MYLK4 (myosin light chain kinase family member 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 340156
• Gene name: Myosin light chain kinase family member 4
• Gene symbol: MYLK4
• Synonyms (NCBI Gene): SgK085
• Chromosome: 6
• Chromosome location: 6p25.2

miRNA Show/Hide all (187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT656057	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT656056	hsa-miR-1197	HITS-CLIP	23824327
MIRT656055	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT656054	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT656053	hsa-miR-4530	HITS-CLIP	23824327
MIRT656052	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT656051	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656050	hsa-miR-3117-3p	HITS-CLIP	23824327
MIRT656049	hsa-miR-623	HITS-CLIP	23824327
MIRT656048	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656047	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656046	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT656045	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656044	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656043	hsa-miR-521	HITS-CLIP	23824327
MIRT656057	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT656056	hsa-miR-1197	HITS-CLIP	23824327
MIRT656055	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT656054	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT656053	hsa-miR-4530	HITS-CLIP	23824327
MIRT656052	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT656051	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT656050	hsa-miR-3117-3p	HITS-CLIP	23824327
MIRT656049	hsa-miR-623	HITS-CLIP	23824327
MIRT656048	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656047	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656046	hsa-miR-651-5p	HITS-CLIP	23824327
MIRT656045	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656044	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656043	hsa-miR-521	HITS-CLIP	23824327
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT1169006	hsa-miR-1208	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT1169008	hsa-miR-145	CLIP-seq
MIRT1169009	hsa-miR-147	CLIP-seq
MIRT1169010	hsa-miR-2467-3p	CLIP-seq
MIRT1169011	hsa-miR-297	CLIP-seq
MIRT1169012	hsa-miR-3064-3p	CLIP-seq
MIRT1169013	hsa-miR-3149	CLIP-seq
MIRT1169014	hsa-miR-3150a-5p	CLIP-seq
MIRT1169015	hsa-miR-3150b-5p	CLIP-seq
MIRT1169016	hsa-miR-3198	CLIP-seq
MIRT1169017	hsa-miR-339-3p	CLIP-seq
MIRT1169018	hsa-miR-3650	CLIP-seq
MIRT1169019	hsa-miR-3911	CLIP-seq
MIRT1169020	hsa-miR-3925-3p	CLIP-seq
MIRT1169021	hsa-miR-4252	CLIP-seq
MIRT1169022	hsa-miR-4303	CLIP-seq
MIRT1169023	hsa-miR-4309	CLIP-seq
MIRT1169024	hsa-miR-432	CLIP-seq
MIRT1169025	hsa-miR-4453	CLIP-seq
MIRT1169026	hsa-miR-452	CLIP-seq
MIRT1169027	hsa-miR-4538	CLIP-seq
MIRT1169028	hsa-miR-4653-3p	CLIP-seq
MIRT1169029	hsa-miR-4676-3p	CLIP-seq
MIRT1169030	hsa-miR-4710	CLIP-seq
MIRT1169031	hsa-miR-4715-3p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT1169034	hsa-miR-4776-3p	CLIP-seq
MIRT1169035	hsa-miR-4792	CLIP-seq
MIRT1169036	hsa-miR-4803	CLIP-seq
MIRT1169037	hsa-miR-485-5p	CLIP-seq
MIRT1169038	hsa-miR-508-5p	CLIP-seq
MIRT1169039	hsa-miR-567	CLIP-seq
MIRT1169040	hsa-miR-599	CLIP-seq
MIRT1169041	hsa-miR-644	CLIP-seq
MIRT1169042	hsa-miR-873	CLIP-seq
MIRT1169043	hsa-miR-889	CLIP-seq
MIRT1169044	hsa-miR-922	CLIP-seq
MIRT2048608	hsa-miR-1207-3p	CLIP-seq
MIRT2048609	hsa-miR-139-3p	CLIP-seq
MIRT2048610	hsa-miR-3607-5p	CLIP-seq
MIRT2048611	hsa-miR-3910	CLIP-seq
MIRT2048612	hsa-miR-3913-3p	CLIP-seq
MIRT2048613	hsa-miR-3922-5p	CLIP-seq
MIRT2048614	hsa-miR-4329	CLIP-seq
MIRT2048615	hsa-miR-4420	CLIP-seq
MIRT2048616	hsa-miR-4491	CLIP-seq
