E5U
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02136 NTF2 386 → 536 Nuclear transport factor 2 (NTF2) domain Domain
PF03943 TAP_C 569 → 617 TAP C-terminal domain Domain
PF09162 Tap-RNA_bind 116 → 198 Tap, RNA-binding Domain
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously.
Sequence
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVA
MSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWF
KITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKIL
DRENRRISIIINSSAPPH
TILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVA
QNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSG
NELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPI
AFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSI
PFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFV
VDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFV
RNAS
SEEIQRAFAMPAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSA
QAFTHLKAKGEIPEVAF
MK
Sequence length 619
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ribosome biogenesis in eukaryotes Transport of the SLBP independent Mature mRNA
Nucleocytoplasmic transport Transport of the SLBP Dependant Mature mRNA
mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript
Amyotrophic lateral sclerosis Transport of Mature mRNA derived from an Intron-Containing Transcript
Influenza A  
Herpes simplex virus 1 infection