Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	8519
Gene name	Interferon induced transmembrane protein 1
Gene symbol	IFITM1
Synonyms (NCBI Gene)	9-27CD225DSPA2aIFI17LEU13
Chromosome	11
Chromosome location	11p15.5

116 Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006992	hsa-miR-130a-3p	Luciferase reporter assay	22787204
MIRT018732	hsa-miR-335-5p	Microarray	18185580
MIRT021233	hsa-miR-146a-5p	Microarray	18057241
MIRT452119	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT452118	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT452117	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT452116	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT452115	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT452114	hsa-miR-503-3p	PAR-CLIP	23592263
MIRT452113	hsa-miR-3650	PAR-CLIP	23592263
MIRT452112	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT452111	hsa-miR-6793-5p	PAR-CLIP	23592263
MIRT452110	hsa-miR-3911	PAR-CLIP	23592263
MIRT452109	hsa-miR-644a	PAR-CLIP	23592263
MIRT452108	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT452107	hsa-miR-6759-5p	PAR-CLIP	23592263
MIRT452106	hsa-miR-147a	PAR-CLIP	23592263
MIRT006992	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT755950	hsa-miR-363-3p	PAR-CLIP	27292025
MIRT452119	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT452118	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT452117	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT452116	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT452115	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT452114	hsa-miR-503-3p	PAR-CLIP	23592263
MIRT452113	hsa-miR-3650	PAR-CLIP	23592263
MIRT452112	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT452111	hsa-miR-6793-5p	PAR-CLIP	23592263
MIRT452110	hsa-miR-3911	PAR-CLIP	23592263
MIRT452109	hsa-miR-644a	PAR-CLIP	23592263
MIRT452108	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT452107	hsa-miR-6759-5p	PAR-CLIP	23592263
MIRT452106	hsa-miR-147a	PAR-CLIP	23592263
MIRT755950	hsa-miR-363-3p	Luciferase reporter assayWestern blottingqRT-PCRImmunohistochemistry (IHC)	37746648
MIRT1060540	hsa-miR-1183	CLIP-seq
MIRT1060541	hsa-miR-3117-5p	CLIP-seq
MIRT1060542	hsa-miR-425	CLIP-seq
MIRT1060543	hsa-miR-4325	CLIP-seq
MIRT1060540	hsa-miR-1183	CLIP-seq
MIRT2437699	hsa-miR-147	CLIP-seq
MIRT1060541	hsa-miR-3117-5p	CLIP-seq
MIRT2437700	hsa-miR-3934	CLIP-seq
MIRT2437701	hsa-miR-4718	CLIP-seq
MIRT2437702	hsa-miR-548g	CLIP-seq
MIRT2437703	hsa-miR-552	CLIP-seq
MIRT2437704	hsa-miR-644	CLIP-seq
MIRT1060540	hsa-miR-1183	CLIP-seq
MIRT2549807	hsa-miR-1207-5p	CLIP-seq
MIRT2549808	hsa-miR-122	CLIP-seq
MIRT2549809	hsa-miR-128	CLIP-seq
MIRT2549810	hsa-miR-1286	CLIP-seq
MIRT2549811	hsa-miR-130a	CLIP-seq
MIRT2549812	hsa-miR-130b	CLIP-seq
MIRT2437699	hsa-miR-147	CLIP-seq
MIRT2549813	hsa-miR-1909	CLIP-seq
MIRT2549814	hsa-miR-19a	CLIP-seq
MIRT2549815	hsa-miR-19b	CLIP-seq
MIRT2549816	hsa-miR-25	CLIP-seq
MIRT2549817	hsa-miR-301a	CLIP-seq
MIRT2549818	hsa-miR-301b	CLIP-seq
MIRT1060541	hsa-miR-3117-5p	CLIP-seq
MIRT2549819	hsa-miR-32	CLIP-seq
MIRT2549820	hsa-miR-338-3p	CLIP-seq
MIRT2549821	hsa-miR-363	CLIP-seq
MIRT2549822	hsa-miR-367	CLIP-seq
MIRT2549823	hsa-miR-3918	CLIP-seq
MIRT2437700	hsa-miR-3934	CLIP-seq
MIRT2549824	hsa-miR-4310	CLIP-seq
MIRT2549825	hsa-miR-4323	CLIP-seq
MIRT2549826	hsa-miR-454	CLIP-seq
MIRT2549827	hsa-miR-4640-5p	CLIP-seq
MIRT2549828	hsa-miR-4688	CLIP-seq
MIRT2437701	hsa-miR-4718	CLIP-seq
MIRT2549829	hsa-miR-4726-5p	CLIP-seq
MIRT2549830	hsa-miR-4763-3p	CLIP-seq
MIRT2549831	hsa-miR-486-3p	CLIP-seq
MIRT2437702	hsa-miR-548g	CLIP-seq
MIRT2437703	hsa-miR-552	CLIP-seq
MIRT2437704	hsa-miR-644	CLIP-seq
MIRT2549832	hsa-miR-92a	CLIP-seq
MIRT2549833	hsa-miR-92b	CLIP-seq
MIRT1060540	hsa-miR-1183	CLIP-seq
MIRT2549807	hsa-miR-1207-5p	CLIP-seq
MIRT2549808	hsa-miR-122	CLIP-seq
MIRT2549809	hsa-miR-128	CLIP-seq
MIRT2549810	hsa-miR-1286	CLIP-seq
MIRT2549811	hsa-miR-130a	CLIP-seq
MIRT2549812	hsa-miR-130b	CLIP-seq
MIRT2437699	hsa-miR-147	CLIP-seq
MIRT2549813	hsa-miR-1909	CLIP-seq
MIRT2549814	hsa-miR-19a	CLIP-seq
MIRT2549815	hsa-miR-19b	CLIP-seq
MIRT2549816	hsa-miR-25	CLIP-seq
MIRT2549817	hsa-miR-301a	CLIP-seq
MIRT2549818	hsa-miR-301b	CLIP-seq
MIRT1060541	hsa-miR-3117-5p	CLIP-seq
MIRT2549819	hsa-miR-32	CLIP-seq
MIRT2549820	hsa-miR-338-3p	CLIP-seq
MIRT2549821	hsa-miR-363	CLIP-seq
MIRT2549822	hsa-miR-367	CLIP-seq
MIRT2549823	hsa-miR-3918	CLIP-seq
MIRT2437700	hsa-miR-3934	CLIP-seq
MIRT2549824	hsa-miR-4310	CLIP-seq
MIRT2549825	hsa-miR-4323	CLIP-seq
MIRT2549826	hsa-miR-454	CLIP-seq
MIRT2549827	hsa-miR-4640-5p	CLIP-seq
MIRT2549828	hsa-miR-4688	CLIP-seq
MIRT2437701	hsa-miR-4718	CLIP-seq
MIRT2549829	hsa-miR-4726-5p	CLIP-seq
MIRT2549830	hsa-miR-4763-3p	CLIP-seq
MIRT2549831	hsa-miR-486-3p	CLIP-seq
MIRT2437702	hsa-miR-548g	CLIP-seq
MIRT2437703	hsa-miR-552	CLIP-seq
MIRT2437704	hsa-miR-644	CLIP-seq
MIRT2549832	hsa-miR-92a	CLIP-seq
MIRT2549833	hsa-miR-92b	CLIP-seq

