Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	3885
Gene name	Keratin 34
Gene symbol	KRT34
Synonyms (NCBI Gene)	HA4Ha-4K34KRTHA4hHa4
Chromosome	17
Chromosome location	17q21.2
Summary	The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome

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miRTarBase ID	miRNA	Experiments
MIRT1101276	hsa-miR-3180-5p	CLIP-seq
MIRT1101277	hsa-miR-33a	CLIP-seq
MIRT1101278	hsa-miR-33b	CLIP-seq
MIRT1101279	hsa-miR-3646	CLIP-seq
MIRT1101280	hsa-miR-3919	CLIP-seq
MIRT1101281	hsa-miR-4279	CLIP-seq
MIRT1101282	hsa-miR-4633-5p	CLIP-seq
MIRT1101283	hsa-miR-4670-3p	CLIP-seq
MIRT1101284	hsa-miR-502-5p	CLIP-seq
MIRT1101285	hsa-miR-520a-5p	CLIP-seq
MIRT1101286	hsa-miR-525-5p	CLIP-seq
MIRT1101287	hsa-miR-539	CLIP-seq
MIRT2027573	hsa-miR-583	CLIP-seq
MIRT2258871	hsa-miR-873	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002009	Process	Morphogenesis of an epithelium	IBA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005198	Function	Structural molecule activity	NAS	9756910
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005882	Component	Intermediate filament	IEA
GO:0008544	Process	Epidermis development	TAS	9756910
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0030855	Process	Epithelial cell differentiation	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045109	Process	Intermediate filament organization	IBA

MIM	HGNC	e!Ensembl
602763	6452	ENSG00000131737

O76011

Protein name

Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00038	Filament	97 → 408	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in the hair follicles. {ECO:0000269|PubMed:9756910}.

Sequence

MLYAKPPPTINGIKGLQRKERLKPAHIHLQQLTCFSITCSSTMSYSCCLPSLGCRTSCSS
RPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLE
RDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEELQQKILCAKAENARLVVNIDNAKLAS
DDFRSKYQTEQSLRLLVESDINSIRRILDELTLCKSDLESQVESLREELICLKKNHEEEV
NTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEALVEINRREVEQWFATQTEELNKQV
VSSSEQLQSCQAEIIELRRTVNALEIELQAQHNLRDSLENTLTESEAHYSSQLSQVQSLI
TNVESQLAEIRCDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLPCNPCATTNAS
GNSCGPCGTSQKGCCN

Sequence length

436

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Estrogen signaling pathway	Keratinization
Staphylococcus aureus infection	Formation of the cornified envelope

KRT34 (keratin 34)

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