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Gene Gene information from NCBI Gene database.
Entrez ID 64769
Gene name MYST/Esa1 associated factor 6
Gene symbol MEAF6
Synonyms (NCBI Gene)
C1orf149CENP-28EAF6NY-SAR-91
Chromosome 1
Chromosome location 1p34.3
Summary This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing result
miRNA miRNA information provided by mirtarbase database.
518 Show/Hide all (518)
miRTarBase ID miRNA Experiments Reference
MIRT029489 hsa-miR-26b-5p Microarray 19088304
MIRT047703 hsa-miR-10a-5p CLASH 23622248
MIRT692722 hsa-miR-320e HITS-CLIP 23313552
MIRT692721 hsa-miR-5683 HITS-CLIP 23313552
MIRT692720 hsa-miR-4676-5p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
BRPF1 Unknown 18794358
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40 Show/Hide all (40)
GO ID Ontology Definition Evidence Reference
GO:0000123 Component Histone acetyltransferase complex IDA 16387653
GO:0000123 Component Histone acetyltransferase complex IEA
GO:0000123 Component Histone acetyltransferase complex IPI 16387653
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000776 Component Kinetochore IDA 20813266
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611001 25674 ENSG00000163875
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HAF1
Protein name Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91)
Protein function Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09340 NuA4 18 → 97 Histone acetyltransferase subunit NuA4 Family
Sequence
MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRG
WDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSA
AAVSALAGVQDQLIEKREPGSGT
ESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRID
LKLNKKPRADY
Sequence length 191
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
ATP-dependent chromatin remodeling HATs acetylate histones
  Regulation of TP53 Activity through Acetylation