KRT33B (keratin 33B)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3884
• Gene name: Keratin 33B
• Gene symbol: KRT33B
• Synonyms (NCBI Gene): HA3II, Ha-3II, K33B, KRTHA3A, KRTHA3B, hHa3-II
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protei

miRNA Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT561155	hsa-miR-548m	PAR-CLIP	20371350
MIRT561154	hsa-miR-3925-5p	PAR-CLIP	20371350
MIRT561153	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT561152	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT561150	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT561151	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT561149	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT561148	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT561147	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT561146	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT561145	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT561144	hsa-miR-922	PAR-CLIP	20371350
MIRT561143	hsa-miR-4650-3p	PAR-CLIP	20371350
MIRT1101254	hsa-miR-15a	CLIP-seq
MIRT1101255	hsa-miR-15b	CLIP-seq
MIRT1101256	hsa-miR-16	CLIP-seq
MIRT1101257	hsa-miR-1827	CLIP-seq
MIRT1101258	hsa-miR-195	CLIP-seq
MIRT1101259	hsa-miR-2117	CLIP-seq
MIRT1101260	hsa-miR-24	CLIP-seq
MIRT1101261	hsa-miR-3180-5p	CLIP-seq
MIRT1101262	hsa-miR-323b-5p	CLIP-seq
MIRT1101263	hsa-miR-3667-3p	CLIP-seq
MIRT1101264	hsa-miR-3919	CLIP-seq
MIRT1101265	hsa-miR-424	CLIP-seq
MIRT1101266	hsa-miR-4273	CLIP-seq
MIRT1101267	hsa-miR-4279	CLIP-seq
MIRT1101268	hsa-miR-4677-5p	CLIP-seq
MIRT1101269	hsa-miR-4756-3p	CLIP-seq
MIRT1101270	hsa-miR-497	CLIP-seq
MIRT1101271	hsa-miR-520a-5p	CLIP-seq
MIRT1101272	hsa-miR-525-5p	CLIP-seq
MIRT1101273	hsa-miR-591	CLIP-seq
MIRT1101274	hsa-miR-645	CLIP-seq
MIRT1101275	hsa-miR-759	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002009	Process	Morphogenesis of an epithelium	IBA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	23455924, 25416956, 25910212, 26871637, 31515488, 32296183, 32814053
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005882	Component	Intermediate filament	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0030855	Process	Epithelial cell differentiation	IBA
GO:0042633	Process	Hair cycle	IDA	21916889
GO:0045095	Component	Keratin filament	IBA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 602762
• HGNC: 6451
• e!Ensembl: ENSG00000131738

Protein

• UniProt ID: Q14525
• Protein name: Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00038	Filament	55 → 366	Intermediate filament protein	Coiled-coil

• Sequence:

  MPYNFCLPSLSCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETM
  QFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQKILCS
  KSENARLVVQIDNAKLAADDFRTKYQTEQSLRQLVESDINSLRRILDELTLCRSDLEAQM
  ESLKEELLSLKQNHEQEVNTLRCQLGDRLNVEVDAAPAVDLNQVLNETRNQYEALVETNR
  REVEQWFATQTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHNLRYSLENTL
  TESEARYSSQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLL
  ESEDCKLPSNPCATTNACEKPIGSCVTNPCGPRSRCGPCNTFGY

• Sequence length: 404

Pathways

KEGG Pathway	Reactome Pathway
Estrogen signaling pathway	Keratinization
Staphylococcus aureus infection	Formation of the cornified envelope

Related Genes

Sort by: Blended Diseases Pathways Evidence source

LOC100653049 4 shared pathwaysEstrogen signaling pathway, Staphylococcus aureus infection, Keratinization, Formation of the cornified envelope Related via 4 shared pathways including Estrogen signaling pathway, Staphylococcus aureus infection. KRT40 4 shared pathwaysEstrogen signaling pathway, Staphylococcus aureus infection, Keratinization, Formation of the cornified envelope Related via 4 shared pathways including Estrogen signaling pathway, Staphylococcus aureus infection. KRT25 4 shared pathwaysEstrogen signaling pathway, Staphylococcus aureus infection, Keratinization, Formation of the cornified envelope Related via 4 shared pathways including Estrogen signaling pathway, Staphylococcus aureus infection. KRT28 4 shared pathwaysEstrogen signaling pathway, Staphylococcus aureus infection, Keratinization, Formation of the cornified envelope Related via 4 shared pathways including Estrogen signaling pathway, Staphylococcus aureus infection. KRT24 4 shared pathwaysEstrogen signaling pathway, Staphylococcus aureus infection, Keratinization, Formation of the cornified envelope Related via 4 shared pathways including Estrogen signaling pathway, Staphylococcus aureus infection.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
LOC100653049	0	[]	4	["Estrogen signaling pathway","Staphylococcus aureus infection","Keratinization","Formation of the cornified envelope"]	0	[]
KRT40	0	[]	4	["Estrogen signaling pathway","Staphylococcus aureus infection","Keratinization","Formation of the cornified envelope"]	0	[]
KRT25	0	[]	4	["Estrogen signaling pathway","Staphylococcus aureus infection","Keratinization","Formation of the cornified envelope"]	0	[]
KRT28	0	[]	4	["Estrogen signaling pathway","Staphylococcus aureus infection","Keratinization","Formation of the cornified envelope"]	0	[]
KRT24	0	[]	4	["Estrogen signaling pathway","Staphylococcus aureus infection","Keratinization","Formation of the cornified envelope"]	0	[]

Diseases Linked via Similar Genes

Androgenetic alopecia Linked via 1 of 5 related genesKRT25 Hypotrichosis Linked via 1 of 5 related genesKRT25 Woolly hair Linked via 1 of 5 related genesKRT25 Asthma Linked via 1 of 5 related genesKRT24

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Androgenetic alopecia	1	["KRT25"]
Hypotrichosis	1	["KRT25"]
Woolly hair	1	["KRT25"]
Asthma	1	["KRT24"]