MAPRE3 (microtubule associated protein RP/EB family member 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 22924 |
| Gene name | Microtubule associated protein RP/EB family member 3 |
| Gene symbol | MAPRE3 |
| Synonyms (NCBI Gene) |
EB3EBF3EBF3-SRP3
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| Chromosome | 2 |
| Chromosome location | 2p23.3 |
| Summary | The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UPY8 | |||||||||||||||
| Protein name | Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3) | |||||||||||||||
| Protein function | Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:19255245, PubMed:28814570). Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be inv | |||||||||||||||
| PDB | 1WYO , 3CO1 , 3JAK , 3JAL , 3JAR , 3TQ7 , 7SJ9 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Predominantly expressed in brain and muscle. {ECO:0000269|PubMed:10644998}. | |||||||||||||||
| Sequence |
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRK |
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| Sequence length | 281 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with MAPRE3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to MAPRE3 (see Related Genes above), that are NOT already directly curated for MAPRE3 itself -- a lead worth checking, not a confirmed association.
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