MIOS (meiosis regulator for oocyte development)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54468
• Gene name: Meiosis regulator for oocyte development
• Gene symbol: MIOS
• Synonyms (NCBI Gene): MIO, Sea4, Yulink
• Chromosome: 7
• Chromosome location: 7p21.3

miRNA Show/Hide all (97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027587	hsa-miR-98-5p	Microarray	19088304
MIRT032301	hsa-let-7b-5p	Proteomics	18668040
MIRT1149337	hsa-let-7a	CLIP-seq
MIRT1149338	hsa-let-7b	CLIP-seq
MIRT1149339	hsa-let-7c	CLIP-seq
MIRT1149340	hsa-let-7d	CLIP-seq
MIRT1149341	hsa-let-7e	CLIP-seq
MIRT1149342	hsa-let-7f	CLIP-seq
MIRT1149343	hsa-let-7g	CLIP-seq
MIRT1149344	hsa-let-7i	CLIP-seq
MIRT1149345	hsa-miR-1206	CLIP-seq
MIRT1149346	hsa-miR-1305	CLIP-seq
MIRT1149347	hsa-miR-135a	CLIP-seq
MIRT1149348	hsa-miR-135b	CLIP-seq
MIRT1149349	hsa-miR-145	CLIP-seq
MIRT1149350	hsa-miR-202	CLIP-seq
MIRT1149351	hsa-miR-224	CLIP-seq
MIRT1149352	hsa-miR-3659	CLIP-seq
MIRT1149353	hsa-miR-4255	CLIP-seq
MIRT1149354	hsa-miR-4273	CLIP-seq
MIRT1149355	hsa-miR-4303	CLIP-seq
MIRT1149356	hsa-miR-4307	CLIP-seq
MIRT1149357	hsa-miR-4458	CLIP-seq
MIRT1149358	hsa-miR-4500	CLIP-seq
MIRT1149359	hsa-miR-4649-3p	CLIP-seq
MIRT1149360	hsa-miR-4677-5p	CLIP-seq
MIRT1149361	hsa-miR-4699-5p	CLIP-seq
MIRT1149362	hsa-miR-4709-3p	CLIP-seq
MIRT1149363	hsa-miR-4762-3p	CLIP-seq
MIRT1149364	hsa-miR-4777-5p	CLIP-seq
MIRT1149365	hsa-miR-4790-3p	CLIP-seq
MIRT1149366	hsa-miR-5095	CLIP-seq
MIRT1149367	hsa-miR-518d-5p	CLIP-seq
MIRT1149368	hsa-miR-519b-5p	CLIP-seq
MIRT1149369	hsa-miR-519c-5p	CLIP-seq
MIRT1149370	hsa-miR-520c-5p	CLIP-seq
MIRT1149371	hsa-miR-526a	CLIP-seq
MIRT1149372	hsa-miR-552	CLIP-seq
MIRT1149373	hsa-miR-567	CLIP-seq
MIRT1149374	hsa-miR-98	CLIP-seq
MIRT1149349	hsa-miR-145	CLIP-seq
MIRT1149361	hsa-miR-4699-5p	CLIP-seq
MIRT1149362	hsa-miR-4709-3p	CLIP-seq
MIRT1149337	hsa-let-7a	CLIP-seq
MIRT1149338	hsa-let-7b	CLIP-seq
MIRT1149339	hsa-let-7c	CLIP-seq
MIRT1149340	hsa-let-7d	CLIP-seq
MIRT1149341	hsa-let-7e	CLIP-seq
MIRT1149342	hsa-let-7f	CLIP-seq
MIRT1149343	hsa-let-7g	CLIP-seq
MIRT1149344	hsa-let-7i	CLIP-seq
MIRT1149349	hsa-miR-145	CLIP-seq
MIRT1149350	hsa-miR-202	CLIP-seq
MIRT1149354	hsa-miR-4273	CLIP-seq
MIRT1149355	hsa-miR-4303	CLIP-seq
MIRT1149356	hsa-miR-4307	CLIP-seq
MIRT1149357	hsa-miR-4458	CLIP-seq
MIRT1149358	hsa-miR-4500	CLIP-seq
MIRT1149359	hsa-miR-4649-3p	CLIP-seq
MIRT1149360	hsa-miR-4677-5p	CLIP-seq
MIRT1149361	hsa-miR-4699-5p	CLIP-seq
MIRT1149362	hsa-miR-4709-3p	CLIP-seq
MIRT1149363	hsa-miR-4762-3p	CLIP-seq
MIRT2042492	hsa-miR-499a-5p	CLIP-seq
MIRT1149373	hsa-miR-567	CLIP-seq
MIRT1149374	hsa-miR-98	CLIP-seq
MIRT2272099	hsa-miR-103a	CLIP-seq
MIRT2272100	hsa-miR-106a	CLIP-seq
MIRT2272101	hsa-miR-106b	CLIP-seq
MIRT2272102	hsa-miR-107	CLIP-seq
MIRT2272103	hsa-miR-1271	CLIP-seq
MIRT1149346	hsa-miR-1305	CLIP-seq
MIRT1149349	hsa-miR-145	CLIP-seq
MIRT2272104	hsa-miR-17	CLIP-seq
MIRT2272105	hsa-miR-182	CLIP-seq
MIRT2272106	hsa-miR-20a	CLIP-seq
MIRT2272107	hsa-miR-20b	CLIP-seq
MIRT1149351	hsa-miR-224	CLIP-seq
MIRT2272108	hsa-miR-28-3p	CLIP-seq
MIRT2272109	hsa-miR-370	CLIP-seq
MIRT2272110	hsa-miR-4310	CLIP-seq
MIRT1149361	hsa-miR-4699-5p	CLIP-seq
MIRT1149362	hsa-miR-4709-3p	CLIP-seq
MIRT2272111	hsa-miR-4714-3p	CLIP-seq
MIRT1149366	hsa-miR-5095	CLIP-seq
MIRT2272112	hsa-miR-519a	CLIP-seq
MIRT2272113	hsa-miR-519b-3p	CLIP-seq
MIRT2272114	hsa-miR-519c-3p	CLIP-seq
MIRT2272115	hsa-miR-519d	CLIP-seq
MIRT2272116	hsa-miR-548n	CLIP-seq
MIRT2272117	hsa-miR-548t	CLIP-seq
MIRT1149372	hsa-miR-552	CLIP-seq
MIRT2272118	hsa-miR-593	CLIP-seq
MIRT2272119	hsa-miR-885-3p	CLIP-seq
MIRT2272120	hsa-miR-885-5p	CLIP-seq
MIRT2272121	hsa-miR-93	CLIP-seq
MIRT2272122	hsa-miR-96	CLIP-seq