35 Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	2398277, 8409388, 26354436
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	26354436
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26354436
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7559564
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	7559564
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	20838853
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	7559564
GO:0009615	Process	Response to virus	IDA	21253575, 22479637
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	20838853
GO:0032991	Component	Protein-containing complex	IDA	28246125
GO:0034341	Process	Response to type II interferon	IBA
GO:0034341	Process	Response to type II interferon	IDA	21253575
GO:0035455	Process	Response to interferon-alpha	IBA
GO:0035455	Process	Response to interferon-alpha	IDA	22479637
GO:0035456	Process	Response to interferon-beta	IBA
GO:0035456	Process	Response to interferon-beta	IDA	21253575
GO:0045071	Process	Negative regulation of viral genome replication	IBA
GO:0045071	Process	Negative regulation of viral genome replication	IDA	21253575
GO:0045071	Process	Negative regulation of viral genome replication	IMP	21976647
GO:0045087	Process	Innate immune response	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IMP	22634173
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IBA
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	21253575, 23358889, 26354436
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0060337	Process	Type I interferon-mediated signaling pathway	IBA

MIM	HGNC	e!Ensembl
604456	5412	ENSG00000185885

P13164

Protein name

Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225)

Protein function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, includi

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04505	CD225	33 → 100	Interferon-induced transmembrane protein	Family

Tissue specificity

TISSUE SPECIFICITY: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. {ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:22634173}.

Sequence

MHKEEHEVAVLGPPPSTILPRSTVINIHSETSVPDHVVWSLFNTLFLNWCCLGFIAFAYS
VKSRDRKMVGDVTGAQAYASTAKCLNIWALILGILMTIGFILLLVFGSVTVYHIMLQIIQ
EKRGY

Sequence length

125

Interactions

View interactions

KEGG Pathway	Reactome Pathway
B cell receptor signaling pathway	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Interferon alpha/beta signaling

IFITM1 (interferon induced transmembrane protein 1)

Bookmark This Gene