MIRT2048617	hsa-miR-4657	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT2048619	hsa-miR-4747-5p	CLIP-seq
MIRT2048620	hsa-miR-489	CLIP-seq
MIRT2048621	hsa-miR-513a-5p	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT2277493	hsa-miR-1273f	CLIP-seq
MIRT2277494	hsa-miR-1275	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277495	hsa-miR-148a	CLIP-seq
MIRT2277496	hsa-miR-148b	CLIP-seq
MIRT2277497	hsa-miR-152	CLIP-seq
MIRT2277498	hsa-miR-1909	CLIP-seq
MIRT2277499	hsa-miR-216a	CLIP-seq
MIRT1169010	hsa-miR-2467-3p	CLIP-seq
MIRT2277500	hsa-miR-298	CLIP-seq
MIRT2277501	hsa-miR-3125	CLIP-seq
MIRT2277502	hsa-miR-3135b	CLIP-seq
MIRT2277503	hsa-miR-3184	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2277505	hsa-miR-3675-5p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277508	hsa-miR-3916	CLIP-seq
MIRT2277509	hsa-miR-423-5p	CLIP-seq
MIRT2277510	hsa-miR-4434	CLIP-seq
MIRT2277511	hsa-miR-4457	CLIP-seq
MIRT2277512	hsa-miR-4516	CLIP-seq
MIRT2277513	hsa-miR-4525	CLIP-seq
MIRT2277514	hsa-miR-4531	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2277516	hsa-miR-4665-5p	CLIP-seq
MIRT2277517	hsa-miR-4688	CLIP-seq
MIRT2277518	hsa-miR-4691-3p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2277519	hsa-miR-4723-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT2277520	hsa-miR-4731-3p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277521	hsa-miR-4801	CLIP-seq
MIRT2277522	hsa-miR-4802-3p	CLIP-seq
MIRT1169037	hsa-miR-485-5p	CLIP-seq
MIRT2277523	hsa-miR-486-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2277525	hsa-miR-625	CLIP-seq
MIRT2277526	hsa-miR-637	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq
MIRT2277528	hsa-miR-720	CLIP-seq
MIRT2391255	hsa-miR-140-3p	CLIP-seq
MIRT2391256	hsa-miR-15a	CLIP-seq
MIRT2391257	hsa-miR-15b	CLIP-seq
MIRT2391258	hsa-miR-16	CLIP-seq
MIRT2391259	hsa-miR-195	CLIP-seq
MIRT2391260	hsa-miR-3176	CLIP-seq
MIRT2391261	hsa-miR-3922-3p	CLIP-seq
MIRT2391262	hsa-miR-3926	CLIP-seq
MIRT2391263	hsa-miR-424	CLIP-seq
MIRT2391264	hsa-miR-4786-5p	CLIP-seq
MIRT2277522	hsa-miR-4802-3p	CLIP-seq
MIRT2391265	hsa-miR-497	CLIP-seq
MIRT2391266	hsa-miR-548s	CLIP-seq
MIRT2391267	hsa-miR-769-5p	CLIP-seq
MIRT2438829	hsa-miR-548k	CLIP-seq
MIRT2454698	hsa-miR-3148	CLIP-seq
MIRT2454699	hsa-miR-3591-3p	CLIP-seq
MIRT2454700	hsa-miR-3652	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2454702	hsa-miR-3688-3p	CLIP-seq
MIRT2454703	hsa-miR-3978	CLIP-seq
MIRT2454704	hsa-miR-4430	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT2454706	hsa-miR-4694-3p	CLIP-seq
MIRT2454707	hsa-miR-4775	CLIP-seq
MIRT2454708	hsa-miR-539	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2454710	hsa-miR-875-3p	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT2277493	hsa-miR-1273f	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq
MIRT1169005	hsa-miR-1205	CLIP-seq
MIRT1169007	hsa-miR-1286	CLIP-seq
MIRT2277504	hsa-miR-3192	CLIP-seq
MIRT2454701	hsa-miR-3675-3p	CLIP-seq
MIRT2277506	hsa-miR-3689a-3p	CLIP-seq
MIRT2277507	hsa-miR-3689c	CLIP-seq
MIRT2277515	hsa-miR-4537	CLIP-seq
MIRT2454705	hsa-miR-4684-5p	CLIP-seq
MIRT1169032	hsa-miR-4722-5p	CLIP-seq
MIRT2048618	hsa-miR-4728-5p	CLIP-seq
MIRT1169033	hsa-miR-4768-3p	CLIP-seq
MIRT2277524	hsa-miR-490-3p	CLIP-seq
MIRT2454709	hsa-miR-548c-3p	CLIP-seq
MIRT2277527	hsa-miR-658	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004687	Function	Myosin light chain kinase activity	IBA
GO:0005515	Function	Protein binding	IPI	22939624, 28514442, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q86YV6
• Protein name: Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
• PDB: 2X4F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	106 → 361	Protein kinase domain	Domain

