KIF27 (kinesin family member 27)

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Gene Gene information from NCBI Gene database.
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Entrez ID 55582
Gene name Kinesin family member 27
Gene symbol KIF27
Synonyms (NCBI Gene)
-
Chromosome 9
Chromosome location 9q21.32
Summary This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal mot
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT017021 hsa-miR-335-5p Microarray 18185580
MIRT447144 hsa-miR-583 PAR-CLIP 22100165
MIRT447143 hsa-miR-196a-5p PAR-CLIP 22100165
MIRT447142 hsa-miR-196b-5p PAR-CLIP 22100165
MIRT447141 hsa-miR-27b-5p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003351 Process Epithelial cilium movement involved in extracellular fluid movement IEA
GO:0003777 Function Microtubule motor activity IBA
GO:0003777 Function Microtubule motor activity IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
611253 18632 ENSG00000165115
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VH2
Protein name Kinesin-like protein KIF27
Protein function Plays an essential role in motile ciliogenesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00225 Kinesin 11 → 341 Kinesin motor domain Domain
Tissue specificity TISSUE SPECIFICITY: Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.
Sequence 
MEEIPVKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEV
YNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQS
ISEHPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAG
EVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKF
HFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITR
LLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEME
FEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFT
FLVDLKDTVRLNEKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKR
ELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIE
QQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQD
SRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTR
CRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILT
EAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQK
QLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANE
LEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDL
DACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKE
ALLQEKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQV
EVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQ
KSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMK
VLERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMETFKTYE
DKIQQLEKDLYFYKKTSRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPEGGGMLSEE
LKWASRPESMKLSGREREMDSSASSLRTQPNPQKLWEDIPELPPIHSSLAPPSGHMLGNE
NKTETDDNQFTKSHSRLSSQIQVVGNVGRLHGVTPVKLCRKELRQISALELSLRRSSLGV
GIGSMAADSIEVSRKPRDLKT
Sequence length 1401
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Motor proteins COPI-dependent Golgi-to-ER retrograde traffic
  Kinesins
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KIF1C 3 shared pathwaysMotor proteins, COPI-dependent Golgi-to-ER retrograde traffic, Kinesins Related via 3 shared pathways including Motor proteins, COPI-dependent Golgi-to-ER retrograde traffic. KIF12 3 shared pathwaysMotor proteins, COPI-dependent Golgi-to-ER retrograde traffic, Kinesins Related via 3 shared pathways including Motor proteins, COPI-dependent Golgi-to-ER retrograde traffic. KIF19 3 shared pathwaysMotor proteins, COPI-dependent Golgi-to-ER retrograde traffic, Kinesins Related via 3 shared pathways including Motor proteins, COPI-dependent Golgi-to-ER retrograde traffic. KIF18B 3 shared pathwaysMotor proteins, COPI-dependent Golgi-to-ER retrograde traffic, Kinesins Related via 3 shared pathways including Motor proteins, COPI-dependent Golgi-to-ER retrograde traffic. KIF6 3 shared pathwaysMotor proteins, COPI-dependent Golgi-to-ER retrograde traffic, Kinesins Related via 3 shared pathways including Motor proteins, COPI-dependent Golgi-to-ER retrograde traffic.
Obesity Linked via 2 of 5 related genesKIF1C, KIF6 Scoliosis Linked via 2 of 5 related genesKIF1C, KIF6 Migraine Linked via 2 of 5 related genesKIF18B, KIF6 Ataxia, spastic, autosomal recessive Linked via 1 of 5 related genesKIF1C Spastic paraplegia Linked via 1 of 5 related genesKIF1C