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Gene Gene information from NCBI Gene database.
Entrez ID 11027
Gene name Leukocyte immunoglobulin like receptor A2
Gene symbol LILRA2
Synonyms (NCBI Gene)
CD85HILT1LIR-7LIR7
Chromosome 19
Chromosome location 19q13.42
Summary This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cel
miRNA miRNA information provided by mirtarbase database.
235 Show/Hide all (235)
miRTarBase ID miRNA Experiments Reference
MIRT635912 hsa-miR-4768-3p HITS-CLIP 23824327
MIRT635913 hsa-miR-4459 HITS-CLIP 23824327
MIRT635911 hsa-miR-4433a-3p HITS-CLIP 23824327
MIRT635910 hsa-miR-6849-3p HITS-CLIP 23824327
MIRT635909 hsa-miR-544b HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29 Show/Hide all (29)
GO ID Ontology Definition Evidence Reference
GO:0001791 Function IgM binding IDA 27572839
GO:0002220 Process Innate immune response activating cell surface receptor signaling pathway IDA 27572839
GO:0002283 Process Neutrophil activation involved in immune response IDA 27572839
GO:0002376 Process Immune system process IEA
GO:0002764 Process Immune response-regulating signaling pathway IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604812 6603 ENSG00000239998
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N149
Protein name Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)
Protein function Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic ba
PDB 2OTP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00047 ig 327 → 409 Immunoglobulin domain Domain
PF13895 Ig_2 28 → 116 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level) (PubMed:12529506, PubMed:22479404). Expression levels are very low or not detectable on monocytes, T-cells, B-cells, d
Sequence
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHL
YRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVV
TGAY
SKPTLSALPSPVVTLGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIF
SVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESL
TLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHN
LSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGA
GHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLP
SDPLELVVSEA
AETLSPSQNKTDSTTTSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDA
AGR
Sequence length 483
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Osteoclast differentiation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
B cell receptor signaling pathway