Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10412
Gene name	NSA2 ribosome biogenesis factor
Gene symbol	NSA2
Synonyms (NCBI Gene)	CDK105HCL-G1HCLG1HUSSY-29HUSSY29TINP1
Chromosome	5
Chromosome location	5q13.3
Summary	This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in lar

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020758	hsa-miR-155-5p	Proteomics	18668040
MIRT032355	hsa-let-7b-5p	Proteomics	18668040
MIRT695388	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT695387	hsa-miR-889-5p	HITS-CLIP	23313552
MIRT695386	hsa-miR-135a-5p	HITS-CLIP	23313552
MIRT695385	hsa-miR-135b-5p	HITS-CLIP	23313552
MIRT695384	hsa-miR-4317	HITS-CLIP	23313552
MIRT695383	hsa-miR-6515-3p	HITS-CLIP	23313552
MIRT695382	hsa-miR-1236-3p	HITS-CLIP	23313552
MIRT695381	hsa-miR-3166	HITS-CLIP	23313552
MIRT695380	hsa-miR-4771	HITS-CLIP	23313552
MIRT695379	hsa-miR-7974	HITS-CLIP	23313552
MIRT695378	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695377	hsa-miR-6740-5p	HITS-CLIP	23313552
MIRT695376	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT695375	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT564092	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT564091	hsa-miR-371a-3p	PAR-CLIP	20371350
MIRT564090	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT564089	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT564088	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT564087	hsa-miR-5697	PAR-CLIP	20371350
MIRT564086	hsa-miR-4480	PAR-CLIP	20371350
MIRT564085	hsa-miR-1297	PAR-CLIP	20371350
MIRT564084	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT564083	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT564081	hsa-miR-4465	PAR-CLIP	20371350
MIRT564082	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT564080	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT695388	hsa-miR-216b-5p	HITS-CLIP	23313552
MIRT695387	hsa-miR-889-5p	HITS-CLIP	23313552
MIRT695386	hsa-miR-135a-5p	HITS-CLIP	23313552
MIRT695385	hsa-miR-135b-5p	HITS-CLIP	23313552
MIRT695384	hsa-miR-4317	HITS-CLIP	23313552
MIRT695383	hsa-miR-6515-3p	HITS-CLIP	23313552
MIRT695382	hsa-miR-1236-3p	HITS-CLIP	23313552
MIRT695381	hsa-miR-3166	HITS-CLIP	23313552
MIRT695380	hsa-miR-4771	HITS-CLIP	23313552
MIRT695379	hsa-miR-7974	HITS-CLIP	23313552
MIRT695378	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT695377	hsa-miR-6740-5p	HITS-CLIP	23313552
MIRT695376	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT695375	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT564092	hsa-miR-371b-3p	PAR-CLIP	20371350
MIRT564091	hsa-miR-371a-3p	PAR-CLIP	20371350
MIRT564090	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT564089	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT564088	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT564087	hsa-miR-5697	PAR-CLIP	20371350
MIRT564086	hsa-miR-4480	PAR-CLIP	20371350
MIRT564085	hsa-miR-1297	PAR-CLIP	20371350
MIRT564084	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT564083	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT564081	hsa-miR-4465	PAR-CLIP	20371350
MIRT564082	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT564080	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT1194623	hsa-miR-128	CLIP-seq
MIRT1194624	hsa-miR-135a	CLIP-seq
MIRT1194625	hsa-miR-135b	CLIP-seq
MIRT1194626	hsa-miR-27a	CLIP-seq
MIRT1194627	hsa-miR-27b	CLIP-seq
MIRT1194628	hsa-miR-34a	CLIP-seq
MIRT1194629	hsa-miR-34c-5p	CLIP-seq
MIRT1194630	hsa-miR-449a	CLIP-seq
MIRT1194631	hsa-miR-449b	CLIP-seq
MIRT1194632	hsa-miR-4659a-3p	CLIP-seq
MIRT1194633	hsa-miR-4659b-3p	CLIP-seq
MIRT1194634	hsa-miR-494	CLIP-seq
MIRT1194635	hsa-miR-499-3p	CLIP-seq
MIRT1194636	hsa-miR-499a-3p	CLIP-seq
MIRT1194623	hsa-miR-128	CLIP-seq
MIRT1194626	hsa-miR-27a	CLIP-seq
MIRT1194627	hsa-miR-27b	CLIP-seq
MIRT1194628	hsa-miR-34a	CLIP-seq
MIRT1194629	hsa-miR-34c-5p	CLIP-seq
MIRT2056547	hsa-miR-3650	CLIP-seq
MIRT1194630	hsa-miR-449a	CLIP-seq
MIRT1194631	hsa-miR-449b	CLIP-seq
MIRT2056548	hsa-miR-4540	CLIP-seq
MIRT1194632	hsa-miR-4659a-3p	CLIP-seq
MIRT1194633	hsa-miR-4659b-3p	CLIP-seq
MIRT1194634	hsa-miR-494	CLIP-seq
MIRT1194635	hsa-miR-499-3p	CLIP-seq
MIRT1194636	hsa-miR-499a-3p	CLIP-seq
MIRT2056549	hsa-miR-944	CLIP-seq
MIRT2284997	hsa-miR-1236	CLIP-seq
MIRT1194624	hsa-miR-135a	CLIP-seq
MIRT1194625	hsa-miR-135b	CLIP-seq
MIRT2284998	hsa-miR-216b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000460	Process	Maturation of 5.8S rRNA	IBA
GO:0000470	Process	Maturation of LSU-rRNA	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0030684	Component	Preribosome	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
612497	30728	ENSG00000164346

O95478

Protein name

Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)

Protein function

Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

PDB

8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8IDY , 8IE3 , 8INE , 8INF , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8RL2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01201	Ribosomal_S8e	1 → 259	Ribosomal protein S8e	Family

Sequence

MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQ
MKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVP
LPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKK
AHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGK
YAQVTNNPENDGCINAVLLV

Sequence length

260

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY CIRRHOSIS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, BILIARY	—	CTD	18422935	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CHOLANGITIS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (14)
Biliary cirrhosis	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Biliary Cirrhosis, Primary, 1	Biliary cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36407085	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	22095236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35139491	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hairy Cell Leukemia	Hairy Cell Leukemia	BEFREE	23912275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	22095236, 23220173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	22095236		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23912275		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary Biliary Cholangitis	Biliary Cholangitis	CTD_human_DG	18422935		★★★★★ ★☆☆☆☆ Found in Text Mining only

NSA2 (NSA2 ribosome biogenesis factor)

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