Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4666
Gene name	Nascent polypeptide associated complex subunit alpha
Gene symbol	NACA
Synonyms (NCBI Gene)	HSD48NAC-alphaNACA1skNAC
Chromosome	12
Chromosome location	12q13.3
Summary	This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocki

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032033	hsa-miR-16-5p	Proteomics	18668040
MIRT052206	hsa-let-7b-5p	CLASH	23622248
MIRT050758	hsa-miR-17-3p	CLASH	23622248
MIRT045676	hsa-miR-149-5p	CLASH	23622248
MIRT039822	hsa-miR-615-3p	CLASH	23622248
MIRT039822	hsa-miR-615-3p	CLASH	23622248
MIRT039260	hsa-miR-671-5p	CLASH	23622248
MIRT037224	hsa-miR-877-5p	CLASH	23622248
MIRT037036	hsa-miR-877-3p	CLASH	23622248
MIRT037036	hsa-miR-877-3p	CLASH	23622248
MIRT574584	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT574583	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT574582	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT574581	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT574580	hsa-miR-607	PAR-CLIP	20371350
MIRT574584	hsa-miR-101-3p	PAR-CLIP	20371350
MIRT574583	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT574582	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT574581	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT574580	hsa-miR-607	PAR-CLIP	20371350
MIRT1172528	hsa-miR-101	CLIP-seq
MIRT1172528	hsa-miR-101	CLIP-seq
MIRT1172529	hsa-miR-4786-3p	CLIP-seq
MIRT1172530	hsa-miR-935	CLIP-seq
MIRT1172528	hsa-miR-101	CLIP-seq
MIRT2049873	hsa-miR-4760-3p	CLIP-seq
MIRT1172529	hsa-miR-4786-3p	CLIP-seq
MIRT2278850	hsa-miR-3121-5p	CLIP-seq
MIRT2278851	hsa-miR-3672	CLIP-seq
MIRT1172530	hsa-miR-935	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0003231	Process	Cardiac ventricle development	ISS
GO:0003677	Function	DNA binding	IEA
GO:0003713	Function	Transcription coactivator activity	NAS	21071677
GO:0005515	Function	Protein binding	IPI	21903422, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21071677
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10982809
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8047162
GO:0005854	Component	Nascent polypeptide-associated complex	IEA
GO:0005854	Component	Nascent polypeptide-associated complex	IPI	20214399
GO:0005854	Component	Nascent polypeptide-associated complex	TAS	8047162
GO:0006412	Process	Translation	TAS	8047162
GO:0006612	Process	Protein targeting to membrane	IBA
GO:0010664	Process	Negative regulation of striated muscle cell apoptotic process	ISS
GO:0015031	Process	Protein transport	IEA
GO:0042060	Process	Wound healing	ISS
GO:0043403	Process	Skeletal muscle tissue regeneration	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0048633	Process	Positive regulation of skeletal muscle tissue growth	ISS
GO:0048742	Process	Regulation of skeletal muscle fiber development	ISS
GO:0051082	Function	Unfolded protein binding	IBA
GO:0061384	Process	Heart trabecula morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1905551	Process	Negative regulation of protein localization to endoplasmic reticulum	IDA	10982809
GO:2000138	Process	Positive regulation of cell proliferation involved in heart morphogenesis	ISS

MIM	HGNC	e!Ensembl
601234	7629	ENSG00000196531

Q13765

Protein name

Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)

Protein function

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which

PDB

3LKX , 3MCB , 3MCE , 7QWQ , 7QWR , 7QWS , 8P2K , 9F1B , 9F1C , 9F1D , 9FQ0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01849	NAC	73 → 129	NAC domain	Family
PF19026	HYPK_UBA	174 → 214	HYPK UBA domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:16201836}.

Sequence

MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEID
EEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTY
IVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKD
IELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM

Sequence length

215

E9PAV3

Protein name

Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)

Protein function

Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01849	NAC	1936 → 1992	NAC domain	Family
PF19026	HYPK_UBA	2037 → 2077	HYPK UBA domain	Domain

Sequence

MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSA
ANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALAS
PMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIA
PSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLA
IASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD
FPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPL
PSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPN
ATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSP
AALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLE
GAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLP
IGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAP
TTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAP
LATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASAT
ASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENS
LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP
ATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK
WAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPK
GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAP
TPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGL
ATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAA
TPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPP
KGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSP
KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKG
GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTP
VSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM
GAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKK
TPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVT
PPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTA
LKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLP
VQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSL
PLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLV
NMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAA
EIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPAS
DTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVE
VKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM

Sequence length

2078

Interactions

View interactions

KEGG Pathway
Parathyroid hormone synthesis, secretion and action

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	29892015, 29892015, 30061737, 30061737, 34594039, 35872910, 36653681, 39024449, 39537608, 40050429, 40645996	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA	—	GWAS catalog	32514122	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	34290314	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (8)
Atrial Fibrillation	Atrial Fibrillation	CTD_human_DG	29892015, 30061737	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Down Syndrome	Down Syndrome	BEFREE	12109594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	LHGDN	12109594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Juvenile Myelomonocytic Leukemia	Myelomonocytic Leukemia	LHGDN	12699894	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25209525	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	12109594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	CTD_human_DG	29892015, 30061737	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	25209525	★★★★★ ★☆☆☆☆ Found in Text Mining only

NACA (nascent polypeptide associated complex subunit alpha)

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