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25263562, 26449471, 26586190, 26972053, 28199315, 28514442, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005765	Component	Lysosomal membrane	IDA	28199306
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005829	Component	Cytosol	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0031503	Process	Protein-containing complex localization	IMP	23723238
GO:0031669	Process	Cellular response to nutrient levels	IDA	35831510, 36528027
GO:0032289	Process	Central nervous system myelin formation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IBA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	23723238
GO:0046872	Function	Metal ion binding	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0048709	Process	Oligodendrocyte differentiation	ISS
GO:0061700	Component	GATOR2 complex	IDA	35831510, 36528027
GO:0061700	Component	GATOR2 complex	NAS	23723238
GO:0070444	Process	Oligodendrocyte progenitor proliferation	IEA
GO:0070444	Process	Oligodendrocyte progenitor proliferation	ISS
GO:1904262	Process	Negative regulation of TORC1 signaling	NAS	23723238
GO:1904263	Process	Positive regulation of TORC1 signaling	IBA
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	35831510, 36528027
GO:1904263	Process	Positive regulation of TORC1 signaling	IEA
GO:1904263	Process	Positive regulation of TORC1 signaling	NAS	23723238

Other IDs

• MIM: 615359
• HGNC: 21905
• e!Ensembl: ENSG00000164654

Protein

• UniProt ID: Q9NXC5
• Protein name: GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog)
• Protein function: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly
• PDB: 7UHY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17034	zinc_ribbon_16	737 → 861	Zinc-ribbon like family	Family

• Sequence:

  MSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDT
  PYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLA
  WNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYE
  LGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRV
  ASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQH
  TPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAW
  SPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNED
  PQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQ
  SDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQI
  LNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETG
  SYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVD
  LMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHR
  SKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRK
  PLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHML
  SWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP

• Sequence length: 875

Pathways

KEGG Pathway:

mTOR signaling pathway

Reactome Pathway:

Amino acids regulate mTORC1

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NPRL2 2 shared pathwaysmTOR signaling pathway, Amino acids regulate mTORC1 Related via 2 shared pathways including mTOR signaling pathway, Amino acids regulate mTORC1. FNIP2 2 shared pathwaysmTOR signaling pathway, Amino acids regulate mTORC1 Related via 2 shared pathways including mTOR signaling pathway, Amino acids regulate mTORC1. CASTOR1 2 shared pathwaysmTOR signaling pathway, Amino acids regulate mTORC1 Related via 2 shared pathways including mTOR signaling pathway, Amino acids regulate mTORC1. CASTOR2 2 shared pathwaysmTOR signaling pathway, Amino acids regulate mTORC1 Related via 2 shared pathways including mTOR signaling pathway, Amino acids regulate mTORC1. WDR59 2 shared pathwaysmTOR signaling pathway, Amino acids regulate mTORC1 Related via 2 shared pathways including mTOR signaling pathway, Amino acids regulate mTORC1.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NPRL2	0	[]	2	["mTOR signaling pathway","Amino acids regulate mTORC1"]	0	[]
FNIP2	0	[]	2	["mTOR signaling pathway","Amino acids regulate mTORC1"]	0	[]
CASTOR1	0	[]	2	["mTOR signaling pathway","Amino acids regulate mTORC1"]	0	[]
CASTOR2	0	[]	2	["mTOR signaling pathway","Amino acids regulate mTORC1"]	0	[]
WDR59	0	[]	2	["mTOR signaling pathway","Amino acids regulate mTORC1"]	0	[]

Diseases Linked via Similar Genes

Schizophrenia Linked via 2 of 5 related genesNPRL2, FNIP2 Partial epilepsy Linked via 1 of 5 related genesNPRL2 Familial focal epilepsy with variable foci Linked via 1 of 5 related genesNPRL2 Progressive myoclonic epilepsy Linked via 1 of 5 related genesNPRL2 Focal epilepsy Linked via 1 of 5 related genesNPRL2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Schizophrenia	2	["NPRL2","FNIP2"]
Partial epilepsy	1	["NPRL2"]
Familial focal epilepsy with variable foci	1	["NPRL2"]
Progressive myoclonic epilepsy	1	["NPRL2"]
Focal epilepsy	1	["NPRL2"]