MST1 (macrophage stimulating 1)

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Gene Gene information from NCBI Gene database.
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Entrez ID 4485
Gene name Macrophage stimulating 1
Gene symbol MST1
Synonyms (NCBI Gene)
D3F15S2DNF15S2HGFLMSPNF15S2
Chromosome 3
Chromosome location 3p21.31
Summary The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT025230 hsa-miR-34a-5p Proteomics 21566225
MIRT025230 hsa-miR-34a-5p Proteomics 21566225
MIRT735859 hsa-miR-1184 Western blottingqRT-PCR 32681581
MIRT735859 hsa-miR-1184 Western blottingImmunoprecipitaion (IP)qRT-PCR 32681581
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Transcription factor Regulation Reference
EZH2 Repression 24499724
MYC Repression 24499724
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IBA
GO:0005515 Function Protein binding IPI 22087277, 25193665, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
142408 7380 ENSG00000173531
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P26927
Protein name Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
PDB 2ASU , 4QT8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00024 PAN_1 16 → 106 PAN domain Domain
PF00051 Kringle 370 → 448 Kringle domain Domain
PF00051 Kringle 191 → 268 Kringle domain Domain
PF00051 Kringle 283 → 361 Kringle domain Domain
PF00051 Kringle 110 → 186 Kringle domain Domain
PF00089 Trypsin 484 → 704 Trypsin Domain
Sequence 
MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRC
GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRG
TMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQS
CGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYC
RNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTA
GVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRR
CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCR
NPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRS
KLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGT
LFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGT
KCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGD
YGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG
Sequence length 711
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Calcium signaling pathway Signaling by MST1
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (16)
Phenotype Name Clinical Significance Source Reference Evidence Score
ANKYLOSING SPONDYLITIS — GWAS catalog 26974007
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD 28114269
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLANGITIS, SCLEROSING — CTD, Disgenet
CTD, Disgenet 		21151127
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC LEFT-SIDED ULCERATIVE COLITIS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLITIS, ULCERATIVE — CTD 18438406, 20228799
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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MST1R 2 shared pathwaysCalcium signaling pathway, Signaling by MST1 Related via 2 shared pathways including Calcium signaling pathway, Signaling by MST1. ICOSLG 2 shared diseasesCombined immunodeficiency disease, Immunodeficiency 3 shared evidence sourcesDisgenet (Ulcerative colitis), CTD (Ulcerative colitis), Disgenet (Immunodeficiency) Related via 2 shared diseases including Combined immunodeficiency disease, Immunodeficiency — evidence mostly Disgenet. IFNGR2 2 shared diseasesImmunodeficiency, Sclerosing cholangitis 3 shared evidence sourcesGWAS catalog (Ankylosing spondylitis), Disgenet (Immunodeficiency), GWAS catalog (Sclerosing cholangitis) Related via 2 shared diseases including Immunodeficiency, Sclerosing cholangitis — evidence mostly GWAS catalog. CORO1A 3 shared diseasesEpidermodysplasia verruciformis, Immunodeficiency, Sclerosing cholangitis 3 shared evidence sourcesGWAS catalog (Ankylosing spondylitis), GenCC (Epidermodysplasia verruciformis), GWAS catalog (Sclerosing cholangitis) Related via 3 shared diseases including Epidermodysplasia verruciformis, Immunodeficiency — evidence mostly GWAS catalog. RORC 2 shared diseasesImmunodeficiency, Sclerosing cholangitis 2 shared evidence sourcesGWAS catalog (Ankylosing spondylitis), GWAS catalog (Sclerosing cholangitis) Related via 2 shared diseases including Immunodeficiency, Sclerosing cholangitis — evidence mostly GWAS catalog.
Insomnia Linked via 3 of 5 related genesMST1R, CORO1A, RORC Rheumatoid arthritis Linked via 3 of 5 related genesICOSLG, IFNGR2, CORO1A Autism Linked via 2 of 5 related genesMST1R, CORO1A Multiple sclerosis Linked via 2 of 5 related genesIFNGR2, CORO1A Attention deficit hyperactivity disorder Linked via 1 of 5 related genesMST1R