• Sequence:

  MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN
  ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV
  HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM
  EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA
  KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL
  SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW
  LSDHKLHSRLNAQKKKNRGSDAQDFVTK

• Sequence length: 388

Pathways

KEGG Pathway

Calcium signaling pathway

cGMP-PKG signaling pathway

Vascular smooth muscle contraction

Apelin signaling pathway

Focal adhesion

Platelet activation

Regulation of actin cytoskeleton

Oxytocin signaling pathway

Gastric acid secretion

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Long QT syndrome	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cardiomyopathies	Cardiomyopathy	Pubtator	24709777	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	24709777	Inhibit	★☆☆☆☆ Found in Text Mining only
Infiltrating duct carcinoma of female breast	Infiltrating Duct Carcinoma Of Female Breast	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MYLK2 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Apelin signaling pathway, Focal adhesion, Platelet activation, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Gastric acid secretion Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. MYLK3 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Apelin signaling pathway, Focal adhesion, Platelet activation, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Gastric acid secretion Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. MYLK 9 shared pathwaysCalcium signaling pathway, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Apelin signaling pathway, Focal adhesion, Platelet activation, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Gastric acid secretion Related via 9 shared pathways including Calcium signaling pathway, cGMP-PKG signaling pathway. PPP1R12A 6 shared pathwayscGMP-PKG signaling pathway, Vascular smooth muscle contraction, Focal adhesion, Platelet activation, Regulation of actin cytoskeleton, Oxytocin signaling pathway Related via 6 shared pathways including cGMP-PKG signaling pathway, Vascular smooth muscle contraction. PPP1R12C 4 shared pathwaysVascular smooth muscle contraction, Focal adhesion, Regulation of actin cytoskeleton, Oxytocin signaling pathway Related via 4 shared pathways including Vascular smooth muscle contraction, Focal adhesion.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MYLK2	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Vascular smooth muscle contraction","Apelin signaling pathway","Focal adhesion","Platelet activation","Regulation of actin cytoskeleton","Oxytocin signaling pathway","Gastric acid secretion"]	0	[]
MYLK3	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Vascular smooth muscle contraction","Apelin signaling pathway","Focal adhesion","Platelet activation","Regulation of actin cytoskeleton","Oxytocin signaling pathway","Gastric acid secretion"]	0	[]
MYLK	0	[]	9	["Calcium signaling pathway","cGMP-PKG signaling pathway","Vascular smooth muscle contraction","Apelin signaling pathway","Focal adhesion","Platelet activation","Regulation of actin cytoskeleton","Oxytocin signaling pathway","Gastric acid secretion"]	0	[]
PPP1R12A	0	[]	6	["cGMP-PKG signaling pathway","Vascular smooth muscle contraction","Focal adhesion","Platelet activation","Regulation of actin cytoskeleton","Oxytocin signaling pathway"]	0	[]
PPP1R12C	0	[]	4	["Vascular smooth muscle contraction","Focal adhesion","Regulation of actin cytoskeleton","Oxytocin signaling pathway"]	0	[]

Diseases Linked via Similar Genes

Dilated cardiomyopathy Linked via 2 of 5 related genesMYLK2, MYLK3 Cardiomyopathy Linked via 1 of 5 related genesMYLK2 Fabry disease Linked via 1 of 5 related genesMYLK2 Hypertrophic cardiomyopathy Linked via 1 of 5 related genesMYLK2 Left ventricular noncompaction cardiomyopathy Linked via 1 of 5 related genesMYLK2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Dilated cardiomyopathy	2	["MYLK2","MYLK3"]
Cardiomyopathy	1	["MYLK2"]
Fabry disease	1	["MYLK2"]
Hypertrophic cardiomyopathy	1	["MYLK2"]
Left ventricular noncompaction cardiomyopathy	1	["MYLK2"]